ATE203248T1 - Proteinsynthese mittels nativer chemischer ligation (07.01.97) - Google Patents

Proteinsynthese mittels nativer chemischer ligation (07.01.97)

Info

Publication number
ATE203248T1
ATE203248T1 AT95919029T AT95919029T ATE203248T1 AT E203248 T1 ATE203248 T1 AT E203248T1 AT 95919029 T AT95919029 T AT 95919029T AT 95919029 T AT95919029 T AT 95919029T AT E203248 T1 ATE203248 T1 AT E203248T1
Authority
AT
Austria
Prior art keywords
ligation
native
full length
native chemical
chemical ligation
Prior art date
Application number
AT95919029T
Other languages
English (en)
Inventor
Stephen B H Kent
Tom W Muir
Philip E Dawson
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE203248T1 publication Critical patent/ATE203248T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95919029T 1995-05-04 1995-05-04 Proteinsynthese mittels nativer chemischer ligation (07.01.97) ATE203248T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/005668 WO1996034878A1 (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation
CA002218620A CA2218620C (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation

Publications (1)

Publication Number Publication Date
ATE203248T1 true ATE203248T1 (de) 2001-08-15

Family

ID=25679740

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95919029T ATE203248T1 (de) 1995-05-04 1995-05-04 Proteinsynthese mittels nativer chemischer ligation (07.01.97)

Country Status (13)

Country Link
EP (1) EP0832096B1 (de)
JP (1) JP3599346B2 (de)
AT (1) ATE203248T1 (de)
AU (1) AU711451B2 (de)
CA (1) CA2218620C (de)
DE (1) DE69521815T2 (de)
DK (1) DK0832096T3 (de)
ES (1) ES2161885T3 (de)
GR (1) GR3036895T3 (de)
MX (1) MX9708500A (de)
PT (1) PT832096E (de)
SI (1) SI0832096T1 (de)
WO (1) WO1996034878A1 (de)

Families Citing this family (67)

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US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
JP2001512306A (ja) 1997-01-08 2001-08-21 ライフ テクノロジーズ，インコーポレイテッド タンパク質の産生方法
DE69837170T2 (de) * 1997-06-13 2007-11-22 Amylin Pharmaceuticals, Inc., San Diego Festphasige native chemische Ligation von ungeschützten oder n-cystein-geschützten Peptiden in wässrigen Lösungen
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US6168784B1 (en) 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
US6844161B2 (en) 1997-09-04 2005-01-18 Gryphon Therapeutics, Inc. Modular protein libraries and methods of preparation
US6875594B2 (en) * 1997-11-13 2005-04-05 The Rockefeller University Methods of ligating expressed proteins
ATE332306T1 (de) 1998-08-31 2006-07-15 Gryphon Therapeutics Inc Chemische anknüpfung unter einbeziehung von einer lipid-matrix und herstellung von membranpolypeptiden
AUPP589598A0 (en) 1998-09-14 1998-10-08 University Of Queensland, The Novel peptides
AU3391900A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Encryption of traits using split gene sequences
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US6277957B1 (en) * 2000-03-23 2001-08-21 Derek Hudson Method for production of acylthio derivatives
WO2001098458A2 (en) * 2000-06-19 2001-12-27 Zyomyx, Inc. Methods for immobilizing polypeptides
US6977292B2 (en) 2000-09-01 2005-12-20 Gryphon Therapeutics Nucleophile-stable thioester generating compounds, methods of production and use
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
US20030191291A1 (en) * 2000-09-08 2003-10-09 Kochendoerfer Gerd G. Synthetic erythropoiesis stimulating proteins
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
GB0123262D0 (en) * 2001-09-27 2001-11-21 Adprotech Ltd Polymeric compounds
US6908963B2 (en) * 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
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US8034900B2 (en) 2002-12-30 2011-10-11 Amylin Pharmaceuticals, Inc. Water-soluble thioester and selenoester compounds and methods for making and using the same
DE10335584B4 (de) 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
JP2007527864A (ja) * 2003-09-05 2007-10-04 スローン − ケッタリング インスティチュート フォー キャンサー リサーチ 自然に起こる化学的連結による、多官能化ペプチドおよび／またはタンパク質の調製方法
EP1680443B9 (de) 2003-11-05 2014-09-03 Dana-Farber Cancer Institute, Inc. Peptide mit stabilisierter alpha-helix und deren verwendungen
EP2010556B1 (de) 2006-04-11 2015-09-23 Sloan-Kettering Institute for Cancer Research Homogenes erythropoïetin sowie ein verfahren zur deren bereitung
EP2628749A3 (de) * 2006-06-20 2013-12-04 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Antimikrobielle Kinocidinzusammensetzungen und Verwendungsverfahren
CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (de) 2007-03-28 2016-10-19 President and Fellows of Harvard College Geheftete Polypeptide
KR101534881B1 (ko) 2007-07-31 2015-07-07 가부시키가이샤 도우사 고가쿠 겐큐쇼 펩티드의 제조방법
EP2356139A4 (de) * 2008-07-23 2013-01-09 Harvard College Ligieren zusammengehefteter polypeptide
AU2009283678B2 (en) 2008-08-19 2014-01-16 Glytech, Inc. Glycoprotein production method and screening method
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
EP2376100B1 (de) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
KR101676515B1 (ko) * 2009-06-26 2016-11-15 가부시키가이샤 도우사 고가쿠 겐큐쇼 펩티드 티오에스테르체의 제조방법
WO2011008260A2 (en) 2009-07-13 2011-01-20 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
US20120114595A1 (en) 2009-07-16 2012-05-10 Otsuka Chemical Co., Ltd. Sugar chain-added ailim extracellular domain and method for producing same
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
FR2971509B1 (fr) 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
JP5925760B2 (ja) 2011-03-10 2016-05-25 株式会社糖鎖工学研究所 シアリル糖鎖を有する糖ペプチドの製造方法、当該製造方法に使用するシアリル糖鎖付加アミノ酸誘導体、及び当該糖ペプチド
WO2012174423A1 (en) 2011-06-17 2012-12-20 President And Fellows Of Harvard College Stabilized polypeptides as regulators of rab gtpase function
IN2014CN02854A (de) 2011-09-26 2015-07-03 Glytech Inc
FR2981352B1 (fr) 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
FR2988392B1 (fr) 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native
CA3113959A1 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3782638A1 (de) 2013-03-13 2021-02-24 President and Fellows of Harvard College Gestapelte und geheftete polypeptide und verwendungen davon
WO2014201370A1 (en) 2013-06-14 2014-12-18 President And Fellows Of Harvard College Stabilized polypeptide insulin receptor modulators
CN114805527A (zh) 2014-05-21 2022-07-29 哈佛大学的校长及成员们 Ras抑制肽和其用途
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
EP3590951A4 (de) * 2017-03-02 2021-01-06 Glytech, Inc. Herstellungsverfahren für aminosäurepolymer
EP4741410A1 (de) 2023-07-06 2026-05-13 Glytech, Inc. Solubilisierungsgruppe für schwer wasserlösliche proteine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228537B (it) * 1987-07-30 1991-06-20 Magis Farmaceutici Derivati della cisteina ad azione espettorante
EP0396116B1 (de) * 1989-05-02 1997-02-05 Abbott Laboratories Kovalente Kupplung von spezifischen Bindungspartnern an einer Festphase

Also Published As

Publication number Publication date
JP3599346B2 (ja) 2004-12-08
DE69521815T2 (de) 2002-04-04
ES2161885T3 (es) 2001-12-16
EP0832096B1 (de) 2001-07-18
EP0832096A4 (de) 1998-08-05
CA2218620C (en) 2007-02-27
JPH11508874A (ja) 1999-08-03
PT832096E (pt) 2002-01-30
GR3036895T3 (en) 2002-01-31
DK0832096T3 (da) 2001-10-01
EP0832096A1 (de) 1998-04-01
AU2474095A (en) 1996-11-21
CA2218620A1 (en) 1996-11-07
DE69521815D1 (de) 2001-08-23
MX9708500A (es) 1998-02-28
WO1996034878A1 (en) 1996-11-07
AU711451B2 (en) 1999-10-14
SI0832096T1 (en) 2001-12-31

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