ATE205475T1 - Verfahren zur herstellung von azetidinonen - Google Patents

Verfahren zur herstellung von azetidinonen

Info

Publication number: ATE205475T1
Authority: AT; Austria
Prior art keywords: substituted; pct; beta; amino; azetidinones
Prior art date: 1993-07-09

Application number

AT94921407T

Other languages

English (en)

Inventor

Tiruvettipuram K Thiruvengadam

Timothy Mcallister

Chou-Hong Tann

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-09

Filing date

1994-07-01

Publication date

2001-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE205475(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1994-07-01 Application filed by Schering Corp filed Critical Schering Corp

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205475T1 publication Critical patent/ATE205475T1/de

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT94921407T 1993-07-09 1994-07-01 Verfahren zur herstellung von azetidinonen ATE205475T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8935793A	1993-07-09	1993-07-09
PCT/US1994/007291 WO1995001961A1 (en)	1993-07-09	1994-07-01	Process for the synthesis of azetidinones

Publications (1)

Publication Number	Publication Date
ATE205475T1 true ATE205475T1 (de)	2001-09-15

Family

ID=22217215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921407T ATE205475T1 (de)	1993-07-09	1994-07-01	Verfahren zur herstellung von azetidinonen

Country Status (21)

Country	Link
US (1)	US5728827A (de)
EP (1)	EP0707567B1 (de)
JP (1)	JP2840452B2 (de)
KR (1)	KR0176001B1 (de)
CN (1)	CN1071745C (de)
AT (1)	ATE205475T1 (de)
AU (1)	AU681419B2 (de)
CA (1)	CA2166784C (de)
CZ (1)	CZ7696A3 (de)
DE (1)	DE69428280T2 (de)
DK (1)	DK0707567T3 (de)
ES (1)	ES2160125T3 (de)
FI (1)	FI960095L (de)
HU (1)	HUT73237A (de)
MX (1)	MX9405152A (de)
NO (1)	NO306294B1 (de)
NZ (1)	NZ268798A (de)
PL (1)	PL312502A1 (de)
PT (1)	PT707567E (de)
SK (1)	SK3796A3 (de)
WO (1)	WO1995001961A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5631365A (en)	1993-09-21	1997-05-20	Schering Corporation	Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6207822B1 (en)	1998-12-07	2001-03-27	Schering Corporation	Process for the synthesis of azetidinones
AU2030100A (en) *	1998-12-07	2000-06-26	Schering Corporation	Process for the synthesis of azetidinones
WO2000063703A1 (en)	1999-04-16	2000-10-26	Schering Corporation	Use of azetidinone compounds
US6982251B2 (en)	2000-12-20	2006-01-03	Schering Corporation	Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en)	2001-01-26	2006-07-04	Schering Corporation	Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl)	2001-01-26	2008-02-29	Schering Corp	Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
US20060287254A1 (en) *	2001-01-26	2006-12-21	Schering Corporation	Use of substituted azetidinone compounds for the treatment of sitosterolemia
JP4711600B2 (ja)	2001-01-26	2011-06-29	シェーリングコーポレイション	シトステロール血症の処置のための置換アゼチジノン化合物の使用
EA006898B1 (ru)	2001-03-28	2006-04-28	Шеринг Корпорейшн	Энантиоселективный синтез промежуточных соединений для получения азетидинонов
US7053080B2 (en)	2001-09-21	2006-05-30	Schering Corporation	Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7132415B2 (en) *	2001-09-21	2006-11-07	Schering Corporation	Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US20030204096A1 (en) *	2002-03-25	2003-10-30	Schering Corporation	Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en)	2002-07-05	2002-08-14	Astrazeneca Ab	Chemical compounds
US7135556B2 (en) *	2002-07-19	2006-11-14	Schering Corporation	NPC1L1 (NPC3) and methods of use thereof
CA2504878A1 (en)	2002-11-06	2004-05-27	Schering Corporation	Cholesterol absorption inhibitors for the treatment of demyelination
JP4589919B2 (ja) *	2003-03-07	2010-12-01	シェーリングコーポレイション	高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7459442B2 (en) *	2003-03-07	2008-12-02	Schering Corporation	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN100439361C (zh)	2003-03-07	2008-12-03	先灵公司	取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh)	2003-03-07	2006-04-05	先灵公司	取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
EP1699760B1 (de) *	2003-12-23	2017-05-17	Merck Sharp & Dohme Corp.	Antihypercholesterinämische verbindungen
CA2550215A1 (en)	2003-12-23	2005-07-07	Astrazeneca Ab	Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
EP1723414A4 (de) *	2004-01-16	2008-03-26	Merck & Co Inc	Npc1l1 (npc3) und verfahren zur identifizierung seiner liganden
DE102004025071B4 (de) *	2004-05-21	2006-12-21	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
JP2007538042A (ja) *	2004-05-21	2007-12-27	サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	１，４−ジフェニルアゼチジノン誘導体の製造方法
HRP20121007T1 (hr)	2004-12-20	2013-01-31	Merck Sharp & Dohme Corp.	Postupak za sintezu azetidinona
EP1902046B1 (de) *	2005-06-20	2009-12-02	Schering Corporation	Als antagonisten von histamin h3 geeignete piperidinderivate
SA06270191B1 (ar)	2005-06-22	2010-03-29	استرازينيكا ايه بي	مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
EP1986489A2 (de) *	2006-02-24	2008-11-05	Schering Corporation	Npc1l1-orthologe
TW200811098A (en)	2006-04-27	2008-03-01	Astrazeneca Ab	Chemical compounds
WO2008030382A1 (en) *	2006-09-05	2008-03-13	Schering Corporation	Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008032338A2 (en) *	2006-09-11	2008-03-20	Manne Satyanarayana Reddy	Improved process for the preparation of ezetimibe and its intermediates
CN101679236B (zh)	2007-01-24	2013-03-06	克尔克公司	依泽替米贝的制备方法和其的衍生物
WO2010113175A2 (en)	2009-04-01	2010-10-07	Matrix Laboratories Ltd	Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN104803858B (zh) *	2014-01-23	2019-03-01	东莞东阳光科研发有限公司	一种制备四丁基氟化铵三水合物的方法
FI4097099T3 (fi)	2020-02-07	2024-07-30	Gasherbrum Bio Inc	Heterosyklisiä glp-1-agonisteja
AU2024222719A1 (en)	2023-02-16	2025-08-21	Gasherbrum Bio, Inc.	Heterocyclic glp-1 agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0333268A1 (de) *	1988-03-18	1989-09-20	Merck & Co. Inc.	Verfahren zur Synthese eines chiralen 3-beta-Wasserstoff-(3R) 4-aroyloxyazetidinons
US4876365A (en) *	1988-12-05	1989-10-24	Schering Corporation	Intermediate compounds for preparing penems and carbapenems
US4983597A (en) *	1989-08-31	1991-01-08	Merck & Co., Inc.	Beta-lactams as anticholesterolemic agents
US5085473A (en) *	1990-10-09	1992-02-04	Yuhe Yang	Air actuated car curtain device
CZ14294A3 (en) *	1991-07-23	1994-07-13	Schering Corp	Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof

1994
- 1994-07-01 PT PT94921407T patent/PT707567E/pt unknown
- 1994-07-01 JP JP7504054A patent/JP2840452B2/ja not_active Expired - Fee Related
- 1994-07-01 FI FI960095A patent/FI960095L/fi unknown
- 1994-07-01 NZ NZ268798A patent/NZ268798A/en unknown
- 1994-07-01 DE DE69428280T patent/DE69428280T2/de not_active Expired - Lifetime
- 1994-07-01 AT AT94921407T patent/ATE205475T1/de active
- 1994-07-01 EP EP94921407A patent/EP0707567B1/de not_active Expired - Lifetime
- 1994-07-01 WO PCT/US1994/007291 patent/WO1995001961A1/en not_active Ceased
- 1994-07-01 ES ES94921407T patent/ES2160125T3/es not_active Expired - Lifetime
- 1994-07-01 CN CN94192732A patent/CN1071745C/zh not_active Expired - Fee Related
- 1994-07-01 US US08/578,594 patent/US5728827A/en not_active Expired - Lifetime
- 1994-07-01 KR KR1019960700068A patent/KR0176001B1/ko not_active Expired - Fee Related
- 1994-07-01 CZ CZ9676A patent/CZ7696A3/cs unknown
- 1994-07-01 PL PL94312502A patent/PL312502A1/xx unknown
- 1994-07-01 HU HU9503748A patent/HUT73237A/hu unknown
- 1994-07-01 AU AU72146/94A patent/AU681419B2/en not_active Ceased
- 1994-07-01 CA CA002166784A patent/CA2166784C/en not_active Expired - Fee Related
- 1994-07-01 DK DK94921407T patent/DK0707567T3/da active
- 1994-07-01 SK SK37-96A patent/SK3796A3/sk unknown
- 1994-07-06 MX MX9405152A patent/MX9405152A/es not_active IP Right Cessation
1996
- 1996-01-08 NO NO960083A patent/NO306294B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0707567A1 (de)	1996-04-24
MX9405152A (es)	1995-01-31
FI960095A7 (fi)	1996-01-09
CA2166784C (en)	2001-12-11
CA2166784A1 (en)	1995-01-19
DK0707567T3 (da)	2001-11-26
NZ268798A (en)	1997-01-29
HUT73237A (en)	1996-07-29
KR0176001B1 (ko)	1999-03-20
SK3796A3 (en)	1997-02-05
FI960095A0 (fi)	1996-01-09
CN1071745C (zh)	2001-09-26
CZ7696A3 (en)	1996-04-17
PL312502A1 (en)	1996-04-29
PT707567E (pt)	2002-01-30
JPH08507085A (ja)	1996-07-30
CN1126989A (zh)	1996-07-17
KR960703853A (ko)	1996-08-31
WO1995001961A1 (en)	1995-01-19
EP0707567B1 (de)	2001-09-12
HU9503748D0 (en)	1996-02-28
NO960083D0 (no)	1996-01-08
DE69428280D1 (de)	2001-10-18
ES2160125T3 (es)	2001-11-01
US5728827A (en)	1998-03-17
AU7214694A (en)	1995-02-06
NO306294B1 (no)	1999-10-18
NO960083L (no)	1996-03-04
JP2840452B2 (ja)	1998-12-24
DE69428280T2 (de)	2002-06-13
AU681419B2 (en)	1997-08-28
FI960095L (fi)	1996-01-09

Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE205475T1 (de)	2001-09-15	Verfahren zur herstellung von azetidinonen
BG108168A (en)	2004-09-30	Enantioselective synthesis of azetidinone intermediate compounds
DE69432140D1 (de)	2003-03-27	Verfahren zur Herstellung von 9-Desoxotaxanen
IL148944A0 (en)	2002-09-12	Process to separate 1,3-propanediol or gylcerol, or a mixture thereof from a biological mixture
PL319692A1 (en)	1997-08-18	Method of obtaining substituted 3-amino benzonitriles
YU12000A (sh)	2002-11-15	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
BG104243A (en)	2001-05-31	Method for the synthesis of quinoline derivatives
ATE169013T1 (de)	1998-08-15	Verfahren zur herstellung von gamma-butyrolacton
MY133666A (en)	2007-11-30	Enzymatic process for stereoselective preparation of therapeutic amides
AU694653B2 (en)	1998-07-23	D4T polymorphic form I process
ATE417919T1 (de)	2009-01-15	Mikrobiologisches verfahren zur herstellung von amiden
ATE234288T1 (de)	2003-03-15	Verfahren zur herstellung eines buthylthuio- isochinolinderivates und zwischenprodukte dafür
ES2193524T3 (es)	2003-11-01	Procedimiento de preparacion de acido azetidino-2-carboxilico.
DE69803979D1 (de)	2002-04-04	Verfahren zur herstellung von carboxamido-4-azasteroiden
DE60107292D1 (de)	2004-12-23	Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
ATE234820T1 (de)	2003-04-15	Aminoalkyloxime, verfahren zur dessen herstellung,ihre verwendung als medikamente und zwischenprodukte
DE69623117D1 (de)	2002-09-26	Verfahren zur herstellung von 4-hydroxy-2-pyrrolidon
ATE286013T1 (de)	2005-01-15	Verfahren zur herstellung von polyhalogenierten para-trifluoroanilinen
DE69812858D1 (de)	2003-05-08	Verfahren zur Herstellung von (R)-3-Hydroxy-4-Butyrolacton, nützlich für die Herstellung von (R)-Carnitin
YU37902A (sh)	2005-07-19	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3- benzazocini i njihova primena kao lekova
HUT69373A (en)	1995-09-28	N-substituted 2-azetidinones, as intermediates in novel process of n-ansubstituted 2-azetidinones
MXPA04007055A (es)	2004-10-11	Metodo.
MX9706724A (es)	1997-11-29	Sintesis catalitica enantioselectiva de una azetidinona espirofusionada.