ATE206122T1 - Verbindungen, die als antiproliferative mittel und als garft inhibitoren verwendbar sind - Google Patents

Verbindungen, die als antiproliferative mittel und als garft inhibitoren verwendbar sind

Info

Publication number
ATE206122T1
ATE206122T1 AT95927503T AT95927503T ATE206122T1 AT E206122 T1 ATE206122 T1 AT E206122T1 AT 95927503 T AT95927503 T AT 95927503T AT 95927503 T AT95927503 T AT 95927503T AT E206122 T1 ATE206122 T1 AT E206122T1
Authority
AT
Austria
Prior art keywords
compounds
antiproliferative agents
inhibitors
gaft
compounds usable
Prior art date
Application number
AT95927503T
Other languages
English (en)
Inventor
Michael D Varney
William H Romines
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Application granted granted Critical
Publication of ATE206122T1 publication Critical patent/ATE206122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
AT95927503T 1994-07-28 1995-07-28 Verbindungen, die als antiproliferative mittel und als garft inhibitoren verwendbar sind ATE206122T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/281,639 US5608082A (en) 1994-07-28 1994-07-28 Compounds useful as antiproliferative agents and GARFT inhibitors
PCT/US1995/009519 WO1996003406A1 (en) 1994-07-28 1995-07-28 Compounds useful as antiproliferative agents and garft inhibitors

Publications (1)

Publication Number Publication Date
ATE206122T1 true ATE206122T1 (de) 2001-10-15

Family

ID=23078167

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927503T ATE206122T1 (de) 1994-07-28 1995-07-28 Verbindungen, die als antiproliferative mittel und als garft inhibitoren verwendbar sind

Country Status (20)

Country Link
US (2) US5608082A (de)
EP (1) EP0773943B1 (de)
JP (1) JPH10503762A (de)
KR (1) KR100380610B1 (de)
CN (2) CN1091770C (de)
AT (1) ATE206122T1 (de)
AU (1) AU697138B2 (de)
CA (1) CA2195420A1 (de)
DE (1) DE69522945T2 (de)
DK (1) DK0773943T3 (de)
ES (1) ES2162933T3 (de)
FI (1) FI112079B (de)
MX (1) MX9700675A (de)
NO (1) NO308248B1 (de)
NZ (1) NZ290703A (de)
PT (1) PT773943E (de)
RU (1) RU2152945C2 (de)
SI (1) SI0773943T1 (de)
TW (1) TW432062B (de)
WO (1) WO1996003406A1 (de)

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US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
JP4815083B2 (ja) * 1999-08-31 2011-11-16 メルク・シャープ・エンド・ドーム・コーポレイション 複素環化合物およびそれの使用方法
US6774138B2 (en) 1999-08-31 2004-08-10 Merck & Co., Inc. Thiazolyl(pyridyl)ethyne compounds
AU2002306413A1 (en) * 2001-02-16 2002-10-15 Eli Lilly And Company Use of pyrido`2,3-d pyrimidin derivatives for the treatment of human cytomegalovirus infections
WO2003033477A1 (en) * 2001-10-12 2003-04-24 Warner-Lambert Company Llc Alkynlated fused ring pyrimidine compounds as matrix metalloprotease-13 inhibitor
EP1434585A1 (de) 2001-10-12 2004-07-07 Warner-Lambert Company LLC Alkine als inhibitoren von metalloproteinasen
MXPA04003008A (es) * 2001-10-12 2004-07-16 Warner Lambert Co Compuestos pirimidina de anillo fusionado alquinilado como inhibidores de metaloproteasa 13 de la matriz.
US6962922B2 (en) * 2001-10-12 2005-11-08 Warner-Lambert Company Llc Alkynylated quinazoline compounds
US20040043959A1 (en) * 2002-03-04 2004-03-04 Bloom Laura A. Combination therapies for treating methylthioadenosine phosphorylase deficient cells
US6894057B2 (en) * 2002-03-08 2005-05-17 Warner-Lambert Company Oxo-azabicyclic compounds
US6747147B2 (en) 2002-03-08 2004-06-08 Warner-Lambert Company Oxo-azabicyclic compounds
US20040006077A1 (en) * 2002-06-25 2004-01-08 Bernard Gaudilliere Thiazine and oxazine derivatives as MMP-13 inhibitors
EP1534274A1 (de) * 2002-07-17 2005-06-01 Warner-Lambert Company LLC Kombination eines allosterischen alkyn-hemmers der matrixmetalloproteinase-13 mit celecoxib oder valdecoxib
WO2004113337A1 (en) * 2003-06-25 2004-12-29 Pfizer Inc. Convergent synthesis of a garft inhibitor containing a methyl substitute thiophene core and a tetrahydropyrido`2,3-d! pyrimidine ring system and intermediates therefor
WO2004113328A1 (en) * 2003-06-25 2004-12-29 Pfizer Inc. Convergent asymmetric synthesis route to produce a key intermediate towards the synthesis of a garft inhibitor
WO2005016926A1 (en) * 2003-08-19 2005-02-24 Warner-Lambert Company Llc Pyrido [3,4-d] pyrimidine derivatives as matrix metalloproteinase-13 inhibitors
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
KR101203328B1 (ko) 2005-04-26 2012-11-20 화이자 인코포레이티드 Ｐ-카드헤린 항체
HN2006031275A (es) 2005-09-07 2010-10-29 Amgen Fremont Inc Anticuerpos monoclonales humanos para la quinasa-1 tipo receptor de activina
EA200802058A1 (ru) 2006-05-09 2009-06-30 Пфайзер Продактс Инк. Производные циклоалкиламинокислот и их фармацевтические композиции
US8252804B2 (en) 2008-10-01 2012-08-28 Duquesne University Of The Holy Spirit Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods of using the same
AP3649A (en) 2011-02-23 2016-03-18 Lupin Ltd Heteroaryl derivatives as alpha7 nachr modulators
GB201103578D0 (en) 2011-03-02 2011-04-13 Sabrepharm Ltd Dipyridinium derivatives
EP2729455B1 (de) 2011-07-05 2016-09-14 Lupin Limited Biarylderivate als nachr-modulatoren
CA2850610A1 (en) * 2011-09-29 2013-04-04 Dennis C Liotta Sphingosine analogs, compositions, and methods related thereto
IN2014MN01756A (de) 2012-03-06 2015-07-03 Lupin Ltd
GB2543550A (en) 2015-10-21 2017-04-26 Hox Therapeutics Ltd Peptides
CN115634228B (zh) * 2021-07-20 2024-03-19 首都医科大学 嘌呤合成抑制剂在制备治疗缺血和缺血再灌注损伤药物中的应用

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AT376436B (de) * 1982-11-05 1984-11-26 Laevosan Gmbh & Co Kg Verfahren zur herstellung neuer thiophen-2carbons[urederivate und pharmazeutisch vertraeglicher saeure- oder basenadditionssalze davon
US5026851A (en) * 1985-03-08 1991-06-25 The Trustees Of Princeton University Pyrido[2,3-]pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
US4927828A (en) * 1985-03-08 1990-05-22 The Trustees Of Princeton University Diastereoisomeric tetrahydropyrido-(2,3,d) pyrimidine derivatives
US4831037A (en) * 1987-04-20 1989-05-16 The Trustees Of Princeton University 4 (3H)-oxo-5,6,7,8-tetrahydropyrido-(2,3-d)pyrimidine derivatives
US4988813A (en) * 1986-10-20 1991-01-29 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4895946A (en) * 1987-10-26 1990-01-23 The Trustees Of Princeton University Process for the preparation of fused pyridine compounds
US4889859A (en) * 1988-02-05 1989-12-26 The Trustees Of Princeton University Pyrido[2,3-d]pyrimidine derivatives
US4882333A (en) * 1988-05-25 1989-11-21 The Trustess Of Princeton University N-(5,6,7,8-tetrahydropyrido[2,3-d]pyrimidin-6-yl-alkanoyl)-glutamic acid derivatives
US4882334A (en) * 1988-05-25 1989-11-21 The Trustees Of Princeton University N-(5,6,7,8-tetrahydropyrido]2,3-d]pyrimidin-6-ylethl-thineyl-and furylcarbonyl)-glutamic acid derivatives
DK172753B1 (da) * 1988-05-25 1999-06-28 Lilly Co Eli N-(5,6,7,8-tetrahydropyrido[2,3--d]pyrimidin-6-yl-alkanoyl)-glutaminsyrederivater, deres anvendelse, farmaceutiske præparat
US4871746A (en) * 1988-05-31 1989-10-03 The Trustees Of Princeton University N-[N-(tetrahydropyrido[2,3-D]pyrimidinylmethyl)-aminomethylbenzoyl]glutamic acid derivatives as neoplastic growth inhibitors
US4883799A (en) * 1988-06-29 1989-11-28 The Trustees Of Princeton University N-(4-(1-hydroxy-3-(5,6,7,8-tetrahydropyrido(2,3,-d)-pyrimidin-6-yl)prop-2-yl)benzoyl)glutamic acid derivatives
EP0438261A3 (en) * 1990-01-16 1992-02-26 Takeda Chemical Industries, Ltd. Condensed heterocyclic glutamic acid derivatives, their production and use
IL99500A0 (en) * 1990-09-17 1992-08-18 Agouron Pharma Naphthalene compounds,processes for the preparation thereof and pharmaceutical compositions containing the same
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
US5223503A (en) * 1991-04-29 1993-06-29 Eli Lilly And Company 6-substituted pyrido[2,3-d]pyrimidines as antineoplastic agents
DE69216509T2 (de) * 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
US5969136A (en) * 1992-10-15 1999-10-19 Eli Lilly And Company Cyclization for preparing antifolate compounds
PT674516E (pt) * 1992-12-16 2000-05-31 Agouron Pharma Compostos de 5-tiapirimidinona e 5-selenopirimidinona substituidos antiproliferativos

Also Published As

Publication number Publication date
KR100380610B1 (ko) 2003-08-27
US5608082A (en) 1997-03-04
RU2152945C2 (ru) 2000-07-20
FI970317A0 (fi) 1997-01-24
PT773943E (pt) 2002-01-30
AU697138B2 (en) 1998-09-24
WO1996003406A1 (en) 1996-02-08
FI112079B (fi) 2003-10-31
SI0773943T1 (en) 2001-12-31
CN1394857A (zh) 2003-02-05
NZ290703A (en) 1998-11-25
CN1091770C (zh) 2002-10-02
DE69522945T2 (de) 2002-03-28
TW432062B (en) 2001-05-01
ES2162933T3 (es) 2002-01-16
NO970349D0 (no) 1997-01-27
CA2195420A1 (en) 1996-02-08
AU3151795A (en) 1996-02-22
NO970349L (no) 1997-03-12
EP0773943A1 (de) 1997-05-21
US5646141A (en) 1997-07-08
EP0773943B1 (de) 2001-09-26
FI970317A7 (fi) 1997-03-05
DE69522945D1 (de) 2001-10-31
CN1154110A (zh) 1997-07-09
JPH10503762A (ja) 1998-04-07
NO308248B1 (no) 2000-08-21
MX9700675A (es) 1997-04-30
DK0773943T3 (da) 2002-03-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee