ATE204878T1 - Therapeutische verbindungen - Google Patents

Therapeutische verbindungen

Info

Publication number: ATE204878T1
Authority: AT; Austria
Prior art keywords: hydrogen; compounds; oac; therapeutic compounds; nhac
Prior art date: 1995-06-23

Application number

AT96920967T

Other languages

English (en)

Inventor

Stephen Martin Courtney

Hitching Court Limited

Original Assignee

Oxford Glycosciences Uk Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-23

Filing date

1996-06-24

Publication date

2001-09-15

1995-06-23 Priority claimed from GBGB9512868.2A external-priority patent/GB9512868D0/en

1996-04-23 Priority claimed from GBGB9608372.0A external-priority patent/GB9608372D0/en

1996-04-25 Priority claimed from GBGB9608547.7A external-priority patent/GB9608547D0/en

1996-06-24 Application filed by Oxford Glycosciences Uk Ltd filed Critical Oxford Glycosciences Uk Ltd

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE204878T1 publication Critical patent/ATE204878T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 5
230000001225 therapeutic effect Effects 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
150000002431 hydrogen Chemical group 0.000 abstract 5
125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical group O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Percussion Or Vibration Massage (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pyrane Compounds (AREA)
Steroid Compounds (AREA)

AT96920967T 1995-06-23 1996-06-24 Therapeutische verbindungen ATE204878T1 (de)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
GBGB9512868.2A GB9512868D0 (en)	1995-06-23	1995-06-23	Therapeutic compounds
GBGB9608372.0A GB9608372D0 (en)	1996-04-23	1996-04-23	Therapeutic compounds
GBGB9608547.7A GB9608547D0 (en)	1996-04-25	1996-04-25	Therapeutic compounds
US1676296P	1996-05-03	1996-05-03
US1697396P	1996-05-07	1996-05-07
PCT/GB1996/001519 WO1997000882A1 (en)	1995-06-23	1996-06-24	Therapeutic compounds

Publications (1)

Publication Number	Publication Date
ATE204878T1 true ATE204878T1 (de)	2001-09-15

Family

ID=27517294

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96920967T ATE204878T1 (de)	1995-06-23	1996-06-24	Therapeutische verbindungen

Country Status (16)

Country	Link
US (1)	US5945406A (de)
EP (1)	EP0851866B1 (de)
JP (1)	JPH11507942A (de)
KR (1)	KR19990028344A (de)
CN (1)	CN1196059A (de)
AT (1)	ATE204878T1 (de)
AU (1)	AU6234296A (de)
CA (1)	CA2225247A1 (de)
DE (1)	DE69614867T2 (de)
ES (1)	ES2162078T3 (de)
HU (1)	HUP9901438A3 (de)
ID (1)	ID16479A (de)
IL (1)	IL122700A0 (de)
NO (1)	NO976043L (de)
PL (1)	PL328266A1 (de)
WO (1)	WO1997000882A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ID16479A (id) *	1995-06-23	1997-10-02	Oxford Glycosciences Uk Ltd	Senyawa-senyawa pengobatan
DE19741715A1 (de)	1997-09-22	1999-03-25	Hoechst Ag	Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
DE19741738A1 (de) *	1997-09-22	1999-03-25	Hoechst Ag	Linker-Nucleosid, seine Herstellung und Verwendung
DE19837387A1 (de)	1998-08-18	2000-02-24	Aventis Res & Tech Gmbh & Co	3'-Desoxypentopyranosyl-Nucleinsäure, ihre Herstellung und Verwendung
US6344460B1 (en) *	1999-03-19	2002-02-05	Lonza Inc.	Propynyl uracils
US20050143300A1 (en) *	2003-10-10	2005-06-30	Ma Jian-Xing	Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same
ES2628180T3 (es) *	2008-07-11	2017-08-02	Board Of Regents, The University Of Texas System	Nuevos acetatos de 2-desoxi monosacáridos con actividad anticancerosa
PL2981270T3 (pl)	2013-04-05	2022-05-09	Board Of Regents, The University Of Texas System	Estry 2-deoksy-monosacharydów o działaniu przeciwproliferacyjnym

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3354160A (en) *	1965-07-22	1967-11-21	Hoffmann La Roche	Tri-lower alkyl-silyl-5-fluoropyrimidines
US4248999A (en) *	1976-10-28	1981-02-03	Sankyo Company Limited	5-Fluorouracil derivatives and process for preparing thereof
DK149818C (da) *	1976-10-28	1987-04-06	Sankyo Co	Analogifremgangsmaade til fremstilling af 5-fluoruracil-derivater
JPS55153796A (en) *	1979-05-21	1980-11-29	Meiji Seika Kaisha Ltd	5-fluorouracil nucleoside and its preparation
JPS5829798A (ja) *	1981-08-15	1983-02-22	Tetsuo Suami	ヌクレオシド類似体
JPS5872599A (ja) *	1981-10-27	1983-04-30	Kanto Ishi Pharma Co Ltd	複合糖質誘導体
EP0119650A3 (de) *	1983-03-21	1987-09-30	THE PROCTER & GAMBLE COMPANY	Galactosyl-Insulin-Konjugate für die Behandlung von Zuckerkranken
JP2696393B2 (ja) *	1989-05-09	1998-01-14	株式会社日本抗体研究所	チミン誘導体及びこれを含有する抗ｈｉｖ剤
JPH0517494A (ja) *	1991-07-10	1993-01-26	Nippon Shoji Kk	グルコサミン誘導体
ATE284894T1 (de) *	1994-10-24	2005-01-15	Genencor Int	L-pyranosyl-nukleoside
ID16479A (id) *	1995-06-23	1997-10-02	Oxford Glycosciences Uk Ltd	Senyawa-senyawa pengobatan
GB9626450D0 (en) *	1996-12-20	1997-02-05	Oxford Glycosciences Uk Ltd	Therapeutic compounds

1996
- 1996-06-24 ID IDP961794A patent/ID16479A/id unknown
- 1996-06-24 AU AU62342/96A patent/AU6234296A/en not_active Abandoned
- 1996-06-24 DE DE69614867T patent/DE69614867T2/de not_active Expired - Fee Related
- 1996-06-24 JP JP9503686A patent/JPH11507942A/ja not_active Ceased
- 1996-06-24 AT AT96920967T patent/ATE204878T1/de active
- 1996-06-24 KR KR1019970709659A patent/KR19990028344A/ko not_active Withdrawn
- 1996-06-24 PL PL96328266A patent/PL328266A1/xx unknown
- 1996-06-24 EP EP96920967A patent/EP0851866B1/de not_active Expired - Lifetime
- 1996-06-24 CA CA002225247A patent/CA2225247A1/en not_active Abandoned
- 1996-06-24 WO PCT/GB1996/001519 patent/WO1997000882A1/en not_active Ceased
- 1996-06-24 HU HU9901438A patent/HUP9901438A3/hu unknown
- 1996-06-24 IL IL12270096A patent/IL122700A0/xx unknown
- 1996-06-24 CN CN96196248A patent/CN1196059A/zh active Pending
- 1996-06-24 ES ES96920967T patent/ES2162078T3/es not_active Expired - Lifetime
1997
- 1997-12-22 NO NO976043A patent/NO976043L/no not_active Application Discontinuation
- 1997-12-23 US US08/997,309 patent/US5945406A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO976043D0 (no)	1997-12-22
NO976043L (no)	1998-02-20
EP0851866A1 (de)	1998-07-08
HUP9901438A2 (hu)	1999-08-30
ES2162078T3 (es)	2001-12-16
AU6234296A (en)	1997-01-22
WO1997000882A1 (en)	1997-01-09
CA2225247A1 (en)	1997-01-09
CN1196059A (zh)	1998-10-14
EP0851866B1 (de)	2001-08-29
KR19990028344A (ko)	1999-04-15
ID16479A (id)	1997-10-02
JPH11507942A (ja)	1999-07-13
DE69614867D1 (de)	2001-10-04
DE69614867T2 (de)	2002-04-11
PL328266A1 (en)	1999-01-18
HUP9901438A3 (en)	2000-07-28
IL122700A0 (en)	1998-12-06
MX9710529A (es)	1998-08-30
US5945406A (en)	1999-08-31

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