DK0799210T3 - Piperazin-2,5-dionderivater som modulatorer af multiresistens - Google Patents

Piperazin-2,5-dionderivater som modulatorer af multiresistens

Info

Publication number
DK0799210T3
DK0799210T3 DK95941799T DK95941799T DK0799210T3 DK 0799210 T3 DK0799210 T3 DK 0799210T3 DK 95941799 T DK95941799 T DK 95941799T DK 95941799 T DK95941799 T DK 95941799T DK 0799210 T3 DK0799210 T3 DK 0799210T3
Authority
DK
Denmark
Prior art keywords
pct
modulators
formula
piperazine
resistance
Prior art date
Application number
DK95941799T
Other languages
English (en)
Inventor
Philip Anthony Ashworth
Sukhjit Hunjan
Ian Andrew Pretswell
Hamish Ryder
Stephen James Brocchini
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Application granted granted Critical
Publication of DK0799210T3 publication Critical patent/DK0799210T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electron Tubes For Measurement (AREA)
DK95941799T 1994-12-23 1995-12-22 Piperazin-2,5-dionderivater som modulatorer af multiresistens DK0799210T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9426090.8A GB9426090D0 (en) 1994-12-23 1994-12-23 Pharmaceutical compounds
PCT/GB1995/003029 WO1996020180A1 (en) 1994-12-23 1995-12-22 Piperazine-2,5-dione derivatives as modulators of multidrug resistance

Publications (1)

Publication Number Publication Date
DK0799210T3 true DK0799210T3 (da) 2001-10-01

Family

ID=10766502

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95941799T DK0799210T3 (da) 1994-12-23 1995-12-22 Piperazin-2,5-dionderivater som modulatorer af multiresistens

Country Status (27)

Country Link
US (1) US5935955A (da)
EP (1) EP0799210B1 (da)
JP (1) JPH10511385A (da)
KR (1) KR100412167B1 (da)
CN (1) CN1108294C (da)
AT (1) ATE204569T1 (da)
AU (1) AU700891B2 (da)
BG (1) BG63305B1 (da)
BR (1) BR9510429A (da)
CA (1) CA2207548A1 (da)
CZ (1) CZ288935B6 (da)
DE (1) DE69522342T2 (da)
DK (1) DK0799210T3 (da)
ES (1) ES2160726T3 (da)
FI (1) FI972661L (da)
GB (2) GB9426090D0 (da)
HU (1) HUT77740A (da)
IL (1) IL116526A (da)
MY (1) MY131762A (da)
NO (1) NO308532B1 (da)
NZ (1) NZ297849A (da)
PL (1) PL186851B1 (da)
PT (1) PT799210E (da)
SK (1) SK283385B6 (da)
UA (1) UA61879C2 (da)
WO (1) WO1996020180A1 (da)
ZA (1) ZA9510908B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9708805D0 (en) 1997-05-01 1997-06-25 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
CA2346689A1 (en) 1998-10-08 2000-04-20 Gregor James Macdonald Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents)
US6828412B1 (en) * 1999-09-03 2004-12-07 School Of Pharmacy, University Of London Degradable polymers
JP2003528939A (ja) * 1999-09-03 2003-09-30 スクール オブ ファーマシー， ユニヴァーシティ オブ ロンドン 分解性ポリマー
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
WO2002020663A2 (en) 2000-09-06 2002-03-14 Ap Pharma, Inc. Degradable polyacetal polymers
US6376514B1 (en) 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CA2465886A1 (en) * 2001-11-07 2003-05-15 Kathleen S. Crowley Methods of promoting uptake and nuclear accumulation of polyamides in eukaryotic cells
US8710062B2 (en) * 2011-03-11 2014-04-29 Taipei Medical University Piperazinedione compounds
CN103396372B (zh) * 2013-08-09 2015-05-20 中国科学院南海海洋研究所 一类2,5-二酮哌嗪衍生物及其制备方法和在制备抗海洋污损生物防除剂中的应用
US12139491B2 (en) * 2018-12-27 2024-11-12 Holosmedic Diketopiperazine derivatives as calcium ATPase inhibitor for enhancing anticancer activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5663179A (en) * 1992-07-10 1997-09-02 Laboratoires Glaxo Sa Certain isoquinoline derivatives having anti-tumor properties
CA2120760A1 (en) * 1992-08-14 1994-03-03 Tohru Ando Peptide having allergenicity
GB9217331D0 (en) * 1992-08-14 1992-09-30 Xenova Ltd Pharmaceutical compounds
GB9402807D0 (en) * 1994-02-14 1994-04-06 Xenova Ltd Pharmaceutical compounds
GB9410387D0 (en) * 1994-05-24 1994-07-13 Xenova Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
NO308532B1 (no) 2000-09-25
EP0799210A1 (en) 1997-10-08
FI972661A0 (fi) 1997-06-19
HUT77740A (hu) 1998-07-28
DE69522342T2 (de) 2002-01-03
BG101601A (bg) 1998-02-27
CZ288935B6 (cs) 2001-09-12
NO972938D0 (no) 1997-06-23
PT799210E (pt) 2002-01-30
US5935955A (en) 1999-08-10
GB2311780A (en) 1997-10-08
AU700891B2 (en) 1999-01-14
PL320915A1 (en) 1997-11-10
FI972661A7 (fi) 1997-08-22
CN1108294C (zh) 2003-05-14
GB2311780B (en) 1999-03-03
PL186851B1 (pl) 2004-03-31
ES2160726T3 (es) 2001-11-16
BG63305B1 (bg) 2001-09-28
CZ190297A3 (cs) 1998-01-14
UA61879C2 (en) 2003-12-15
FI972661L (fi) 1997-08-22
SK83597A3 (en) 1998-04-08
ZA9510908B (en) 1996-06-24
SK283385B6 (sk) 2003-06-03
IL116526A0 (en) 1996-03-31
CN1176637A (zh) 1998-03-18
WO1996020180A1 (en) 1996-07-04
IL116526A (en) 1999-11-30
JPH10511385A (ja) 1998-11-04
NO972938L (no) 1997-06-23
HK1001974A1 (en) 1998-07-24
DE69522342D1 (de) 2001-09-27
AU4310296A (en) 1996-07-19
NZ297849A (en) 1999-04-29
MY131762A (en) 2007-08-30
GB9426090D0 (en) 1995-02-22
EP0799210B1 (en) 2001-08-22
CA2207548A1 (en) 1996-07-04
GB9712179D0 (en) 1997-08-13
ATE204569T1 (de) 2001-09-15
BR9510429A (pt) 1998-07-07
KR100412167B1 (ko) 2004-05-27

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