ATE206418T1 - 1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten - Google Patents

1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten

Info

Publication number
ATE206418T1
ATE206418T1 AT96943182T AT96943182T ATE206418T1 AT E206418 T1 ATE206418 T1 AT E206418T1 AT 96943182 T AT96943182 T AT 96943182T AT 96943182 T AT96943182 T AT 96943182T AT E206418 T1 ATE206418 T1 AT E206418T1
Authority
AT
Austria
Prior art keywords
benzenesulfonylpyrrolidine
derivatives
receptor antagonists
bradykinine
bradykinine receptor
Prior art date
Application number
AT96943182T
Other languages
English (en)
Inventor
Pierre Dodey
Michel Bondoux
Patrick Houziaux
Martine Barth
Khan Ou
Original Assignee
Fournier Ind & Sante
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fournier Ind & Sante filed Critical Fournier Ind & Sante
Application granted granted Critical
Publication of ATE206418T1 publication Critical patent/ATE206418T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT96943182T 1995-12-29 1996-12-23 1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten ATE206418T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9515706A FR2743073B1 (fr) 1995-12-29 1995-12-29 Nouveaux composes de 1-benzenesulfonylpyrrolidine, procede de preparation et utilisation en therapeutique
PCT/FR1996/002066 WO1997024349A1 (fr) 1995-12-29 1996-12-23 Derives de 1-benzenesulfonylpyrrolidine comme antagonistes du recepteur de la bradykinine

Publications (1)

Publication Number Publication Date
ATE206418T1 true ATE206418T1 (de) 2001-10-15

Family

ID=9486120

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96943182T ATE206418T1 (de) 1995-12-29 1996-12-23 1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten

Country Status (11)

Country Link
US (1) US6211181B1 (de)
EP (1) EP0874841B1 (de)
JP (1) JP2000502693A (de)
AT (1) ATE206418T1 (de)
AU (1) AU1198897A (de)
DE (1) DE69615707T2 (de)
DK (1) DK0874841T3 (de)
ES (1) ES2167617T3 (de)
FR (1) FR2743073B1 (de)
PT (1) PT874841E (de)
WO (1) WO1997024349A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751650B1 (fr) * 1996-07-24 1998-10-09 Fournier Ind & Sante Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
US6872742B2 (en) 1996-08-28 2005-03-29 The Procter & Gamble Company Substituted cyclic amine metalloprotease inhibitors
BR9713465A (pt) * 1996-08-28 2000-03-28 Procter & Gamble Inibidores metalotprotease de amina cìclica sibstituìda
CN1265647A (zh) 1997-07-31 2000-09-06 普罗克特和甘保尔公司 无环金属蛋白酶抑制剂
FR2790260B1 (fr) * 1999-02-26 2001-05-04 Fournier Ind & Sante Nouveaux composes de n-(benzenesulfonamide), procede de preparation et utilisation en therapeutique
KR20010102486A (ko) 1999-03-03 2001-11-15 데이비드 엠 모이어 알케닐- 및 알키닐-함유 메탈로프로테아제 저해제
ATE250053T1 (de) 1999-07-15 2003-10-15 Pharmacopeia Inc Bradikinin b1 rezeptor antagonisten
CA2364178C (en) * 2000-12-05 2006-01-10 Yasuhiro Katsu N-benzenesulfonyl l-proline compounds as bradykinin antagonists
FR2819254B1 (fr) * 2001-01-08 2003-04-18 Fournier Lab Sa Nouveaux composes de la n-(phenylsulfonyl) glycine, leur procede de preparation et leur utilisation pour obtenir des compostions pharmaceutiques
EP1914236A1 (de) 2002-04-10 2008-04-23 Ortho-McNeil Pharmaceutical, Inc. Neue Heteroaryl-Alkylamid-Derivate als Bradykininrezeptormodulatoren
FR2840897B1 (fr) 2002-06-14 2004-09-10 Fournier Lab Sa Nouveaux derives d'arylsulfonamides et leur utilisation en therapeutique
WO2004087700A1 (fr) 2003-03-25 2004-10-14 Laboratoires Fournier S.A. Derives du benzenesulfonamide, leur procede de preparation et leur utilisation de la douleur
NZ631419A (en) * 2012-02-29 2017-03-31 Baruch S Blumberg Inst Inhibitors of hepatitis b virus covalently closed circular dna formation and their method of use
WO2016170382A1 (en) 2015-04-23 2016-10-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Pharmaceutical compositions comprising a bradykinin 2 receptor antagonist for prevention or treatment of impaired skin wound healing

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3632329A1 (de) 1986-09-24 1988-03-31 Bayer Ag Substituierte phenylsulfonamide
US5288725A (en) * 1992-10-15 1994-02-22 Merck & Co., Inc. Pyrroloquinoline Bradykinin antagonist
AU686115B2 (en) 1992-11-02 1998-02-05 Fujisawa Pharmaceutical Co., Ltd. Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation
AU680870B2 (en) * 1993-04-28 1997-08-14 Astellas Pharma Inc. New heterocyclic compounds

Also Published As

Publication number Publication date
JP2000502693A (ja) 2000-03-07
US6211181B1 (en) 2001-04-03
PT874841E (pt) 2002-03-28
ES2167617T3 (es) 2002-05-16
EP0874841B1 (de) 2001-10-04
FR2743073A1 (fr) 1997-07-04
FR2743073B1 (fr) 1998-02-20
EP0874841A1 (de) 1998-11-04
AU1198897A (en) 1997-07-28
DE69615707T2 (de) 2002-08-08
WO1997024349A1 (fr) 1997-07-10
DE69615707D1 (de) 2001-11-08
DK0874841T3 (da) 2002-01-28

Similar Documents

Publication Publication Date Title
DE69615707D1 (de) 1-benzolsulfonylpyrrolidinderivate als bradykinin rezeptor antagonisten
YU34896A (sh) Supstituisani n-(indol-2-karbonil)-glicinamidi, njihovi intermedijeri i farmaceutske kompozicije
ID21538A (id) Turunan anilida, produksi dan pemakaiannya
DE69524251D1 (de) Neue verbindung, verfahren zu ihrer herstellung und antitumormittel
DK0931083T3 (da) Fremgangsmåde til fremstilling af ecteinascidinforbindelser
ATE315567T1 (de) A-1-adenosin rezeptor antagoniste
ES2161373T3 (es) Derivados de meta-guanidina, urea, tiourea o acido azaciclico-aminobenzoico como antagonistas de integrinas.
DK0807633T3 (da) Hidtil ukendte 2,3-disubstituerede-(5,6)-heteroarylkondenserede pyrimidin-4-oner
ATE135701T1 (de) Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten
PT896533E (pt) Pentafluorobenzenosulfonamidas e analogos
NZ331060A (en) Quinoxalinediones, preparation and pharmaceutical compositions thereof
NO911121D0 (no) Fremgangsmaate for fremstilling av nye skvalen-synetase-inhibitorer.
EA200000336A1 (ru) Антагонисты рецептора витронектина
DK0594263T3 (da) Mellemprodukter til fremstilling af thioalkylthio-cephalosporinderivater
DE69424039D1 (de) Neue verbindungen
DK0902018T3 (da) 2-(arylpheny)amino-imidazolinderivater
EA200400641A1 (ru) Производные 4-фенил-1-пиперазинила, -пиперидинила и -тетрагидропиридила и содержащая их фармацевтическая композиция
ATE19773T1 (de) Nitroaliphatische verbindungen, verfahren zu deren herstellung und deren verwendung.
YU69699A (sh) Derivati aril karbonske kiseline i tetrazola
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
DE69528978D1 (de) Lactamverbindungen als Inhibitoren der Cholesterin-Esterase
ID25477A (id) Turunan-turunan spiropiperidin
NO980145D0 (no) Polyucykliske alkaloid-derivater som NMDA-reseptor-antagonister
DK0782574T3 (da) Bicycliske carboxiamider som 5-HT1A-receptorligander
DE69622393D1 (de) Neue verwendung von pyrazolopyridinverbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee