ATE203992T1 - Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren - Google Patents

Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren

Info

Publication number: ATE203992T1
Authority: AT; Austria
Prior art keywords: phenyl; substituted; amino; 6alkyl; pyrroloimidazolyl
Prior art date: 1992-01-27

Application number

AT93903211T

Other languages

English (en)

Inventor

Marcel August Constant Janssen

Alfons Herman Marg Raeymaekers

Eddy Jean Edgard Freyne

Michael Nicholas Greco

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-27

Filing date

1993-01-20

Publication date

2001-08-15

1993-01-20 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2001-08-15 Application granted granted Critical

2001-08-15 Publication of ATE203992T1 publication Critical patent/ATE203992T1/de

Links

-1 PYRROLOIMIDAZOLYL Chemical group 0.000 title abstract 9
HYZJCKYKOHLVJF-SFIIULIVSA-N 1H-benzimidazole Chemical class C1=CC=C2N[11CH]=NC2=C1 HYZJCKYKOHLVJF-SFIIULIVSA-N 0.000 title 1
239000003886 aromatase inhibitor Substances 0.000 title 1
229940046844 aromatase inhibitors Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000003163 gonadal steroid hormone Substances 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 1
125000006619 (C1-C6) dialkylamino group Chemical group 0.000 abstract 1
125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
229940058303 antinematodal benzimidazole derivative Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000002757 morpholinyl group Chemical group 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT93903211T 1992-01-27 1993-01-20 Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren ATE203992T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US82656492A	1992-01-27	1992-01-27
PCT/EP1993/000129 WO1993015079A1 (en)	1992-01-27	1993-01-20	Pyrroloimidazolyl and imidazopyridinyl substituted 1h-benzimidazole derivatives as aromatase inhibitors

Publications (1)

Publication Number	Publication Date
ATE203992T1 true ATE203992T1 (de)	2001-08-15

Family

ID=25246906

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93903211T ATE203992T1 (de)	1992-01-27	1993-01-20	Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren

Country Status (20)

Country	Link
EP (1)	EP0625155B1 (de)
JP (1)	JPH07503242A (de)
KR (1)	KR100263412B1 (de)
CN (2)	CN1036007C (de)
AT (1)	ATE203992T1 (de)
AU (1)	AU668708B2 (de)
CA (1)	CA2127689A1 (de)
DE (1)	DE69330557T2 (de)
DK (1)	DK0625155T3 (de)
ES (1)	ES2161714T3 (de)
FI (1)	FI106462B (de)
GR (1)	GR3036545T3 (de)
HU (1)	HU222117B1 (de)
IL (1)	IL104498A (de)
MX (1)	MX9300412A (de)
NO (1)	NO301118B1 (de)
PT (1)	PT625155E (de)
TW (1)	TW221690B (de)
WO (1)	WO1993015079A1 (de)
ZA (1)	ZA93561B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997000257A1 (en) *	1995-06-14	1997-01-03	Yamanouchi Pharmaceutical Co., Ltd.	Fused imidazole derivatives and medicinal composition thereof
EP1334106B1 (de) *	2000-11-17	2006-05-24	Takeda Pharmaceutical Company Limited	Imidazol derivate, ihre herstellung und ihre verwendung
JP2007500245A (ja) *	2003-06-10	2007-01-11	スミスクラインビーチャムコーポレーション	化合物
CN100496525C (zh) *	2004-04-02	2009-06-10	李嫦梅	从洋蓟根、茎、叶中提取活性成份的方法及其应用
AR050251A1 (es) *	2004-05-28	2006-10-11	Speedel Experimenta Ag	Compuestos heterociclicos con nitrogeno heteroatomico y composicion farmaceutica en base al compuesto
US20080076784A1 (en) *	2004-05-28	2008-03-27	Peter Herold	Bicyclic, Nitrogen-Containing Heterocycles and Aromatase Inhibitors
CA2568165A1 (en) *	2004-05-28	2005-12-15	Speedel Experimenta Ag	Heterocyclic compounds and their use as aldosterone synthase inhibitors
AR049667A1 (es) *	2004-07-09	2006-08-23	Speedel Experimenta Ag	Heterociclos condensados conteniendo n como inhibidores de aromatasa y procedimiento para prepararlos
JP5159303B2 (ja) *	2005-03-03	2013-03-06	武田薬品工業株式会社	放出制御組成物
GT200600381A (es) *	2005-08-25	2007-03-28		Compuestos organicos
CN101250559B (zh) *	2008-03-14	2010-12-29	厦门大学	一种利用天然抗菌剂防治酒精发酵染菌的方法
IN2014DN06781A (de)	2012-01-17	2015-05-22	Novartis Ag
CN106665636A (zh) *	2015-11-07	2017-05-17	郑州明德生物科技有限公司	采用月桂酰精氨酸乙酯抑制酒精发酵污染微生物的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4426450A (en) *	1981-08-24	1984-01-17	Fermentec Corporation	Fermentation process and apparatus
GB8820730D0 (en) *	1988-09-02	1988-10-05	Erba Carlo Spa	Substituted 5 6 7 8-tetrahydroimidazo/1.5-a/pyridines & process for their preparation
CA2026792A1 (en) *	1989-11-01	1991-05-02	Michael N. Greco	(6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
US5059431A (en) *	1990-12-07	1991-10-22	State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University	Process for deacidifying wine

1993
- 1993-01-20 CA CA002127689A patent/CA2127689A1/en not_active Abandoned
- 1993-01-20 DK DK93903211T patent/DK0625155T3/da active
- 1993-01-20 HU HU9402208A patent/HU222117B1/hu not_active IP Right Cessation
- 1993-01-20 DE DE69330557T patent/DE69330557T2/de not_active Expired - Fee Related
- 1993-01-20 PT PT93903211T patent/PT625155E/pt unknown
- 1993-01-20 EP EP93903211A patent/EP0625155B1/de not_active Expired - Lifetime
- 1993-01-20 AT AT93903211T patent/ATE203992T1/de not_active IP Right Cessation
- 1993-01-20 WO PCT/EP1993/000129 patent/WO1993015079A1/en not_active Ceased
- 1993-01-20 JP JP5512909A patent/JPH07503242A/ja active Pending
- 1993-01-20 KR KR1019940702246A patent/KR100263412B1/ko not_active Expired - Fee Related
- 1993-01-20 AU AU34505/93A patent/AU668708B2/en not_active Ceased
- 1993-01-20 ES ES93903211T patent/ES2161714T3/es not_active Expired - Lifetime
- 1993-01-21 TW TW082100454A patent/TW221690B/zh active
- 1993-01-25 IL IL10449893A patent/IL104498A/en not_active IP Right Cessation
- 1993-01-26 CN CN93100707A patent/CN1036007C/zh not_active Expired - Fee Related
- 1993-01-26 MX MX9300412A patent/MX9300412A/es unknown
- 1993-01-26 ZA ZA93561A patent/ZA93561B/xx unknown
- 1993-05-15 CN CN93107070A patent/CN1049687C/zh not_active Expired - Fee Related
1994
- 1994-07-22 NO NO942748A patent/NO301118B1/no not_active IP Right Cessation
- 1994-07-26 FI FI943511A patent/FI106462B/fi active
2001
- 2001-09-06 GR GR20010401398T patent/GR3036545T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2161714T3 (es)	2001-12-16
GR3036545T3 (en)	2001-12-31
NO942748L (no)	1994-09-26
CN1036007C (zh)	1997-10-01
AU3450593A (en)	1993-09-01
HU9402208D0 (en)	1994-09-28
CN1074907A (zh)	1993-08-04
MX9300412A (es)	1993-07-01
NO301118B1 (no)	1997-09-15
WO1993015079A1 (en)	1993-08-05
CN1049687C (zh)	2000-02-23
TW221690B (de)	1994-03-11
ZA93561B (en)	1994-07-26
EP0625155A1 (de)	1994-11-23
DK0625155T3 (da)	2001-11-12
IL104498A0 (en)	1993-05-13
FI106462B (fi)	2001-02-15
JPH07503242A (ja)	1995-04-06
KR100263412B1 (ko)	2000-08-01
HU222117B1 (hu)	2003-04-28
NO942748D0 (no)	1994-07-22
FI943511A0 (fi)	1994-07-26
AU668708B2 (en)	1996-05-16
CA2127689A1 (en)	1993-08-05
EP0625155B1 (de)	2001-08-08
DE69330557D1 (de)	2001-09-13
FI943511A7 (fi)	1994-07-26
HUT70853A (en)	1995-11-28
CN1095415A (zh)	1994-11-23
PT625155E (pt)	2002-01-30
DE69330557T2 (de)	2002-06-20
IL104498A (en)	1996-07-23

Legal Events

Date	Code	Title	Description
2004-10-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69330557D1 (de)	2001-09-13	Pyrroloimidazolyl und imidazopyridinyl substituierte 1h-benzimidazolderivate als aromatase inhibitoren
CA2272291A1 (en)	1998-10-29	Crf antagonistic quino- and quinazolines
PT772601E (pt)	2003-02-28	Compostos imidazolilo 4,5-substituidos para o tratamento da inflamacao
NZ507144A (en)	2002-10-25	Benzamide derivatives useful for the treatment of diseases mediated by cytokines
DK0418845T3 (da)	1995-09-18	Pyrazolderivater, fremgangsmåder til fremstilling deraf og farmaceutisk præparat omfattende samme
ATE165825T1 (de)	1998-05-15	Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
ATE211139T1 (de)	2002-01-15	Tetrahydroimidazopyridoindoldione als cgmp spezifische pde hemmer
NO963706L (no)	1996-11-06	Benzenkondenserte heterosykliske derivater og deres anvendelse
ATE163921T1 (de)	1998-03-15	Azoxycyanbenzol-derivate
ATE223376T1 (de)	2002-09-15	Bisarylcyclobutenderivate als cyclooxygenasehemmer
DE60110124D1 (de)	2005-05-19	Kondensierte pyrazindionderivate als pde inhibitoren
ATE372328T1 (de)	2007-09-15	Angiogenese-hemmende 5-substituierte-1,2,4- thiadiazolylderivate
DE68927599D1 (de)	1997-02-13	Hydantoin-Derivate
EA200401099A1 (ru)	2005-02-24	Производные гетероциклического амида
DE69714980D1 (de)	2002-10-02	Isoxazolidine derivate
DK1135387T3 (da)	2002-11-25	3-(heterocyclyl)-benzoylpyrazol-derivater
DE60111768D1 (de)	2005-08-04	N-formyl hydroxylamine derivate als inhibitoren der bakteriellen polypeptid deformylase zur behandlung von mikrobiellen infektionen