ATE203990T1 - Indolderivat als 5-ht1a antagonist und als inhibitor der serotonin-wiederaufnahme - Google Patents

Indolderivat als 5-ht1a antagonist und als inhibitor der serotonin-wiederaufnahme

Info

Publication number
ATE203990T1
ATE203990T1 AT97304280T AT97304280T ATE203990T1 AT E203990 T1 ATE203990 T1 AT E203990T1 AT 97304280 T AT97304280 T AT 97304280T AT 97304280 T AT97304280 T AT 97304280T AT E203990 T1 ATE203990 T1 AT E203990T1
Authority
AT
Austria
Prior art keywords
inhibitor
serotonin reuptake
serotonin
indole derivative
ht1a antagonist
Prior art date
Application number
AT97304280T
Other languages
English (en)
Inventor
Daniel James Koch
Vincent Patrick Rocco
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE203990T1 publication Critical patent/ATE203990T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AT97304280T 1996-06-20 1997-06-18 Indolderivat als 5-ht1a antagonist und als inhibitor der serotonin-wiederaufnahme ATE203990T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2013196P 1996-06-20 1996-06-20

Publications (1)

Publication Number Publication Date
ATE203990T1 true ATE203990T1 (de) 2001-08-15

Family

ID=21796938

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97304280T ATE203990T1 (de) 1996-06-20 1997-06-18 Indolderivat als 5-ht1a antagonist und als inhibitor der serotonin-wiederaufnahme

Country Status (12)

Country Link
US (1) US5912256A (de)
EP (1) EP0814084B1 (de)
JP (1) JP2000513358A (de)
AT (1) ATE203990T1 (de)
AU (1) AU3401797A (de)
CA (1) CA2257962A1 (de)
DE (1) DE69706000T2 (de)
DK (1) DK0814084T3 (de)
ES (1) ES2160894T3 (de)
GR (1) GR3037072T3 (de)
PT (1) PT814084E (de)
WO (1) WO1997048698A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6399618B1 (en) 1997-07-09 2002-06-04 Cardiome Pharma Corp Compositions and methods for modulating sexual activity
US6310066B1 (en) 1998-04-29 2001-10-30 American Home Products Corp. Antipsychotic indolyl derivatives
EP1076647A2 (de) * 1998-04-29 2001-02-21 American Home Products Corporation Antipsychotisch wirkende indolyl-derivate
SI1113797T1 (sl) * 1998-09-15 2010-02-26 Lilly Co Eli Uporaba duloksetina pri zdravljenju fibromialgije
FR2788772B1 (fr) * 1999-01-26 2001-03-02 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2244438T3 (es) * 1999-05-24 2005-12-16 Mitsubishi Pharma Corporation Compuestos de fenoxipropilamina.
AR021155A1 (es) * 1999-07-08 2002-06-12 Lundbeck & Co As H Tratamiento de desordenes neuroticos
EP1671628B1 (de) * 1999-09-03 2012-10-03 APBI Holdings, LLC Selektive Serotonin-Aufnahme Inhibitoren mit schnellem Wirkungseintritt zur Behandlung von sexueller Dysfunktionen
EP1220658A1 (de) * 1999-09-28 2002-07-10 H. Lundbeck A/S Schmelzgranulierte zusammensetzung und aus dieser hergestellte darreichungsform mit modifizierter freisetzung
FR2799463B1 (fr) * 1999-10-12 2004-04-16 Adir Nouveaux composes cyano-indoles inhibiteurs de recapture de serotonine, leur procede de preparation et ces compositions pharmaceutiques qui les contiennent
AU1018801A (en) * 1999-10-29 2001-05-14 Novo Nordisk A/S Use of 3,4-substituted piperidines
ES2220582T3 (es) 1999-12-20 2004-12-16 Eli Lilly And Company Derivados de piperidina y su uso como antagonistas de receptor de serotonina.
ATE319709T1 (de) * 1999-12-20 2006-03-15 Lilly Co Eli Indolderivate zur behandlung von depression und angstzuständen
EP1242419A1 (de) * 1999-12-20 2002-09-25 Eli Lilly And Company Azabicyclo[3.2.1]octane derivate
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
AR035898A1 (es) 2001-05-25 2004-07-21 Wyeth Corp Aril-8-azabiciclo[3.2.1]octanos, un proceso para su preparacion, una formulacion y el uso de dichos compuestos para la manufactura de un medicamento para el tratamiento de la depresion
US6602911B2 (en) * 2001-11-05 2003-08-05 Cypress Bioscience, Inc. Methods of treating fibromyalgia
CA2475763A1 (en) * 2002-02-12 2003-08-21 Cypress Bioscience, Inc. Methods of treating attention deficit/hyperactivity disorder (adhd)
JP2006500366A (ja) * 2002-08-15 2006-01-05 ワイス 温度調節機能障害の治療ための５ＨＴ２ａ受容体の拮抗
EP1558231A4 (de) * 2002-10-03 2010-09-08 Cypress Bioscience Inc Dosiseskalation und geteilte tagesdosis von antidepressiva zurbehandlung von neurologischen erkrankungen
AU2003287024A1 (en) * 2002-11-05 2004-06-03 Eli Lilly And Company 3-aryloxy/thio-3-substituted propanamines and their use in inhibiting serotonin and norephinephrine reuptake
US20050004105A1 (en) * 2003-01-29 2005-01-06 Emer Leahy Treatment for a attention-deficit hyperactivity disorder
WO2004082686A2 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Use of compounds with combined 5-ht1a and ssri activities to treat sexual dysfunction
WO2004087156A1 (en) 2003-04-04 2004-10-14 H. Lundbeck A/S 4-(2-phenylsulfanyl-phenyl)-piperidine derivatives as serotonin reuptake inhibitors
US7160888B2 (en) 2003-08-22 2007-01-09 Warner Lambert Company Llc [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
TWI347183B (en) * 2003-12-23 2011-08-21 Lundbeck & Co As H 2-(1h-indolylsulfanyl)-benzyl amine derivatives
KR100872023B1 (ko) * 2003-12-23 2008-12-05 하. 룬트벡 아크티에 셀스카브 Ｓｓｒｉ로서 2-(1ｈ-인돌릴술파닐)-벤질 아민 유도체
PL1701940T3 (pl) * 2003-12-23 2008-11-28 H Lundbeck As Pochodne 2-(1H-indolilosulfanylo)benzyloaminy jako SSRI
AR052308A1 (es) 2004-07-16 2007-03-14 Lundbeck & Co As H Derivados de 2-(1h-indolilsulfanil)-arilamina y una composicion farmaceutica que contiene al compuesto
US7629473B2 (en) 2005-06-17 2009-12-08 H. Lundbeck A/S 2-(1H-indolylsulfanyl)-aryl amine derivatives
AR054393A1 (es) 2005-06-17 2007-06-20 Lundbeck & Co As H Derivados de benzo(b)furano y benzo(b)tiofeno, composiciones farmaceuticas que los contienen y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la inhibicion de la reabsorcion de neurotransmisores de amina biogenicos.
US7994220B2 (en) * 2005-09-28 2011-08-09 Cypress Bioscience, Inc. Milnacipran for the long-term treatment of fibromyalgia syndrome
ZA200901739B (en) * 2006-09-28 2010-06-30 Lundbeck & Co As H [2-(6-flouro-1H-indol-3-ylsulfanyl)benzyl]methyl amine for the treatment of affective disorders
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013761A (en) * 1988-06-03 1991-05-07 Eli Lilly And Company Serotonin antagonists
US5614523A (en) * 1995-01-17 1997-03-25 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5627196A (en) * 1995-01-17 1997-05-06 Eli Lilly And Company Compounds having effects on serotonin-related systems

Also Published As

Publication number Publication date
US5912256A (en) 1999-06-15
WO1997048698A1 (en) 1997-12-24
EP0814084A1 (de) 1997-12-29
GR3037072T3 (en) 2002-01-31
PT814084E (pt) 2001-11-30
CA2257962A1 (en) 1997-12-24
DK0814084T3 (da) 2001-10-08
HK1008525A1 (en) 1999-05-14
DE69706000T2 (de) 2002-04-04
JP2000513358A (ja) 2000-10-10
ES2160894T3 (es) 2001-11-16
DE69706000D1 (de) 2001-09-13
EP0814084B1 (de) 2001-08-08
AU3401797A (en) 1998-01-07

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