ATE206058T1 - Kunsthaut, enthaltend als träger bioverträgliche materialen aus hyaluronsäurederivaten - Google Patents

Kunsthaut, enthaltend als träger bioverträgliche materialen aus hyaluronsäurederivaten

Info

Publication number: ATE206058T1
Authority: AT; Austria
Prior art keywords: hyaluronic acid; pct; biovatable; materials; support
Prior art date: 1995-04-27

Application number

AT96913526T

Other languages

English (en)

Inventor

Carlo Soranzo

Giovanni Abatangelo

Lanfranco Callegaro

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-27

Filing date

1996-04-25

Publication date

2001-10-15

1996-04-25 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

2001-10-15 Application granted granted Critical

2001-10-15 Publication of ATE206058T1 publication Critical patent/ATE206058T1/de

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical class CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
239000000463 material Substances 0.000 title 1
210000003491 skin Anatomy 0.000 abstract 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
210000001519 tissue Anatomy 0.000 abstract 2
238000013270 controlled release Methods 0.000 abstract 1
238000012377 drug delivery Methods 0.000 abstract 1
210000002950 fibroblast Anatomy 0.000 abstract 1
210000002510 keratinocyte Anatomy 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000012528 membrane Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2503/00—Use of cells in diagnostics
- C12N2503/04—Screening or testing on artificial tissues
- C12N2503/06—Screening or testing on artificial skin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Transplantation (AREA)
Dermatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Materials For Medical Uses (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Prostheses (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

AT96913526T 1995-04-27 1996-04-25 Kunsthaut, enthaltend als träger bioverträgliche materialen aus hyaluronsäurederivaten ATE206058T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95PD000083A IT1281870B1 (it)	1995-04-27	1995-04-27	Pelle artificiale umana costituita da materiali biocompatibili a base di derivati dell'acido ialuronico
PCT/EP1996/001734 WO1996033750A1 (en)	1995-04-27	1996-04-25	Artificial skin containing as support biocompatible materials based on hyaluronic acid derivatives

Publications (1)

Publication Number	Publication Date
ATE206058T1 true ATE206058T1 (de)	2001-10-15

Family

ID=11391027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96913526T ATE206058T1 (de)	1995-04-27	1996-04-25	Kunsthaut, enthaltend als träger bioverträgliche materialen aus hyaluronsäurederivaten

Country Status (12)

Country	Link
US (1)	US6110208A (de)
EP (1)	EP0822839B1 (de)
JP (1)	JP3646882B2 (de)
AT (1)	ATE206058T1 (de)
AU (1)	AU700762B2 (de)
CA (1)	CA2219272A1 (de)
DE (1)	DE69615549T2 (de)
DK (1)	DK0822839T3 (de)
ES (1)	ES2162052T3 (de)
IT (1)	IT1281870B1 (de)
PT (1)	PT822839E (de)
WO (1)	WO1996033750A1 (de)

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US7112320B1 (en)	1995-06-07	2006-09-26	Andre Beaulieu	Solid wound healing formulations containing fibronectin
US6528483B2 (en)	1995-06-07	2003-03-04	André Beaulieu	Method of producing concentrated non-buffered solutions of fibronectin
IT1293484B1 (it) *	1997-06-11	1999-03-01	Fidia Advanced Biopolymers Srl	Materiale biologico comprendente una efficiente coltura di cellule e una matrice tridimensionale biocompatibile e biodegradabile
ES2132027B1 (es) *	1997-07-04	2000-04-01	Comunitario De Transfusion Del	Desarrollo de una piel artificial mediante cultivo de queratinocitos sobre una base de fibrina y fibroblastos humanos y metodo de preparacion de esta piel para trasplante.
US6958148B1 (en)	1998-01-20	2005-10-25	Pericor Science, Inc.	Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en)	1998-01-20	2005-07-19	Pericor Science, Inc.	Conjugates of agents and transglutaminase substrate linking molecules
RU2141847C1 (ru) *	1998-02-16	1999-11-27	Институт клинической и экспериментальной лимфологии СО РАМН	Композиция "искусственный временный лимфатический узел" для протезирования функций регионарного лимфатического узла
US6221875B1 (en)	1998-04-02	2001-04-24	Neurogen Corporation	Substituted 9H-pyridino [2,3-B]indole and 9H-pyrimidino [4,5-B]indole derivatives: selective neuropeptide Y receptor ligands
US6872819B1 (en)	1998-05-27	2005-03-29	Fidia Advanced Biopolymers S.R.L.	Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells
ITPD980149A1 (it) *	1998-06-17	1999-12-17	Fidia Advanced Biopolymers Srl	Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la
ITPD980168A1 (it) *	1998-07-06	2000-01-06	Fidia Advanced Biopolymers Srl	Composizioni biocompatibili e biodegradabili comprendenti acido ialuronico e suoi derivati per il trattamento delle ulcere dell'appara
US6783546B2 (en)	1999-09-13	2004-08-31	Keraplast Technologies, Ltd.	Implantable prosthetic or tissue expanding device
US6371984B1 (en) *	1999-09-13	2002-04-16	Keraplast Technologies, Ltd.	Implantable prosthetic or tissue expanding device
JP4074043B2 (ja) *	2000-03-27	2008-04-09	株式会社資生堂	皮膚基底膜形成促進剤、人工皮膚形成促進剤及び人工皮膚の製造方法
DE10041468C1 (de) *	2000-08-23	2002-03-07	Surface Care Gmbh	Hautmatrix zur Abdeckung und Regenerierung verletzter Hautpartien sowie Verfahren zu ihrer Herstellung
EP1731132B1 (de)	2000-10-13	2008-12-10	Block Drug Company, Inc.	Dentalzusammensetzungen für überempfindliche Zähne
AU2002246747A1 (en) *	2000-12-27	2002-08-06	Ortec International, Inc.	Processes for making cryopreserved composite living constructs and products resulting therefrom
US7262174B2 (en) *	2001-05-09	2007-08-28	Geron Corporation	Treatment for wounds
US8394371B2 (en)	2002-02-11	2013-03-12	Neocutis Sa	Compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
EP1539799B1 (de)	2002-06-21	2013-12-11	The University of Utah Research Foundation	Quervernetzte verbindungen und verfahren zu deren herstellung und anwendung
WO2004028584A1 (en) *	2002-09-30	2004-04-08	Bioland Ltd.	Dermal substitute consisting of amnion and biodegradable polymer, the preparation method and the use thereof
US7749728B2 (en) *	2003-06-04	2010-07-06	Cabenda Pharmaceutical Research Limited	Method and system for measuring the penetration of drugs and other substances into tissue
US20050271712A1 (en) *	2004-06-04	2005-12-08	Shannon Donald T	Multilayer wound covering and therapeutic methods thereof
US20060058238A1 (en) *	2004-09-15	2006-03-16	Lee Laurent-Applegate	Fetal skin cell protein compositions for the treatment of skin conditions, disorders or diseases and methods of making and using the same
US8105380B2 (en) *	2006-10-23	2012-01-31	Stemedica Cell Technologies, Inc.	Cellular scaffold
US8709081B2 (en)	2006-10-23	2014-04-29	Stemedica Cell Technologies, Inc.	Cellular scaffold
CN101687009A (zh) *	2007-05-11	2010-03-31	宾夕法尼亚大学理事会	治疗皮肤溃疡的方法
WO2009045359A1 (en) *	2007-10-01	2009-04-09	Stemnion, Inc.	Skin replacement compositions and methods
WO2009154569A1 (en) *	2008-06-20	2009-12-23	The Thailand Research Fund	Method and system for producing artificial skin
CA2761909A1 (en) *	2009-05-14	2010-11-18	Central Michigan University	Composition and method of preparation of polysaccharide gel-based artificial, biodegradable skin scaffolds
DE102009022351A1 (de) *	2009-05-15	2010-11-25	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Modulares Produktionssystem zur automatischen Herstellung von dreidimensionalen Gewebestrukturen
FR2950074B1 (fr)	2009-09-16	2017-10-06	Oreal	Equivalent de peau in vitro et procede de preparation
US10865383B2 (en)	2011-07-12	2020-12-15	Lineage Cell Therapeutics, Inc.	Methods and formulations for orthopedic cell therapy
FR2999083B1 (fr) *	2012-12-12	2015-01-23	Univ Nantes	Pansement contenant des fibroblastes et des keratinocytes foetaux
CA3071928A1 (en) *	2013-03-13	2014-10-02	Stratatech Corporation	Cryopreservation of viable human skin substitutes
US9238090B1 (en)	2014-12-24	2016-01-19	Fettech, Llc	Tissue-based compositions
DK3072535T5 (en) *	2015-03-26	2017-06-06	Univ Bordeaux	METHOD OF RECONSTRUCTION OF SKIN
CN105169491B (zh) *	2015-10-16	2017-10-24	武汉纺织大学	一种制备真菌高支化多糖‑黄原胶水凝胶支架的方法
CN105944150B (zh) *	2016-03-25	2019-05-10	华东理工大学	一种水凝胶和应用该水凝胶的人工皮肤及其制备方法
PL244125B1 (pl)	2020-05-15	2023-12-04	Politechnika Slaska Im Wincent	Kompartmentowy zasobnik do hodowli i namnażania powierzchniowego ludzkich autologicznych fibroblastów na nośniku membranowym
IT202300002910A1 (it) *	2023-02-21	2024-08-21	Kcfb S A	Patch cutaneo comprendente un sostituto cutaneo bioassorbibile e relativo processo di produzione

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US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
IT1198449B (it) *	1986-10-13	1988-12-21	F I D I Farmaceutici Italiani	Esteri di alcoli polivalenti di acido ialuronico
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IT1248934B (it) *	1990-06-01	1995-02-11	Fidia Spa	Membrane forate biocompatibili,processi per la loro preparazione,loro impiego come supporto per la crescita in vitro di cellule epiteliali, pelli artificiali cosi' ottenute e loro impiego nei trapianti di pelle
IT1254704B (it) *	1991-12-18	1995-10-09	Mini Ricerca Scient Tecnolog	Tessuto non tessuto essenzialmente costituito da derivati dell'acido ialuronico

1995
- 1995-04-27 IT IT95PD000083A patent/IT1281870B1/it active IP Right Grant
1996
- 1996-04-25 CA CA002219272A patent/CA2219272A1/en not_active Abandoned
- 1996-04-25 AT AT96913526T patent/ATE206058T1/de not_active IP Right Cessation
- 1996-04-25 WO PCT/EP1996/001734 patent/WO1996033750A1/en not_active Ceased
- 1996-04-25 ES ES96913526T patent/ES2162052T3/es not_active Expired - Lifetime
- 1996-04-25 US US08/955,796 patent/US6110208A/en not_active Expired - Fee Related
- 1996-04-25 DK DK96913526T patent/DK0822839T3/da active
- 1996-04-25 JP JP53217596A patent/JP3646882B2/ja not_active Expired - Fee Related
- 1996-04-25 EP EP96913526A patent/EP0822839B1/de not_active Expired - Lifetime
- 1996-04-25 DE DE69615549T patent/DE69615549T2/de not_active Expired - Lifetime
- 1996-04-25 PT PT96913526T patent/PT822839E/pt unknown
- 1996-04-25 AU AU56479/96A patent/AU700762B2/en not_active Ceased

Also Published As

Publication number	Publication date
CA2219272A1 (en)	1996-10-31
ES2162052T3 (es)	2001-12-16
DK0822839T3 (da)	2002-01-21
ITPD950083A0 (it)	1995-04-27
PT822839E (pt)	2002-03-28
AU5647996A (en)	1996-11-18
ITPD950083A1 (it)	1996-10-27
DE69615549D1 (de)	2001-10-31
JP3646882B2 (ja)	2005-05-11
US6110208A (en)	2000-08-29
EP0822839B1 (de)	2001-09-26
IT1281870B1 (it)	1998-03-03
DE69615549T2 (de)	2002-06-06
EP0822839A1 (de)	1998-02-11
JPH11503946A (ja)	1999-04-06
AU700762B2 (en)	1999-01-14
WO1996033750A1 (en)	1996-10-31

Legal Events

Date	Code	Title	Description
2002-01-15	UEP	Publication of translation of european patent specification
2012-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE206058T1 (de)	2001-10-15	Kunsthaut, enthaltend als träger bioverträgliche materialen aus hyaluronsäurederivaten
Loss et al.	2000	Artificial skin, split-thickness autograft and cultured autologous keratinocytes combined to treat a severe burn injury of 93% of TBSA
Andreassi et al.	1998	A new model of epidermal culture for the surgical treatment of vitiligo
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Mansilla et al.	2015	Cadaveric bone marrow mesenchymal stem cells: first experience treating a patient with large severe burns
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