ATE202474T1 - Amantadine und verwandte verbindungen zur anwendung zur behandlung von neuropathie - Google Patents
Amantadine und verwandte verbindungen zur anwendung zur behandlung von neuropathieInfo
- Publication number
- ATE202474T1 ATE202474T1 AT93921355T AT93921355T ATE202474T1 AT E202474 T1 ATE202474 T1 AT E202474T1 AT 93921355 T AT93921355 T AT 93921355T AT 93921355 T AT93921355 T AT 93921355T AT E202474 T1 ATE202474 T1 AT E202474T1
- Authority
- AT
- Austria
- Prior art keywords
- amantadine
- neuropathy
- treatment
- compounds used
- related compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- DKNWSYNQZKUICI-UHFFFAOYSA-N amantadine Chemical compound C1C(C2)CC3CC2CC1(N)C3 DKNWSYNQZKUICI-UHFFFAOYSA-N 0.000 title 1
- 229960003805 amantadine Drugs 0.000 title 1
- 201000001119 neuropathy Diseases 0.000 title 1
- 230000007823 neuropathy Effects 0.000 title 1
- 208000033808 peripheral neuropathy Diseases 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 abstract 2
- 108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 abstract 2
- 206010029350 Neurotoxicity Diseases 0.000 abstract 2
- 206010044221 Toxic encephalopathy Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 230000007135 neurotoxicity Effects 0.000 abstract 2
- 231100000228 neurotoxicity Toxicity 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000003961 neuronal insult Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/939,824 US5334618A (en) | 1991-04-04 | 1992-09-03 | Method of preventing NMDA receptor-mediated neuronal damage |
| PCT/US1993/008344 WO1994005275A1 (en) | 1992-09-03 | 1993-09-03 | Method of preventing nmda receptor-mediated neuronal damage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE202474T1 true ATE202474T1 (de) | 2001-07-15 |
Family
ID=25473800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93921355T ATE202474T1 (de) | 1992-09-03 | 1993-09-03 | Amantadine und verwandte verbindungen zur anwendung zur behandlung von neuropathie |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5334618A (de) |
| EP (1) | EP0660707B1 (de) |
| JP (2) | JPH08501297A (de) |
| AT (1) | ATE202474T1 (de) |
| AU (1) | AU4847693A (de) |
| CA (1) | CA2143752C (de) |
| DE (1) | DE69330387T2 (de) |
| DK (1) | DK0660707T3 (de) |
| ES (1) | ES2159528T3 (de) |
| GR (1) | GR3036657T3 (de) |
| PT (1) | PT660707E (de) |
| WO (1) | WO1994005275A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2714828B1 (fr) * | 1994-01-12 | 1996-02-02 | Rhone Poulenc Rorer Sa | Application du riluzole dans le traitement des maladies mitochondriales. |
| US6025369A (en) * | 1996-05-03 | 2000-02-15 | The Board Of Regents Of The University Nebraska | N-methyl-D-aspartate (NMDA) receptor blockers for the prevention of atherosclerosis |
| EP1061924A1 (de) * | 1998-03-09 | 2000-12-27 | Trustees Of Tufts College | Behandlung von compulsiven verhalten bei menschen und tieren |
| US20070197651A1 (en) * | 1998-03-09 | 2007-08-23 | Tufts University | Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors |
| US20060167114A1 (en) * | 1998-03-09 | 2006-07-27 | Louis Shuster | Treatment of stereotypic, self-injurious and compulsive behaviors in man and animals using antagonists of NMDA receptors |
| GB9901691D0 (en) * | 1999-01-26 | 1999-03-17 | Cerebrus Ltd | Chemical compounds |
| US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
| AU5702201A (en) * | 2000-04-13 | 2001-10-30 | Mayo Foundation | Abeta<sub>42</sub> lowering agents |
| EP1201234A3 (de) * | 2000-09-21 | 2003-03-12 | Tinnitus Forschungs- und Entwicklungs GmbH | Behandlung von Erkrankungen mit Adamantan-derivaten |
| EP1190711A1 (de) * | 2000-09-21 | 2002-03-27 | Tinnitus Forschungs- und Entwicklungs GmbH | Behandlung von Erkrankungen mit Adamantan-derivaten |
| EP1190708A1 (de) * | 2000-09-21 | 2002-03-27 | Tinnitus Forschungs- und Entwicklungs GmbH | Medizinische Verwendung von Verbindungen |
| EP1852113A3 (de) * | 2000-12-07 | 2008-03-12 | Neuromolecular Inc. | Verfahren zur Behandlung neuropsychiatrischer Erkrankungen mit NMDA-Rezeptorantagonisten |
| MXPA03005130A (es) * | 2000-12-07 | 2004-12-06 | Neuromolecular Inc | Metodos para tratar trastornos neurosiquiatricos con antagonistas del receptor del nmda. |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| WO2003020257A2 (de) * | 2001-08-29 | 2003-03-13 | Eucro European Contract Research Gmbh & Co. Kg | VERWENDUNG VON β-ADRENOZEPTOR-AGONISTEN ZUR BEHANDLUNG VON NEURODEGENERATIVEN ERKRANKUNGEN |
| GB0202161D0 (en) * | 2002-01-30 | 2002-03-20 | Vernalis Res Ltd | Chemical compounds V |
| WO2004034963A2 (en) * | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| US8557855B2 (en) * | 2002-07-03 | 2013-10-15 | Allergan, Inc. | Methods of using ryanodine antagonists in treating neural injury |
| US20050148673A1 (en) * | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
| CN100339070C (zh) | 2002-10-24 | 2007-09-26 | 莫茨药物股份两合公司 | 包含1-氨基环己烷衍生物类和乙酰胆碱酯酶抑制剂类的药物组合物 |
| EP1603548A4 (de) * | 2003-02-05 | 2007-10-10 | Myriad Genetics Inc | Verfahren und zusammensetzung zur behandlung neurodegenerativer erkrankungen |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| UA80055C2 (en) * | 2003-05-27 | 2007-08-10 | Forest Laboratories | Combination of nmda-receptor antagonist and selective inhibitor of serotonin reuptake for a depression and other pscihiatric disorders treatment |
| WO2005065069A2 (en) * | 2003-07-11 | 2005-07-21 | Myriad Genetics, Inc. | Pharmaceutical methods, dosing regimes and dosage forms for the treatment of alzheimer's disease |
| AR046314A1 (es) | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
| UY28650A1 (es) * | 2003-12-05 | 2005-02-28 | Forest Laboratories | Memantina para la prevencion o disminucion de la conducta suicida y para el tratamiento de la depresion mayor asociada con esta conducta |
| SI1703902T1 (sl) * | 2004-01-05 | 2011-02-28 | Merz Pharma Gmbh & Co Kgaa | Memantin za zdravljenje blage do zmerne Alzheimerjeve bolezni |
| EP1715843A1 (de) * | 2004-01-29 | 2006-11-02 | Neuromolecular Inc. | Kombination eines nmda-rezeptor-antagonisten und eines mao-hemmers oder eines gadph-hemmers zur behandlung von erkrankungen im zusammenhang mit dem zentralen nervensystem |
| TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
| WO2006001877A2 (en) * | 2004-04-13 | 2006-01-05 | Myriad Genetics, Inc. | Combination treatment for neurodegenerative disorders comprising r-flurbiprofen |
| BRPI0512263A (pt) | 2004-06-17 | 2008-02-26 | Merz Pharma Gmbh & Co Kgaa | formulações de liberação imediata de formas de dosagem oral de memantina |
| WO2006009769A1 (en) * | 2004-06-17 | 2006-01-26 | Forest Laboratories, Inc. | Modified release formulation of memantine |
| US20060002999A1 (en) | 2004-06-17 | 2006-01-05 | Forest Laboratories, Inc. | Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane |
| TW200616608A (en) * | 2004-07-09 | 2006-06-01 | Forest Laboratories | Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients |
| WO2006020852A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| CA2618985A1 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| WO2006020850A2 (en) * | 2004-08-11 | 2006-02-23 | Myriad Genetics, Inc. | Pharmaceutical composition and method for treating neurodegenerative disorders |
| CN100351225C (zh) * | 2004-10-28 | 2007-11-28 | 中国医学科学院医药生物技术研究所 | 一组金刚烷胺类衍生物及其合成方法和作为神经元损伤保护剂的应用 |
| AU2005309601A1 (en) | 2004-11-23 | 2006-06-01 | Neuromolecular Pharmaceuticals, Inc. | Composition comprising a sustained release coating or matrix and an NMDA receptor antagonist, method for administration such NMDA antagonist to a subject |
| US8058291B2 (en) | 2005-04-06 | 2011-11-15 | Adamas Pharmaceuticals, Inc. | Methods and compositions for the treatment of CNS-related conditions |
| US7619007B2 (en) * | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
| EP2623099A1 (de) | 2004-11-24 | 2013-08-07 | Neuromolecular Pharmaceuticals, Inc | Zusammensetzung und Verfahren zur Behandlung neurologischer Erkrankungen |
| US20060205822A1 (en) * | 2004-12-22 | 2006-09-14 | Forest Laboratories, Inc. | 1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect |
| US20080009546A1 (en) * | 2005-05-06 | 2008-01-10 | Chevron U.S.A. Inc. | Diamondoid derivatives possessing therapeutic activity in the treatment of neurologic disorders |
| EA013474B1 (ru) * | 2005-06-16 | 2010-04-30 | Форест Лэборэтериз, Инк. | Композиция в виде гранул с модифицированным и немедленным высвобождением мемантина |
| EP2040676A2 (de) * | 2006-07-06 | 2009-04-01 | Forest Laboratories, Inc. | Oral lösliche memantin-formulierungen |
| EP2046119A2 (de) * | 2006-07-07 | 2009-04-15 | Myriad Genetics, Inc. | Behandlung von psychiatrischen störungen |
| US20090247644A1 (en) * | 2008-03-28 | 2009-10-01 | Forest Laboratories Holdings Limited | Memantine formulations |
| EP2138173A1 (de) | 2008-06-26 | 2009-12-30 | Merz Pharma GmbH & Co.KGaA | Pharmazeutische Zusammensetzungen mit Aminoadamantan-Derivaten |
| JP5885668B2 (ja) | 2009-12-02 | 2016-03-15 | アダマス ファーマシューティカルズ, インコーポレイテッド | アマンタジン組成物および使用方法 |
| SG10201503402XA (en) | 2010-01-27 | 2015-06-29 | Takeda Pharmaceutical | Compounds for suppressing a peripheral nerve disorder induced by an anti-cancer agent |
| JP5562716B2 (ja) * | 2010-05-12 | 2014-07-30 | 花王株式会社 | 電位依存性カチオンチャネル抑制剤 |
| WO2014204933A1 (en) | 2013-06-17 | 2014-12-24 | Adamas Pharmaceuticals, Inc. | Amantadine compositions and methods of use |
| CA3081604A1 (en) * | 2017-11-22 | 2019-05-31 | Panorama Research, Inc. | Aminoadamantyl nitrate compounds and their use to treat cns disorders |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328251A (en) * | 1965-12-30 | 1967-06-27 | Du Pont | Pharmaceutical compositions and methods utilizing 2-aminoadamantane and its derivatives |
| US3391142A (en) * | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
| US3456057A (en) * | 1968-06-28 | 1969-07-15 | Du Pont | Pharmaceutical compositions and methods utilizing 3-aminotricyclo(4.3.1.1**3.8)undecanes |
| NL7305644A (de) * | 1972-04-20 | 1973-10-23 | ||
| IL53441A0 (en) * | 1977-11-22 | 1978-01-31 | Teva Pharma | Methyladamantyl hydrazines their preparation and pharmaceutical compositions containing them |
| US4148896A (en) * | 1978-02-22 | 1979-04-10 | E. I. Du Pont De Nemours And Company | Antidepressant combination |
| US4351847A (en) * | 1981-06-26 | 1982-09-28 | Pennwalt Corporation | Antiviral alpha, alpha-dialkyl adamantylethylamines |
| US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
| US4837218A (en) * | 1987-10-23 | 1989-06-06 | Washington University | Alkylated bicycloalkaneamines for treatment of neurotoxic injury |
| DE10299048I2 (de) * | 1989-04-14 | 2006-07-13 | Merz Pharma Gmbh & Co Kgaa | Verwendung von Adamantan-Derivaten zur Pr{vention und Behandlung der cerebralen Isch{mie |
| DE3940410A1 (de) * | 1989-12-04 | 1991-06-06 | Schering Ag | Neue verwendung von nmda-rezeptor-antagonisten |
| WO1992017168A1 (en) * | 1991-04-04 | 1992-10-15 | The Children's Medical Center Corporation | Method of preventing nmda receptor-mediated neuronal damage |
| US5124319A (en) * | 1991-10-11 | 1992-06-23 | American Home Products Corporation | Benzimidazole phosphono-amino acids |
-
1992
- 1992-09-03 US US07/939,824 patent/US5334618A/en not_active Expired - Lifetime
-
1993
- 1993-09-03 EP EP93921355A patent/EP0660707B1/de not_active Expired - Lifetime
- 1993-09-03 CA CA002143752A patent/CA2143752C/en not_active Expired - Lifetime
- 1993-09-03 PT PT93921355T patent/PT660707E/pt unknown
- 1993-09-03 DE DE69330387T patent/DE69330387T2/de not_active Expired - Lifetime
- 1993-09-03 DK DK93921355T patent/DK0660707T3/da active
- 1993-09-03 AT AT93921355T patent/ATE202474T1/de active
- 1993-09-03 ES ES93921355T patent/ES2159528T3/es not_active Expired - Lifetime
- 1993-09-03 WO PCT/US1993/008344 patent/WO1994005275A1/en not_active Ceased
- 1993-09-03 AU AU48476/93A patent/AU4847693A/en not_active Abandoned
- 1993-09-03 JP JP6507482A patent/JPH08501297A/ja active Pending
-
2001
- 2001-09-18 GR GR20010401515T patent/GR3036657T3/el unknown
-
2005
- 2005-12-07 JP JP2005354152A patent/JP2006077034A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69330387T2 (de) | 2002-05-16 |
| EP0660707B1 (de) | 2001-06-27 |
| EP0660707A1 (de) | 1995-07-05 |
| WO1994005275A1 (en) | 1994-03-17 |
| DK0660707T3 (da) | 2001-10-01 |
| CA2143752C (en) | 2008-11-18 |
| EP0660707A4 (de) | 1998-05-13 |
| AU4847693A (en) | 1994-03-29 |
| DE69330387D1 (de) | 2001-08-02 |
| JPH08501297A (ja) | 1996-02-13 |
| JP2006077034A (ja) | 2006-03-23 |
| US5334618A (en) | 1994-08-02 |
| PT660707E (pt) | 2001-11-30 |
| ES2159528T3 (es) | 2001-10-16 |
| CA2143752A1 (en) | 1994-03-17 |
| GR3036657T3 (en) | 2001-12-31 |
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