ATE202780T1 - 3-(substituierte)-1-carba(dethia)-3- cephemverbindungen und cephalosporine und ein verfahren zu ihrer herstellung - Google Patents

3-(substituierte)-1-carba(dethia)-3- cephemverbindungen und cephalosporine und ein verfahren zu ihrer herstellung

Info

Publication number: ATE202780T1
Authority: AT; Austria
Prior art keywords: dethia; carba; substituted; cephalosporins; production
Prior art date: 1988-03-23

Application number

AT89302773T

Other languages

English (en)

Inventor

Gwendolyn Kay Cook

Iii John Hampton Mcdonald

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-23

Filing date

1989-03-21

Publication date

2001-07-15

1989-03-21 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE202780T1 publication Critical patent/ATE202780T1/de

Links

229930186147 Cephalosporin Natural products 0.000 title abstract 4
229940124587 cephalosporin Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
150000001780 cephalosporins Chemical class 0.000 abstract 3
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
-1 sulfonyloxy ester Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/02—Preparation
- C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT89302773T 1988-03-23 1989-03-21 3-(substituierte)-1-carba(dethia)-3- cephemverbindungen und cephalosporine und ein verfahren zu ihrer herstellung ATE202780T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/172,091 US4855418A (en)	1988-03-23	1988-03-23	Process for production of ceophalosporins

Publications (1)

Publication Number	Publication Date
ATE202780T1 true ATE202780T1 (de)	2001-07-15

Family

ID=22626323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT89302773T ATE202780T1 (de)	1988-03-23	1989-03-21	3-(substituierte)-1-carba(dethia)-3- cephemverbindungen und cephalosporine und ein verfahren zu ihrer herstellung

Country Status (11)

Country	Link
US (1)	US4855418A (de)
EP (2)	EP0677523A1 (de)
JP (1)	JPH024788A (de)
KR (1)	KR890014557A (de)
AT (1)	ATE202780T1 (de)
CA (1)	CA1338571C (de)
DE (1)	DE68929310T2 (de)
ES (1)	ES2157884T3 (de)
GR (1)	GR3036781T3 (de)
HU (1)	HU208014B (de)
IL (1)	IL89699A0 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5128336A (en) *	1988-03-23	1992-07-07	Eli Lilly And Company	3-(substituted)-1-carba(dethia)-3-cephems
US5245027A (en) *	1989-11-21	1993-09-14	Bristol-Myers Squibb Company	3-fluorosulfonyloxyceph-3-em compounds
US5043439A (en) *	1990-03-08	1991-08-27	Bristol-Myers Squibb Company	Process for production of cephalosporins
DE4030706A1 (de) *	1990-09-28	1992-04-02	Bayer Ag	Neue 3-substituierte cephalosporine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US5106842A (en) *	1990-10-22	1992-04-21	Bristol-Myers Squibb Co.	Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof
US5604222A (en) *	1993-12-27	1997-02-18	Lupin Laboratories, Ltd.	Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en) *	1994-07-11	1996-11-26	Lupin Laboratories Limited	Process for preparation of 3-exomethylene cepham sulfoxide esters
CA2701286A1 (en) *	2007-10-25	2009-04-30	Achaogen, Inc.	Carbacephem .beta.-lactam antibiotics
WO2010030810A1 (en) *	2008-09-10	2010-03-18	Achaogen, Inc.	Carbacephem beta-lactam antibiotics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0112481A1 (de) *	1982-11-12	1984-07-04	Kyowa Hakko Kogyo Co., Ltd	Beta-Lactam-Verbindung
US4665171A (en)	1985-07-17	1987-05-12	Harvard University	Process and intermediates for β-lactam antibiotics
US4673737A (en) *	1985-08-02	1987-06-16	Harvard University	7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof

1988
- 1988-03-23 US US07/172,091 patent/US4855418A/en not_active Expired - Lifetime
1989
- 1989-03-21 IL IL89699A patent/IL89699A0/xx not_active IP Right Cessation
- 1989-03-21 AT AT89302773T patent/ATE202780T1/de not_active IP Right Cessation
- 1989-03-21 ES ES89302773T patent/ES2157884T3/es not_active Expired - Lifetime
- 1989-03-21 DE DE68929310T patent/DE68929310T2/de not_active Expired - Fee Related
- 1989-03-21 EP EP95201529A patent/EP0677523A1/de not_active Ceased
- 1989-03-21 EP EP89302773A patent/EP0334590B1/de not_active Expired - Lifetime
- 1989-03-21 CA CA000594273A patent/CA1338571C/en not_active Expired - Fee Related
- 1989-03-22 HU HU891400A patent/HU208014B/hu not_active IP Right Cessation
- 1989-03-22 KR KR1019890003592A patent/KR890014557A/ko not_active Ceased
- 1989-03-23 JP JP1073698A patent/JPH024788A/ja active Pending
2001
- 2001-10-03 GR GR20010401642T patent/GR3036781T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
US4855418A (en)	1989-08-08
ES2157884T3 (es)	2001-09-01
DE68929310D1 (de)	2001-08-09
EP0334590A2 (de)	1989-09-27
JPH024788A (ja)	1990-01-09
KR890014557A (ko)	1989-10-24
CA1338571C (en)	1996-09-03
HUT49888A (en)	1989-11-28
EP0677523A1 (de)	1995-10-18
HU208014B (en)	1993-07-28
EP0334590B1 (de)	2001-07-04
GR3036781T3 (en)	2002-01-31
IL89699A0 (en)	1989-09-28
EP0334590A3 (de)	1991-07-24
DE68929310T2 (de)	2002-05-02

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Legal Events

Date	Code	Title	Description
2003-06-15	REN	Ceased due to non-payment of the annual fee