ATE205490T1 - Substituierte heteroaromatische derivate - Google Patents

Substituierte heteroaromatische derivate

Info

Publication number: ATE205490T1
Authority: AT; Austria
Prior art keywords: heteroaromatic ring; signifies; diseases; gastrointestinal; halogen
Prior art date: 1995-10-13

Application number

AT96932827T

Other languages

English (en)

Inventor

Toshiaki Banyu Mase

Morihiro Banyu Mitsuya

Kensuke Banyu Kobayashi

Kazuhito Banyu Noguchi

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-07

Publication date

2001-09-15

1996-10-07 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205490T1 publication Critical patent/ATE205490T1/de

Links

125000001072 heteroaryl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
208000000884 Airway Obstruction Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010020651 Hyperkinesia Diseases 0.000 abstract 1
208000000269 Hyperkinesis Diseases 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
208000028938 Urination disease Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
239000003149 muscarinic antagonist Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
208000014001 urinary system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT96932827T 1995-10-13 1996-10-07 Substituierte heteroaromatische derivate ATE205490T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP29171695		1995-10-13
JP35134295		1995-12-26
PCT/JP1996/002904 WO1997013766A1 (en)	1995-10-13	1996-10-07	Substituted heteroaromatic derivatives

Publications (1)

Publication Number	Publication Date
ATE205490T1 true ATE205490T1 (de)	2001-09-15

Family

ID=26558669

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96932827T ATE205490T1 (de)	1995-10-13	1996-10-07	Substituierte heteroaromatische derivate

Country Status (7)

Country	Link
US (1)	US6130232A (de)
EP (1)	EP0863141B1 (de)
AT (1)	ATE205490T1 (de)
AU (1)	AU7145996A (de)
CA (1)	CA2234619A1 (de)
DE (1)	DE69615214T2 (de)
WO (1)	WO1997013766A1 (de)

Families Citing this family (54)

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WO2000066579A1 (en) *	1999-04-28	2000-11-09	Banyu Pharmaceutical Co., Ltd.	Processes for the preparation of piperidylmethylpyridine derivatives
WO2001013918A1 (en) *	1999-08-23	2001-03-01	H. Lundbeck A/S	Treatment of urinary incontinence
GB9923077D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
MXPA02005596A (es)	1999-12-07	2004-09-10	Theravance Inc	Derivados de carbamato con actividad antagonista para el rerceptor muscarinico.
UA73543C2 (uk)	1999-12-07	2005-08-15	Тераванс, Інк.	Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
GB0000228D0 (en) *	2000-01-06	2000-03-01	Phytopharm Plc	Fluoro substituted sapogenins and their use
CA2398388A1 (en) *	2000-01-20	2001-07-26	Koji Kato	Novel piperidine compound and pharmaceutical thereof
FR2816940A1 (fr) *	2000-11-23	2002-05-24	Lipha	Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
HUP0303529A3 (en)	2000-12-22	2008-03-28	Almirall Ag	New quinuclidine carbamate derivatives, process for their preparation and pharmaceutical compositions containing them and their use
CN1250545C (zh)	2000-12-28	2006-04-12	阿尔米雷尔普罗迪斯制药有限公司	新的奎宁环衍生物类及含有这类衍生物的药物组合物
GB0107822D0 (en) *	2001-03-28	2001-05-23	Phytopharm Plc	Sapogenin derivatives their synthesis and use methods based upon their use
CN102727501A (zh) *	2002-03-27	2012-10-17	菲特法姆股份有限公司	皂角苷配基及其衍生物的用途
US20050130948A1 (en) *	2002-03-27	2005-06-16	Daryl Rees	Therapeutic methods and uses of sapogenins and their derivatives
ES2206021B1 (es) *	2002-04-16	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de pirrolidinio.
ES2203327B1 (es)	2002-06-21	2005-06-16	Almirall Prodesfarma, S.A.	Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es)	2002-07-02	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de quinuclidina-amida.
NZ537584A (en) *	2002-07-08	2006-07-28	Ranbaxy Lab Ltd	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
WO2004014853A1 (en) *	2002-07-31	2004-02-19	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
AU2002321711A1 (en) *	2002-08-09	2004-02-25	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo (3.1.0) hexane derivatives useful as muscarinic receptor antagonist
JP2006501236A (ja) *	2002-08-23	2006-01-12	ランバクシーラボラトリーズリミテッド	ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体
JP2006506392A (ja) *	2002-10-29	2006-02-23	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ムスカリン受容体アンタゴニストとしての第四級アンモニウム化合物
TW200800953A (en) *	2002-10-30	2008-01-01	Theravance Inc	Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
US7232835B2 (en)	2002-12-10	2007-06-19	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo derivatives as muscarinic receptor antagonists
AU2002347552A1 (en) *	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
AU2002347553A1 (en) *	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	Flavaxate derivatives as muscarinic receptor antagonists
US7488748B2 (en) *	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es)	2003-02-14	2005-01-01	Theravance Inc	DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
WO2004089898A1 (en)	2003-04-09	2004-10-21	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
CA2521788A1 (en) *	2003-04-10	2004-10-21	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
BRPI0409302A (pt) *	2003-04-11	2006-04-11	Ranbaxy Lab Ltd	derivados azabiciclo como antagonistas de recetores muscarìnicos, método para sua preparação e composição farmacêutica contendo os mesmos
TW200510298A (en) *	2003-06-13	2005-03-16	Theravance Inc	Substituted pyrrolidine and related compounds
JP2007524641A (ja) *	2003-07-11	2007-08-30	セラヴァンス，インコーポレーテッド	置換４−アミノ−１−ベンジルピペリジン化合物
KR100500760B1 (ko) *	2003-07-22	2005-07-14	동방에프티엘 주식회사	염산 프로피베린의 제조방법
ES2329586T3 (es)	2003-11-21	2009-11-27	Theravance, Inc.	Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
US7071224B2 (en) *	2004-03-11	2006-07-04	Theravance, Inc.	Diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2005087763A1 (en) *	2004-03-11	2005-09-22	Theravance, Inc.	Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1765809B1 (de) *	2004-06-16	2008-12-31	Ranbaxy Laboratories Limited	Als antagonisten des muscarinrezeptors geeignete xanthinderivate
EP1781607A2 (de) *	2004-08-19	2007-05-09	Ranbaxy Laboratories Limited	Pyrrolidinderivate als antagonisten des muscarinrezeptors
WO2006032994A2 (en) *	2004-09-24	2006-03-30	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
WO2006035303A1 (en) *	2004-09-29	2006-04-06	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
WO2006054162A1 (en) *	2004-11-19	2006-05-26	Ranbaxy Laboratories Limited	Azabicyclic muscarinic receptor antagonists
WO2006064304A1 (en) *	2004-12-15	2006-06-22	Ranbaxy Laboratories Limited	Acid addition salts of muscarinic receptor antagonists
EP1888525A1 (de) *	2005-05-03	2008-02-20	Ranbaxy Laboratories Limited	3,6-disubstituierte azabicyclo[3.1.0]hexanderivate als antagonisten des muskarinrezeptors
WO2007045979A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
GB0602778D0 (en)	2006-02-10	2006-03-22	Glaxo Group Ltd	Novel compound
US20090010923A1 (en) *	2007-04-24	2009-01-08	University Of Maryland, Baltimore	Treatment of cancer with anti-muscarinic receptor agents

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JPS6018661B2 (ja) *	1976-01-01	1985-05-11	太田製薬株式会社	１−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体
JPS5679688A (en) *	1979-12-04	1981-06-30	Ota Seiyaku Kk	4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production
IT1231238B (it) *	1987-09-21	1991-11-26	Angeli Inst Spa	Derivati ammidinici
GB8825505D0 (en) *	1988-11-01	1988-12-07	Pfizer Ltd	Therapeutic agents
JP3294961B2 (ja) *	1993-12-10	2002-06-24	杏林製薬株式会社	新規イミダゾール誘導体及びその製造法
JP2717928B2 (ja) *	1994-01-31	1998-02-25	東洋電機製造株式会社	給水装置
JPH07258250A (ja) *	1994-03-25	1995-10-09	Yamanouchi Pharmaceut Co Ltd	エステル誘導体
EP0823423B1 (de) *	1995-04-28	2004-06-16	Banyu Pharmaceutical Co., Ltd.	1,4-disubstituierte piperidinderivate
CA2179574A1 (en) *	1995-06-26	1996-12-27	Tomomi Okada	Substituted piperidine derivative and medicine comprising the same

1996
- 1996-10-07 DE DE69615214T patent/DE69615214T2/de not_active Expired - Fee Related
- 1996-10-07 CA CA002234619A patent/CA2234619A1/en not_active Abandoned
- 1996-10-07 AT AT96932827T patent/ATE205490T1/de active
- 1996-10-07 WO PCT/JP1996/002904 patent/WO1997013766A1/ja not_active Ceased
- 1996-10-07 AU AU71459/96A patent/AU7145996A/en not_active Abandoned
- 1996-10-07 US US09/051,287 patent/US6130232A/en not_active Expired - Fee Related
- 1996-10-07 EP EP96932827A patent/EP0863141B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69615214D1 (de)	2001-10-18
EP0863141B1 (de)	2001-09-12
CA2234619A1 (en)	1997-04-17
DE69615214T2 (de)	2002-06-27
EP0863141A1 (de)	1998-09-09
EP0863141A4 (de)	1999-01-27
US6130232A (en)	2000-10-10
AU7145996A (en)	1997-04-30
WO1997013766A1 (en)	1997-04-17

Publication	Publication Date	Title
DE69615214D1 (de)	2001-10-18	Substituierte heteroaromatische derivate
ATE269305T1 (de)	2004-07-15	1,4-disubstituierte piperidinderivate
AU780419C (en)	2005-09-29	Triazaspiro(5.5)undecane derivatives and drugs containing the same as the active ingredient
NO20020823D0 (no)	2002-02-19	Heterosykliske forbindelser og deres anvendelse som metabotrofisk glutamatreseptor-antagonister
KR970701174A (ko)	1997-03-17	신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same)
WO2004026248A3 (en)	2004-07-15	Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
EP0915094A4 (de)	2004-09-22	Morphinanderivate und ihre medizinische Anwendung
EP0518530A3 (en)	1993-01-20	Improvements in or relating to excitatory amino acid receptor antagonists
JO2321B1 (en)	2005-09-12	4-phenyl-pyridine derivatives
WO2006038006A3 (en)	2006-05-18	5-sulfonyl-1-piperidinyl substituted indole derivatives as 5-ht6 receptor antagonists for the treatment of cns disorders
MXPA03010321A (es)	2004-02-17	Derivados de 1-oxa-3,9-diaza-spiro-5,5-undecan-2-onas y su uso como antagonista del receptor de neurocinina.
ATE219486T1 (de)	2002-07-15	Trizyklische indol-2-carbonsäure derivate als selektive nmda rezeptor antagonisten
PT1122253E (pt)	2005-11-30	Derivados de quinazolinona
ES2111086T3 (es)	1998-03-01	Compuestos triciclicos anfoteros como agentes antihistaminicos y antialergicos.
DE69319939D1 (de)	1998-09-03	Aminobenzoesäure Derivate
AU6017800A (en)	2001-02-13	Novel amide derivatives
DK0940401T3 (da)	2003-03-03	2-Carbonylthiazolderivater og anvendelse deraf
DK0613897T3 (da)	1997-07-28	Piperidinderivater med anti-histamin-og anti-leukotrienaktivitet
BR0311805A (pt)	2005-03-15	Diazocicloalcanos n,n-dissubstituìdos úteis para o tratamento de distúrbios do snc devido à disfunção serotonérgica
HK1018057A1 (en)	1999-12-10	Tricyclic benzazepine compounds