SK3796A3 - Process for the synthesis of azetidinones - Google Patents

Process for the synthesis of azetidinones Download PDF

Info

Publication number
SK3796A3
SK3796A3 SK37-96A SK3796A SK3796A3 SK 3796 A3 SK3796 A3 SK 3796A3 SK 3796 A SK3796 A SK 3796A SK 3796 A3 SK3796 A3 SK 3796A3
Authority
SK
Slovakia
Prior art keywords
phenyl
group
substituted
lower alkyl
benzyl
Prior art date
Application number
SK37-96A
Other languages
English (en)
Slovak (sk)
Inventor
Tiruvertipuram K Thiruvengadam
Timothy Mcallister
Chou-Hong Tann
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22217215&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK3796(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of SK3796A3 publication Critical patent/SK3796A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SK37-96A 1993-07-09 1994-07-01 Process for the synthesis of azetidinones SK3796A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8935793A 1993-07-09 1993-07-09
PCT/US1994/007291 WO1995001961A1 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Publications (1)

Publication Number Publication Date
SK3796A3 true SK3796A3 (en) 1997-02-05

Family

ID=22217215

Family Applications (1)

Application Number Title Priority Date Filing Date
SK37-96A SK3796A3 (en) 1993-07-09 1994-07-01 Process for the synthesis of azetidinones

Country Status (21)

Country Link
US (1) US5728827A (de)
EP (1) EP0707567B1 (de)
JP (1) JP2840452B2 (de)
KR (1) KR0176001B1 (de)
CN (1) CN1071745C (de)
AT (1) ATE205475T1 (de)
AU (1) AU681419B2 (de)
CA (1) CA2166784C (de)
CZ (1) CZ7696A3 (de)
DE (1) DE69428280T2 (de)
DK (1) DK0707567T3 (de)
ES (1) ES2160125T3 (de)
FI (1) FI960095L (de)
HU (1) HUT73237A (de)
MX (1) MX9405152A (de)
NO (1) NO306294B1 (de)
NZ (1) NZ268798A (de)
PL (1) PL312502A1 (de)
PT (1) PT707567E (de)
SK (1) SK3796A3 (de)
WO (1) WO1995001961A1 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
AU2030100A (en) * 1998-12-07 2000-06-26 Schering Corporation Process for the synthesis of azetidinones
WO2000063703A1 (en) 1999-04-16 2000-10-26 Schering Corporation Use of azetidinone compounds
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
SI1413331T1 (sl) 2001-01-26 2008-02-29 Schering Corp Kombinacije fenofibrata peroksisomskega proliferator aktivirajocega receptorja (PPAR) z ezetimib zaviralcem absorpcije sterola za vaskularne indikacije
US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
JP4711600B2 (ja) 2001-01-26 2011-06-29 シェーリング コーポレイション シトステロール血症の処置のための置換アゼチジノン化合物の使用
EA006898B1 (ru) 2001-03-28 2006-04-28 Шеринг Корпорейшн Энантиоселективный синтез промежуточных соединений для получения азетидинонов
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
US7132415B2 (en) * 2001-09-21 2006-11-07 Schering Corporation Methods and therapeutic combinations for the treatment of xanthoma using sterol absorption inhibitors
US20030204096A1 (en) * 2002-03-25 2003-10-30 Schering Corporation Enantioselective synthesis of azetidinone intermediate compounds
GB0215579D0 (en) 2002-07-05 2002-08-14 Astrazeneca Ab Chemical compounds
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
JP4589919B2 (ja) * 2003-03-07 2010-12-01 シェーリング コーポレイション 高コレステロール血症の処置のための、置換アゼチジノン化合物、これらの処方物および使用
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
CN100439361C (zh) 2003-03-07 2008-12-03 先灵公司 取代的2-吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
CN1756755A (zh) 2003-03-07 2006-04-05 先灵公司 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途
EP1699760B1 (de) * 2003-12-23 2017-05-17 Merck Sharp & Dohme Corp. Antihypercholesterinämische verbindungen
CA2550215A1 (en) 2003-12-23 2005-07-07 Astrazeneca Ab Diphenylazetidinone derivates possessing cholesterol absorption inhibitory activity
EP1723414A4 (de) * 2004-01-16 2008-03-26 Merck & Co Inc Npc1l1 (npc3) und verfahren zur identifizierung seiner liganden
DE102004025071B4 (de) * 2004-05-21 2006-12-21 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diphenylazetidinon-Derivaten
JP2007538042A (ja) * 2004-05-21 2007-12-27 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング １，４−ジフェニルアゼチジノン誘導体の製造方法
HRP20121007T1 (hr) 2004-12-20 2013-01-31 Merck Sharp & Dohme Corp. Postupak za sintezu azetidinona
EP1902046B1 (de) * 2005-06-20 2009-12-02 Schering Corporation Als antagonisten von histamin h3 geeignete piperidinderivate
SA06270191B1 (ar) 2005-06-22 2010-03-29 استرازينيكا ايه بي مشتقات من 2- أزيتيدينون جديدة باعتبارها مثبطات لامتصاص الكوليسترول لعلاج حالات فرط نسبة الدهون في الدم
EP1986489A2 (de) * 2006-02-24 2008-11-05 Schering Corporation Npc1l1-orthologe
TW200811098A (en) 2006-04-27 2008-03-01 Astrazeneca Ab Chemical compounds
WO2008030382A1 (en) * 2006-09-05 2008-03-13 Schering Corporation Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis
WO2008032338A2 (en) * 2006-09-11 2008-03-20 Manne Satyanarayana Reddy Improved process for the preparation of ezetimibe and its intermediates
CN101679236B (zh) 2007-01-24 2013-03-06 克尔克公司 依泽替米贝的制备方法和其的衍生物
WO2010113175A2 (en) 2009-04-01 2010-10-07 Matrix Laboratories Ltd Enzymatic process for the preparation of (s)-5-(4-fluoro-phenyl)-5-hydroxy- 1morpholin-4-yl-pentan-1-one, an intermediate of ezetimibe and further conversion to ezetimibe
CN104803858B (zh) * 2014-01-23 2019-03-01 东莞东阳光科研发有限公司 一种制备四丁基氟化铵三水合物的方法
FI4097099T3 (fi) 2020-02-07 2024-07-30 Gasherbrum Bio Inc Heterosyklisiä glp-1-agonisteja
AU2024222719A1 (en) 2023-02-16 2025-08-21 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333268A1 (de) * 1988-03-18 1989-09-20 Merck & Co. Inc. Verfahren zur Synthese eines chiralen 3-beta-Wasserstoff-(3R) 4-aroyloxyazetidinons
US4876365A (en) * 1988-12-05 1989-10-24 Schering Corporation Intermediate compounds for preparing penems and carbapenems
US4983597A (en) * 1989-08-31 1991-01-08 Merck & Co., Inc. Beta-lactams as anticholesterolemic agents
US5085473A (en) * 1990-10-09 1992-02-04 Yuhe Yang Air actuated car curtain device
CZ14294A3 (en) * 1991-07-23 1994-07-13 Schering Corp Substituted beta-lactam compounds usable as hypocholesterol pharmaceutical preparations and process for preparing thereof

Also Published As

Publication number Publication date
EP0707567A1 (de) 1996-04-24
MX9405152A (es) 1995-01-31
FI960095A7 (fi) 1996-01-09
CA2166784C (en) 2001-12-11
CA2166784A1 (en) 1995-01-19
DK0707567T3 (da) 2001-11-26
NZ268798A (en) 1997-01-29
HUT73237A (en) 1996-07-29
KR0176001B1 (ko) 1999-03-20
FI960095A0 (fi) 1996-01-09
CN1071745C (zh) 2001-09-26
CZ7696A3 (en) 1996-04-17
PL312502A1 (en) 1996-04-29
PT707567E (pt) 2002-01-30
JPH08507085A (ja) 1996-07-30
CN1126989A (zh) 1996-07-17
KR960703853A (ko) 1996-08-31
WO1995001961A1 (en) 1995-01-19
EP0707567B1 (de) 2001-09-12
HU9503748D0 (en) 1996-02-28
NO960083D0 (no) 1996-01-08
DE69428280D1 (de) 2001-10-18
ES2160125T3 (es) 2001-11-01
US5728827A (en) 1998-03-17
AU7214694A (en) 1995-02-06
ATE205475T1 (de) 2001-09-15
NO306294B1 (no) 1999-10-18
NO960083L (no) 1996-03-04
JP2840452B2 (ja) 1998-12-24
DE69428280T2 (de) 2002-06-13
AU681419B2 (en) 1997-08-28
FI960095L (fi) 1996-01-09

Similar Documents

Publication Publication Date Title
SK3796A3 (en) Process for the synthesis of azetidinones
US6093812A (en) Process for the stereospecific synthesis of azetidinones
US5561227A (en) Process for the stereospecific synthesis of azetidinones
JP3145993B2 (ja) 抗腫瘍化合物及びその調製方法
JPH03176468A (ja) イソインドロン誘導体
KR950013767B1 (ko) 키랄성 아제티디논 화합물 및 이의 제조방법
EP0336369A1 (de) 3-Acylamino-1-[[[(substituierte Sulfonyl)amino]carbonyl]amino]2-azetidinone
IE55839B1 (en) Azetidine compounds
EP0110280B1 (de) Verfahren zur Herstellung von Penem-Verbindungen
US6858727B2 (en) Intermediate of carbapenem antibiotics and process for the preparation thereof
US4559333A (en) Hydrazone substituted penems
EP0001715A2 (de) Azetidinon Antibiotika und ihre pharmazeutischen Präparate und Verwendung
WO1996016067A1 (en) Silylation process
FI83959B (fi) Foerfarande foer framstaellning av antibiotiskt aktiva 1-karba-(1-detia) cefalosporinderivat.
KR880001989B1 (ko) 펜엠 화합물의 제조방법
JPS61176563A (ja) ４，４‐ジアルキル‐２‐アゼチジノン類の製造法
US4587241A (en) Heterocyclic substituted penems
JP2696807B2 (ja) カルバペネム誘導体の製法
JPS6366187A (ja) ２α−置換ペニシリン誘導体
JPS59134796A (ja) ６−アミノペニシラン酸のテトラアルキルアンモニウム塩を用いる６−アミノペニシラン酸エステルの製造法
JPH0273057A (ja) カルバペネム系抗生物質合成用中間体の製造法
US20060281918A1 (en) Resolution of enantiomeric mixtures of beta-lactams
GB2276166A (en) Benzimidazoles as angiotensin II antagonists
JPH0572396B2 (de)
JP2001514169A (ja) β−メチルカルバペネム中間体の製造