ATE317912T1 - Verfahren zur herstellung von beta-lactamen - Google Patents

Verfahren zur herstellung von beta-lactamen

Info

Publication number
ATE317912T1
ATE317912T1 AT91912658T AT91912658T ATE317912T1 AT E317912 T1 ATE317912 T1 AT E317912T1 AT 91912658 T AT91912658 T AT 91912658T AT 91912658 T AT91912658 T AT 91912658T AT E317912 T1 ATE317912 T1 AT E317912T1
Authority
AT
Austria
Prior art keywords
beta
lactamen
producing beta
lactam
concentration
Prior art date
Application number
AT91912658T
Other languages
English (en)
Inventor
Svend Gunnar Kaasgaard
Ulla Veitland
Original Assignee
Dsm Ip Assets Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv filed Critical Dsm Ip Assets Bv
Application granted granted Critical
Publication of ATE317912T1 publication Critical patent/ATE317912T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT91912658T 1990-07-04 1991-07-03 Verfahren zur herstellung von beta-lactamen ATE317912T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP90610045 1990-07-04

Publications (1)

Publication Number Publication Date
ATE317912T1 true ATE317912T1 (de) 2006-03-15

Family

ID=8205872

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91912658T ATE317912T1 (de) 1990-07-04 1991-07-03 Verfahren zur herstellung von beta-lactamen

Country Status (17)

Country Link
US (1) US5525483A (de)
EP (1) EP0537255B1 (de)
JP (1) JP3115593B2 (de)
KR (1) KR100222606B1 (de)
AT (1) ATE317912T1 (de)
AU (1) AU8208691A (de)
CA (1) CA2086250C (de)
CZ (1) CZ381392A3 (de)
DE (1) DE69133509T2 (de)
ES (1) ES2258260T3 (de)
FI (1) FI925988A0 (de)
NO (1) NO307710B1 (de)
PT (1) PT98205B (de)
RU (1) RU2136759C1 (de)
SK (1) SK381392A3 (de)
WO (1) WO1992001061A1 (de)
ZA (1) ZA915142B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3345193A (en) * 1991-12-19 1993-07-19 Novo Nordisk A/S An improved method for the preparation of certain beta-lactam antibiotics
ES2135446T3 (es) * 1992-04-24 1999-11-01 Lilly Co Eli Procedimiento para la preparacion de cefalosporinas.
WO1994017800A1 (en) * 1993-02-15 1994-08-18 Gist-Brocades B.V. AN IMPROVED β-LACTAM ANTIBIOTIC COMPOSITION
BE1007296A3 (nl) * 1993-07-19 1995-05-09 Dsm Nv Werkwijze voor de bereiding van een beta-lactamderivaat.
JPH0719083U (ja) * 1993-09-20 1995-04-04 株式会社江崎製作所 自動二輪車のヘッドパイプ
AUPM543894A0 (en) * 1994-05-04 1994-05-26 Commonwealth Scientific And Industrial Research Organisation An adjuvant
WO1995034675A1 (en) * 1994-06-10 1995-12-21 Gist-Brocades B.V. Improved acylation method for penicillins and cephalosporins
ES2139923T3 (es) * 1994-07-18 2000-02-16 Dsm Nv Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.
BE1009071A3 (nl) * 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
IT1274658B (it) * 1995-02-28 1997-07-18 Acs Dobfar Spa Procedimento enzimatico migliorato per la produzione di penicilline e cefalosporine
PT730036E (pt) * 1995-02-28 2000-07-31 Acs Dobfar Spa Processo para a sintese enzimatica de antibioticos beta-lactamicos na presenca de um inibidor da enzima
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
WO1997022610A1 (en) * 1995-12-08 1997-06-26 Gist-Brocades B.V. Process for the preparation of an antibiotic
TW555855B (en) * 1996-07-26 2003-10-01 Bristol Myers Squibb Co Synthesis of beta-lactam antibacterials using soluble side chain esters and enzyme acylase
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007302C2 (nl) * 1997-10-17 1999-04-20 Dsm Nv Werkwijze voor de bereiding van een ß-lactam antibioticum.
NL1010506C2 (nl) * 1998-11-06 2000-05-09 Dsm Nv Werkwijze voor de bereiding van bêta-lactam antibiotica.
EP1394262A1 (de) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen
KR101420451B1 (ko) 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파드록실의 결정화 방법
BRPI0808685A2 (pt) 2007-03-09 2014-08-19 Dsm Ip Assets Bv Processo para a preparação de derivados semissintéticos de beta-lactama.
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
EP2723882B1 (de) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3079305A (en) * 1959-09-24 1963-02-26 Bayer Ag Process for the enzymatic acylation of 6-aminopenicillanic acid
US3152050A (en) * 1962-12-27 1964-10-06 American Home Prod Enzymatic process for preparing penicillins
JPS5417030B2 (de) * 1972-12-06 1979-06-27
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DE3507403A1 (de) * 1985-03-02 1986-09-04 Hoechst Ag, 6230 Frankfurt Enzymatische semisynthese von ss-lactamantibiotika
ATE138690T1 (de) * 1988-04-26 1996-06-15 Gist Brocades Nv Verfahren zur enzymatischen herstellung von beta- lactamen
ES2036149A6 (es) * 1989-12-12 1993-05-01 Consejo Superior Investigacion Procedimiento de sintesis de antibioticos semiestaticos en sistemas termodinamicamente controlados agua-cosolventes organicos miscibles apolares con el empleo de penicilina g acilasa.
JP5417030B2 (ja) 2009-04-30 2014-02-12 ニスカ株式会社 シート処理装置及びこれを備えた画像形成システム

Also Published As

Publication number Publication date
KR100222606B1 (en) 1999-10-01
US5525483A (en) 1996-06-11
RU2136759C1 (ru) 1999-09-10
ZA915142B (en) 1992-05-27
JP3115593B2 (ja) 2000-12-11
PT98205B (pt) 1998-12-31
NO930006D0 (no) 1993-01-04
EP0537255A1 (de) 1993-04-21
PT98205A (pt) 1992-05-29
AU8208691A (en) 1992-02-04
DE69133509D1 (de) 2006-04-20
NO930006L (no) 1993-01-04
EP0537255B1 (de) 2006-02-15
DE69133509T2 (de) 2006-08-24
SK381392A3 (en) 1995-11-08
FI925988L (fi) 1992-12-31
CA2086250A1 (en) 1992-01-05
CZ381392A3 (en) 1993-12-15
JPH05507623A (ja) 1993-11-04
ES2258260T3 (es) 2006-08-16
FI925988A7 (fi) 1992-12-31
FI925988A0 (fi) 1992-12-31
WO1992001061A1 (en) 1992-01-23
NO307710B1 (no) 2000-05-15
CA2086250C (en) 2001-05-29

Similar Documents

Publication Publication Date Title
ATE317912T1 (de) Verfahren zur herstellung von beta-lactamen
ATE121088T1 (de) Verfahren zur herstellung von imidazo(4,5- c>chinolin-4-aminen.
RU92016568A (ru) Способ получения производных бета-лактамов
DE69407272D1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
DE68916086D1 (de) Verfahren zur Herstellung von Kohlenstoff/Kohlenstoff-Verbundstoffen.
MX9700565A (es) Proceso para la preparacion de beta-lactamas a concentracion constantemente alta de reactivos.
DE68909627D1 (de) Verfahren zur Herstellung von Aktivkohle.
DE3683883D1 (de) Verfahren zur herstellung von organopolysilanen und verwendung der so hergestellten organopolysilane.
DE3576952D1 (de) Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten.
DE69022631D1 (de) Verfahren zur Herstellung von L-Tryptophan.
DE69325452D1 (de) Verfahren zur herstellung von (s)-3-amino-1-substituiert-pirrolidine
DE68923643D1 (de) Verfahren zur Herstellung von L-Tryptophan.
DE68908576D1 (de) Verfahren zur Herstellung von Aktivkohle.
ATE78239T1 (de) Verfahren zur herstellung von zeolithen.
DE69611835D1 (de) Verfahren zur herstellung von 1-aryl-1-cyanocyclobutan-derivaten
DE59711504D1 (de) Verfahren zur herstellung von metallkomplexcarbonsäureamiden
DE59606567D1 (de) Neuer Mikroorganismus, dessen Verwendung und Verfahren zur Herstellung von L-Alpha-Aminosäuren
ATE226198T1 (de) Ein verfahren zur herstellung von tetraaza makrocyclen
DE68912809D1 (de) Verfahren zur Herstellung von Bis(2,2,6,6-tetramethyl-4-piperidyl)amin.
DE69132091D1 (de) Verfahren zur Herstellung von Indolderivaten
DE69021001D1 (de) Enzymatisches Verfahren zur Herstellung von L-Serin.
DE59803194D1 (de) Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
DE69112236D1 (de) Verfahren zur mikrobiologischen Herstellung von Ironen.
DE69516162D1 (de) Mikrobiologisches Verfahren zur Herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3-Oxo-4-Azaandrostan-3-onen
ATE200776T1 (de) Verfahren zur herstellung von 2,4,5-tribrompyrrol-3-carbonitril

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0537255

Country of ref document: EP

EELA Cancelled due to lapse of time