ATE206413T1 - Substituierte oxazolidine als calpain und/oder cathepsin b-hemmer - Google Patents

Substituierte oxazolidine als calpain und/oder cathepsin b-hemmer

Info

Publication number
ATE206413T1
ATE206413T1 AT95943478T AT95943478T ATE206413T1 AT E206413 T1 ATE206413 T1 AT E206413T1 AT 95943478 T AT95943478 T AT 95943478T AT 95943478 T AT95943478 T AT 95943478T AT E206413 T1 ATE206413 T1 AT E206413T1
Authority
AT
Austria
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidine
oxazolidine
Prior art date
Application number
AT95943478T
Other languages
English (en)
Inventor
Norton P Peet
Shujaath Mehdi
Matthew D Linnik
Michael R Angelastro
Hwa-Ok Kim
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE206413T1 publication Critical patent/ATE206413T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT95943478T 1995-01-11 1995-12-15 Substituierte oxazolidine als calpain und/oder cathepsin b-hemmer ATE206413T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11
PCT/US1995/016565 WO1996021655A2 (en) 1995-01-11 1995-12-15 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Publications (1)

Publication Number Publication Date
ATE206413T1 true ATE206413T1 (de) 2001-10-15

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95943478T ATE206413T1 (de) 1995-01-11 1995-12-15 Substituierte oxazolidine als calpain und/oder cathepsin b-hemmer

Country Status (23)

Country Link
US (1) US5691368A (de)
EP (1) EP0802909B1 (de)
JP (1) JP4157601B2 (de)
KR (1) KR100393701B1 (de)
CN (1) CN1088456C (de)
AR (1) AR001787A1 (de)
AT (1) ATE206413T1 (de)
AU (1) AU692044B2 (de)
CA (1) CA2210258C (de)
DE (1) DE69523072T2 (de)
DK (1) DK0802909T3 (de)
ES (1) ES2165441T3 (de)
FI (1) FI972935A0 (de)
HU (1) HUT77649A (de)
IL (1) IL116724A (de)
MX (1) MX9705235A (de)
NO (1) NO309267B1 (de)
NZ (1) NZ298999A (de)
PT (1) PT802909E (de)
SI (1) SI0802909T1 (de)
TW (1) TW454001B (de)
WO (1) WO1996021655A2 (de)
ZA (1) ZA96100B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270882B (it) * 1993-10-05 1997-05-13 Isagro Srl Oligopeptidi ad attivita' fungicida
US5925633A (en) * 1996-03-06 1999-07-20 Synphar Laboraties, Inc. 3-Substituted-4-oxa-1-azabicyclo 3,2,0!heptan-7-one as cysteine protease inhibitors
AU6134498A (en) * 1997-03-07 1998-09-22 Hoechst Marion Roussel, Inc. Method of treating trauma associated with brain, spinal cord or peripheral nerveinjury using carbobenzyloxy n-protected di- and tripeptide phenylalaninals
WO2000021550A2 (en) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methods and compositions for treating neurodegenerative diseases
CA2350133A1 (en) * 1998-11-12 2000-05-18 Research Corporation Technologies, Inc. A method for treating tissue damaged from ischemia
WO2000051998A1 (en) * 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
JP2002539190A (ja) 1999-03-15 2002-11-19 アクシス・ファーマシューティカルズ・インコーポレイテッド プロテアーゼ阻害剤としての新規化合物および組成物
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
EP1516877A1 (de) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Amin-derivative als Protease-Hemmer
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
PT1233962E (pt) * 1999-11-05 2006-07-31 Sod Conseils Rech Applic Compostos heterociclicos e a sua utilizacao como medicamentos
EP1315971A2 (de) * 2000-07-31 2003-06-04 The Regents of The University of California Modell für alzheimer und neurodegenerative krankheiten
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2004523506A (ja) 2000-12-22 2004-08-05 アクシス・ファーマシューティカルズ・インコーポレイテッド カテプシン阻害剤としての新規な化合物と組成物
BR0212535A (pt) 2001-09-14 2004-10-19 Aventis Pharma Inc Compostos e composições como inibidores de catepsina
RU2004117877A (ru) 2001-11-14 2006-01-10 Авентис Фармасьютикалз Инк. (Us) Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s
WO2004084830A2 (en) * 2003-03-21 2004-10-07 Buck Institute Method for treating alzheimer’s dementia
US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (en) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Use of an inhibitor of cathepsin-s or -b to treat or prevent chronic obstructive pulmonary disease
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
US9126987B2 (en) 2006-11-30 2015-09-08 Probiodrug Ag Inhibitors of glutaminyl cyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
EP2300000A1 (de) * 2008-07-03 2011-03-30 University of Massachusetts Verfahren und zusammensetzungen zur entzündungsminderung und behandlung von entzündungserkrankungen
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
EP2542549B1 (de) 2010-03-03 2016-05-11 Probiodrug AG Glutaminylcyclase-hemmer
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa
WO2024018245A1 (en) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en) 2023-01-20 2024-07-25 Institut National de la Santé et de la Recherche Médicale Autophagy activators for the treatment of rhabdomyolysis
WO2025153685A1 (en) * 2024-01-18 2025-07-24 Firmenich Sa 3-acyl-oxazolidin-5-one properfumes

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3867364A (en) * 1968-11-21 1975-02-18 Microbial Chem Res Found Process for the synthesis of leupeptins and their analogues
US5142056A (en) * 1989-05-23 1992-08-25 Abbott Laboratories Retroviral protease inhibiting compounds
US4277395A (en) * 1980-06-16 1981-07-07 Richardson-Merrell Inc. Novel enzyme inhibitors
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
US4535167A (en) * 1981-12-14 1985-08-13 Merck & Co. Inc. Chiral, N-protected, N-substituted α-amino acids
WO1984000365A1 (en) * 1982-07-19 1984-02-02 Nat Res Dev Synthetic peptides and their preparation
US5091575A (en) * 1985-01-23 1992-02-25 Abbott Laboratories Peptidylaminodiols
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
US5214129A (en) * 1985-01-23 1993-05-25 Abbott Laboratories Peptidylaminodiols
US5496927A (en) * 1985-02-04 1996-03-05 Merrell Pharmaceuticals Inc. Peptidase inhibitors
JPH079705B2 (ja) * 1986-05-28 1995-02-01 オリンパス光学工業株式会社 光カ−ド用デ−タ記録再生装置
DE3789347D1 (de) * 1986-10-14 1994-04-21 Banyu Pharma Co Ltd 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung.
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
US4820691A (en) * 1987-06-24 1989-04-11 E. R. Squibb & Sons, Inc. Amino acid 1,2-diketo derivatives as renin inhibitors
EP0313847A3 (de) * 1987-10-01 1989-11-29 G.D. Searle & Co. Nichtpeptide alpha-succinamidoacyl-Aminodiole als antihypertensive Agenzien
EP0329295A1 (de) * 1988-02-01 1989-08-23 The Upjohn Company Renin inhibierende Peptide mit polaren Endgruppen
AU3964489A (en) * 1988-07-08 1990-02-05 Smithkline Beckman Corporation Retroviral protease binding peptides
ZA897515B (en) * 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
US4990525A (en) * 1988-12-22 1991-02-05 Rohm And Haas Company Synergistic microbicidal combinations containing 3-isothiazolone and commerical biocides
US5510531A (en) * 1989-04-10 1996-04-23 Suntory Limited Proteinase inhibitor
JP2701932B2 (ja) * 1989-04-10 1998-01-21 サントリー株式会社 タンパク質分解酵素阻害剤
CA2032259A1 (en) * 1989-12-18 1991-06-19 Wayne J. Thompson Hiv protease inhibitors useful for the treatment of aids
EP0665215A1 (de) * 1990-06-01 1995-08-02 The Du Pont Merck Pharmaceutical Company 1,4-Diamino-2,3-dihydroxybutanen
DE4037437A1 (de) * 1990-11-24 1992-05-27 Hoechst Ag Aminodiol-derivate
US5444042A (en) * 1990-12-28 1995-08-22 Cortex Pharmaceuticals Method of treatment of neurodegeneration with calpain inhibitors
JPH06504547A (ja) * 1990-12-28 1994-05-26 ジョージア・テック・リサーチ・コーポレーション ペプチドケトアミド、ケト酸およびケトエステル
AU667463B2 (en) * 1990-12-28 1996-03-28 Cortex Pharmaceuticals, Inc. Use of calpain inhibitors in the inhibition and treatment of neurodegeneration
CA2071621C (en) * 1991-06-19 1996-08-06 Ahihiko Hosoda Aldehyde derivatives
JP3190431B2 (ja) * 1991-07-01 2001-07-23 三菱化学株式会社 ケトン誘導体
AU655831B2 (en) * 1991-08-22 1995-01-12 Merrell Pharmaceuticals Inc. Novel orally-active elastase inhibitors
EP0580161A1 (de) * 1992-07-22 1994-01-26 THE McLEAN HOSPITAL CORPORATION Prophylaktische und therapeutische Behandlung der Alzheimer'schen Krankheit
EP0603769B1 (de) * 1992-12-25 1998-09-16 Mitsubishi Chemical Corporation Alpha-aminoketon Derivate
JP2848232B2 (ja) * 1993-02-19 1999-01-20 武田薬品工業株式会社 アルデヒド誘導体
US5541290A (en) * 1993-06-24 1996-07-30 Harbeson; Scott L. Optically pure calpain inhibitor compounds
HU221629B1 (hu) * 1993-10-01 2002-12-28 Merrell Pharmaceuticals Inc. Béta-amiloid fehérje képződést gátló peptidek, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Also Published As

Publication number Publication date
AU4473196A (en) 1996-07-31
MX9705235A (es) 1997-10-31
NZ298999A (en) 1999-01-28
PT802909E (pt) 2002-03-28
AR001787A1 (es) 1997-12-10
HUT77649A (hu) 1998-07-28
FI972935L (fi) 1997-07-10
NO309267B1 (no) 2001-01-08
DK0802909T3 (da) 2002-01-28
NO973216L (no) 1997-09-09
IL116724A0 (en) 1996-05-14
EP0802909A2 (de) 1997-10-29
KR100393701B1 (ko) 2003-11-28
CN1088456C (zh) 2002-07-31
FI972935A7 (fi) 1997-07-10
WO1996021655A2 (en) 1996-07-18
SI0802909T1 (en) 2002-02-28
WO1996021655A3 (en) 1996-09-06
DE69523072D1 (en) 2001-11-08
CN1173174A (zh) 1998-02-11
JPH10512257A (ja) 1998-11-24
CA2210258A1 (en) 1996-07-18
DE69523072T2 (de) 2002-06-20
TW454001B (en) 2001-09-11
NO973216D0 (no) 1997-07-10
FI972935A0 (fi) 1997-07-10
US5691368A (en) 1997-11-25
ZA96100B (en) 1996-07-24
ES2165441T3 (es) 2002-03-16
JP4157601B2 (ja) 2008-10-01
AU692044B2 (en) 1998-05-28
EP0802909B1 (de) 2001-10-04
IL116724A (en) 2000-08-31
CA2210258C (en) 2002-10-01

Similar Documents

Publication Publication Date Title
ATE206413T1 (de) Substituierte oxazolidine als calpain und/oder cathepsin b-hemmer
DE59710384D1 (de) Ketobenzamide als calpain-inhibitoren
ATE222240T1 (de) Hiv - protease inhibitoren
DE69400543D1 (de) Rotierender Schalldämpfer
ATE429490T1 (de) Protease-varianten und verbindungen
DE59608538D1 (de) Bohr- und/oder Meisselgerät
DE69728139D1 (de) Pyrrolopyrrolone als inhibitoren von neutrophiler elastase
FI953483A0 (fi) Jätekaasuöljyn käsittely
EP0836382A4 (de) Cryptophycine
DE69408593D1 (de) 4-Aryl-4-Hydroxy-Tetrahydropyrane und 3-Aryl-3-Hydroxy-Tetrahydrofurane als 5-Lipoxygenaseinhibitoren
DE69417915D1 (de) Reinigung von uranhexafluorid
DE59705708D1 (de) Lagebestimmung von peripherieeinheiten
FI960333L (fi) Tryptaasi-inhibiittori
DE69500188D1 (de) Trapezoidal oder gebogen geformtes Chipbauteil
KR950000477U (ko) 지압용 장갑
KR970026629U (ko) 작업용 장갑
KR970000138U (ko) 지압용 장갑
KR940019985U (ko) 지압장갑
KR960036031U (ko) 장갑
KR970026630U (ko) 작업용 장갑
KR970026631U (ko) 작업용 장갑
FI962341A7 (fi) Uudet substituoidut oksatsolidiinit
ATA20094A (de) Fingerring
KR960033285U (ko) 광택용장갑
BR9303279A (pt) Inibição de nitrosamina e nitreto

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee