ATE203665T1 - Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung - Google Patents

Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung

Info

Publication number: ATE203665T1
Authority: AT; Austria
Prior art keywords: pharmaceutical compositions; production; methods; stabilized pharmaceutical; stabilized
Prior art date: 1996-12-18

Application number

AT97951339T

Other languages

English (en)

Inventor

Antal Toth

Laszlu Csernak

Klara Koritsanszky

Endrene Salamon

Marta Venczel

Erzsebet Vegeli

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-18

Filing date

1997-12-15

Publication date

2001-08-15

1997-12-15 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

2001-08-15 Application granted granted Critical

2001-08-15 Publication of ATE203665T1 publication Critical patent/ATE203665T1/de

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
108010061435 Enalapril Proteins 0.000 abstract 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
229960000309 enalapril maleate Drugs 0.000 abstract 1
OYFJQPXVCSSHAI-QFPUQLAESA-N enalapril maleate Chemical group OC(=O)\C=C/C(O)=O.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)CC1=CC=CC=C1 OYFJQPXVCSSHAI-QFPUQLAESA-N 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
239000011976 maleic acid Substances 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)

AT97951339T 1996-12-18 1997-12-15 Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung ATE203665T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU9603489A HU222497B1 (hu)	1996-12-18	1996-12-18	Enalapril-maleátot tartalmazó stabilizált gyógyszerkészítmény és eljárás előállítására
PCT/HU1997/000084 WO1998026765A1 (en)	1996-12-18	1997-12-15	Stabilized pharmaceutical compositions and process for the preparation thereof

Publications (1)

Publication Number	Publication Date
ATE203665T1 true ATE203665T1 (de)	2001-08-15

Family

ID=89994561

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97951339T ATE203665T1 (de)	1996-12-18	1997-12-15	Stabilisierte pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung

Country Status (8)

Country	Link
EP (1)	EP0952823B1 (de)
AT (1)	ATE203665T1 (de)
AU (1)	AU5493298A (de)
DE (1)	DE69705967T2 (de)
ES (1)	ES2160978T3 (de)
HU (1)	HU222497B1 (de)
PT (1)	PT952823E (de)
WO (1)	WO1998026765A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6296871B1 (en)	1998-04-12	2001-10-02	Ranbaxy Laboratories Limited	Stable solid pharmaceutical compositions containing enalapril maleate
MY121470A (en) *	1999-05-03	2006-01-28	Ranbaxy Lab Ltd	Stable solid pharmaceutical compositions containing enalapril maleate
WO2001019348A1 (en) *	1999-09-17	2001-03-22	Mylan Pharmaceuticals Inc.	Stabilization of enalapril maleate with maleic acid
AT5874U1 (de) *	2000-12-29	2003-01-27	Bioorg Bv	Pharmazeutische zubereitungen enthaltend amlodipinmaleat
RU2207869C1 (ru) *	2002-04-04	2003-07-10	Акционерное Курганское общество медицинских препаратов и изделий "Синтез"	Фармацевтическая твердая композиция на основе эналаприла малеата и способ ее получения
WO2012085249A2 (en)	2010-12-24	2012-06-28	Krka, D.D., Novo Mesto	Homogenous pharmaceutical oral dosage forms comprising lercanidipine and enalapril or their pharmaceutically acceptable salts
CN102357084B (zh) *	2011-10-11	2014-02-26	广东彼迪药业有限公司	一种马来酸依那普利的片剂组合物及其制备与应用
EP2765855A4 (de) *	2011-10-12	2015-03-25	Merck Sharp & Dohme	Pharmazeutische zusammensetzungen zur disproportionierungshemmung
RS66600B1 (sr)	2014-07-31	2025-04-30	Pharmathen Sa	Mini-tablete koje su disperzibilne u vodi koje sadrže enalapril maleat za lečenje hipertenzije u pedijatrijskoj populaciji i postupak za njihovo dobijanje
CN107007838B (zh) *	2016-09-30	2021-07-20	南京优科制药有限公司	一种含有马来酸依那普利、叶酸和酸稳定剂的药物组合物
CN106963938B (zh) *	2016-09-30	2021-04-30	南京优科制药有限公司	一种马来酸依那普利叶酸的药物组合物及其制备方法
CN117205165A (zh) *	2023-10-12	2023-12-12	安徽爱宠生物科技有限公司	宠物用马来酸依那普利片处方工艺开发

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4793998A (en) *	1986-10-20	1988-12-27	Warner-Lambert Company	Stabilized drug compositions
HU222489B1 (hu) *	1990-07-25	2003-07-28	Novartis Ag.	Stabilizált gyógyszerkészítmények és eljárás az előállításukra

1996
- 1996-12-18 HU HU9603489A patent/HU222497B1/hu not_active IP Right Cessation
1997
- 1997-12-15 EP EP97951339A patent/EP0952823B1/de not_active Expired - Lifetime
- 1997-12-15 WO PCT/HU1997/000084 patent/WO1998026765A1/en not_active Ceased
- 1997-12-15 PT PT97951339T patent/PT952823E/pt unknown
- 1997-12-15 ES ES97951339T patent/ES2160978T3/es not_active Expired - Lifetime
- 1997-12-15 DE DE69705967T patent/DE69705967T2/de not_active Expired - Lifetime
- 1997-12-15 AU AU54932/98A patent/AU5493298A/en not_active Abandoned
- 1997-12-15 AT AT97951339T patent/ATE203665T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU9603489D0 (en)	1997-02-28
AU5493298A (en)	1998-07-15
DE69705967T2 (de)	2002-04-04
WO1998026765A1 (en)	1998-06-25
EP0952823B1 (de)	2001-08-01
ES2160978T3 (es)	2001-11-16
DE69705967D1 (de)	2001-09-06
HUP9603489A2 (hu)	1998-08-28
PT952823E (pt)	2001-12-28
HU222497B1 (hu)	2003-07-28
HUP9603489A3 (en)	1998-12-28
EP0952823A1 (de)	1999-11-03

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Legal Events

Date	Code	Title	Description
2002-02-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties