ES2161885T3 - Sintesis de proteinas mediante ligacion quimica natural. - Google Patents

Sintesis de proteinas mediante ligacion quimica natural.

Info

Publication number
ES2161885T3
ES2161885T3 ES95919029T ES95919029T ES2161885T3 ES 2161885 T3 ES2161885 T3 ES 2161885T3 ES 95919029 T ES95919029 T ES 95919029T ES 95919029 T ES95919029 T ES 95919029T ES 2161885 T3 ES2161885 T3 ES 2161885T3
Authority
ES
Spain
Prior art keywords
union
native
proteins
peptidic
synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95919029T
Other languages
English (en)
Spanish (es)
Inventor
Stephen B H Kent
Tom W Muir
Philip E Dawson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of ES2161885T3 publication Critical patent/ES2161885T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES95919029T 1995-05-04 1995-05-04 Sintesis de proteinas mediante ligacion quimica natural. Expired - Lifetime ES2161885T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/US1995/005668 WO1996034878A1 (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation
CA002218620A CA2218620C (en) 1995-05-04 1995-05-04 Synthesis of proteins by native chemical ligation

Publications (1)

Publication Number Publication Date
ES2161885T3 true ES2161885T3 (es) 2001-12-16

Family

ID=25679740

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95919029T Expired - Lifetime ES2161885T3 (es) 1995-05-04 1995-05-04 Sintesis de proteinas mediante ligacion quimica natural.

Country Status (13)

Country Link
EP (1) EP0832096B1 (de)
JP (1) JP3599346B2 (de)
AT (1) ATE203248T1 (de)
AU (1) AU711451B2 (de)
CA (1) CA2218620C (de)
DE (1) DE69521815T2 (de)
DK (1) DK0832096T3 (de)
ES (1) ES2161885T3 (de)
GR (1) GR3036895T3 (de)
MX (1) MX9708500A (de)
PT (1) PT832096E (de)
SI (1) SI0832096T1 (de)
WO (1) WO1996034878A1 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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US6184344B1 (en) * 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6307018B1 (en) * 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
EP0963435B1 (de) 1997-01-08 2008-05-28 Invitrogen Corporation Verfahren zur herstellung von proteinen
EP1518862B1 (de) * 1997-06-13 2007-02-21 Gryphon Therapeutics, Inc. Festphasige native chemische Ligation von ungeschützten oder n-cystein-geschützten Peptiden in wässrigen Lösungen
AU745094B2 (en) * 1997-06-13 2002-03-14 Gryphon Sciences Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
US6168784B1 (en) 1997-09-03 2001-01-02 Gryphon Sciences N-terminal modifications of RANTES and methods of use
WO1999011655A1 (en) 1997-09-04 1999-03-11 Gryphon Sciences Modular protein libraries and methods of preparation
US6875594B2 (en) * 1997-11-13 2005-04-05 The Rockefeller University Methods of ligating expressed proteins
CN1325405A (zh) 1998-08-31 2001-12-05 格莱风科学公司 膜多肽的脂基质协助的化学结合和合成
AUPP589598A0 (en) 1998-09-14 1998-10-08 University Of Queensland, The Novel peptides
AU3391900A (en) 1999-03-05 2000-09-21 Maxygen, Inc. Encryption of traits using split gene sequences
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US7482425B2 (en) 1999-08-26 2009-01-27 Amylin Pharmaceuticals, Inc. Compositions for lipid matrix-assisted chemical ligation
US6277957B1 (en) * 2000-03-23 2001-08-21 Derek Hudson Method for production of acylthio derivatives
WO2001098458A2 (en) * 2000-06-19 2001-12-27 Zyomyx, Inc. Methods for immobilizing polypeptides
KR20030046389A (ko) * 2000-09-01 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법
KR20030057529A (ko) * 2000-09-08 2003-07-04 그리폰 테라퓨틱스, 인코포레이티드 합성 적혈구생성 자극 단백질
US7118737B2 (en) 2000-09-08 2006-10-10 Amylin Pharmaceuticals, Inc. Polymer-modified synthetic proteins
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components
GB0123262D0 (en) * 2001-09-27 2001-11-21 Adprotech Ltd Polymeric compounds
US6908963B2 (en) 2001-10-09 2005-06-21 Nektar Therapeutics Al, Corporation Thioester polymer derivatives and method of modifying the N-terminus of a polypeptide therewith
PL372298A1 (en) * 2002-02-19 2005-07-11 Rmf Dictagene S.A. Method for producing interferon
EP1616003A4 (de) 2002-12-30 2007-06-20 Gryphon Therapeutics Inc Wasserlösliche thioester- und selenoesterverbindungen sowie verfahren zur herstellung und verwendung davon
DE10335584B4 (de) 2003-07-31 2006-06-29 Philipps-Universität Marburg Verfahren zur Herstellung zyklischer Moleküle
US7635750B2 (en) 2003-09-05 2009-12-22 Sloan-Kettering Institute For Cancer Research Method for preparing polyfunctionalized peptides and/or proteins via native chemical ligation
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
EP2010556B1 (de) 2006-04-11 2015-09-23 Sloan-Kettering Institute for Cancer Research Homogenes erythropoïetin sowie ein verfahren zur deren bereitung
EP2089426B1 (de) * 2006-06-20 2016-04-20 Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center Antimikrobielle kinocidinzusammensetzungen und anwendungsverfahren
BRPI0720306A2 (pt) 2006-12-14 2014-02-04 Aileron Therapeutics Inc Sistemas de macrociclização da bis-sufidrila
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
ES2649941T3 (es) 2007-02-23 2018-01-16 Aileron Therapeutics, Inc. Aminoácidos sustituidos para preparar péptidos macrocíclicos unidos a triazol
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
CA2694542C (en) 2007-07-31 2017-08-29 Otsuka Chemical Co., Ltd. Method for producing peptide
EP2356139A4 (de) * 2008-07-23 2013-01-09 Harvard College Ligieren zusammengehefteter polypeptide
HUE037238T2 (hu) 2008-08-19 2018-08-28 Glytech Inc Glikoprotein elõállítási eljárás és screening eljárás
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010087994A2 (en) 2009-01-30 2010-08-05 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
TW201031749A (en) 2009-02-10 2010-09-01 Otsuka Chemical Co Ltd IgG-Fc fragment and method for manufacturing the same
BRPI1016151B1 (pt) 2009-06-26 2021-01-19 Glytech, Inc. processo para produção de um tioéster de peptídeo, processos para a produção de um polipeptídeo, processo para a produção de um segundo intermediário utilizado para o processo para a produção do tioéster de peptídeo e processo para a remoção de uma marca para a purificação adicionada a um lado terminal c de uma proteína recombinante
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
EP2455396A4 (de) 2009-07-16 2013-05-01 Otsuka Chemical Co Ltd Mit zuckerketten versetzte extrazelluläre ailim-domäne und verfahren zu ihrer herstellung
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
FR2952058B1 (fr) 2009-10-29 2013-10-04 Centre Nat Rech Scient Procede de ligation native de polypeptides
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
WO2012040459A2 (en) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Beta-catenin targeting peptides and uses thereof
FR2971509B1 (fr) 2011-02-16 2013-02-22 Centre Nat Rech Scient Procede de preparation de peptides par assemblage de multiples fragments peptidiques
RU2586524C2 (ru) 2011-03-10 2016-06-10 Глитек, Инк. Способ получения гликопептида, имеющего сиалированную сахарную цепь, и способ получения производного сиалилгликоаспарагина
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
US20140377807A1 (en) 2011-09-26 2014-12-25 Glytech, Inc. Method for producing polypeptide fragment with high efficiency, which is suitable for ncl method
FR2981352B1 (fr) 2011-10-17 2015-07-03 Centre Nat Rech Scient Procede de synthese de proteines
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
EP2819688A4 (de) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Triazol- und thioethervernetzte peptidomimetische makrozyklen
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
FR2988392B1 (fr) 2012-03-21 2014-04-11 Centre Nat Rech Scient Procede de ligation native
WO2014052647A2 (en) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Proline-locked stapled peptides and uses thereof
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
EP3391898A3 (de) 2013-03-13 2019-02-13 President and Fellows of Harvard College Gestapelte und geheftete polypeptide und verwendungen davon
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
CA2949535C (en) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Ras inhibitory peptides and uses thereof
EP3197478A4 (de) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017044633A1 (en) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of mcl-1
CN110382516B (zh) * 2017-03-02 2022-11-08 株式会社糖锁工学研究所 氨基酸聚合物的制备方法
JPWO2025009591A1 (de) 2023-07-06 2025-01-09

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1228537B (it) * 1987-07-30 1991-06-20 Magis Farmaceutici Derivati della cisteina ad azione espettorante
EP0396116B1 (de) * 1989-05-02 1997-02-05 Abbott Laboratories Kovalente Kupplung von spezifischen Bindungspartnern an einer Festphase

Also Published As

Publication number Publication date
CA2218620C (en) 2007-02-27
SI0832096T1 (en) 2001-12-31
AU2474095A (en) 1996-11-21
CA2218620A1 (en) 1996-11-07
GR3036895T3 (en) 2002-01-31
DK0832096T3 (da) 2001-10-01
DE69521815D1 (de) 2001-08-23
EP0832096A4 (de) 1998-08-05
ATE203248T1 (de) 2001-08-15
AU711451B2 (en) 1999-10-14
MX9708500A (es) 1998-02-28
WO1996034878A1 (en) 1996-11-07
EP0832096B1 (de) 2001-07-18
DE69521815T2 (de) 2002-04-04
PT832096E (pt) 2002-01-30
JPH11508874A (ja) 1999-08-03
EP0832096A1 (de) 1998-04-01
JP3599346B2 (ja) 2004-12-08

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