ATE269305T1 - 1,4-disubstituierte piperidinderivate - Google Patents
1,4-disubstituierte piperidinderivateInfo
- Publication number
- ATE269305T1 ATE269305T1 AT96912236T AT96912236T ATE269305T1 AT E269305 T1 ATE269305 T1 AT E269305T1 AT 96912236 T AT96912236 T AT 96912236T AT 96912236 T AT96912236 T AT 96912236T AT E269305 T1 ATE269305 T1 AT E269305T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- diseases
- piperidine derivatives
- digestive
- disubstituted piperidine
- Prior art date
Links
- -1 1,4-DISUBSTITUTED PIPERIDINE Chemical class 0.000 title abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 230000027939 micturition Effects 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 102000017925 CHRM3 Human genes 0.000 abstract 1
- 101150060249 CHRM3 gene Proteins 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 abstract 1
- 206010061876 Obstruction Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 208000028938 Urination disease Diseases 0.000 abstract 1
- 208000012931 Urologic disease Diseases 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 208000010643 digestive system disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 210000002429 large intestine Anatomy 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000005069 pulmonary fibrosis Diseases 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 239000011593 sulfur Chemical group 0.000 abstract 1
- 208000014001 urinary system disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12982795 | 1995-04-28 | ||
| PCT/JP1996/001128 WO1996033973A1 (en) | 1995-04-28 | 1996-04-25 | 1,4-disubstituted piperidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE269305T1 true ATE269305T1 (de) | 2004-07-15 |
Family
ID=15019212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96912236T ATE269305T1 (de) | 1995-04-28 | 1996-04-25 | 1,4-disubstituierte piperidinderivate |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5750540A (de) |
| EP (1) | EP0823423B1 (de) |
| KR (1) | KR19990008109A (de) |
| AT (1) | ATE269305T1 (de) |
| AU (1) | AU700837B2 (de) |
| CA (1) | CA2218479C (de) |
| DE (1) | DE69632728T2 (de) |
| WO (1) | WO1996033973A1 (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2179574A1 (en) | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
| ATE205490T1 (de) * | 1995-10-13 | 2001-09-15 | Banyu Pharma Co Ltd | Substituierte heteroaromatische derivate |
| AU2793197A (en) * | 1996-05-31 | 1998-01-05 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituted piperidine derivatives |
| PE92198A1 (es) * | 1996-08-01 | 1999-01-09 | Banyu Pharma Co Ltd | Derivados de 1,4-piperidina disustituida que contienen fluor |
| CN100391942C (zh) * | 1996-11-11 | 2008-06-04 | 索佛特克两合公司 | 对映异构纯的碱性芳基-环烷基-羟基羧酸酯,其制备方法及其在药品中的应用 |
| KR19990037220A (ko) * | 1997-10-31 | 1999-05-25 | 타이도 나오카타 | 아릴아세트산 아미드 유도체 또는 그 염 및 이를 함유하는 의약 |
| WO1999055674A1 (en) * | 1998-04-28 | 1999-11-04 | Dainippon Pharmaceutical Co., Ltd. | 1-[(1-substituted-4-piperidinyl)methyl]-4-piperidine derivatives, process for producing the same, medicinal compositions containing the same and intermediates of these compounds |
| US6180823B1 (en) * | 1998-11-06 | 2001-01-30 | Sepracor Inc. | Stereoselective process for alkyl phenylglycolic acids |
| DE19933926A1 (de) * | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Pharma | Biphenylderivate, ihre Herstellung und ihre Verwendung als Arzneimittel |
| US6809108B1 (en) | 1999-07-23 | 2004-10-26 | Banyu Pharmaceutical Co., Ltd. | Amide derivatives |
| US6403818B1 (en) | 2000-02-28 | 2002-06-11 | Eisai Co., Ltd. | Process for producing α-hydroxy-carbonyl compound |
| EP1302458A4 (de) * | 2000-07-11 | 2005-10-19 | Banyu Pharma Co Ltd | Esterderivate |
| JP4120586B2 (ja) * | 2002-01-18 | 2008-07-16 | アステラス製薬株式会社 | ２−アシルアミノチアゾール誘導体又はその塩 |
| DE10216429A1 (de) * | 2002-04-12 | 2003-10-23 | Boehringer Ingelheim Pharma | Arzneimittel enthaltend Steroide und ein neues Anticholinergikum |
| US7084153B2 (en) | 2002-04-12 | 2006-08-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicaments comprising steroids and a novel anticholinergic |
| AU2002345266B2 (en) | 2002-07-08 | 2009-07-02 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists |
| HK1079787A1 (zh) | 2002-07-31 | 2006-04-13 | Ranbaxy Laboratories Limited | 用作毒蕈碱受体拮抗剂的3，6-二取代的氮杂双环[3．1．0]己烷衍生物 |
| WO2004014363A1 (en) | 2002-08-09 | 2004-02-19 | Ranbaxy Laboratories Limited | 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist |
| EP1534675B1 (de) | 2002-08-23 | 2009-02-25 | Ranbaxy Laboratories, Ltd. | Fluor- und sulfonylaminohaltige, 3,6-disubstituierte azabicyclo¬3.1.0 hexanderivate als muscarinrezeptorantagonisten |
| TWI295669B (en) * | 2002-10-30 | 2008-04-11 | Theravance Inc | Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds |
| ATE400553T1 (de) * | 2002-12-10 | 2008-07-15 | Ranbaxy Lab Ltd | 3,6-disubstituierte azabicyclo 3.1.0 - hexanderivative als antagonisten des muscarinrezeptors |
| AU2002347552A1 (en) | 2002-12-23 | 2004-07-14 | Ranbaxy Laboratories Limited | 1-substituted-3-pyrrolidine derivatives as muscarinic receptor antagonists |
| DE60225195T2 (de) | 2002-12-23 | 2009-02-26 | Ranbaxy Laboratories, Ltd. | Flavaxat-derivate als muscarin-rezeptor antagonisten |
| US7488748B2 (en) * | 2003-01-28 | 2009-02-10 | Ranbaxy Laboratories Limited | 3,6-Disubstituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| US20070010568A1 (en) * | 2003-02-07 | 2007-01-11 | Anita Mehta | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| EP1618091A1 (de) * | 2003-04-09 | 2006-01-25 | Ranbaxy Laboratories, Ltd. | Substituierte azabicyclohexanderivate als antagonisten von muscarinrezeptoren |
| EA009059B1 (ru) | 2003-04-10 | 2007-10-26 | Рэнбакси Лабораториз Лимитед | Замещенные производные азабициклогексана в качестве антагонистов мускаринового рецептора |
| AU2003223010A1 (en) | 2003-04-10 | 2004-11-01 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
| JP2006522787A (ja) | 2003-04-11 | 2006-10-05 | ランバクシー ラボラトリーズ リミテッド | ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体 |
| TW200510298A (en) * | 2003-06-13 | 2005-03-16 | Theravance Inc | Substituted pyrrolidine and related compounds |
| PE20050231A1 (es) | 2003-06-24 | 2005-05-20 | Novartis Ag | Derivados de piperidinium y pirrolidinium como antagonistas del receptor muscarinico m3 |
| WO2005007645A1 (en) * | 2003-07-11 | 2005-01-27 | Theravance, Inc. | Substituted 4-amino-1-benzylpiperidine compounds |
| JP2007522861A (ja) * | 2004-02-20 | 2007-08-16 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Ｃｔスキャン中の薬剤投与 |
| JP2007528418A (ja) * | 2004-03-11 | 2007-10-11 | セラヴァンス， インコーポレーテッド | ムスカリンレセプターアンタゴニストとしての有用なジフェニルメチル化合物 |
| EP1725525A1 (de) * | 2004-03-11 | 2006-11-29 | Theravance, Inc. | Als muscarinrezeptorantagonisten geeignete diphenylmethylverbindungen |
| TW200540154A (en) * | 2004-06-10 | 2005-12-16 | Theravance Inc | Crystalline form of a substituted pyrrolidine compound |
| US20070014819A1 (en) * | 2005-07-13 | 2007-01-18 | Weckteck Biotechnology Company Limited | Method of emulsifying phytosterol by natural saponin,emulsion prepared thereby and water dispersible phytosterol powder product |
| AU2006305619A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
| WO2007054783A2 (en) * | 2005-11-08 | 2007-05-18 | Astellas Pharma Inc. | Compositions and methods for treating thrombocytopenia |
| WO2007110782A1 (en) * | 2005-12-30 | 2007-10-04 | Ranbaxy Laboratories Limited | Muscarinic receptor antagonists |
| US20080039475A1 (en) * | 2006-08-08 | 2008-02-14 | Akarx, Inc. | Compositions and methods for increasing blood platelet levels in humans |
| AU2009239778B2 (en) | 2008-04-24 | 2014-03-13 | F2G Ltd | Pyrrole antifungal agents |
| US8263623B2 (en) | 2008-07-11 | 2012-09-11 | Pfizer Inc. | Triazol derivatives useful for the treatment of diseases |
| JP2013501811A (ja) * | 2009-08-14 | 2013-01-17 | エーザイ インコーポレーテッド | 血小板産生を刺激するためのｅ５５０１の使用 |
| US9056855B2 (en) * | 2010-10-28 | 2015-06-16 | Viamet Pharmaceuticals, Inc. | Metalloenzyme inhibitor compounds |
| BR112016028081A2 (pt) * | 2014-05-30 | 2017-08-22 | Sphaera Pharma Private Ltd | Novos compostos como agentes antituberculares |
| DK3221308T3 (en) | 2014-11-21 | 2018-12-10 | F2G Ltd | Antifungals |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022787A (en) * | 1975-07-18 | 1977-05-10 | Carter-Wallace, Inc. | Anticholinergic ester and salts thereof |
| US4721722A (en) * | 1985-07-12 | 1988-01-26 | United Pharmaceuticals, Inc. | Anti-spasmodic agents containing quaternary nitrogen |
| IT1231238B (it) * | 1987-09-21 | 1991-11-26 | Angeli Inst Spa | Derivati ammidinici |
| US4843074A (en) * | 1988-05-17 | 1989-06-27 | Marion Laboratories, Inc. | 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts |
| US5482940A (en) * | 1988-05-24 | 1996-01-09 | American Home Products Corporation | Use of aryl- and heteroaryl piperazinyl carboxamides in the treatment of various central nervous system disorders |
| US5066680A (en) * | 1989-02-14 | 1991-11-19 | Fujisawa Pharmaceutical Co., Ltd. | Novel substituted-acetamide compound and a process for the preparation thereof |
| JP3026845B2 (ja) * | 1991-02-20 | 2000-03-27 | 日清製粉株式会社 | ピペリジン誘導体 |
| GB9202443D0 (en) * | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
| CA2179574A1 (en) * | 1995-06-26 | 1996-12-27 | Tomomi Okada | Substituted piperidine derivative and medicine comprising the same |
-
1996
- 1996-04-25 US US08/682,785 patent/US5750540A/en not_active Expired - Lifetime
- 1996-04-25 AT AT96912236T patent/ATE269305T1/de not_active IP Right Cessation
- 1996-04-25 KR KR1019970707634A patent/KR19990008109A/ko not_active Withdrawn
- 1996-04-25 AU AU55139/96A patent/AU700837B2/en not_active Ceased
- 1996-04-25 WO PCT/JP1996/001128 patent/WO1996033973A1/ja not_active Ceased
- 1996-04-25 DE DE69632728T patent/DE69632728T2/de not_active Expired - Lifetime
- 1996-04-25 CA CA002218479A patent/CA2218479C/en not_active Expired - Fee Related
- 1996-04-25 EP EP96912236A patent/EP0823423B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO1996033973A1 (en) | 1996-10-31 |
| AU700837B2 (en) | 1999-01-14 |
| DE69632728D1 (de) | 2004-07-22 |
| CA2218479C (en) | 2008-01-15 |
| AU5513996A (en) | 1996-11-18 |
| DE69632728T2 (de) | 2004-10-14 |
| US5750540A (en) | 1998-05-12 |
| KR19990008109A (ko) | 1999-01-25 |
| EP0823423A1 (de) | 1998-02-11 |
| EP0823423A4 (de) | 1998-09-02 |
| EP0823423B1 (de) | 2004-06-16 |
| CA2218479A1 (en) | 1996-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |