ATE205718T1 - Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren - Google Patents

Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren

Info

Publication number
ATE205718T1
ATE205718T1 AT92401788T AT92401788T ATE205718T1 AT E205718 T1 ATE205718 T1 AT E205718T1 AT 92401788 T AT92401788 T AT 92401788T AT 92401788 T AT92401788 T AT 92401788T AT E205718 T1 ATE205718 T1 AT E205718T1
Authority
AT
Austria
Prior art keywords
polyoxyethylene
polylactic acid
block copolymers
acid block
nanoparticles made
Prior art date
Application number
AT92401788T
Other languages
English (en)
Inventor
Gilles Spenlehauer
Didier Bazile
Michel Veillard
Homme Christian Prud
Jean-Paul Michalon
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE205718T1 publication Critical patent/ATE205718T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT92401788T 1991-06-28 1992-06-25 Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren ATE205718T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108041A FR2678168B1 (fr) 1991-06-28 1991-06-28 Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.

Publications (1)

Publication Number Publication Date
ATE205718T1 true ATE205718T1 (de) 2001-10-15

Family

ID=9414444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401788T ATE205718T1 (de) 1991-06-28 1992-06-25 Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren

Country Status (16)

Country Link
US (1) US5683723A (de)
EP (2) EP0520888B1 (de)
JP (1) JP3465260B2 (de)
AT (1) ATE205718T1 (de)
CA (1) CA2102186C (de)
DE (1) DE69232062T2 (de)
DK (1) DK0520888T3 (de)
ES (1) ES2162793T3 (de)
FI (1) FI109576B (de)
FR (1) FR2678168B1 (de)
GR (1) GR3036773T3 (de)
IE (1) IE922110A1 (de)
MX (1) MX9203353A (de)
NO (1) NO306119B1 (de)
PT (1) PT520888E (de)
WO (1) WO1993000101A1 (de)

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US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
EP0822217B1 (de) * 1995-04-19 2002-10-23 Kazunori Kataoka Heterotelechelische blockcopolymere und verfahren zu deren herstellung
PT752245E (pt) * 1995-07-05 2002-09-30 Europ Economic Community Nanoparticulas biocompativeis e biodegradaveis destinadas a absorcao e administracao de farmacos proteinaceos
WO1997006202A1 (en) * 1995-08-10 1997-02-20 Kazunori Kataoka Block polymer having functional groups at both ends
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
ES2390066T3 (es) 2000-05-12 2012-11-06 Samyang Biopharmaceuticals Corporation Procedimiento para la preparación de micelas poliméricas mediante separación de fase de un copolímero en bloque
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
DK1381382T3 (da) * 2000-11-01 2009-02-02 Merck Patent Gmbh Fremgangsmåder og præparater til behandling af öjensygdomme
KR100354828B1 (ko) * 2001-03-12 2002-10-05 주식회사 씨엠리서치 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
WO2002082900A1 (en) 2001-03-30 2002-10-24 Rhodia Inc. Aqeuous suspension of nanoparticles comprising an agrochemical active ingredient
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7498045B2 (en) * 2001-08-31 2009-03-03 Thomas M. S. Chang Biodegradable polymeric nanocapsules and uses thereof
WO2003068253A1 (en) * 2002-02-14 2003-08-21 Merck Patent Gmbh Methods and compositions for the treatment of eye diseases
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
WO2003086369A2 (en) * 2002-04-05 2003-10-23 Valorisation-Recherche, Societe En Commandite Stealthy polymeric biodegradable nanospheres and uses thereof
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US7847021B2 (en) * 2004-02-16 2010-12-07 Mitsui Chemicals, Inc. Aliphatic polyester resin composition containing copolymer
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US8697120B2 (en) 2006-05-01 2014-04-15 Johns Hopkins University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
JP2010504318A (ja) * 2006-09-22 2010-02-12 ラボファーム インコーポレイテッド ｐＨ標的化薬剤送達のための組成物及び方法
JP2008195656A (ja) 2007-02-14 2008-08-28 Nipro Corp 人工酸素運搬体製剤
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
EP2162120B1 (de) 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
EP2231169B1 (de) 2007-12-06 2016-05-04 Bend Research, Inc. Pharmazeutische zusammensetzungen mit nanopartikeln und resuspensionsmaterial
EP2240162A4 (de) 2007-12-06 2013-10-09 Bend Res Inc Nanoteilchen mit einem nicht-ionisierbaren polymer und einem amin-funktionalisierten methacrylat-copolymer
WO2010101240A1 (ja) * 2009-03-06 2010-09-10 国立大学法人岡山大学 生分解性多孔質中空微粒子、その製造方法および用途
EP2382966A1 (de) 2010-03-12 2011-11-02 DSM IP Assets B.V. Mizellenzusammensetzungen und Herstellungsverfahren dafür
EP2634179A1 (de) 2012-02-28 2013-09-04 Sanofi Funktionale PLA-PEG-Copolymere, Nanopartikel, Herstellung und Verwendung zur gezielten Arzneimittelabgabe und Abbildung
EP3177669B1 (de) 2014-08-08 2021-03-17 DSM IP Assets B.V. Amphiphile blockcopolymere mit reduktionsempfindlichen, biologisch abbaubaren polyesteramiden
CN107208120B (zh) 2014-12-09 2021-11-23 斯威特沃特能源公司 快速预处理
US11821047B2 (en) 2017-02-16 2023-11-21 Apalta Patent OÜ High pressure zone formation for pretreatment
US11692000B2 (en) 2019-12-22 2023-07-04 Apalta Patents OÜ Methods of making specialized lignin and lignin products from biomass
CN113651950B (zh) * 2021-08-23 2023-12-22 陈强 一种可生物降解高分子微球及其制备方法
CN117999304A (zh) * 2021-09-03 2024-05-07 南京再明医药有限公司 一种疏水性药物聚合物胶束及其制备方法

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WO1978000011A1 (fr) * 1977-06-07 1978-12-21 Garching Instrumente Forme d'implant medicamenteux et procede de preparation
DE3378250D1 (en) 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
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US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5238714A (en) * 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers

Also Published As

Publication number Publication date
FR2678168A1 (fr) 1992-12-31
JP3465260B2 (ja) 2003-11-10
MX9203353A (es) 1992-12-01
NO306119B1 (no) 1999-09-20
CA2102186A1 (fr) 1992-12-29
FI109576B (fi) 2002-09-13
FI935868A0 (fi) 1993-12-27
CA2102186C (fr) 2005-09-13
FI935868L (fi) 1993-12-27
EP0520888B1 (de) 2001-09-19
JPH06508831A (ja) 1994-10-06
EP0520888A1 (de) 1992-12-30
IE922110A1 (en) 1992-12-30
US5683723A (en) 1997-11-04
EP0591374A1 (de) 1994-04-13
WO1993000101A1 (fr) 1993-01-07
NO934358L (no) 1993-12-01
GR3036773T3 (en) 2002-01-31
DE69232062T2 (de) 2002-04-25
PT520888E (pt) 2002-02-28
FR2678168B1 (fr) 1993-09-03
NO934358D0 (no) 1993-12-01
DK0520888T3 (da) 2001-11-12
ES2162793T3 (es) 2002-01-16
DE69232062D1 (de) 2001-10-25

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Legal Events

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UEP Publication of translation of european patent specification