ATE203017T1 - Verfahren zur herstellung von heteroaryl- phenylalaninen - Google Patents
Verfahren zur herstellung von heteroaryl- phenylalaninenInfo
- Publication number
- ATE203017T1 ATE203017T1 AT97952942T AT97952942T ATE203017T1 AT E203017 T1 ATE203017 T1 AT E203017T1 AT 97952942 T AT97952942 T AT 97952942T AT 97952942 T AT97952942 T AT 97952942T AT E203017 T1 ATE203017 T1 AT E203017T1
- Authority
- AT
- Austria
- Prior art keywords
- heteroaryl
- phenylalanines
- formula
- preparation
- compounds
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000006880 cross-coupling reaction Methods 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 150000002993 phenylalanine derivatives Chemical class 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/55—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Peptides Or Proteins (AREA)
- Furan Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002738A IT1289522B1 (it) | 1996-12-24 | 1996-12-24 | Processo per la preparazione di eteroaril-fenilalanine |
| PCT/EP1997/007024 WO1998028284A1 (en) | 1996-12-24 | 1997-12-15 | Process for the preparation of heteroaryl-phenylalanines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE203017T1 true ATE203017T1 (de) | 2001-07-15 |
Family
ID=11375489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97952942T ATE203017T1 (de) | 1996-12-24 | 1997-12-15 | Verfahren zur herstellung von heteroaryl- phenylalaninen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6448408B1 (de) |
| EP (1) | EP0948492B1 (de) |
| JP (1) | JP4226659B2 (de) |
| AT (1) | ATE203017T1 (de) |
| BR (1) | BR9713924B1 (de) |
| CA (1) | CA2275764C (de) |
| CZ (1) | CZ296240B6 (de) |
| DE (1) | DE69705640T2 (de) |
| DK (1) | DK0948492T3 (de) |
| ES (1) | ES2159892T3 (de) |
| GR (1) | GR3036855T3 (de) |
| IL (1) | IL130364A (de) |
| IT (1) | IT1289522B1 (de) |
| PT (1) | PT948492E (de) |
| WO (1) | WO1998028284A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4452899B2 (ja) * | 2001-12-13 | 2010-04-21 | 味の素株式会社 | 新規フェニルアラニン誘導体 |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1277737B1 (it) * | 1995-12-28 | 1997-11-12 | Zambon Spa | Derivati tiolici ad attivita' inibitrice delle metallopeptidasi |
-
1996
- 1996-12-24 IT IT96MI002738A patent/IT1289522B1/it active IP Right Grant
-
1997
- 1997-12-15 ES ES97952942T patent/ES2159892T3/es not_active Expired - Lifetime
- 1997-12-15 AT AT97952942T patent/ATE203017T1/de active
- 1997-12-15 DE DE69705640T patent/DE69705640T2/de not_active Expired - Lifetime
- 1997-12-15 DK DK97952942T patent/DK0948492T3/da active
- 1997-12-15 WO PCT/EP1997/007024 patent/WO1998028284A1/en not_active Ceased
- 1997-12-15 US US09/331,164 patent/US6448408B1/en not_active Expired - Lifetime
- 1997-12-15 CZ CZ0230799A patent/CZ296240B6/cs not_active IP Right Cessation
- 1997-12-15 IL IL13036497A patent/IL130364A/xx not_active IP Right Cessation
- 1997-12-15 JP JP52833298A patent/JP4226659B2/ja not_active Expired - Fee Related
- 1997-12-15 PT PT97952942T patent/PT948492E/pt unknown
- 1997-12-15 CA CA002275764A patent/CA2275764C/en not_active Expired - Fee Related
- 1997-12-15 EP EP97952942A patent/EP0948492B1/de not_active Expired - Lifetime
- 1997-12-15 BR BRPI9713924-6A patent/BR9713924B1/pt not_active IP Right Cessation
-
2001
- 2001-10-10 GR GR20010401721T patent/GR3036855T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL130364A (en) | 2003-07-06 |
| JP2001506662A (ja) | 2001-05-22 |
| ITMI962738A1 (it) | 1998-06-24 |
| DE69705640T2 (de) | 2002-05-02 |
| DK0948492T3 (da) | 2001-10-15 |
| IT1289522B1 (it) | 1998-10-15 |
| EP0948492A1 (de) | 1999-10-13 |
| BR9713924B1 (pt) | 2009-01-13 |
| CA2275764A1 (en) | 1998-07-02 |
| CA2275764C (en) | 2007-09-18 |
| EP0948492B1 (de) | 2001-07-11 |
| ES2159892T3 (es) | 2001-10-16 |
| JP4226659B2 (ja) | 2009-02-18 |
| WO1998028284A1 (en) | 1998-07-02 |
| IL130364A0 (en) | 2000-06-01 |
| CZ296240B6 (cs) | 2006-02-15 |
| US6448408B1 (en) | 2002-09-10 |
| PT948492E (pt) | 2001-11-30 |
| US20020028946A1 (en) | 2002-03-07 |
| BR9713924A (pt) | 2000-03-21 |
| CZ230799A3 (cs) | 1999-12-15 |
| GR3036855T3 (en) | 2002-01-31 |
| DE69705640D1 (de) | 2001-08-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |