ATE202847T1 - Vorrichtung und verfahren zur zytometrie unter verwendung einer kapillarküvette mit definiertem volumen - Google Patents

Vorrichtung und verfahren zur zytometrie unter verwendung einer kapillarküvette mit definiertem volumen

Info

Publication number
ATE202847T1
ATE202847T1 AT95302976T AT95302976T ATE202847T1 AT E202847 T1 ATE202847 T1 AT E202847T1 AT 95302976 T AT95302976 T AT 95302976T AT 95302976 T AT95302976 T AT 95302976T AT E202847 T1 ATE202847 T1 AT E202847T1
Authority
AT
Austria
Prior art keywords
capillary tube
sample
reacted
columnar
cytometry
Prior art date
Application number
AT95302976T
Other languages
English (en)
Inventor
Thomas M Baer
Louis J Dietz
Robert S Dubrow
Paul G Hayter
Michael Hodges
Bala S Manian
Robert J Shartle
Original Assignee
Biometric Imaging Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biometric Imaging Inc filed Critical Biometric Imaging Inc
Application granted granted Critical
Publication of ATE202847T1 publication Critical patent/ATE202847T1/de

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Classifications

    • G—PHYSICS
    • G06—COMPUTING OR CALCULATING; COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1468—Optical investigation techniques, e.g. flow cytometry with spatial resolution of the texture or inner structure of the particle

Landscapes

  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Multimedia (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Optical Measuring Cells (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT95302976T 1994-05-02 1995-05-02 Vorrichtung und verfahren zur zytometrie unter verwendung einer kapillarküvette mit definiertem volumen ATE202847T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/236,342 US5547849A (en) 1993-02-17 1994-05-02 Apparatus and method for volumetric capillary cytometry

Publications (1)

Publication Number Publication Date
ATE202847T1 true ATE202847T1 (de) 2001-07-15

Family

ID=22889109

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95302976T ATE202847T1 (de) 1994-05-02 1995-05-02 Vorrichtung und verfahren zur zytometrie unter verwendung einer kapillarküvette mit definiertem volumen

Country Status (6)

Country Link
US (1) US5547849A (de)
EP (1) EP0681178B1 (de)
JP (1) JP3647504B2 (de)
AT (1) ATE202847T1 (de)
CA (1) CA2148205A1 (de)
DE (1) DE69521558T2 (de)

Families Citing this family (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585246A (en) * 1993-02-17 1996-12-17 Biometric Imaging, Inc. Method for preparing a sample in a scan capillary for immunofluorescent interrogation
CA2198853A1 (en) * 1994-09-02 1996-03-14 Biometric Imaging, Inc. Calibration method and apparatus for optical scanner
US5784152A (en) * 1995-03-16 1998-07-21 Bio-Rad Laboratories Tunable excitation and/or tunable detection microplate reader
AU6542196A (en) * 1995-06-30 1997-02-05 Biometric Imaging, Inc. Volumetric cell quantification method and system
EA001936B1 (ru) * 1995-10-23 2001-10-22 Сайтометрикс, Инк. Способ измерения характеристик поглощающего объекта и устройство для его осуществления
US6165739A (en) * 1996-03-13 2000-12-26 Compucyte Corporation Multiple simultaneous testing media
US5942443A (en) 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US20060000722A1 (en) * 1996-06-28 2006-01-05 Caliper Life Sciences, Inc. High throughput screening assay systems in microscale fluidic devices
BR9710054A (pt) 1996-06-28 2000-01-11 Caliper Techn Corp Aparelhos para separar compostos de teste para um efeito sobre um sistema bioquìmico e para detectar ummefeito de um composto de teste sobre um sistema bioquìmico, processos de determinação de se uma amostra contém um composto capaz de afetar um sistema bioquìmico, de separação de uma pluralidade de compostos de teste para um efeito sobre um sistema bioquìmico e usos de um sistema microfluido e de um substrato de ensaio.
JPH1058743A (ja) * 1996-08-22 1998-03-03 Fuji Xerox Co Ltd アレイ状光源を備えたスキャナー装置および画像記録装置
AU5895898A (en) * 1996-12-20 1998-07-17 Gamera Bioscience Corporation An affinity binding-based system for detecting particulates in a fluid
ATE298084T1 (de) 1997-01-31 2005-07-15 Horticulture & Food Res Inst Optische vorrichtung und methode
US5985214A (en) * 1997-05-16 1999-11-16 Aurora Biosciences Corporation Systems and methods for rapidly identifying useful chemicals in liquid samples
US5876946A (en) * 1997-06-03 1999-03-02 Pharmacopeia, Inc. High-throughput assay
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6004821A (en) * 1998-03-07 1999-12-21 Levine; Robert A. Method and apparatus for performing chemical, qualitative, quantitative, and semi-quantitative analyses of a urine sample
US6284526B1 (en) 1998-03-07 2001-09-04 Wardlaw Partners Lp Method and apparatus for determining the sensitivity of a microorganism to a growth altering agent
US5948686A (en) * 1998-03-07 1999-09-07 Robert A. Leuine Method for performing blood cell counts
US6723290B1 (en) * 1998-03-07 2004-04-20 Levine Robert A Container for holding biologic fluid for analysis
US6127184A (en) * 1998-03-07 2000-10-03 Robert A. Levine Calibration of a whole blood sample analyzer
US6022734A (en) * 1998-03-07 2000-02-08 Wardlaw Partners, L.P. Disposable apparatus for determining antibiotic sensitivity of bacteria
US6140069A (en) * 1998-03-07 2000-10-31 Wardlaw Partners, Ll.P. Method for determining antibiotic sensitivity of bacteria
US6929953B1 (en) * 1998-03-07 2005-08-16 Robert A. Levine Apparatus for analyzing biologic fluids
US6235536B1 (en) * 1998-03-07 2001-05-22 Robert A. Levine Analysis of quiescent anticoagulated whole blood samples
US6350613B1 (en) 1998-03-07 2002-02-26 Belton Dickinson & Co. Determination of white blood cell differential and reticulocyte counts
US6388788B1 (en) 1998-03-16 2002-05-14 Praelux, Inc. Method and apparatus for screening chemical compounds
US20030036855A1 (en) * 1998-03-16 2003-02-20 Praelux Incorporated, A Corporation Of New Jersey Method and apparatus for screening chemical compounds
US6818437B1 (en) * 1998-05-16 2004-11-16 Applera Corporation Instrument for monitoring polymerase chain reaction of DNA
US7498164B2 (en) 1998-05-16 2009-03-03 Applied Biosystems, Llc Instrument for monitoring nucleic acid sequence amplification reaction
EP1978351B1 (de) * 1998-05-16 2011-11-30 Life Technologies Corporation Instrument zur Überwachung der Polymerase-Kettenreaktion von DNS
WO2000011024A2 (en) * 1998-08-21 2000-03-02 Surromed, Inc. Novel optical architectures for microvolume laser-scanning cytometers
US6423505B1 (en) 1998-12-03 2002-07-23 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR and CD11b expression on peripheral blood cells
US6200766B1 (en) 1998-12-03 2001-03-13 Becton Dickinson And Company Methods and reagents for quantitation of HLA-DR expression on peripheral blood cells
US6130745A (en) * 1999-01-07 2000-10-10 Biometric Imaging, Inc. Optical autofocus for use with microtiter plates
US6473171B1 (en) 1999-01-15 2002-10-29 Coors Brewing Company Biocompatible apparatus for ultrasensitive and rapid detection of contaminants in liquids
US20060257884A1 (en) * 2004-05-20 2006-11-16 Amnis Corporation Methods for preparing and analyzing cells having chromosomal abnormalities
US8131053B2 (en) * 1999-01-25 2012-03-06 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US8406498B2 (en) 1999-01-25 2013-03-26 Amnis Corporation Blood and cell analysis using an imaging flow cytometer
US8885913B2 (en) 1999-01-25 2014-11-11 Amnis Corporation Detection of circulating tumor cells using imaging flow cytometry
US6937330B2 (en) 1999-04-23 2005-08-30 Ppd Biomarker Discovery Sciences, Llc Disposable optical cuvette cartridge with low fluorescence material
US6682940B2 (en) * 1999-05-04 2004-01-27 Dan A. Pankowsky Products and methods for single parameter and multiparameter phenotyping of cells
US20050279949A1 (en) * 1999-05-17 2005-12-22 Applera Corporation Temperature control for light-emitting diode stabilization
US7410793B2 (en) 1999-05-17 2008-08-12 Applera Corporation Optical instrument including excitation source
US7423750B2 (en) * 2001-11-29 2008-09-09 Applera Corporation Configurations, systems, and methods for optical scanning with at least one first relative angular motion and at least one second angular motion or at least one linear motion
US7387891B2 (en) * 1999-05-17 2008-06-17 Applera Corporation Optical instrument including excitation source
WO2000071991A1 (en) * 1999-05-25 2000-11-30 Biometric Imaging, Inc. Apparatus and method for optical detection in a limited depth of field
WO2001002850A1 (en) * 1999-07-06 2001-01-11 Caliper Technologies Corp. Microfluidic systems and methods for determining modulator kinetics
US6687395B1 (en) * 1999-07-21 2004-02-03 Surromed, Inc. System for microvolume laser scanning cytometry
GB9917240D0 (en) * 1999-07-23 1999-09-22 Eauxsys Uk Limited Method and means for particle measurement
US6181413B1 (en) * 1999-09-03 2001-01-30 Biometric Imaging, Inc. Displacing volume in field of view
US20040178076A1 (en) * 1999-10-01 2004-09-16 Stonas Walter J. Method of manufacture of colloidal rod particles as nanobarcodes
US7045049B1 (en) 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US20040209376A1 (en) * 1999-10-01 2004-10-21 Surromed, Inc. Assemblies of differentiable segmented particles
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US20020028434A1 (en) 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
US6674058B1 (en) 2000-09-20 2004-01-06 Compucyte Corporation Apparatus and method for focusing a laser scanning cytometer
WO2002025280A1 (en) 2000-09-20 2002-03-28 Surromed, Inc. Method for monitoring resting and activated platelets in unfixed blood samples
AU2002213157A1 (en) 2000-10-12 2002-04-22 Amnis Corporation System and method for high numeric aperture imaging systems
US6787761B2 (en) * 2000-11-27 2004-09-07 Surromed, Inc. Median filter for liquid chromatography-mass spectrometry data
WO2002044715A1 (en) * 2000-11-28 2002-06-06 Surromed, Inc. Methods for efficiently minig broad data sets for biological markers
CA2468774C (en) 2000-11-29 2015-06-30 George E. Seidel System for in-vitro fertilization with spermatozoa separated into x-chromosome and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US20020146745A1 (en) * 2001-04-03 2002-10-10 Surromed, Inc. Methods and reagents for multiplexed analyte capture, surface array self-assembly, and analysis of complex biological samples
US6544793B2 (en) * 2001-04-27 2003-04-08 Becton, Dickinson And Company Method for calibrating a sample analyzer
US6979530B2 (en) 2001-05-21 2005-12-27 Applera Corporation Peptide conjugates and fluorescence detection methods for intracellular caspase assay
US6468803B1 (en) * 2001-05-25 2002-10-22 Becton, Dickinson And Company Method for calibrating a sample analyzer
US20030110840A1 (en) * 2001-07-24 2003-06-19 Arriaga Edgar A. Systems and methods for detecting a particle
US7016087B2 (en) * 2001-08-08 2006-03-21 Becton Dickinson And Company Photon efficient scanner
US6873915B2 (en) * 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
US6750457B2 (en) * 2001-08-29 2004-06-15 Becton Dickinson And Company System for high throughput analysis
US20030078739A1 (en) * 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US7635588B2 (en) * 2001-11-29 2009-12-22 Applied Biosystems, Llc Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
US7738945B2 (en) * 2002-04-19 2010-06-15 University Of Washington Method and apparatus for pseudo-projection formation for optical tomography
WO2003095978A2 (en) * 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
AU2003245302A1 (en) 2002-05-17 2003-12-02 Applera Corporation Apparatus and method for differentiating multiple fluorescence signals by excitation wavelength
MXPA05001100A (es) 2002-08-01 2005-04-28 Xy Inc Sistema de separacion de baja presion para celulas de esperma.
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
MXPA05001654A (es) 2002-08-15 2005-10-18 Xy Inc Citometro de flujo de alta resolucion.
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7190522B2 (en) 2002-09-12 2007-03-13 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
JP2005536769A (ja) 2002-08-20 2005-12-02 シヴェラ コーポレイション 回折格子をベースとする光学同定要素
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
CA2499046A1 (en) 2002-09-12 2004-03-25 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
AU2003278827A1 (en) 2002-09-12 2004-04-30 Cyvera Corp. Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
CA2498933C (en) 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
AU2003275940A1 (en) * 2002-10-31 2004-05-25 Chemometec A/S A method for assessment of particles
EP1608963B1 (de) 2003-03-28 2009-12-30 Inguran, LLC Vorrichtung und verfahren zur bereitstellung von geschlechts-sortierten tierspermien
CA2566749C (en) 2003-05-15 2017-02-21 Xy, Inc. Efficient haploid cell sorting for flow cytometer systems
WO2004113869A2 (en) * 2003-06-17 2004-12-29 Surromed, Inc. Labeling and authentication of metal objects
DE10327839A1 (de) * 2003-06-20 2005-01-05 Arvinmeritor Gmbh Fahrzeugdachmodul
US20050048546A1 (en) * 2003-07-11 2005-03-03 Sharron Penn Multiplexed molecular beacon assay for detection of human pathogens
US20050157299A1 (en) * 2004-01-15 2005-07-21 Heffelfinger David M. Optical analysis systems
US6995901B2 (en) * 2004-01-15 2006-02-07 Alpha Innotech Corporation Optical analysis systems
US6853454B1 (en) 2004-01-15 2005-02-08 Alpha Innotech Corporation Optical analysis systems
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US8953866B2 (en) 2004-03-16 2015-02-10 Amnis Corporation Method for imaging and differential analysis of cells
WO2005098430A2 (en) 2004-03-16 2005-10-20 Amnis Corporation Image based quantitation of molecular translocation
CA2596101A1 (en) 2004-03-16 2005-09-29 Amnis Corporation Method for imaging and differential analysis of cells
MXPA06011345A (es) 2004-03-29 2006-12-15 Monsanto Technology Llc Suspensiones de espermatozoides para usar en inseminacion.
US7248360B2 (en) 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
ES2643836T3 (es) 2004-04-07 2017-11-24 Abbott Laboratories Cámara desechable para analizar fluidos biológicos
US7369230B1 (en) * 2004-04-30 2008-05-06 Donald Scott Rogers Apparatus and method for measuring particulate flow rate
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
BRPI0513685A (pt) 2004-07-22 2008-05-13 Monsanto Technology Llc processo para enriquecimento de uma população de células de esperma
US7340957B2 (en) 2004-07-29 2008-03-11 Los Alamos National Security, Llc Ultrasonic analyte concentration and application in flow cytometry
JP2008514955A (ja) * 2004-09-28 2008-05-08 シンギュレックス・インコーポレイテッド サンプル分析システムおよび方法
US8685711B2 (en) 2004-09-28 2014-04-01 Singulex, Inc. Methods and compositions for highly sensitive detection of molecules
US7572640B2 (en) * 2004-09-28 2009-08-11 Singulex, Inc. Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties
US9040305B2 (en) * 2004-09-28 2015-05-26 Singulex, Inc. Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry
CN101116086A (zh) 2004-11-16 2008-01-30 伊路敏纳公司 读取编码微珠的方法和设备
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
GB0500687D0 (en) * 2005-01-14 2005-02-23 Unidata Europ Ltd Particulate detector
US7731901B2 (en) * 2005-10-19 2010-06-08 Abbott Laboratories Apparatus and method for performing counts within a biologic fluid sample
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
JP4730068B2 (ja) * 2005-11-28 2011-07-20 株式会社日立製作所 小型遺伝子解析装置
WO2007067999A2 (en) * 2005-12-09 2007-06-14 Amnis Corporation Extended depth of field imaging for high speed object analysis
JP2007206107A (ja) * 2006-01-31 2007-08-16 Olympus Corp 顕微鏡撮像装置、顕微鏡撮像方法、および情報記憶媒体
SE531233C2 (sv) * 2006-03-28 2009-01-27 Hemocue Ab Anordning och förfarande för detektion av fluorecensmärkta biologiska komponenter
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
EP4357783A3 (de) 2006-04-04 2024-07-17 Novilux, LLC Hochempfindliches system und verfahren zur troponinanalyse
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
US7835000B2 (en) 2006-11-03 2010-11-16 Los Alamos National Security, Llc System and method for measuring particles in a sample stream of a flow cytometer or the like
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US7738094B2 (en) 2007-01-26 2010-06-15 Becton, Dickinson And Company Method, system, and compositions for cell counting and analysis
WO2008122051A1 (en) 2007-04-02 2008-10-09 Acoustic Cytometry Systems, Inc. Methods and devices for enhanced analysis of field focused cells and particles
US8083068B2 (en) * 2007-04-09 2011-12-27 Los Alamos National Security, Llc Apparatus for separating particles utilizing engineered acoustic contrast capture particles
US7837040B2 (en) 2007-04-09 2010-11-23 Los Alamos National Security, Llc Acoustic concentration of particles in fluid flow
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
JP4556975B2 (ja) 2007-09-04 2010-10-06 ソニー株式会社 光照射方法、光照射装置及び微粒子解析装置
US8263407B2 (en) 2007-10-24 2012-09-11 Los Alamos National Security, Llc Method for non-contact particle manipulation and control of particle spacing along an axis
US8528406B2 (en) 2007-10-24 2013-09-10 Los Alamos National Security, LLP Method for non-contact particle manipulation and control of particle spacing along an axis
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
AU2008352940B2 (en) 2007-12-19 2014-06-05 Singulex, Inc. Scanning analyzer for single molecule detection and methods of use
US8266950B2 (en) 2007-12-19 2012-09-18 Los Alamos National Security, LLP Particle analysis in an acoustic cytometer
US8714014B2 (en) 2008-01-16 2014-05-06 Life Technologies Corporation System and method for acoustic focusing hardware and implementations
EP2263085A4 (de) * 2008-03-05 2011-07-06 Singulex Inc Verfahren und zusammensetzungen zur hochempfindlichen erkennung von molekülen
GB2464183A (en) * 2008-09-19 2010-04-14 Singulex Inc Sandwich assay
JP6059872B2 (ja) * 2009-03-04 2017-01-18 マルベルン インスツルメンツ リミテッドＭａｌｖｅｒｎ Ｉｎｓｔｒｕｍｅｎｔｓ Ｌｉｍｉｔｅｄ 粒子特性の測定
US8450069B2 (en) * 2009-06-08 2013-05-28 Singulex, Inc. Highly sensitive biomarker panels
US8451524B2 (en) * 2009-09-29 2013-05-28 Amnis Corporation Modifying the output of a laser to achieve a flat top in the laser's Gaussian beam intensity profile
CN106110923A (zh) 2009-12-18 2016-11-16 艾博特健康公司 生物流体样本分析卡盒
US9199233B2 (en) 2010-03-31 2015-12-01 Abbott Point Of Care, Inc. Biologic fluid analysis cartridge with deflecting top panel
US8817115B1 (en) 2010-05-05 2014-08-26 Amnis Corporation Spatial alignment of image data from a multichannel detector using a reference image
JP2013525820A (ja) 2010-05-06 2013-06-20 シングレクス、インコーポレイテッド 関節リウマチの発症に関するリスクを診断し、病期分類し、予測し、治療レスポンダーを同定するための方法
US10114020B2 (en) 2010-10-11 2018-10-30 Mbio Diagnostics, Inc. System and device for analyzing a fluidic sample
EP2635895A1 (de) 2010-11-03 2013-09-11 Reametrix Inc. Messsystem zur fluoreszenzdetekion und verfahren dafür
EP2635896A1 (de) 2010-11-03 2013-09-11 Reametrix Inc. Verfahren und vorrichtung zur fluoreszenzmessung von proben
EP2658653B1 (de) 2010-12-30 2015-03-04 Abbott Point Of Care, Inc. Kassette zur analyse biologischer proben mit probebehandlungsteil und analysekammerteil
JP5815123B2 (ja) 2011-05-05 2015-11-17 イー・エム・デイー・ミリポア・コーポレイシヨン 毛細管ベースのフローサイトメトリーにおける集光効率を高めるための装置及び方法
WO2013019491A1 (en) 2011-08-01 2013-02-07 Denovo Sciences Cell capture system and method of use
US9404864B2 (en) 2013-03-13 2016-08-02 Denovo Sciences, Inc. System for imaging captured cells
US10466160B2 (en) 2011-08-01 2019-11-05 Celsee Diagnostics, Inc. System and method for retrieving and analyzing particles
CN103733047B (zh) 2011-08-11 2016-03-30 奥林巴斯株式会社 目标粒子的检测方法
TW201310018A (zh) * 2011-08-19 2013-03-01 Ind Tech Res Inst 光聲影像裝置
CN105817276B (zh) 2011-08-24 2018-02-06 艾博特健康公司 生物流体样品分析盒
WO2013031365A1 (ja) 2011-08-30 2013-03-07 オリンパス株式会社 標的粒子の検出方法
CN103782157B (zh) * 2011-08-30 2016-01-20 奥林巴斯株式会社 包含胰液的生物试样中的目标粒子的检测方法
US9523682B2 (en) 2011-11-16 2016-12-20 Becton, Dickinson And Company Methods and systems for detecting an analyte in a sample
CN104115003B (zh) 2012-02-22 2016-03-23 奥林巴斯株式会社 目标粒子的检测方法
JP6095645B2 (ja) 2012-03-21 2017-03-15 オリンパス株式会社 標的核酸分子の検出方法
CN104685346B (zh) 2012-05-02 2018-05-29 查尔斯河实验室公司 细胞捕获系统及其使用
WO2013166337A1 (en) 2012-05-02 2013-11-07 Charles River Laboratories, Inc. Method of detecting viable cells in a cell sample
AU2013256174B2 (en) 2012-05-02 2017-03-02 Charles River Laboratories, Inc. Viability staining method
WO2014070235A1 (en) 2012-10-29 2014-05-08 Mbio Diagnostics, Inc. Biological particle identification system, cartridge and associated methods
AU2014205215B2 (en) 2013-01-11 2019-02-14 Becton, Dickinson And Company Low-cost point-of-care assay device
US9707562B2 (en) 2013-03-13 2017-07-18 Denovo Sciences, Inc. System for capturing and analyzing cells
US9856535B2 (en) 2013-05-31 2018-01-02 Denovo Sciences, Inc. System for isolating cells
US10391490B2 (en) 2013-05-31 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
WO2015069789A1 (en) 2013-11-06 2015-05-14 Becton, Dickinson And Company Microfluidic devices, and methods of making and using the same
AU2014348910B2 (en) 2013-11-13 2017-04-20 Becton, Dickinson And Company Optical imaging system and methods for using the same
US9709556B2 (en) 2013-12-11 2017-07-18 Analiza, Inc. Devices and methods for determining and/or isolating circulating cancer cells
US20150160246A1 (en) 2013-12-11 2015-06-11 Analiza, Inc. Devices and methods for determining and/or isolating cells such as circulating cancer or fetal cells
ES2962033T3 (es) 2014-10-14 2024-03-14 Becton Dickinson Co Gestión de muestras de sangre utilizando espuma de célula abierta
EP3403579B1 (de) 2014-10-14 2020-04-29 Becton, Dickinson and Company Blutprobenverwaltung mittels offenzelligem schaumstoff
EP3259574B1 (de) * 2015-02-18 2024-03-27 Becton, Dickinson and Company Optische erfassungssysteme und verfahren zur verwendung davon
CN106604780B (zh) 2015-03-10 2019-06-25 贝克顿·迪金森公司 生物流体微样本管理装置
CA3109854C (en) 2015-09-01 2023-07-25 Becton, Dickinson And Company Depth filtration device for separating specimen phases
CN105420091B (zh) * 2015-09-28 2018-06-26 广州睿辰生物科技有限公司 激光活体肿瘤细胞或其它病理细胞检测装置及检测方法
US11069054B2 (en) 2015-12-30 2021-07-20 Visiongate, Inc. System and method for automated detection and monitoring of dysplasia and administration of immunotherapy and chemotherapy
WO2017223147A1 (en) 2016-06-23 2017-12-28 Life Technologies Corporation Methods and compositions for detecting or measuring caspases or apoptosis
JP7034087B2 (ja) 2016-12-09 2022-03-11 大塚製薬株式会社 測定装置、測定異常検知方法、およびプログラム
AU2018307742A1 (en) * 2017-07-24 2020-01-30 Quantum-Si Incorporated Optical rejection photonic structures
CN110869746B (zh) 2017-08-17 2023-08-11 雅培医护站股份有限公司 利用通用电路系统执行光学和电化学测定的技术
WO2019035079A1 (en) 2017-08-17 2019-02-21 Abbott Point Of Care Inc. DEVICES, SYSTEMS AND METHODS FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS
US11253852B2 (en) 2017-08-17 2022-02-22 Abbott Point Of Care Inc. Devices, systems, and methods for performing optical assays
US10391492B2 (en) 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
CN109496565B (zh) * 2018-12-27 2020-11-06 浙江蓝天知识产权运营管理有限公司 多齿锯片式截顶剪草机
US10633693B1 (en) 2019-04-16 2020-04-28 Celsee Diagnostics, Inc. System and method for leakage control in a particle capture system
US11273439B2 (en) 2019-05-07 2022-03-15 Bio-Rad Laboratories, Inc. System and method for target material retrieval from microwells
AU2020267743B2 (en) 2019-05-07 2023-04-06 Bio-Rad Laboratories, Inc. System and method for automated single cell processing
CN118291246A (zh) 2019-06-14 2024-07-05 伯乐实验室有限公司 用于自动化单细胞处理和分析的系统和方法
EP4444910A4 (de) 2021-12-10 2025-11-05 Bio Rad Laboratories Inc Zusammensetzungen, verfahren und systeme zur probenverarbeitung mit morphologisch anpassbaren funktionalisierten partikeln
CN116337728B (zh) * 2023-05-30 2023-08-18 天津大学 一种单片集成微流式细胞仪荧光检测装置

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2850239A (en) * 1952-08-16 1958-09-02 American Optical Corp Counting device
US3777283A (en) * 1972-04-21 1973-12-04 C Elkins Transparent slide for the examination of liquid specimens
US3918812A (en) * 1973-05-07 1975-11-11 Us Energy Diagnoses of disease states by fluorescent measurements utilizing scanning laser beams
JPS53135660A (en) * 1977-04-30 1978-11-27 Olympus Optical Co Ltd Fluorescent photometric microscope using laser light
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
US4318886A (en) * 1979-11-19 1982-03-09 Nippon Kogaku K.K. Automatic HLA typing apparatus
US4665553A (en) * 1984-05-01 1987-05-12 Ortho Diagnostics Systems Inc. Methods and apparatus for analysis of particles and cells
US4727020A (en) * 1985-02-25 1988-02-23 Becton, Dickinson And Company Method for analysis of subpopulations of blood cells
US4683579A (en) * 1985-12-27 1987-07-28 Wardlaw Stephen C Method and apparatus for measuring blood constituent counts
US4758727A (en) * 1986-02-12 1988-07-19 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
US4877966A (en) * 1986-02-12 1989-10-31 Ohio State University Research Foundation Method and apparatus for the measurement of low-level laser-induced fluorescence
US5037207A (en) * 1986-02-12 1991-08-06 Ohio State University Research Foundation Laser imaging system
EP0266881A3 (de) * 1986-09-30 1990-04-04 Astromed Limited Verfahren und Vorrichtung für optische Mehrfachprüfung
US4979824A (en) * 1989-05-26 1990-12-25 Board Of Trustees Of The Leland Stanford Junior University High sensitivity fluorescent single particle and single molecule detection apparatus and method
US5072382A (en) * 1989-10-02 1991-12-10 Kamentsky Louis A Methods and apparatus for measuring multiple optical properties of biological specimens
US5107422A (en) * 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5091652A (en) * 1990-01-12 1992-02-25 The Regents Of The University Of California Laser excited confocal microscope fluorescence scanner and method
US5274240A (en) * 1990-01-12 1993-12-28 The Regents Of The University Of California Capillary array confocal fluorescence scanner and method
US5127730A (en) * 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5117466A (en) * 1991-04-30 1992-05-26 The United States Of America As Represented By The United States Department Of Energy Integrated fluorescence analysis system

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DE69521558T2 (de) 2002-06-06
EP0681178B1 (de) 2001-07-04
US5547849A (en) 1996-08-20
CA2148205A1 (en) 1995-11-03

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