ATE205719T1 - Reinigung von plasmaproteinen - Google Patents

Reinigung von plasmaproteinen

Info

Publication number: ATE205719T1
Authority: AT; Austria
Prior art keywords: pct; aqueous phase; detergent; sec; salt
Prior art date: 1993-05-07

Application number

AT94915731T

Other languages

English (en)

Inventor

Sven Isaksson

Stefan Winge

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-07

Filing date

1994-05-06

Publication date

2001-10-15

1994-05-06 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE205719T1 publication Critical patent/ATE205719T1/de

Links

102000004506 Blood Proteins Human genes 0.000 title abstract 3
108010017384 Blood Proteins Proteins 0.000 title abstract 3
238000000746 purification Methods 0.000 title 1
239000008346 aqueous phase Substances 0.000 abstract 3
239000003599 detergent Substances 0.000 abstract 3
230000000415 inactivating effect Effects 0.000 abstract 3
239000000126 substance Substances 0.000 abstract 3
241000700605 Viruses Species 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
102000009027 Albumins Human genes 0.000 abstract 1
108010088751 Albumins Proteins 0.000 abstract 1
102000004411 Antithrombin III Human genes 0.000 abstract 1
108090000935 Antithrombin III Proteins 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
102000004338 Transferrin Human genes 0.000 abstract 1
108090000901 Transferrin Proteins 0.000 abstract 1
229960005348 antithrombin iii Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
238000001914 filtration Methods 0.000 abstract 1
238000005191 phase separation Methods 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
238000005185 salting out Methods 0.000 abstract 1
229910021653 sulphate ion Inorganic materials 0.000 abstract 1
239000012581 transferrin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/303—Extraction; Separation; Purification by precipitation by salting out
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8125—Alpha-1-antitrypsin

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Analytical Chemistry (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Physical Or Chemical Processes And Apparatus (AREA)

AT94915731T 1993-05-07 1994-05-06 Reinigung von plasmaproteinen ATE205719T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE19939301582A SE9301582D0 (sv)	1993-05-07	1993-05-07	Purification of plasma proteins
PCT/SE1994/000422 WO1994026287A1 (en)	1993-05-07	1994-05-06	Purification of plasma proteins

Publications (1)

Publication Number	Publication Date
ATE205719T1 true ATE205719T1 (de)	2001-10-15

Family

ID=20389869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94915731T ATE205719T1 (de)	1993-05-07	1994-05-06	Reinigung von plasmaproteinen

Country Status (15)

Country	Link
US (1)	US5817765A (de)
EP (1)	EP0700300B1 (de)
JP (1)	JP3771935B2 (de)
AT (1)	ATE205719T1 (de)
AU (1)	AU677332B2 (de)
CA (1)	CA2161804C (de)
DE (1)	DE69428356T2 (de)
DK (1)	DK0700300T3 (de)
ES (1)	ES2164702T3 (de)
FI (1)	FI113779B (de)
NO (1)	NO313084B1 (de)
NZ (1)	NZ266234A (de)
PT (1)	PT700300E (de)
SE (1)	SE9301582D0 (de)
WO (1)	WO1994026287A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE9500724D0 (sv)	1994-06-23	1995-02-24	Pharmacia Ab	Filtrering
ES2099678B1 (es) *	1995-11-03	1998-02-16	Grifols Grupo Sa	Procedimiento para la inactivacion de virus en proteinas.
US6518406B1 (en)	1999-06-23	2003-02-11	Octapharma Ag	Method for purification of proteins
SE9902388D0 (sv) *	1999-06-23	1999-06-23	Pharmacia & Upjohn Ab	Method for purification of proteins
DE19932782A1 (de) *	1999-07-14	2001-01-18	Biotest Pharma Gmbh	Verfahren zur chromatographischen Fraktionierung von Plasma oder Serum, so erhaltene Präparate und deren Verwendung
CN1192781C (zh) *	1999-12-20	2005-03-16	三菱制药株式会社	用多孔膜处理的无病毒血浆蛋白组合物及其生产方法
BRPI0412835A (pt) *	2003-08-12	2006-09-26	Octapharma Ag	processo para preparação de uma solução de alfa-1-antitripsina
RU2411959C2 (ru) *	2004-06-29	2011-02-20	Релайанс Лайф Сайенсиз Пвт Лтд	Способ получения безопасных в вирусном отношении биологических текучих сред
AU2005229674B2 (en) *	2004-11-18	2010-11-04	Kedrion Melville Inc.	Low concentration solvent/detergent process of immuneglobulin with pre-treatment
US20100136584A1 (en) *	2008-09-22	2010-06-03	Icb International, Inc.	Methods for using antibodies and analogs thereof
WO2010033913A1 (en) *	2008-09-22	2010-03-25	Icb International, Inc.	Antibodies, analogs and uses thereof
JP5730211B2 (ja)	2008-11-20	2015-06-03	バイオジェンアイデックエムエーインコーポレイティドＢｉｏｇｅｎＩｄｅｃＩｎｃ．	ウイルスのアルギニン不活化
JP2013523143A (ja) *	2010-04-08	2013-06-17	キアゲンゲーエムベーハー	核酸を単離および精製するための方法
EP2395082A1 (de)	2010-06-14	2011-12-14	QIAGEN GmbH	Extraktion von Nukleinsäuren aus in Wachs eingebetteten Proben
US8921062B2 (en)	2010-11-09	2014-12-30	Quest Diagnostics Investments Incorporated	Diagnostic and prognostic assays based on circulating tyrosine kinase activity
US10112987B2 (en)	2012-01-09	2018-10-30	Icb International, Inc.	Blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an amyloid-beta peptide
US10112988B2 (en)	2012-01-09	2018-10-30	Icb International, Inc.	Methods of assessing amyloid-beta peptides in the central nervous system by blood-brain barrier permeable peptide compositions comprising a vab domain of a camelid single domain heavy chain antibody against an anti-amyloid-beta peptide
US9534029B2 (en)	2012-10-03	2017-01-03	Csl Behring Ag	Method of purifying proteins
JP6370792B2 (ja) *	2012-10-03	2018-08-08	ツェー・エス・エル・ベーリング・アクチエンゲゼルシャフト	タンパク質の精製方法
ES2991988T3 (es)	2017-10-30	2024-12-05	Takeda Pharmaceuticals Co	Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica
US10815270B1 (en) *	2019-09-20	2020-10-27	Plasma Technologies, Llc	Compositions and methods for high efficiency protein precipitation
AU2020349391B2 (en) *	2019-09-20	2024-05-09	Plasma Technologies, Llc	Therapeutic protein compositions and methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4820805A (en) *	1983-07-14	1989-04-11	New York Blood Center, Inc.	Undenatured virus-free trialkyl phosphate treated biologically active protein derivatives
US4540573A (en) *	1983-07-14	1985-09-10	New York Blood Center, Inc.	Undenatured virus-free biologically active protein derivatives
US4764369A (en) *	1983-07-14	1988-08-16	New York Blood Center Inc.	Undenatured virus-free biologically active protein derivatives
US4684723A (en) *	1985-09-11	1987-08-04	Miles Laboratories, Inc.	Method of separating proteins from aqueous solutions
US4789545A (en) *	1986-03-31	1988-12-06	New York Blood Center, Inc.	Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
DE3878245D1 (de) *	1988-11-05	1993-03-18	Octapharma Ag	Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie.
US5395923A (en) *	1993-02-23	1995-03-07	Haemacure-Biotech, Inc.	Process for the obtention of a biological adhesive made of concentrated coagulation factors by "salting-out"

1993
- 1993-05-07 SE SE19939301582A patent/SE9301582D0/xx unknown
1994
- 1994-05-06 DK DK94915731T patent/DK0700300T3/da active
- 1994-05-06 US US08/537,872 patent/US5817765A/en not_active Expired - Lifetime
- 1994-05-06 CA CA002161804A patent/CA2161804C/en not_active Expired - Fee Related
- 1994-05-06 AU AU67634/94A patent/AU677332B2/en not_active Ceased
- 1994-05-06 NZ NZ266234A patent/NZ266234A/en not_active IP Right Cessation
- 1994-05-06 DE DE69428356T patent/DE69428356T2/de not_active Expired - Lifetime
- 1994-05-06 PT PT94915731T patent/PT700300E/pt unknown
- 1994-05-06 WO PCT/SE1994/000422 patent/WO1994026287A1/en not_active Ceased
- 1994-05-06 EP EP94915731A patent/EP0700300B1/de not_active Expired - Lifetime
- 1994-05-06 ES ES94915731T patent/ES2164702T3/es not_active Expired - Lifetime
- 1994-05-06 AT AT94915731T patent/ATE205719T1/de active
- 1994-05-06 JP JP52470494A patent/JP3771935B2/ja not_active Expired - Fee Related
1995
- 1995-11-06 NO NO19954428A patent/NO313084B1/no not_active IP Right Cessation
- 1995-11-06 FI FI955306A patent/FI113779B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE69428356D1 (de)	2001-10-25
EP0700300B1 (de)	2001-09-19
DE69428356T2 (de)	2002-04-25
ES2164702T3 (es)	2002-03-01
EP0700300A1 (de)	1996-03-13
FI955306L (fi)	1995-11-06
WO1994026287A1 (en)	1994-11-24
CA2161804C (en)	2003-12-02
JP3771935B2 (ja)	2006-05-10
DK0700300T3 (da)	2001-12-31
US5817765A (en)	1998-10-06
AU677332B2 (en)	1997-04-17
JPH08509746A (ja)	1996-10-15
FI113779B (fi)	2004-06-15
PT700300E (pt)	2002-03-28
FI955306A0 (fi)	1995-11-06
NZ266234A (en)	1996-06-25
AU6763494A (en)	1994-12-12
SE9301582D0 (sv)	1993-05-07
NO954428L (no)	1995-11-06
NO313084B1 (no)	2002-08-12
CA2161804A1 (en)	1994-11-24
NO954428D0 (no)	1995-11-06

Legal Events

Date	Code	Title	Description
2002-03-15	EEFA	Change of the company name
2003-07-15	EEIH	Change in the person of patent owner

Publication	Publication Date	Title
ATE205719T1 (de)	2001-10-15	Reinigung von plasmaproteinen
DK0707594T3 (da)	2002-05-21	Adskillelse af proteiner
DE69832209D1 (de)	2005-12-08	Verfahren zur Herstellung von 3,3-Dimethylbutyraldehyd durch Oxidation von 3,3-Dimethylbutanol
KR860008276A (ko)	1986-11-14	단백질이 생성된 배양기로 부터 그것을 추출, 정제하는 방법
ATE171189T1 (de)	1998-10-15	Trennung von proteinen
ATE184884T1 (de)	1999-10-15	Fibrinogenkonzentrate aus blutplasma, verfahren und anlage für ihre herstellung
ATE346088T1 (de)	2006-12-15	Kristallisierbare zusammensetzungen, die einen komplex von protease-domäne ns3 und ns4a aus dem hepatitis c virus enthalten, und damit bereitgestellte kristalle
EA199700221A1 (ru)	1998-04-30	Замещенный аминокислотой гидроксиэтиламиносульфонамид в качестве ингибиторов ретровирусной протеазы
DE69626976D1 (de)	2003-04-30	BEHANDLUNG EINER PROTEINLÖSUNG MIT A1/Fe UND ANSCHLIESENDE MEMBRANKONZENTRATION
ATE432946T1 (de)	2009-06-15	Abtrennung von fibrinogen von plasmaproteasen
DK0567448T3 (da)	1999-03-22	Fremgangsmåde til fremstilling af faktor VIII
DE3763601D1 (de)	1990-08-16	Verfahren zum isolieren und reinigen von haemin.
DE69029471D1 (de)	1997-01-30	Wiedergewinnungsverfahren von mikrobiell erzeugtem chymosin
DE69820580D1 (de)	2004-01-29	Verfahren zur Abtrennung von Metallen durch micellare Ultrafiltration, geeignet zur Behandlung von radioaktiven Abfallstoffen
FI1343809T4 (fi)	2023-09-04	Menetelmä alfa-1 proteinaasinestäjän valmistamiseksi
DE69811758D1 (de)	2003-04-10	Verwendung von Hyaluronsäure zur Herstellung einer wässrigen Lösung verwendbar als intra-artikulare Reinigungslösung
DE69804325D1 (de)	2002-04-25	Desinfektion durch partikelgebundene und insolubilisierte detergentien
DK0512087T3 (da)	1997-08-25	Fremgangsmåde til reaktivering af denaturerede proteiner
EP0666841A1 (de)	1995-08-16	Succinoylhydroxyäthylaminosulfamidsäurederivaten und ihre verwendung als retrovirale proteasehemmer.
ATE199556T1 (de)	2001-03-15	Verfahren zur fraktionierung von deacylierten glycerophospholipiden
ES2134920T3 (es)	1999-10-16	Composiciones acuosas de caracter fuertemente acido, estables, que contienen sales de persulfato.
ATE103606T1 (de)	1994-04-15	Verfahren zur herstellung von sulfinylpristinamycin iib.
DE60105760D1 (de)	2004-10-28	Verfahren zur behandlung von mitteln zur reinigung von abgasen
ATE162523T1 (de)	1998-02-15	Wasserchathrate von piperazinylpyridin
NO944951L (no)	1995-02-10	Fjerning av hydrogensulfid