ATE205490T1 - Substituierte heteroaromatische derivate - Google Patents

Substituierte heteroaromatische derivate

Info

Publication number: ATE205490T1
Authority: AT; Austria
Prior art keywords: heteroaromatic ring; signifies; diseases; gastrointestinal; halogen
Prior art date: 1995-10-13

Application number

AT96932827T

Other languages

English (en)

Inventor

Toshiaki Banyu Mase

Morihiro Banyu Mitsuya

Kensuke Banyu Kobayashi

Kazuhito Banyu Noguchi

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-10-13

Filing date

1996-10-07

Publication date

2001-09-15

1996-10-07 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

2001-09-15 Application granted granted Critical

2001-09-15 Publication of ATE205490T1 publication Critical patent/ATE205490T1/de

Links

125000001072 heteroaryl group Chemical group 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
208000000884 Airway Obstruction Diseases 0.000 abstract 1
208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
206010020651 Hyperkinesia Diseases 0.000 abstract 1
208000000269 Hyperkinesis Diseases 0.000 abstract 1
229940121948 Muscarinic receptor antagonist Drugs 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
206010046543 Urinary incontinence Diseases 0.000 abstract 1
208000028938 Urination disease Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
230000002496 gastric effect Effects 0.000 abstract 1
210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
239000003149 muscarinic antagonist Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
230000000069 prophylactic effect Effects 0.000 abstract 1
208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
208000023504 respiratory system disease Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
208000014001 urinary system disease Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT96932827T 1995-10-13 1996-10-07 Substituierte heteroaromatische derivate ATE205490T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP29171695		1995-10-13
JP35134295		1995-12-26
PCT/JP1996/002904 WO1997013766A1 (en)	1995-10-13	1996-10-07	Substituted heteroaromatic derivatives

Publications (1)

Publication Number	Publication Date
ATE205490T1 true ATE205490T1 (de)	2001-09-15

Family

ID=26558669

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96932827T ATE205490T1 (de)	1995-10-13	1996-10-07	Substituierte heteroaromatische derivate

Country Status (7)

Country	Link
US (1)	US6130232A (de)
EP (1)	EP0863141B1 (de)
AT (1)	ATE205490T1 (de)
AU (1)	AU7145996A (de)
CA (1)	CA2234619A1 (de)
DE (1)	DE69615214T2 (de)
WO (1)	WO1997013766A1 (de)

Families Citing this family (54)

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CA2179574A1 (en) *	1995-06-26	1996-12-27	Tomomi Okada	Substituted piperidine derivative and medicine comprising the same
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US6693202B1 (en)	1999-02-16	2004-02-17	Theravance, Inc.	Muscarinic receptor antagonists
GB9923078D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
WO2000066579A1 (en) *	1999-04-28	2000-11-09	Banyu Pharmaceutical Co., Ltd.	Processes for the preparation of piperidylmethylpyridine derivatives
WO2001013918A1 (en) *	1999-08-23	2001-03-01	H. Lundbeck A/S	Treatment of urinary incontinence
GB9923077D0 (en) *	1999-09-29	1999-12-01	Phytopharm Plc	Sapogenin derivatives and their use
UA73543C2 (uk)	1999-12-07	2005-08-15	Тераванс, Інк.	Похідні сечовини, фармацевтична композиція та застосування похідного при приготуванні лікарського засобу для лікування захворювання, яке опосередковується мускариновим рецептором
DE60021282T2 (de)	1999-12-07	2006-05-18	Theravance, Inc., South San Francisco	Carbamat-derivate als muscarin-rezeptor antonisten
GB0000228D0 (en) *	2000-01-06	2000-03-01	Phytopharm Plc	Fluoro substituted sapogenins and their use
BR0107732A (pt) *	2000-01-20	2003-03-11	Eisai Ltd	Método para prevenir ou tratar uma doença
FR2816940A1 (fr) *	2000-11-23	2002-05-24	Lipha	Derives de 4-(biphenylcarbonylamino)-piperidine, compositions les contenant et leur utilisation
NZ526580A (en)	2000-12-22	2005-04-29	Almirall Prodesfarma Ag	Quinuclidine carbamate derivatives and their use as M3 antagonists
DE60121813T2 (de) *	2000-12-28	2007-09-20	Almirall Ag	Neue chinuclidinderivate und medizinische zusammensetzungen, die diese verbindungen enthalten
GB0107822D0 (en) *	2001-03-28	2001-05-23	Phytopharm Plc	Sapogenin derivatives their synthesis and use methods based upon their use
CN102727501A (zh) *	2002-03-27	2012-10-17	菲特法姆股份有限公司	皂角苷配基及其衍生物的用途
US20050130948A1 (en) *	2002-03-27	2005-06-16	Daryl Rees	Therapeutic methods and uses of sapogenins and their derivatives
ES2206021B1 (es)	2002-04-16	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de pirrolidinio.
ES2203327B1 (es)	2002-06-21	2005-06-16	Almirall Prodesfarma, S.A.	Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
ES2204295B1 (es)	2002-07-02	2005-08-01	Almirall Prodesfarma, S.A.	Nuevos derivados de quinuclidina-amida.
AU2002345266B2 (en) *	2002-07-08	2009-07-02	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
HK1079787A1 (zh) *	2002-07-31	2006-04-13	Ranbaxy Laboratories Limited	用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物
WO2004014363A1 (en) *	2002-08-09	2004-02-19	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (de) *	2002-08-23	2009-02-25	Ranbaxy Laboratories, Ltd.	Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten
JP2006506392A (ja) *	2002-10-29	2006-02-23	ファルマシア・アンド・アップジョン・カンパニー・エルエルシー	ムスカリン受容体アンタゴニストとしての第四級アンモニウム化合物
TWI295669B (en)	2002-10-30	2008-04-11	Theravance Inc	Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
ATE400553T1 (de) *	2002-12-10	2008-07-15	Ranbaxy Lab Ltd	3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors
DE60225195T2 (de) *	2002-12-23	2009-02-26	Ranbaxy Laboratories, Ltd.	Flavaxat-derivate als muscarin-rezeptor antagonisten
AU2002347552A1 (en)	2002-12-23	2004-07-14	Ranbaxy Laboratories Limited	1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists
US7488748B2 (en) *	2003-01-28	2009-02-10	Ranbaxy Laboratories Limited	3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists
PE20040950A1 (es)	2003-02-14	2005-01-01	Theravance Inc	DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
EP1618091A1 (de)	2003-04-09	2006-01-25	Ranbaxy Laboratories, Ltd.	Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren
EA009059B1 (ru) *	2003-04-10	2007-10-26	Рэнбакси Лабораториз Лимитед	Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора
AU2003223010A1 (en)	2003-04-10	2004-11-01	Ranbaxy Laboratories Limited	Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
JP2006522787A (ja)	2003-04-11	2006-10-05	ランバクシーラボラトリーズリミテッド	ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
TW200510298A (en) *	2003-06-13	2005-03-16	Theravance Inc	Substituted pyrrolidine and related compounds
WO2005007645A1 (en) *	2003-07-11	2005-01-27	Theravance, Inc.	Substituted 4-amino-1-benzylpiperidine compounds
KR100500760B1 (ko) *	2003-07-22	2005-07-14	동방에프티엘 주식회사	염산 프로피베린의 제조방법
ES2329586T3 (es)	2003-11-21	2009-11-27	Theravance, Inc.	Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino.
EP1725525A1 (de) *	2004-03-11	2006-11-29	Theravance, Inc.	Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen
JP2007528418A (ja) *	2004-03-11	2007-10-11	セラヴァンス，インコーポレーテッド	ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物
WO2006005980A1 (en) *	2004-06-16	2006-01-19	Ranbaxy Laboratories Limited	Xanthine derivatives useful as muscarinic receptor antagonists
US20080262075A1 (en) *	2004-08-19	2008-10-23	Ranbaxy Laboratories Limited	Pyrrolidine Derivatives as Muscarinic Receptor Antagonists
WO2006032994A2 (en) *	2004-09-24	2006-03-30	Ranbaxy Laboratories Limited	Muscarinic receptor antagonists
EP1797040A1 (de) *	2004-09-29	2007-06-20	Ranbaxy Laboratories Limited	Muscarin-rezeptor-antagonisten
US20100016400A1 (en) *	2004-11-19	2010-01-21	Naresh Kumar	Azabicyclic muscarinic receptor antagonists
EP1828126A1 (de) *	2004-12-15	2007-09-05	Ranbaxy Laboratories Limited	Säureadditionssalze von antagonisten des muskarinrezeptors
WO2006117754A1 (en) *	2005-05-03	2006-11-09	Ranbaxy Laboratories Limited	3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
AU2006305619A1 (en)	2005-10-19	2007-04-26	Ranbaxy Laboratories Limited	Pharmaceutical compositions of muscarinic receptor antagonists
GB0602778D0 (en)	2006-02-10	2006-03-22	Glaxo Group Ltd	Novel compound
US20090010923A1 (en) *	2007-04-24	2009-01-08	University Of Maryland, Baltimore	Treatment of cancer with anti-muscarinic receptor agents

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JPS6018661B2 (ja) *	1976-01-01	1985-05-11	太田製薬株式会社	１−（１，３−ジオキソラン−４−イルメチル）ピペリジノ−ル誘導体
JPS5679688A (en) *	1979-12-04	1981-06-30	Ota Seiyaku Kk	4-acyloxy-1- 1,3-dioxoran-2-ylmethyl piperidine derivative and its production
IT1231238B (it) *	1987-09-21	1991-11-26	Angeli Inst Spa	Derivati ammidinici
GB8825505D0 (en) *	1988-11-01	1988-12-07	Pfizer Ltd	Therapeutic agents
JP3294961B2 (ja) *	1993-12-10	2002-06-24	杏林製薬株式会社	新規イミダゾール誘導体及びその製造法
JP2717928B2 (ja) *	1994-01-31	1998-02-25	東洋電機製造株式会社	給水装置
JPH07258250A (ja) *	1994-03-25	1995-10-09	Yamanouchi Pharmaceut Co Ltd	エステル誘導体
US5750540A (en) *	1995-04-28	1998-05-12	Banyu Pharmaceutical Co., Ltd.	1,4-di-substituted piperidine derivatives
CA2179574A1 (en) *	1995-06-26	1996-12-27	Tomomi Okada	Substituted piperidine derivative and medicine comprising the same

1996
- 1996-10-07 AT AT96932827T patent/ATE205490T1/de active
- 1996-10-07 AU AU71459/96A patent/AU7145996A/en not_active Abandoned
- 1996-10-07 CA CA002234619A patent/CA2234619A1/en not_active Abandoned
- 1996-10-07 US US09/051,287 patent/US6130232A/en not_active Expired - Fee Related
- 1996-10-07 DE DE69615214T patent/DE69615214T2/de not_active Expired - Fee Related
- 1996-10-07 WO PCT/JP1996/002904 patent/WO1997013766A1/ja not_active Ceased
- 1996-10-07 EP EP96932827A patent/EP0863141B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1997013766A1 (en)	1997-04-17
DE69615214D1 (de)	2001-10-18
EP0863141A4 (de)	1999-01-27
EP0863141A1 (de)	1998-09-09
DE69615214T2 (de)	2002-06-27
CA2234619A1 (en)	1997-04-17
AU7145996A (en)	1997-04-30
EP0863141B1 (de)	2001-09-12
US6130232A (en)	2000-10-10

Publication	Publication Date	Title
ATE205490T1 (de)	2001-09-15	Substituierte heteroaromatische derivate
DE69632728D1 (de)	2004-07-22	1,4-disubstituierte piperidinderivate
AU780419C (en)	2005-09-29	Triazaspiro(5.5)undecane derivatives and drugs containing the same as the active ingredient
NO20020823D0 (no)	2002-02-19	Heterosykliske forbindelser og deres anvendelse som metabotrofisk glutamatreseptor-antagonister
KR970701174A (ko)	1997-03-17	신규한 카바메이트 유도체 및 이의 의약 조성물(Novel carbamate derivative and medicinal composition containing the same)
WO2004026248A3 (en)	2004-07-15	Octahydro-2-h-naphtho[1,2-f] indole-4-carboxamide derivatives as selective glucocorticoid receptor modulators
EP0915094A4 (de)	2004-09-22	Morphinanderivate und ihre medizinische Anwendung
EP0518530A3 (en)	1993-01-20	Improvements in or relating to excitatory amino acid receptor antagonists
JO2321B1 (en)	2005-09-12	4-phenyl-pyridine derivatives
WO2006038006A3 (en)	2006-05-18	5-sulfonyl-1-piperidinyl substituted indole derivatives as 5-ht6 receptor antagonists for the treatment of cns disorders
MXPA03010321A (es)	2004-02-17	Derivados de 1-oxa-3,9-diaza-spiro-5,5-undecan-2-onas y su uso como antagonista del receptor de neurocinina.
ATE219486T1 (de)	2002-07-15	Trizyklische indol-2-carbonsäure derivate als selektive nmda rezeptor antagonisten
DK0556813T3 (da)	1998-08-10	Amfotere tricykliske forbindelser som antihistaminske og antiallergiske midler
ATE169015T1 (de)	1998-08-15	Aminobenzoesäure derivate
AU6017800A (en)	2001-02-13	Novel amide derivatives
EP1172106A3 (de)	2002-05-15	Werwendung von fluoralkoxybenzylaminoderivate stickstoffhaltiger heterocyclen als substanz p antagonisten
DK0940401T3 (da)	2003-03-03	2-Carbonylthiazolderivater og anvendelse deraf
DK0613897T3 (da)	1997-07-28	Piperidinderivater med anti-histamin-og anti-leukotrienaktivitet
BR0311805A (pt)	2005-03-15	Diazocicloalcanos n,n-dissubstituìdos úteis para o tratamento de distúrbios do snc devido à disfunção serotonérgica