ATE202776T1 - Piperinderivate als neurokininantagoniste - Google Patents

Piperinderivate als neurokininantagoniste

Info

Publication number: ATE202776T1
Authority: AT; Austria
Prior art keywords: neurokinin antagonists; piperine derivatives; compounds; piperine; derivatives
Prior art date: 1995-08-31

Application number

AT96931188T

Other languages

English (en)

Inventor

Ho-Jane Shue

Neng-Yang Shih

David J Blythin

Xiao Chen

John J Piwinski

Kevin D Mccormick

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-31

Filing date

1996-08-29

Publication date

2001-07-15

1996-05-01 Priority claimed from PCT/US1996/005660 external-priority patent/WO1996034864A1/en

1996-06-14 Priority claimed from US08/663,880 external-priority patent/US5795894A/en

1996-08-29 Application filed by Schering Corp filed Critical Schering Corp

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202776T1 publication Critical patent/ATE202776T1/de

Links

239000005557 antagonist Substances 0.000 title abstract 2
MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical class C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
208000006673 asthma Diseases 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Dermatology (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT96931188T 1995-08-31 1996-08-29 Piperinderivate als neurokininantagoniste ATE202776T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US308495P	1995-08-31	1995-08-31
PCT/US1996/005660 WO1996034864A1 (en)	1995-05-02	1996-05-01	Piperazino derivatives as neurokinin antagonists
US08/663,880 US5795894A (en)	1995-05-02	1996-06-14	Piperazino derivatives as neurokinn antagonists
PCT/IB1996/001018 WO1997008166A1 (en)	1995-08-31	1996-08-29	Piperazino derivatives as neurokinin antagonists

Publications (1)

Publication Number	Publication Date
ATE202776T1 true ATE202776T1 (de)	2001-07-15

Family

ID=46202966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96931188T ATE202776T1 (de)	1995-08-31	1996-08-29	Piperinderivate als neurokininantagoniste

Country Status (17)

Country	Link
EP (1)	EP0850236B1 (de)
JP (2)	JP3447745B2 (de)
CN (1)	CN1111529C (de)
AT (1)	ATE202776T1 (de)
AU (1)	AU708834B2 (de)
BR (1)	BR9610277A (de)
CA (1)	CA2228370C (de)
CZ (1)	CZ22898A3 (de)
DE (1)	DE69613705T2 (de)
ES (1)	ES2158345T3 (de)
GR (1)	GR3036675T3 (de)
HU (1)	HUP9802552A3 (de)
IL (1)	IL123112A (de)
NO (1)	NO980848L (de)
PL (1)	PL325339A1 (de)
SK (1)	SK27498A3 (de)
WO (1)	WO1997008166A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5892039A (en) *	1995-08-31	1999-04-06	Schering Corporation	Piperazino derivatives as neurokinin antagonists
AU733454B2 (en) *	1996-10-30	2001-05-17	Schering Corporation	Piperazino derivatives as neurokinin antagonists
US5968929A (en) *	1996-10-30	1999-10-19	Schering Corporation	Piperazino derivatives as neurokinin antagonists
AUPO735997A0 (en)	1997-06-17	1997-07-10	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
UA64751C2 (uk)	1997-06-25	2004-03-15	Пфайзер Продактс Інк.	Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
ZA99171B (en) *	1998-01-14	1999-07-12	Schering Corp	Piperazino derivatives as neurokinin antagonists.
AUPQ356899A0 (en) *	1999-10-21	1999-11-11	Fujisawa Pharmaceutical Co., Ltd.	Piperazine derivatives
TR200101649T2 (tr) *	1998-12-14	2001-10-22	Fujisawa Pharmaceutical Co., Ltd.	Piperazin türevleri.
KR100879647B1 (ko)	2000-03-06	2009-01-20	아카디아 파마슈티칼스 인코포레이티드	세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물
TW591025B (en)	2000-06-13	2004-06-11	Fujisawa Pharmaceutical Co	Production of the piperazine derivative
NZ533567A (en)	2001-12-28	2007-06-29	Acadia Pharm Inc	Spiroazacyclic compounds as monoamine receptor for modulating 5-HT2A receptor-mediated events
US6855724B2 (en)	2002-04-08	2005-02-15	Agouron Pharmaceuticals, Inc.	Tropane derivatives useful in therapy
JP2005533813A (ja)	2002-06-24	2005-11-10	アカディアファーマシューティカルズ，インコーポレーテッド	セロトニン受容体作用物質としてのｎ−置換ピペリジン誘導体
US7538222B2 (en)	2002-06-24	2009-05-26	Acadia Pharmaceuticals, Inc.	N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en)	2002-06-24	2007-08-07	Carl-Magnus Andersson	N-substituted piperidine derivatives as serotonin receptor agents
ATE407117T1 (de)	2003-01-16	2008-09-15	Acadia Pharm Inc	Selektive serotonin 2a/2c inverse rezeptoragonisten als therapeutika für neurodegenerative erkrankungen
US7820695B2 (en)	2004-05-21	2010-10-26	Acadia Pharmaceuticals, Inc.	Selective serotonin receptor inverse agonists as therapeutics for disease
US20050261278A1 (en)	2004-05-21	2005-11-24	Weiner David M	Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en)	2004-09-27	2010-09-07	Acadia Pharmaceuticals, Inc.	Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CN101031548B (zh)	2004-09-27	2011-04-06	阿卡蒂亚药品公司	N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备
US8093268B2 (en)	2007-01-24	2012-01-10	Glaxo Group Limited	Pharmaceutical compositions comprising 2-methoxy-5-(5-trifluoromethyl-tetrazol-1-yl-benzyl)-(2S-phenylpiperidin-3S-yl-)
WO2008116024A2 (en)	2007-03-19	2008-09-25	Acadia Pharmaceuticals Inc.	Combinations of 5-ht2a inverse agonists and antagonists with antipsychotics
CN107848972B (zh)	2015-07-20	2021-06-18	阿卡蒂亚药品公司	用于制备n-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐和多晶型c的方法
WO2017165635A1 (en)	2016-03-25	2017-09-28	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome p450 modulators
US10953000B2 (en)	2016-03-25	2021-03-23	Acadia Pharmaceuticals Inc.	Combination of pimavanserin and cytochrome P450 modulators
EP3558311A1 (de)	2016-12-20	2019-10-30	Acadia Pharmaceuticals Inc.	Pimavanserin allein oder in kombination zur verwendung in der behandlung von morbus-alzheimer-psychose
WO2018200977A1 (en)	2017-04-28	2018-11-01	Acadia Pharmaceuticals Inc.	Pimavanserin for treating impulse control disorder
WO2019046167A1 (en)	2017-08-30	2019-03-07	Acadia Pharmaceuticals Inc.	PIMAVANSERIN FORMULATIONS
CN115368296A (zh) *	2022-07-27	2022-11-22	苏州汉德创宏生化科技有限公司	一种n-叔丁氧羰基-4-氨基哌啶的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8908587D0 (en) *	1989-04-15	1989-06-01	Scras Societe De Conseils De R	New 2-substituted n,n'-ditrimethoxybenzoyl piperazines
US5292726A (en) *	1991-05-22	1994-03-08	Merck & Co., Inc.	N,N-diacylpiperazines
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
IL111730A (en) *	1993-11-29	1998-12-06	Fujisawa Pharmaceutical Co	Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
US5607936A (en) *	1994-09-30	1997-03-04	Merck & Co., Inc.	Substituted aryl piperazines as neurokinin antagonists

1996
- 1996-05-01 BR BR9610277A patent/BR9610277A/pt not_active Application Discontinuation
- 1996-08-29 ES ES96931188T patent/ES2158345T3/es not_active Expired - Lifetime
- 1996-08-29 HU HU9802552A patent/HUP9802552A3/hu unknown
- 1996-08-29 PL PL96325339A patent/PL325339A1/xx unknown
- 1996-08-29 WO PCT/IB1996/001018 patent/WO1997008166A1/en not_active Ceased
- 1996-08-29 EP EP96931188A patent/EP0850236B1/de not_active Expired - Lifetime
- 1996-08-29 DE DE69613705T patent/DE69613705T2/de not_active Expired - Lifetime
- 1996-08-29 AU AU69979/96A patent/AU708834B2/en not_active Ceased
- 1996-08-29 IL IL12311296A patent/IL123112A/en not_active IP Right Cessation
- 1996-08-29 CA CA002228370A patent/CA2228370C/en not_active Expired - Fee Related
- 1996-08-29 CN CN96197720A patent/CN1111529C/zh not_active Expired - Fee Related
- 1996-08-29 JP JP51006997A patent/JP3447745B2/ja not_active Expired - Lifetime
- 1996-08-29 AT AT96931188T patent/ATE202776T1/de not_active IP Right Cessation
- 1996-08-29 CZ CZ98228A patent/CZ22898A3/cs unknown
- 1996-08-29 SK SK274-98A patent/SK27498A3/sk unknown
1998
- 1998-02-27 NO NO980848A patent/NO980848L/no not_active Application Discontinuation
2000
- 2000-05-24 JP JP2000153870A patent/JP3315970B2/ja not_active Expired - Fee Related
2001
- 2001-09-20 GR GR20010401532T patent/GR3036675T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU708834B2 (en)	1999-08-12
HUP9802552A2 (hu)	1999-10-28
SK27498A3 (en)	1998-12-02
JP2000344766A (ja)	2000-12-12
HUP9802552A3 (en)	1999-11-29
NO980848L (no)	1998-04-30
CA2228370C (en)	2002-10-01
GR3036675T3 (en)	2001-12-31
CZ22898A3 (cs)	1998-07-15
IL123112A (en)	2001-04-30
JP3315970B2 (ja)	2002-08-19
ES2158345T3 (es)	2001-09-01
EP0850236B1 (de)	2001-07-04
DE69613705D1 (de)	2001-08-09
WO1997008166A1 (en)	1997-03-06
AU6997996A (en)	1997-03-19
CN1200120A (zh)	1998-11-25
JP3447745B2 (ja)	2003-09-16
NO980848D0 (no)	1998-02-27
DE69613705T2 (de)	2002-05-16
CA2228370A1 (en)	1997-03-06
PL325339A1 (en)	1998-07-20
JPH10511105A (ja)	1998-10-27
EP0850236A1 (de)	1998-07-01
IL123112A0 (en)	1998-09-24
CN1111529C (zh)	2003-06-18
BR9610277A (pt)	1999-07-06

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Date	Code	Title	Description
2001-12-15	UEP	Publication of translation of european patent specification
2005-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
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