ATE204569T1 - Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren - Google Patents

Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren

Info

Publication number: ATE204569T1
Authority: AT; Austria
Prior art keywords: pct; moldulators; piperazine; formula; multidrug resistance
Prior art date: 1994-12-23

Application number

AT95941799T

Other languages

English (en)

Inventor

Philip Anthony Ashworth

Sukhjit Hunjan

Ian Andrew Pretswell

Hamish Ryder

Stephen James Brocchini

Original Assignee

Xenova Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-12-23

Filing date

1995-12-22

Publication date

2001-09-15

1995-12-22 Application filed by Xenova Ltd filed Critical Xenova Ltd

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204569T1 publication Critical patent/ATE204569T1/de

Links

230000036457 multidrug resistance Effects 0.000 title abstract 2
BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical class O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
JTHRRMFZHSDGNJ-UHFFFAOYSA-N piperazine-2,3-dione Chemical compound O=C1NCCNC1=O JTHRRMFZHSDGNJ-UHFFFAOYSA-N 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Electron Tubes For Measurement (AREA)

AT95941799T 1994-12-23 1995-12-22 Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren ATE204569T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9426090.8A GB9426090D0 (en)	1994-12-23	1994-12-23	Pharmaceutical compounds
PCT/GB1995/003029 WO1996020180A1 (en)	1994-12-23	1995-12-22	Piperazine-2,5-dione derivatives as modulators of multidrug resistance

Publications (1)

Publication Number	Publication Date
ATE204569T1 true ATE204569T1 (de)	2001-09-15

Family

ID=10766502

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95941799T ATE204569T1 (de)	1994-12-23	1995-12-22	Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren

Country Status (27)

Country	Link
US (1)	US5935955A (de)
EP (1)	EP0799210B1 (de)
JP (1)	JPH10511385A (de)
KR (1)	KR100412167B1 (de)
CN (1)	CN1108294C (de)
AT (1)	ATE204569T1 (de)
AU (1)	AU700891B2 (de)
BG (1)	BG63305B1 (de)
BR (1)	BR9510429A (de)
CA (1)	CA2207548A1 (de)
CZ (1)	CZ288935B6 (de)
DE (1)	DE69522342T2 (de)
DK (1)	DK0799210T3 (de)
ES (1)	ES2160726T3 (de)
FI (1)	FI972661L (de)
GB (2)	GB9426090D0 (de)
HU (1)	HUT77740A (de)
IL (1)	IL116526A (de)
MY (1)	MY131762A (de)
NO (1)	NO308532B1 (de)
NZ (1)	NZ297849A (de)
PL (1)	PL186851B1 (de)
PT (1)	PT799210E (de)
SK (1)	SK283385B6 (de)
UA (1)	UA61879C2 (de)
WO (1)	WO1996020180A1 (de)
ZA (1)	ZA9510908B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9708805D0 (en)	1997-05-01	1997-06-25	Smithkline Beecham Plc	Compounds
GB9810876D0 (en)	1998-05-20	1998-07-22	Smithkline Beecham Plc	Compounds
CA2346689A1 (en)	1998-10-08	2000-04-20	Gregor James Macdonald	Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6828412B1 (en) *	1999-09-03	2004-12-07	School Of Pharmacy, University Of London	Degradable polymers
JP2003528939A (ja) *	1999-09-03	2003-09-30	スクールオブファーマシー，ユニヴァーシティオブロンドン	分解性ポリマー
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
WO2002020663A2 (en)	2000-09-06	2002-03-14	Ap Pharma, Inc.	Degradable polyacetal polymers
US6376514B1 (en)	2000-10-17	2002-04-23	The Procter & Gamble Co.	Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en)	2000-10-17	2004-02-17	The Procter & Gamble Company	Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2465886A1 (en) *	2001-11-07	2003-05-15	Kathleen S. Crowley	Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US8710062B2 (en) *	2011-03-11	2014-04-29	Taipei Medical University	Piperazinedione compounds
CN103396372B (zh) *	2013-08-09	2015-05-20	中国科学院南海海洋研究所	一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
US12139491B2 (en) *	2018-12-27	2024-11-12	Holosmedic	Diketopiperazine derivatives as calcium ATPase inhibitor for enhancing anticancer activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5663179A (en) *	1992-07-10	1997-09-02	Laboratoires Glaxo Sa	Certain isoquinoline derivatives having anti-tumor properties
CA2120760A1 (en) *	1992-08-14	1994-03-03	Tohru Ando	Peptide having allergenicity
GB9217331D0 (en) *	1992-08-14	1992-09-30	Xenova Ltd	Pharmaceutical compounds
GB9402807D0 (en) *	1994-02-14	1994-04-06	Xenova Ltd	Pharmaceutical compounds
GB9410387D0 (en) *	1994-05-24	1994-07-13	Xenova Ltd	Pharmaceutical compounds

1994
- 1994-12-23 GB GBGB9426090.8A patent/GB9426090D0/en active Pending
1995
- 1995-12-21 ZA ZA9510908A patent/ZA9510908B/xx unknown
- 1995-12-22 PL PL95320915A patent/PL186851B1/pl not_active IP Right Cessation
- 1995-12-22 GB GB9712179A patent/GB2311780B/en not_active Expired - Fee Related
- 1995-12-22 CZ CZ19971902A patent/CZ288935B6/cs not_active IP Right Cessation
- 1995-12-22 NZ NZ297849A patent/NZ297849A/en unknown
- 1995-12-22 FI FI972661A patent/FI972661L/fi not_active IP Right Cessation
- 1995-12-22 BR BR9510429A patent/BR9510429A/pt not_active Application Discontinuation
- 1995-12-22 AU AU43102/96A patent/AU700891B2/en not_active Ceased
- 1995-12-22 PT PT95941799T patent/PT799210E/pt unknown
- 1995-12-22 UA UA97062956A patent/UA61879C2/uk unknown
- 1995-12-22 IL IL11652695A patent/IL116526A/xx not_active IP Right Cessation
- 1995-12-22 WO PCT/GB1995/003029 patent/WO1996020180A1/en not_active Ceased
- 1995-12-22 KR KR1019970704226A patent/KR100412167B1/ko not_active Expired - Fee Related
- 1995-12-22 DK DK95941799T patent/DK0799210T3/da active
- 1995-12-22 US US08/860,328 patent/US5935955A/en not_active Expired - Fee Related
- 1995-12-22 ES ES95941799T patent/ES2160726T3/es not_active Expired - Lifetime
- 1995-12-22 SK SK835-97A patent/SK283385B6/sk unknown
- 1995-12-22 CA CA002207548A patent/CA2207548A1/en not_active Abandoned
- 1995-12-22 AT AT95941799T patent/ATE204569T1/de not_active IP Right Cessation
- 1995-12-22 CN CN95197673A patent/CN1108294C/zh not_active Expired - Fee Related
- 1995-12-22 EP EP95941799A patent/EP0799210B1/de not_active Expired - Lifetime
- 1995-12-22 JP JP8520303A patent/JPH10511385A/ja not_active Ceased
- 1995-12-22 HU HU9800446A patent/HUT77740A/hu unknown
- 1995-12-22 DE DE69522342T patent/DE69522342T2/de not_active Expired - Fee Related
- 1995-12-23 MY MYPI95004072A patent/MY131762A/en unknown
1997
- 1997-06-11 BG BG101601A patent/BG63305B1/bg unknown
- 1997-06-23 NO NO972938A patent/NO308532B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO308532B1 (no)	2000-09-25
EP0799210A1 (de)	1997-10-08
FI972661A0 (fi)	1997-06-19
HUT77740A (hu)	1998-07-28
DE69522342T2 (de)	2002-01-03
BG101601A (bg)	1998-02-27
CZ288935B6 (cs)	2001-09-12
NO972938D0 (no)	1997-06-23
PT799210E (pt)	2002-01-30
US5935955A (en)	1999-08-10
GB2311780A (en)	1997-10-08
AU700891B2 (en)	1999-01-14
PL320915A1 (en)	1997-11-10
FI972661A7 (fi)	1997-08-22
CN1108294C (zh)	2003-05-14
GB2311780B (en)	1999-03-03
PL186851B1 (pl)	2004-03-31
ES2160726T3 (es)	2001-11-16
BG63305B1 (bg)	2001-09-28
CZ190297A3 (cs)	1998-01-14
UA61879C2 (en)	2003-12-15
FI972661L (fi)	1997-08-22
SK83597A3 (en)	1998-04-08
ZA9510908B (en)	1996-06-24
SK283385B6 (sk)	2003-06-03
IL116526A0 (en)	1996-03-31
CN1176637A (zh)	1998-03-18
WO1996020180A1 (en)	1996-07-04
IL116526A (en)	1999-11-30
JPH10511385A (ja)	1998-11-04
NO972938L (no)	1997-06-23
HK1001974A1 (en)	1998-07-24
DE69522342D1 (de)	2001-09-27
AU4310296A (en)	1996-07-19
NZ297849A (en)	1999-04-29
MY131762A (en)	2007-08-30
GB9426090D0 (en)	1995-02-22
DK0799210T3 (da)	2001-10-01
EP0799210B1 (de)	2001-08-22
CA2207548A1 (en)	1996-07-04
GB9712179D0 (en)	1997-08-13
BR9510429A (pt)	1998-07-07
KR100412167B1 (ko)	2004-05-27

Legal Events

Date	Code	Title	Description
2002-01-15	UEP	Publication of translation of european patent specification
2005-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE188472T1 (de)	2000-01-15	4-arylmethyloxymethyl piperidine als tachykinin antagonisten
DE69522342D1 (de)	2001-09-27	Piperazine-2,5-dione-derivate als multidrugresistenz moldulatoren
ATE219765T1 (de)	2002-07-15	Indolderivate als cgmp-pde inhibitoren
DE69620443D1 (de)	2002-05-08	Naphthyl substituierte benzimidazolderivate als antikoagulantien
MX9800577A (es)	1998-04-30	Derivados de 4,5-diaril oxazol.
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EP1184373A4 (de)	2004-10-20	Tricyclische verbindungen
ES2123756T3 (es)	1999-01-16	Derivados de piperazina.
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