ATE204260T1 - 4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin- kinase inhibitoren - Google Patents

4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin- kinase inhibitoren

Info

Publication number: ATE204260T1
Authority: AT; Austria
Prior art keywords: alkyl; pct; substituted; amino; preparation
Prior art date: 1993-12-09

Application number

AT95902854T

Other languages

English (en)

Inventor

Andrew Peter Thomas

Park Alderley

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-09

Filing date

1994-12-05

Publication date

2001-09-15

1994-12-05 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204260T1 publication Critical patent/ATE204260T1/de

Links

FGDGJJNJEUYMFK-UHFFFAOYSA-N 4-n,6-n-diphenylpyrimidine-4,6-diamine Chemical class C=1C(NC=2C=CC=CC=2)=NC=NC=1NC1=CC=CC=C1 FGDGJJNJEUYMFK-UHFFFAOYSA-N 0.000 title 1
229940121358 tyrosine kinase inhibitor Drugs 0.000 title 1
239000005483 tyrosine kinase inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
-1 cyano, carboxy Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
230000004663 cell proliferation Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 abstract 1
150000003230 pyrimidines Chemical class 0.000 abstract 1
102000027426 receptor tyrosine kinases Human genes 0.000 abstract 1
108091008598 receptor tyrosine kinases Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT95902854T 1993-12-09 1994-12-05 4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin- kinase inhibitoren ATE204260T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939325217A GB9325217D0 (en)	1993-12-09	1993-12-09	Pyrimidine derivatives
PCT/GB1994/002659 WO1995015952A1 (en)	1993-12-09	1994-12-05	4,6-dianilino-pyrimidine derivatives, their preparation and their use as tyrosine kinase inhibitors

Publications (1)

Publication Number	Publication Date
ATE204260T1 true ATE204260T1 (de)	2001-09-15

Family

ID=10746350

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95902854T ATE204260T1 (de)	1993-12-09	1994-12-05	4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin- kinase inhibitoren

Country Status (13)

Country	Link
US (1)	US5880130A (de)
EP (1)	EP0733045B1 (de)
JP (1)	JP3583783B2 (de)
AT (1)	ATE204260T1 (de)
AU (1)	AU1194895A (de)
DE (1)	DE69427991T2 (de)
DK (1)	DK0733045T3 (de)
ES (1)	ES2163492T3 (de)
GB (2)	GB9325217D0 (de)
IL (1)	IL111896A0 (de)
PT (1)	PT733045E (de)
WO (1)	WO1995015952A1 (de)
ZA (1)	ZA949546B (de)

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DE69839338T2 (de) *	1997-02-05	2008-07-10	Warner-Lambert Company Llc	Pyrido (2,3-d) pyrimidine und 4-amino-pyrimidine als inhibitoren der zellulären proliferation
BRPI9909191B8 (pt)	1998-03-27	2021-07-06	Janssen Pharmaceutica Nv	derivados de pirimidina inibidores do hiv, seu uso e composição farmacêutica que os compreende
DE69933680T2 (de)	1998-08-29	2007-08-23	Astrazeneca Ab	Pyrimidine verbindungen
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PL203782B1 (pl)	1999-11-05	2009-11-30	Astrazeneca Ab	Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
GB0004888D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004886D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004890D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
GB0004887D0 (en)	2000-03-01	2000-04-19	Astrazeneca Uk Ltd	Chemical compounds
US7235551B2 (en)	2000-03-02	2007-06-26	Smithkline Beecham Corporation	1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
GB0007371D0 (en)	2000-03-28	2000-05-17	Astrazeneca Uk Ltd	Chemical compounds
GB0016877D0 (en)	2000-07-11	2000-08-30	Astrazeneca Ab	Chemical compounds
GB0021726D0 (en)	2000-09-05	2000-10-18	Astrazeneca Ab	Chemical compounds
JP4524072B2 (ja)	2000-10-23	2010-08-11	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー	新規化合物
GB0113041D0 (en)	2001-05-30	2001-07-18	Astrazeneca Ab	Chemical compounds
HUP0402657A3 (en)	2001-11-28	2010-03-29	Btg Int Ltd	Preventives or remedies for alzheimer' s disease or amyloid protein fibrosis inhibitors containing nitrogen-containing heteroaryl compounds
DE60303009T2 (de)	2002-01-22	2006-07-13	Warner-Lambert Co. Llc	2-(pyridin-2-ylamino)-pyrido[2,3-d]pyrimidin-7-one
JP2005524672A (ja)	2002-03-09	2005-08-18	アストラゼネカアクチボラグ	Ｃｄｋ阻害活性を有するイミダゾリル置換ピリミジン誘導体
GB0205688D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205693D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0205690D0 (en)	2002-03-09	2002-04-24	Astrazeneca Ab	Chemical compounds
GB0206215D0 (en)	2002-03-15	2002-05-01	Novartis Ag	Organic compounds
MXPA04010267A (es)	2002-04-19	2005-02-03	Smithkline Beecham Corp	Compuestos novedosos.
US20050014753A1 (en) *	2003-04-04	2005-01-20	Irm Llc	Novel compounds and compositions as protein kinase inhibitors
GB0311276D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
GB0311274D0 (en)	2003-05-16	2003-06-18	Astrazeneca Ab	Chemical compounds
TW200528101A (en)	2004-02-03	2005-09-01	Astrazeneca Ab	Chemical compounds
US20090137550A1 (en)	2005-03-25	2009-05-28	Glaxo Group Limited	Novel Compounds
MY145343A (en)	2005-03-25	2012-01-31	Glaxo Group Ltd	Novel compounds
PE20061193A1 (es)	2005-03-25	2006-12-02	Glaxo Group Ltd	DERIVADOS DE 3,4-DIHIDROPIRIMIDO[4,5-d]PIRIMIDIN-2-[1H]-0NA COMO INHIBIDORES DE QUINASA p38
US20080096905A1 (en)	2005-03-25	2008-04-24	Glaxo Group Limited	Process For Preparing Pyrido[2,3-D]Pyrimidin-7-One And 3,4-Dihydropyrimido{4,5-D}Pyrimidin-2(1H)-One Derivatives
BRPI0616722A2 (pt)	2005-09-30	2012-12-25	Astrazeneca Ab	composto ou um sal farmaceuticamente aceitÁvel ou um Éster hidrolisÁvel in vivo do mesmo, processo para preparar o mesmo, composiÇço farmacÊutica, uso de um composto ou um sal farmaceuticamente aceitÁvel ou um Éster hidrolisÁvel in vivo do mesmo, e, mÉtodos para produzir um efeito anti-proliferaÇço celular e um efeito inibidor cdk2, para tratar cÂncer, e para tratar doenÇas
BRPI0618135A2 (pt) *	2005-11-03	2011-08-16	Irm Llc	compostos e composições como inibidores da proteìna quinase
US20070231298A1 (en) *	2006-03-31	2007-10-04	Cell Genesys, Inc.	Cytokine-expressing cancer immunotherapy combinations
CA2681250A1 (en) *	2007-03-20	2008-09-25	Smithkline Beecham Corporation	Chemical compounds
EP2136635A4 (de) *	2007-03-20	2011-07-27	Glaxosmithkline Llc	Chemische verbindungen
US7989465B2 (en)	2007-10-19	2011-08-02	Avila Therapeutics, Inc.	4,6-disubstituted pyrimidines useful as kinase inhibitors
EP2214486A4 (de)	2007-10-19	2011-03-09	Avila Therapeutics Inc	Heteroarylverbindungen und ihre verwendungen
US9346802B2 (en)	2013-03-15	2016-05-24	Epizyme, Inc.	CARM1 inhibitors and uses thereof
US9718816B2 (en)	2013-03-15	2017-08-01	Epizyme, Inc.	1-phenoxy-3-(alkylamino)-propan-2-ol derivatives as CARM1 inhibitors and uses thereof
KR20160003647A (ko)	2013-03-15	2016-01-11	에피자임, 인코포레이티드	Carm1 억제제 및 이의 용도
CN104844526B (zh) *	2015-04-16	2018-08-31	温州医科大学	一种4,6-嘧啶二胺类化合物及其制备方法和应用

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1993
- 1993-12-09 GB GB939325217A patent/GB9325217D0/en active Pending
1994
- 1994-11-28 GB GB9423966A patent/GB9423966D0/en active Pending
- 1994-11-30 ZA ZA949546A patent/ZA949546B/xx unknown
- 1994-12-05 WO PCT/GB1994/002659 patent/WO1995015952A1/en not_active Ceased
- 1994-12-05 DE DE69427991T patent/DE69427991T2/de not_active Expired - Fee Related
- 1994-12-05 PT PT95902854T patent/PT733045E/pt unknown
- 1994-12-05 DK DK95902854T patent/DK0733045T3/da active
- 1994-12-05 AT AT95902854T patent/ATE204260T1/de not_active IP Right Cessation
- 1994-12-05 ES ES95902854T patent/ES2163492T3/es not_active Expired - Lifetime
- 1994-12-05 EP EP95902854A patent/EP0733045B1/de not_active Expired - Lifetime
- 1994-12-05 US US08/663,200 patent/US5880130A/en not_active Expired - Fee Related
- 1994-12-05 JP JP51603195A patent/JP3583783B2/ja not_active Expired - Fee Related
- 1994-12-05 AU AU11948/95A patent/AU1194895A/en not_active Abandoned
- 1994-12-06 IL IL11189694A patent/IL111896A0/xx unknown

Also Published As

Publication number	Publication date
DE69427991T2 (de)	2002-04-11
IL111896A0 (en)	1995-03-15
WO1995015952A1 (en)	1995-06-15
EP0733045B1 (de)	2001-08-16
ZA949546B (en)	1995-06-23
ES2163492T3 (es)	2002-02-01
JP3583783B2 (ja)	2004-11-04
DE69427991D1 (de)	2001-09-20
AU1194895A (en)	1995-06-27
US5880130A (en)	1999-03-09
PT733045E (pt)	2002-02-28
GB9423966D0 (en)	1995-01-11
DK0733045T3 (da)	2001-11-12
EP0733045A1 (de)	1996-09-25
JPH09506363A (ja)	1997-06-24
GB9325217D0 (en)	1994-02-09

Legal Events

Date	Code	Title	Description
2002-01-15	UEP	Publication of translation of european patent specification
2010-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE204260T1 (de)	2001-09-15	4,6-dianilino-pyrimidin derivate, deren herstellung und deren verwendung als tyrosin- kinase inhibitoren
TW283146B (de)	1996-08-11
MY114425A (en)	2002-10-31	Quinazoline derivatives
TW270117B (en)	1996-02-11	Quinazoline derivatives
DE69216158D1 (de)	1997-02-06	Chinazolinderivate enthaltende therapeutische Zusammensetzungen
CA2103383A1 (en)	1994-06-11	Quinazoline derivatives
MX9708177A (es)	1998-01-31	Derivados de quinazolina.
MY140507A (en)	2009-12-31	Quinazoline derivatives, pharmaceutical compositions containing them, processes for their preparation and their use in the production of an antiangiogenic and/or vascular permeability reducing effect