ATE205718T1 - Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren - Google Patents

Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren

Info

Publication number
ATE205718T1
ATE205718T1 AT92401788T AT92401788T ATE205718T1 AT E205718 T1 ATE205718 T1 AT E205718T1 AT 92401788 T AT92401788 T AT 92401788T AT 92401788 T AT92401788 T AT 92401788T AT E205718 T1 ATE205718 T1 AT E205718T1
Authority
AT
Austria
Prior art keywords
polyoxyethylene
polylactic acid
block copolymers
acid block
nanoparticles made
Prior art date
Application number
AT92401788T
Other languages
English (en)
Inventor
Gilles Spenlehauer
Didier Bazile
Michel Veillard
Homme Christian Prud
Jean-Paul Michalon
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE205718T1 publication Critical patent/ATE205718T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Materials For Medical Uses (AREA)
AT92401788T 1991-06-28 1992-06-25 Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren ATE205718T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9108041A FR2678168B1 (fr) 1991-06-28 1991-06-28 Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.

Publications (1)

Publication Number Publication Date
ATE205718T1 true ATE205718T1 (de) 2001-10-15

Family

ID=9414444

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92401788T ATE205718T1 (de) 1991-06-28 1992-06-25 Nanopartikel aus polyoxyäthylen-polymilchsäure blockcopolymeren

Country Status (16)

Country Link
US (1) US5683723A (de)
EP (2) EP0591374A1 (de)
JP (1) JP3465260B2 (de)
AT (1) ATE205718T1 (de)
CA (1) CA2102186C (de)
DE (1) DE69232062T2 (de)
DK (1) DK0520888T3 (de)
ES (1) ES2162793T3 (de)
FI (1) FI109576B (de)
FR (1) FR2678168B1 (de)
GR (1) GR3036773T3 (de)
IE (1) IE922110A1 (de)
MX (1) MX9203353A (de)
NO (1) NO306119B1 (de)
PT (1) PT520888E (de)
WO (1) WO1993000101A1 (de)

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US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
GB2281697A (en) * 1993-09-14 1995-03-15 Euro Celtique Sa Laxative compositions in capsules
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
US6007845A (en) * 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
KR19990007861A (ko) * 1995-04-19 1999-01-25 가타오카가즈노리 헤테로테레케릭 블록 공중합체 및 이의 제조방법
DK0752245T3 (da) * 1995-07-05 2002-09-09 Europ Economic Community Biokompatible og bionedbrydelige nanopartikler udviklet til absorption og afgivelse af proteinholdige lægemidler
WO1997006202A1 (en) * 1995-08-10 1997-02-20 Kazunori Kataoka Block polymer having functional groups at both ends
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
FR2742357B1 (fr) * 1995-12-19 1998-01-09 Rhone Poulenc Rorer Sa Nanoparticules stabilisees et filtrables dans des conditions steriles
US5611344A (en) * 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6211249B1 (en) * 1997-07-11 2001-04-03 Life Medical Sciences, Inc. Polyester polyether block copolymers
AU2001258872C1 (en) 2000-05-12 2005-05-26 Samyang Biopharmaceuticals Corporation Method for the preparation of polymeric micelle via phase separation of block copolymer
US7217770B2 (en) * 2000-05-17 2007-05-15 Samyang Corporation Stable polymeric micelle-type drug composition and method for the preparation thereof
HUP0302718A3 (en) * 2000-11-01 2011-03-28 Merck Patent Gmbh Methods and compositions for the treatment of diseases of the eye
KR100354828B1 (ko) * 2001-03-12 2002-10-05 주식회사 씨엠리서치 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르
US20040185101A1 (en) * 2001-03-27 2004-09-23 Macromed, Incorporated. Biodegradable triblock copolymers as solubilizing agents for drugs and method of use thereof
WO2002078674A1 (en) 2001-03-30 2002-10-10 Trustees Of Princeton University A process and apparatuses for preparing nanoparticle compositions with amphiphilic copolymers and their use
US6939564B2 (en) 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
WO2003017987A1 (en) * 2001-08-31 2003-03-06 Mcgill University Biodegradable polymeric nanocapsules and uses thereof
CN1658894A (zh) * 2002-02-14 2005-08-24 默克专利股份有限公司 用于治疗眼病的方法和组合物
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
WO2003086369A2 (en) * 2002-04-05 2003-10-23 Valorisation-Recherche, Societe En Commandite Stealthy polymeric biodegradable nanospheres and uses thereof
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
EP1719803B1 (de) * 2004-02-16 2011-05-04 Mitsui Chemicals, Inc. Copolymer enthaltende zusammensetzung auf basis von aliphatischem polyesterharz
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US8697120B2 (en) 2006-05-01 2014-04-15 Johns Hopkins University Method and use of nano-scale devices for reduction of tissue injury in ischemic and reperfusion injury
MX2009003092A (es) * 2006-09-22 2009-05-08 Labopharm Inc Composiciones y metodos para suministro de farmaco dirigido a ph.
JP2008195656A (ja) 2007-02-14 2008-08-28 Nipro Corp 人工酸素運搬体製剤
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EP2162120B1 (de) 2007-06-04 2016-05-04 Bend Research, Inc Nanopartikel mit nicht ionisierbarem zellulosepolymer und amphipilem nicht ionisierbarem blockcopolymer
WO2008149230A2 (en) 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glycol succinate
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2240162A4 (de) 2007-12-06 2013-10-09 Bend Res Inc Nanoteilchen mit einem nicht-ionisierbaren polymer und einem amin-funktionalisierten methacrylat-copolymer
WO2010101240A1 (ja) * 2009-03-06 2010-09-10 国立大学法人岡山大学 生分解性多孔質中空微粒子、その製造方法および用途
EP2382966A1 (de) 2010-03-12 2011-11-02 DSM IP Assets B.V. Mizellenzusammensetzungen und Herstellungsverfahren dafür
EP2634179A1 (de) * 2012-02-28 2013-09-04 Sanofi Funktionale PLA-PEG-Copolymere, Nanopartikel, Herstellung und Verwendung zur gezielten Arzneimittelabgabe und Abbildung
EP3177669B1 (de) 2014-08-08 2021-03-17 DSM IP Assets B.V. Amphiphile blockcopolymere mit reduktionsempfindlichen, biologisch abbaubaren polyesteramiden
DK3230463T4 (da) 2014-12-09 2025-09-15 Apalta Patents Oue Hurtig Forbehandling
US11821047B2 (en) 2017-02-16 2023-11-21 Apalta Patent OÜ High pressure zone formation for pretreatment
BR112022012348A2 (pt) 2019-12-22 2022-09-13 Sweetwater Energy Inc Métodos de fazer lignina especializada e produtos de lignina da biomassa
CN113651950B (zh) * 2021-08-23 2023-12-22 陈强 一种可生物降解高分子微球及其制备方法
CN117999304A (zh) * 2021-09-03 2024-05-07 南京再明医药有限公司 一种疏水性药物聚合物胶束及其制备方法

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EP0092918B1 (de) 1982-04-22 1988-10-19 Imperial Chemical Industries Plc Mittel mit verzögerter Freigabe
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IL82834A (en) * 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US5078994A (en) * 1990-04-12 1992-01-07 Eastman Kodak Company Microgel drug delivery system
US5238714A (en) * 1990-10-02 1993-08-24 Board Of Regents, The University Of Texas System Efficient microcapsule preparation and method of use
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers

Also Published As

Publication number Publication date
EP0591374A1 (de) 1994-04-13
FI935868A0 (fi) 1993-12-27
DE69232062T2 (de) 2002-04-25
DK0520888T3 (da) 2001-11-12
EP0520888A1 (de) 1992-12-30
JP3465260B2 (ja) 2003-11-10
US5683723A (en) 1997-11-04
EP0520888B1 (de) 2001-09-19
FR2678168B1 (fr) 1993-09-03
FI109576B (fi) 2002-09-13
PT520888E (pt) 2002-02-28
WO1993000101A1 (fr) 1993-01-07
IE922110A1 (en) 1992-12-30
ES2162793T3 (es) 2002-01-16
CA2102186A1 (fr) 1992-12-29
CA2102186C (fr) 2005-09-13
FR2678168A1 (fr) 1992-12-31
DE69232062D1 (de) 2001-10-25
MX9203353A (es) 1992-12-01
GR3036773T3 (en) 2002-01-31
NO306119B1 (no) 1999-09-20
NO934358L (no) 1993-12-01
FI935868L (fi) 1993-12-27
NO934358D0 (no) 1993-12-01
JPH06508831A (ja) 1994-10-06

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Legal Events

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UEP Publication of translation of european patent specification