ATE202557T1 - 15-fluoro-prostaglandine als augendrucksenkende mittel - Google Patents

15-fluoro-prostaglandine als augendrucksenkende mittel

Info

Publication number
ATE202557T1
ATE202557T1 AT97950592T AT97950592T ATE202557T1 AT E202557 T1 ATE202557 T1 AT E202557T1 AT 97950592 T AT97950592 T AT 97950592T AT 97950592 T AT97950592 T AT 97950592T AT E202557 T1 ATE202557 T1 AT E202557T1
Authority
AT
Austria
Prior art keywords
fluoro
prostaglandins
lowering agent
eye pressure
eye
Prior art date
Application number
AT97950592T
Other languages
English (en)
Inventor
Peter G Klimko
Mark R Hellberg
Paul W Zinke
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21854596&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE202557(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE202557T1 publication Critical patent/ATE202557T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT97950592T 1996-11-12 1997-11-07 15-fluoro-prostaglandine als augendrucksenkende mittel ATE202557T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3051996P 1996-11-12 1996-11-12
PCT/US1997/020671 WO1998021181A2 (en) 1996-11-12 1997-11-07 15-fluoro prostaglandins as ocular hypotensives

Publications (1)

Publication Number Publication Date
ATE202557T1 true ATE202557T1 (de) 2001-07-15

Family

ID=21854596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97950592T ATE202557T1 (de) 1996-11-12 1997-11-07 15-fluoro-prostaglandine als augendrucksenkende mittel

Country Status (9)

Country Link
US (1) US6649653B1 (de)
EP (1) EP0938472B1 (de)
JP (1) JP4248022B2 (de)
AT (1) ATE202557T1 (de)
AU (1) AU5355498A (de)
CA (1) CA2269855A1 (de)
DE (1) DE69705421T2 (de)
ES (1) ES2159889T3 (de)
WO (1) WO1998021181A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69714274T3 (de) * 1996-09-17 2006-06-01 Asahi Glass Co., Ltd. Fluorierte prostaglandinderivate und medikamente
JP3480549B2 (ja) * 1996-12-26 2003-12-22 参天製薬株式会社 ジフルオロプロスタグランジン誘導体およびその用途
ES2232434T3 (es) 1999-03-05 2005-06-01 Duke University Analogos de prostaglandinas c-16 fp selectivas insaturadas.
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
GB0112699D0 (en) * 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
ES2834451T3 (es) 2009-05-01 2021-06-17 Aerie Pharmaceuticals Inc Inhibidores de mecanismo doble para el tratamiento de enfermedades
ES2942898T3 (es) 2013-03-15 2023-06-07 Aerie Pharmaceuticals Inc Compuesto para uso en el tratamiento de trastornos oculares
CN103601708B (zh) * 2013-12-11 2015-06-17 武汉武药科技有限公司 一种前列素药物杂质的制备方法
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
CN118873533A (zh) 2016-08-31 2024-11-01 爱尔康公司 眼用组合物
EP3609871A4 (de) 2017-03-31 2021-01-06 Aerie Pharmaceuticals, Inc. Aryl-cyclopropyl-amino-isochinolinyl-amidverbindungen
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425359A (en) 1975-03-12 1984-01-10 Farmitalia Carlo Erba Fluoro-prostaglandins and process for their preparation
AU501803B2 (en) * 1975-03-21 1979-06-28 Farmitalia Carlo Erba S.P.A. Fluoro-prostaglandins
US4599353A (en) 1982-05-03 1986-07-08 The Trustees Of Columbia University In The City Of New York Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma
GB8324004D0 (en) * 1983-09-07 1983-10-12 Erba Farmitalia 16-fluoro-16 17-didehydro prostanoids
SU1256394A1 (ru) * 1984-04-24 1987-06-07 Институт Органического Синтеза Ан Латвсср Производные 15( @ + @ )-фтор-11,15-дидезоксипростагландина @ ,обладающие антиагрегационной активностью
EP0308135B1 (de) 1987-09-18 1992-11-19 R-Tech Ueno Ltd. Okulare Hypotensivagenzien
US5321128A (en) 1988-09-06 1994-06-14 Kabi Pharmacia Ab Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension
CA2030345C (en) 1989-11-22 1998-12-08 Ryuji Ueno Use of 15-keto-prostaglandin compound for improvement of encephalic function
PT561073E (pt) 1992-03-19 2002-04-29 R Tech Ueno Ltd Tratamento da hipertensao ocular com beta-bloqueadores e derivados de acido prostanoico
DE4229050A1 (de) 1992-08-31 1994-03-03 Schering Ag Neue 9-Chlor-Prostaglandin-Ester und -amide
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
JPH0770054A (ja) 1993-08-30 1995-03-14 R Tec Ueno:Kk 生化学的拮抗および疾患処置剤
JPH1087607A (ja) 1996-09-17 1998-04-07 Asahi Glass Co Ltd 含フッ素プロスタグランジン誘導体の製造方法

Also Published As

Publication number Publication date
JP2001505556A (ja) 2001-04-24
ES2159889T3 (es) 2001-10-16
AU5355498A (en) 1998-06-03
DE69705421D1 (de) 2001-08-02
WO1998021181A3 (en) 1998-07-16
EP0938472A2 (de) 1999-09-01
US6649653B1 (en) 2003-11-18
WO1998021181A2 (en) 1998-05-22
JP4248022B2 (ja) 2009-04-02
EP0938472B1 (de) 2001-06-27
DE69705421T2 (de) 2002-05-16
CA2269855A1 (en) 1998-05-22

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