ATE202580T1 - Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen - Google Patents

Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen

Info

Publication number
ATE202580T1
ATE202580T1 AT93308457T AT93308457T ATE202580T1 AT E202580 T1 ATE202580 T1 AT E202580T1 AT 93308457 T AT93308457 T AT 93308457T AT 93308457 T AT93308457 T AT 93308457T AT E202580 T1 ATE202580 T1 AT E202580T1
Authority
AT
Austria
Prior art keywords
pharmaceutical preparations
antimicrobial polymers
preservatives
pharmaceutical
moieties
Prior art date
Application number
AT93308457T
Other languages
English (en)
Inventor
Joonsup Park
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Application granted granted Critical
Publication of ATE202580T1 publication Critical patent/ATE202580T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
    • A01N33/02—Amines; Quaternary ammonium compounds
    • A01N33/12—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/30—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the groups —CO—N< and, both being directly attached by their carbon atoms to the same carbon skeleton, e.g. H2N—NH—CO—C6H4—COOCH3; Thio-analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A61L12/143—Quaternary ammonium compounds
    • A61L12/145—Polymeric quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Apparatus For Disinfection Or Sterilisation (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
AT93308457T 1992-11-04 1993-10-22 Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen ATE202580T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/971,424 US5300287A (en) 1992-11-04 1992-11-04 Polymeric antimicrobials and their use in pharmaceutical compositions

Publications (1)

Publication Number Publication Date
ATE202580T1 true ATE202580T1 (de) 2001-07-15

Family

ID=25518371

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93308457T ATE202580T1 (de) 1992-11-04 1993-10-22 Antimikrobielle polymere und ihre verwendung in pharmazeutischen zubereitungen

Country Status (9)

Country Link
US (1) US5300287A (de)
EP (1) EP0596631B1 (de)
JP (2) JP3353423B2 (de)
AT (1) ATE202580T1 (de)
AU (1) AU660377B2 (de)
CA (1) CA2102282C (de)
DE (1) DE69330381T2 (de)
ES (1) ES2157916T3 (de)
MX (1) MX9306735A (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760261A (en) * 1990-02-28 1998-06-02 Guttag; Alvin Higher fatty acid derivatives of salicylic acid and salts thereof
US6197529B1 (en) * 1990-11-21 2001-03-06 Torrey Pines Institute For Molecular Studies Linear substituted oligoalkyleneimine libraries
US5683709A (en) * 1994-05-05 1997-11-04 Ciba Vision Corporation Poly(benzalkonium salt) as an anti-microbial agent for aqueous drug compositions
US5536494A (en) * 1994-10-04 1996-07-16 Alcon Laboratories, Inc. Polyethylene oxide-containing quaternary ammunium polymers and pharmaceutical compositions containing an antimicrobial amount of same
US5603929A (en) * 1994-11-16 1997-02-18 Alcon Laboratories, Inc. Preserved ophthalmic drug compositions containing polymeric quaternary ammonium compounds
DE19608555A1 (de) * 1996-03-06 1997-09-11 Basf Ag Verwendung von Polymerisaten als Biozid
US6034129A (en) * 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
DE19654897A1 (de) * 1996-11-14 1998-06-04 Roehm Gmbh Monomere für Polymere mit antimikrobiellen Eigenschaften
US6290947B1 (en) 1997-09-19 2001-09-18 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin-binding agents
US6482402B1 (en) 1999-05-13 2002-11-19 Geltex Pharmaceuticals, Inc. Antimicrobial compositions and methods
US6461598B1 (en) * 2000-01-18 2002-10-08 Biosil Research Institute Inc. Process for conditioning hair
US6372934B1 (en) * 2000-01-18 2002-04-16 Biosil Research Institute Water soluble complexes
WO2001054687A1 (en) 2000-01-25 2001-08-02 Alcon Universal Ltd. Ophthalmic anti-allergy compositions suitable for use with contact lenses
CA2434693A1 (en) * 2001-01-18 2002-10-17 Genzyme Corporation Ionene polymers and their use as antimicrobial agents
DE10205923A1 (de) * 2002-02-12 2003-08-21 Creavis Tech & Innovation Gmbh Wasch- und Reinigungsformulierungen mit antimikrobiellen Polymeren
WO2003088931A2 (en) * 2002-04-16 2003-10-30 Cosmetica, Inc. Polymeric odor absorption ingredients for personal care products
US20040166753A1 (en) * 2002-06-10 2004-08-26 Millward Dan B. Modification of fabric fibers
CA2504898A1 (en) * 2002-11-05 2004-05-27 Nano-Tex, Llc Odor-absorbing cellulosic fibrous substrates
AU2003291087A1 (en) * 2002-11-19 2004-06-15 Genzyme Corporation Ionene oligomers and polymers
SE0403216D0 (sv) * 2004-12-30 2004-12-30 Appeatex Ab Antimicrobial product
EP1928234A4 (de) * 2005-08-22 2012-08-29 Quick Med Technologies Inc Desinfektionsmittel mit quaternären ammoniumpolymeren und copolymeren
KR20080086520A (ko) * 2006-01-27 2008-09-25 시바 홀딩 인코포레이티드 중합체 항균제
WO2008000429A2 (en) * 2006-06-26 2008-01-03 Novartis Ag Polymers with antimicrobial activity containing quaternary ammonium groups
WO2009045384A1 (en) * 2007-10-01 2009-04-09 Nano-Tex, Inc. Modification of cellulosic substrates to control body odor
TWI544927B (zh) 2008-03-17 2016-08-11 愛爾康研究有限公司 具有低濃度的表面活性劑以促進治療劑之生物可利用性的藥學組成物
AU2009225931B9 (en) 2008-03-17 2014-04-03 Novartis Ag Aqueous pharmaceutical compositions containing borate-polyol complexes
JP2011520963A (ja) * 2008-05-19 2011-07-21 アルコン リサーチ， リミテッド カルボキシビニルポリマーおよびポビドンポリマーを有する医薬組成物
AU2009255322B2 (en) * 2008-05-29 2015-12-03 Dsm Ip Assets B.V. Antimicrobial polymers and their uses
US8093352B2 (en) * 2008-08-05 2012-01-10 Alcon Research, Ltd. Polyalkylene oxide polyquaternary ammonium biocides
TW201023912A (en) * 2008-12-05 2010-07-01 Alcon Res Ltd Pharmaceutical suspension
US20100197702A1 (en) * 2009-02-04 2010-08-05 Hellberg Mark R Ophthalmic composition with nitric oxide donor compound and method of forming and using same
US8912236B2 (en) * 2009-03-03 2014-12-16 Alcon Research, Ltd. Pharmaceutical composition for delivery of receptor tyrosine kinase inhibiting (RTKi) compounds to the eye
CN105362221A (zh) * 2009-03-03 2016-03-02 爱尔康研究有限公司 向眼部递送受体酪氨酸激酶抑制性(RTKi)化合物的药物组合物
TW201038295A (en) * 2009-04-17 2010-11-01 Alcon Res Ltd Aqueous ophthalmic compositions containing anionic therapeutic agents
TWI489997B (zh) 2009-06-19 2015-07-01 Alcon Res Ltd 含有硼酸－多元醇錯合物之水性藥學組成物
US20100086514A1 (en) * 2009-10-01 2010-04-08 Liu X Michael Contact Lens Care Solutions with a Low Molecular Weight Oligomer
TWI478730B (zh) * 2009-12-03 2015-04-01 Alcon Res Ltd 眼科乳劑
EP3045163A1 (de) 2011-04-22 2016-07-20 Alcon Research, Ltd. Ophthalmische zusammensetzung mit einem viskositätsverstärkungssystem mit zwei unterschiedlichen viskositätsverstärkern
MX2013012307A (es) 2011-04-22 2014-01-31 Alcon Res Ltd Composicion oftalmica con un sistema de mejoramiento de la viscosidad que tiene dos agentes mejoradores de la viscosidad diferentes.
TWI544922B (zh) 2011-05-19 2016-08-11 愛爾康研究有限公司 高濃度歐羅派特錠（ｏｌｏｐａｔａｄｉｎｅ）眼用組成物
TW201336527A (zh) 2012-02-10 2013-09-16 Alcon Res Ltd 具增強的穩定性之水性藥學組成物
JP6290929B2 (ja) 2013-01-24 2018-03-07 ボシュ・アンド・ロム・インコーポレイテッドＢａｕｓｃｈ ＆ Ｌｏｍｂ Ｉｎｃｏｒｐｏｒａｔｅｄ アルコキシル化天然ワックスを有する眼用組成物
AU2014211319B2 (en) * 2013-02-01 2017-05-18 Croda International Plc Self-disinfecting surfaces
US10174006B2 (en) 2013-06-06 2019-01-08 Novartis Ag Topical aqueous ophthalmic compositions containing a 1H-indole-1-carboxamide derivative and use thereof for treatment of ophthalmic disease
AT515029B1 (de) * 2013-10-21 2015-12-15 Polymer Competence Ct Leoben Kontaktbiozide auf Basis von Poly(oxazin)en, Poly(oxazpein)en und Poly(oxazozin)en
CN114712383B (zh) 2016-03-30 2024-09-24 阿尤维斯研究有限公司 新组合物和治疗方法
TWI913170B (zh) 2018-02-21 2026-01-21 瑞士商愛爾康公司 基於脂質的眼用乳劑
BR112020026989A2 (pt) 2018-07-02 2021-03-30 Ayuvis Research, Inc. Novas pequenas moléculas de imunomodulação
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの製剤
JP2022520410A (ja) 2019-02-15 2022-03-30 ノバルティス アーゲー ４－（７－ヒドロキシ－２－イソプロピル－４－オキソ－４ｈ－キナゾリン－３－イル）－ベンゾニトリルの結晶形態及びその製剤
US12459902B2 (en) 2020-08-06 2025-11-04 Bausch + Lomb Ireland Limited Crystalline forms of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile and formulations thereof
JP2025531367A (ja) 2022-09-21 2025-09-19 ボシュ ＋ ロム アイルランド リミテッド Ｔｒｐｖ１アンタゴニストの結晶多形形態およびその製剤
WO2026115440A1 (en) 2024-11-27 2026-06-04 Alcon Inc. Stable ophthalmic emulsion
US20260144812A1 (en) 2024-11-27 2026-05-28 Alcon Inc. Antioxidant ophthalmic emulsion

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3539684A (en) * 1968-11-21 1970-11-10 Calgon C0Rp Bactericidal polymers
US3778476A (en) * 1970-05-11 1973-12-11 California Inst Of Techn Polymeric organic halogen salts
US3898336A (en) * 1970-05-11 1975-08-05 California Inst Of Techn Insoluble polymeric quaternary trihalogen salt coated substrates
US4032293A (en) * 1974-09-09 1977-06-28 The United States Of America As Represented By The Secretary Of Agriculture Preparation of stable strong base cellulosic anion exchangers with red-ox potentials
US4001432A (en) * 1974-10-29 1977-01-04 Millmaster Onyx Corporation Method of inhibiting the growth of bacteria by the application thereto of capped polymers
US3931319A (en) * 1974-10-29 1976-01-06 Millmaster Onyx Corporation Capped polymers
US4012446A (en) * 1974-10-29 1977-03-15 Millmaster Onyx Corporation Capped polymers
GB1556365A (en) * 1976-08-11 1979-11-21 British Petroleum Co Antiviral agents
US4325940A (en) * 1976-11-24 1982-04-20 Kewanee Industries, Inc. Anti-microbial, cosmetic and water-treating ionene polymeric compounds
JPS5533411A (en) * 1978-08-29 1980-03-08 Mitsubishi Chem Ind Ltd Agent for controlling plant viral disease
US4250269A (en) * 1979-11-26 1981-02-10 Buckman Laboratories, Inc. Water-soluble mixtures of quaternary ammonium polymers, nonionic and/or cationic vinyl-addition polymers, and nonionic and/or cationic surfactants
US4499077A (en) * 1981-02-03 1985-02-12 Stockel Richard F Anti-microbial compositions and associated methods for preparing the same and for the disinfecting of various objects
US4654208A (en) * 1983-03-01 1987-03-31 Stockel Richard F Anti-microbial compositions comprising an aqueous solution of a germicidal polymeric nitrogen compound and a potentiating oxidizing agent
US4836986A (en) * 1984-09-28 1989-06-06 Bausch & Lomb Incorporated Disinfecting and preserving systems and methods of use
CA1259542A (en) * 1984-09-28 1989-09-19 Francis X. Smith Disinfecting and preserving solutions for contact lenses and methods of use
US5071934A (en) * 1987-12-21 1991-12-10 Exxon Research And Engineering Company Cationic hydrophobic monomers and polymers
US5104649A (en) * 1988-05-11 1992-04-14 Monsanto Company Surface-functionalized biocidal polymers
DE3843194A1 (de) * 1988-12-22 1990-07-12 Hoechst Ag Amphiphile monomere mit gemischtkettiger struktur und polymere und film aus mindestens einer monomolekularen schicht daraus
EP0457756B1 (de) * 1989-02-07 1995-04-26 Abb Fläkt Aktiebolag Laufrad-antriebswellenbefestigungsvorrichtung
US4960590A (en) * 1989-02-10 1990-10-02 Buckman Laboratories International, Inc. Novel polymeric quaternary ammonium trihalides
BE1002830A5 (fr) * 1989-02-15 1991-06-25 Fabricom Air Conditioning Sa Composition desinfectante et/ou de conservation et procede de desinfection et/ou de conservation d'aliments.
SE463223B (sv) * 1989-02-17 1990-10-22 Svenska Rotor Maskiner Ab Skruvrotormaskin med ljuddaempare
US5145643A (en) * 1990-01-05 1992-09-08 Allergan, Inc. Nonoxidative ophthalmic compositions and methods for preserving and using same
US5171526A (en) * 1990-01-05 1992-12-15 Allergan, Inc. Ophthalmic compositions and methods for preserving and using same

Also Published As

Publication number Publication date
MX9306735A (es) 1994-06-30
CA2102282A1 (en) 1994-05-05
AU660377B2 (en) 1995-06-22
AU5032793A (en) 1994-05-19
JP3353423B2 (ja) 2002-12-03
DE69330381T2 (de) 2001-10-11
DE69330381D1 (de) 2001-08-02
EP0596631B1 (de) 2001-06-27
JP2002348338A (ja) 2002-12-04
EP0596631A2 (de) 1994-05-11
CA2102282C (en) 1997-12-30
JPH06239997A (ja) 1994-08-30
ES2157916T3 (es) 2001-09-01
EP0596631A3 (de) 1996-07-03
US5300287A (en) 1994-04-05

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