ATE317912T1 - Verfahren zur herstellung von beta-lactamen - Google Patents

Verfahren zur herstellung von beta-lactamen

Info

Publication number
ATE317912T1
ATE317912T1 AT91912658T AT91912658T ATE317912T1 AT E317912 T1 ATE317912 T1 AT E317912T1 AT 91912658 T AT91912658 T AT 91912658T AT 91912658 T AT91912658 T AT 91912658T AT E317912 T1 ATE317912 T1 AT E317912T1
Authority
AT
Austria
Prior art keywords
beta
lactamen
producing beta
lactam
concentration
Prior art date
Application number
AT91912658T
Other languages
English (en)
Inventor
Svend Gunnar Kaasgaard
Ulla Veitland
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE317912T1 publication Critical patent/ATE317912T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91912658T 1990-07-04 1991-07-03 Verfahren zur herstellung von beta-lactamen ATE317912T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90610045 1990-07-04

Publications (1)

Publication Number Publication Date
ATE317912T1 true ATE317912T1 (de) 2006-03-15

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91912658T ATE317912T1 (de) 1990-07-04 1991-07-03 Verfahren zur herstellung von beta-lactamen

Country Status (17)

Country Link
US (1) US5525483A (de)
EP (1) EP0537255B1 (de)
JP (1) JP3115593B2 (de)
KR (1) KR100222606B1 (de)
AT (1) ATE317912T1 (de)
AU (1) AU8208691A (de)
CA (1) CA2086250C (de)
CZ (1) CZ381392A3 (de)
DE (1) DE69133509T2 (de)
ES (1) ES2258260T3 (de)
FI (1) FI925988A7 (de)
NO (1) NO307710B1 (de)
PT (1) PT98205B (de)
RU (1) RU2136759C1 (de)
SK (1) SK381392A3 (de)
WO (1) WO1992001061A1 (de)
ZA (1) ZA915142B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5470717A (en) * 1991-12-19 1995-11-28 Gist-Brocades N.V. Method for the preparation of certain β-lactam antibiotics
ATE183778T1 (de) * 1992-04-24 1999-09-15 Lilly Co Eli Verfahren zur herstellung von cephalosporinen
AU6106794A (en) * 1993-02-15 1994-08-29 Gist-Brocades N.V. An improved beta -lactam antibiotic composition
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
US5753458A (en) * 1994-06-10 1998-05-19 Gist-Brocades B.V. Acylation method for penicillins and cephalosporins
DE69512917D1 (de) * 1994-07-18 1999-11-25 Dsm Nv Verfahren zur herstellung von beta-lactamen mit dauernd hochkonzentrierten reagenzien
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
ATE191932T1 (de) * 1995-02-28 2000-05-15 Acs Dobfar Spa Verfahren zur enzymatischen synthese von beta- laktam antibiotika in anwesenheit von einem enzyminhibitor
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
EP0865443B1 (de) * 1995-12-08 2003-03-19 Dsm N.V. Verfahren zur herstellung eines anitibiotkums
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (de) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen
ES2609633T3 (es) 2006-05-19 2017-04-21 Dsm Sinochem Pharmaceuticals Netherlands B.V. Proceso para la cristalización de cefadroxilo monohidrato
US8497088B2 (en) 2007-03-09 2013-07-30 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the preparation of beta-lactam compounds
CN103635585A (zh) 2011-06-23 2014-03-12 中化帝斯曼制药有限公司荷兰公司 用青霉素g酰化酶制备3’-硫代头孢菌素的方法
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (de) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
EP0339751B1 (de) * 1988-04-26 1996-05-29 Gist-Brocades N.V. Verfahren zur enzymatischen Herstellung von beta-Lactamen
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
JP5417030B2 (ja) 2009-04-30 2014-02-12 ニスカ株式会社 シート処理装置及びこれを備えた画像形成システム

Also Published As

Publication number Publication date
US5525483A (en) 1996-06-11
JPH05507623A (ja) 1993-11-04
ZA915142B (en) 1992-05-27
NO307710B1 (no) 2000-05-15
PT98205B (pt) 1998-12-31
SK381392A3 (en) 1995-11-08
EP0537255B1 (de) 2006-02-15
CA2086250C (en) 2001-05-29
PT98205A (pt) 1992-05-29
DE69133509T2 (de) 2006-08-24
WO1992001061A1 (en) 1992-01-23
DE69133509D1 (de) 2006-04-20
FI925988L (fi) 1992-12-31
NO930006L (no) 1993-01-04
KR100222606B1 (en) 1999-10-01
CA2086250A1 (en) 1992-01-05
EP0537255A1 (de) 1993-04-21
ES2258260T3 (es) 2006-08-16
CZ381392A3 (en) 1993-12-15
RU2136759C1 (ru) 1999-09-10
JP3115593B2 (ja) 2000-12-11
FI925988A0 (fi) 1992-12-31
NO930006D0 (no) 1993-01-04
FI925988A7 (fi) 1992-12-31
AU8208691A (en) 1992-02-04

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