DE69431069D1 - Cyclische amidderivate als neurokinin a antagonisten - Google Patents

Cyclische amidderivate als neurokinin a antagonisten

Info

Publication number
DE69431069D1
DE69431069D1 DE69431069T DE69431069T DE69431069D1 DE 69431069 D1 DE69431069 D1 DE 69431069D1 DE 69431069 T DE69431069 T DE 69431069T DE 69431069 T DE69431069 T DE 69431069T DE 69431069 D1 DE69431069 D1 DE 69431069D1
Authority
DE
Germany
Prior art keywords
neurokinin
antagonist
amid derivatives
cyclic
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431069T
Other languages
English (en)
Other versions
DE69431069T2 (de
Inventor
Bhikkappa Shenvi
Toms Jacobs
Carson Miller
John Ohnmacht
Allan Veale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939325654A external-priority patent/GB9325654D0/en
Priority claimed from GB9423248A external-priority patent/GB9423248D0/en
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69431069D1 publication Critical patent/DE69431069D1/de
Publication of DE69431069T2 publication Critical patent/DE69431069T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69431069T 1993-12-15 1994-12-13 Cyclische amidderivate als neurokinin a antagonisten Expired - Fee Related DE69431069T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939325654A GB9325654D0 (en) 1993-12-15 1993-12-15 Cyclic amide derivatives
GB9423248A GB9423248D0 (en) 1994-11-17 1994-11-17 Cyclic amide derivatives
PCT/GB1994/002726 WO1995016682A1 (en) 1993-12-15 1994-12-13 Cyclic amide derivatives as neurokinin a antagonists

Publications (2)

Publication Number Publication Date
DE69431069D1 true DE69431069D1 (de) 2002-08-29
DE69431069T2 DE69431069T2 (de) 2003-05-08

Family

ID=26304034

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431069T Expired - Fee Related DE69431069T2 (de) 1993-12-15 1994-12-13 Cyclische amidderivate als neurokinin a antagonisten

Country Status (22)

Country Link
US (3) US5589489A (de)
EP (1) EP0734383B1 (de)
JP (1) JP3819934B2 (de)
CN (1) CN1142822A (de)
AT (1) ATE221064T1 (de)
AU (1) AU690951B2 (de)
BR (1) BR9408325A (de)
CA (1) CA2176036A1 (de)
CZ (1) CZ171796A3 (de)
DE (1) DE69431069T2 (de)
DK (1) DK0734383T3 (de)
ES (1) ES2179094T3 (de)
FI (1) FI962418L (de)
HU (1) HUT76275A (de)
IL (1) IL111970A (de)
NO (1) NO962543L (de)
NZ (1) NZ277291A (de)
PL (1) PL315035A1 (de)
PT (1) PT734383E (de)
SG (1) SG52667A1 (de)
SK (1) SK76396A3 (de)
WO (1) WO1995016682A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives
GB9325074D0 (en) * 1993-12-07 1994-02-02 Zeneca Ltd Bicyclic heterocycles
GB9408872D0 (en) * 1994-05-03 1994-06-22 Zeneca Ltd Heterocyclic compounds
US5998444A (en) * 1995-10-24 1999-12-07 Zeneca Ltd. Piperidinyl compounds as NK1 or NK2 antagonists
DE69534213T2 (de) * 1994-10-25 2006-01-12 Astrazeneca Ab Therapeutisch wirksame Heterocyclen
US6008223A (en) * 1994-10-27 1999-12-28 Zeneca Limited Therapeutic compounds
GB9508786D0 (en) * 1995-04-29 1995-06-21 Zeneca Ltd Substituted heterocycles
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
GB9521781D0 (en) * 1995-10-24 1996-01-03 Merck Sharp & Dohme Therapeutic agents
GB9523526D0 (en) * 1995-11-17 1996-01-17 Zeneca Ltd Therapeutic compounds
AU6133098A (en) * 1997-01-21 1998-08-07 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US7671200B2 (en) 1999-10-27 2010-03-02 Cytokinetics, Inc. Quinazolinone KSP inhibitors
US7230000B1 (en) 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US6281248B1 (en) 2000-02-16 2001-08-28 Magda Abdel Fattah Ahmed Composition for treating asthma
US6846814B2 (en) 2000-04-06 2005-01-25 Astra Zeneca Ab Neurokinin antagonists for use as medicaments
US7441688B2 (en) * 2003-11-04 2008-10-28 Reactive Nanotechnologies Methods and device for controlling pressure in reactive multilayer joining and resulting product
US20050142495A1 (en) * 2003-10-09 2005-06-30 David Peter Van Heerden Methods of controlling multilayer foil ignition
US7121402B2 (en) * 2003-04-09 2006-10-17 Reactive Nano Technologies, Inc Container hermetically sealed with crushable material and reactive multilayer material
PT1362844E (pt) 2001-01-26 2008-03-10 Btg Int Ltd Análogo da benzilamina
US7009049B2 (en) 2002-02-15 2006-03-07 Cytokinetics, Inc. Syntheses of quinazolinones
AU2003270015A1 (en) 2002-05-09 2003-12-02 Cytokinetics, Inc. Compounds, compositions, and methods
US7166595B2 (en) 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
WO2003103575A2 (en) 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
CA2489367A1 (en) 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004009036A2 (en) 2002-07-23 2004-01-29 Cytokinetics, Inc. Compounds compositions and methods
WO2004034972A2 (en) 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
JO2696B1 (en) * 2002-12-23 2013-03-03 شركة جانسين فارماسوتيكا ان. في Derivatives of 1-piperdine-4-yl-4-biprolidine-3-yl-piperazine substituted and used as quinine antagonists
BRPI0410277A (pt) * 2003-05-13 2006-05-16 Reactive Nanotechnologies Inc método para simular um comportamento de uma distribuição de energia dentro de um conjunto contendo um material multicamada reativo, dispositivo de armazenamento de programa legìvel por uma máquina, método para unir, e, junta
EP1692112A4 (de) 2003-12-08 2008-09-24 Cytokinetics Inc Verbindungen, zusammensetzungen und verfahren
CN1968932A (zh) 2004-06-18 2007-05-23 惠氏公司 制备6－烷基－5－芳基磺酰基－二氢菲啶的方法
US9359367B2 (en) 2012-07-09 2016-06-07 Lupin Limited Tetrahydroquinazolinone derivatives as PARP inhibitors

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
FR2654725B1 (fr) * 1989-11-23 1992-02-14 Rhone Poulenc Sante Nouveaux derives de l'isoindolone, leur preparation et les compositions pharmaceutiques qui les contiennent.
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676054B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) * 1991-05-03 1993-08-27 Sanofi Elf Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) * 1992-03-03 1994-07-08 Sanofi Elf Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) * 1992-11-03 1993-12-08 Zeneca Ltd Carboxamide derivatives
GB9310066D0 (en) * 1993-05-17 1993-06-30 Zeneca Ltd Alkyl substituted heterocycles
GB9310713D0 (en) * 1993-05-24 1993-07-07 Zeneca Ltd Aryl substituted heterocycles
EP0702681A1 (de) * 1993-06-07 1996-03-27 Merck & Co. Inc. Spiro-substituierte azaringe als neurokinin antagonisten
GB9317104D0 (en) * 1993-08-17 1993-09-29 Zeneca Ltd Therapeutic heterocycles
GB9322643D0 (en) * 1993-11-03 1993-12-22 Zeneca Ltd Lactam derivatives

Also Published As

Publication number Publication date
CN1142822A (zh) 1997-02-12
WO1995016682A1 (en) 1995-06-22
EP0734383A1 (de) 1996-10-02
JPH09506608A (ja) 1997-06-30
ATE221064T1 (de) 2002-08-15
US5589489A (en) 1996-12-31
AU1247195A (en) 1995-07-03
PT734383E (pt) 2002-12-31
JP3819934B2 (ja) 2006-09-13
FI962418A7 (fi) 1996-06-11
AU690951B2 (en) 1998-05-07
HUT76275A (en) 1997-07-28
PL315035A1 (en) 1996-09-30
IL111970A (en) 1999-03-12
EP0734383B1 (de) 2002-07-24
US5705505A (en) 1998-01-06
DE69431069T2 (de) 2003-05-08
SK76396A3 (en) 1996-12-04
CA2176036A1 (en) 1995-06-22
ES2179094T3 (es) 2003-01-16
NO962543L (no) 1996-08-14
US5965576A (en) 1999-10-12
SG52667A1 (en) 1998-09-28
CZ171796A3 (en) 1996-09-11
FI962418A0 (fi) 1996-06-11
NZ277291A (en) 1997-12-19
FI962418L (fi) 1996-06-11
BR9408325A (pt) 1997-08-19
DK0734383T3 (da) 2002-10-14
NO962543D0 (no) 1996-06-14
IL111970A0 (en) 1995-03-15
HU9601568D0 (en) 1996-08-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee