ATE206918T1 - Isoxazolderivate zur behandlung von darmreizungssyndromen - Google Patents

Isoxazolderivate zur behandlung von darmreizungssyndromen

Info

Publication number: ATE206918T1
Authority: AT; Austria
Prior art keywords: treatment; isoxazole derivatives; intestinal irritation; irritation syndrome; syndrome
Prior art date: 1992-07-17

Application number

AT93305611T

Other languages

English (en)

Inventor

Jaswant Singh Gidda

John Mehnert Schaus

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-17

Filing date

1993-07-16

Publication date

2001-11-15

1993-07-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE206918T1 publication Critical patent/ATE206918T1/de

Links

230000000968 intestinal effect Effects 0.000 title 1
230000007794 irritation Effects 0.000 title 1
CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 title 1
208000011580 syndromic disease Diseases 0.000 title 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 2
238000009472 formulation Methods 0.000 abstract 1
150000002545 isoxazoles Chemical class 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003551 muscarinic effect Effects 0.000 abstract 1
239000003723 serotonin 1A agonist Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Nutrition Science (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93305611T 1992-07-17 1993-07-16 Isoxazolderivate zur behandlung von darmreizungssyndromen ATE206918T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US91628192A	1992-07-17	1992-07-17

Publications (1)

Publication Number	Publication Date
ATE206918T1 true ATE206918T1 (de)	2001-11-15

Family

ID=25436992

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93305611T ATE206918T1 (de)	1992-07-17	1993-07-16	Isoxazolderivate zur behandlung von darmreizungssyndromen

Country Status (22)

Country	Link
US (1)	US5434174A (de)
EP (1)	EP0579507B1 (de)
JP (1)	JPH06166620A (de)
CN (1)	CN1049336C (de)
AT (1)	ATE206918T1 (de)
AU (1)	AU666377B2 (de)
CA (1)	CA2100399A1 (de)
CZ (1)	CZ284881B6 (de)
DE (1)	DE69330926T2 (de)
DK (1)	DK0579507T3 (de)
ES (1)	ES2162808T3 (de)
HU (1)	HUT68727A (de)
IL (1)	IL106307A (de)
MX (1)	MX9304205A (de)
NO (1)	NO304054B1 (de)
PH (1)	PH30148A (de)
PL (1)	PL172494B1 (de)
PT (1)	PT579507E (de)
RU (1)	RU2127111C1 (de)
TW (1)	TW232653B (de)
UA (1)	UA27720C2 (de)
ZA (1)	ZA934969B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6562629B1 (en)	1999-08-11	2003-05-13	Cedars-Sinai Medical Center	Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US7048906B2 (en)	1995-05-17	2006-05-23	Cedars-Sinai Medical Center	Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) *	1999-08-11	2005-03-01	Cedars-Sinai Medical Center	Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US5962488A (en) *	1998-04-08	1999-10-05	Roberts Laboratories, Inc.	Stable pharmaceutical formulations for treating internal bowel syndrome containing isoxazole derivatives
US6362371B1 (en) *	1998-06-08	2002-03-26	Advanced Medicine, Inc.	β2- adrenergic receptor agonists
FR2792529B1 (fr) *	1999-04-26	2001-09-28	Sod Conseils Rech Applic	Nouvelles compositions pharmaceutiques comprenant des derives de 2-isoxazole-8-aminotetralines
UA76130C2 (en) *	2000-11-20	2006-07-17	Merck Patent Gmbh	Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
US6624388B1 (en) *	2001-01-25	2003-09-23	The Lincoln Electric Company	System and method providing distributed welding architecture
RU2178700C1 (ru) *	2001-04-11	2002-01-27	Змызгова Анна Васильевна	Способ лечения синдрома раздраженной кишки
GB0216027D0 (en) *	2002-07-10	2002-08-21	Arachnova Therapeutics Ltd	New therapeutic use
US20040048874A1 (en) *	2001-05-22	2004-03-11	Bardsley Hazel Judith	New therapeutic use of 4-(2-fluorophenyl)-6-methyl-2-(1-piperazinyl)thieno[2,3-D]pyrimidine
US20040147581A1 (en) *	2002-11-18	2004-07-29	Pharmacia Corporation	Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
KR20050111318A (ko) *	2003-01-13	2005-11-24	다이노젠 파마세우티컬스, 인코포레이티드	기능성 장 질환을 치료하는 방법
SE0301798D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use IV
SE0301796D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use II
SE0301795D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use I
SE0301794D0 (sv) *	2003-06-19	2003-06-19	Astrazeneca Ab	New use III
DE602004020069D1 (de) *	2004-09-14	2009-04-30	Fiat Ricerche	Vorrichtung und Verfahren zur Qualitätsüberwachung von Industrieprozessen
WO2006105117A2 (en) *	2005-03-28	2006-10-05	Dynogen Pharmaceuticals, Inc.	Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors
US7684402B2 (en)	2006-05-15	2010-03-23	Faraday Technology Corp.	Method and network device for fast look-up in a connection-oriented communication
BR112015015258A2 (pt)	2012-12-24	2017-09-26	Neurogastrx Inc	métodos para tratar distúrbios do trato gastrintestinal
WO2015200369A1 (en)	2014-06-24	2015-12-30	Neurogastrx, Inc.	Prodrugs of metopimazine
US10836757B1 (en)	2020-04-02	2020-11-17	Neurogastrx, Inc.	Polymorphic forms of metopimazine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT90366A (pt) *	1988-04-28	1989-11-10	Beecham Group Plc	Processo para a producao de compostos glicopeptidicos
JP2785879B2 (ja) *	1989-05-31	1998-08-13	ジ・アップジョン・カンパニー	治療学的に有用な２―アミノテトラリン誘導体
SE8904361D0 (sv) *	1989-12-22	1989-12-22	Astra Ab	New chroman and thiochroman derivatives
US5096908A (en) *	1990-05-04	1992-03-17	Eli Lilly And Company	Method of inhibiting gastric acid secretion
US5158956A (en) *	1990-05-04	1992-10-27	Eli Lilly And Company	Method of inhibiting gastric acid secretion with benzodioxanes
IL114760A (en) *	1991-02-08	1997-11-20	Lilly Co Eli	Ring-substituted-2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes intermediates thereto

1993
- 1993-04-20 US US08/049,968 patent/US5434174A/en not_active Expired - Fee Related
- 1993-07-05 UA UA93002204A patent/UA27720C2/uk unknown
- 1993-07-09 CZ CZ931371A patent/CZ284881B6/cs not_active IP Right Cessation
- 1993-07-09 TW TW082105482A patent/TW232653B/zh active
- 1993-07-09 ZA ZA934969A patent/ZA934969B/xx unknown
- 1993-07-12 IL IL106307A patent/IL106307A/xx not_active IP Right Cessation
- 1993-07-13 NO NO932547A patent/NO304054B1/no not_active IP Right Cessation
- 1993-07-13 MX MX9304205A patent/MX9304205A/es not_active IP Right Cessation
- 1993-07-13 CA CA002100399A patent/CA2100399A1/en not_active Abandoned
- 1993-07-15 AU AU41993/93A patent/AU666377B2/en not_active Ceased
- 1993-07-15 HU HU9302035A patent/HUT68727A/hu unknown
- 1993-07-15 JP JP5175396A patent/JPH06166620A/ja not_active Ceased
- 1993-07-15 PL PL93299690A patent/PL172494B1/pl not_active IP Right Cessation
- 1993-07-15 RU RU93037416A patent/RU2127111C1/ru not_active IP Right Cessation
- 1993-07-16 AT AT93305611T patent/ATE206918T1/de not_active IP Right Cessation
- 1993-07-16 DK DK93305611T patent/DK0579507T3/da active
- 1993-07-16 EP EP93305611A patent/EP0579507B1/de not_active Expired - Lifetime
- 1993-07-16 DE DE69330926T patent/DE69330926T2/de not_active Expired - Fee Related
- 1993-07-16 ES ES93305611T patent/ES2162808T3/es not_active Expired - Lifetime
- 1993-07-16 CN CN93108376A patent/CN1049336C/zh not_active Expired - Fee Related
- 1993-07-16 PT PT93305611T patent/PT579507E/pt unknown
- 1993-09-09 PH PH46496A patent/PH30148A/en unknown

Also Published As

Publication number	Publication date
NO932547D0 (no)	1993-07-13
MX9304205A (es)	1995-01-31
EP0579507A1 (de)	1994-01-19
PT579507E (pt)	2002-02-28
JPH06166620A (ja)	1994-06-14
ES2162808T3 (es)	2002-01-16
PH30148A (en)	1997-01-21
HK1013795A1 (en)	1999-09-10
IL106307A0 (en)	1993-11-15
PL299690A1 (en)	1994-03-21
CZ137193A3 (en)	1994-11-16
HUT68727A (en)	1995-07-28
AU4199393A (en)	1994-01-20
PL172494B1 (pl)	1997-09-30
NO304054B1 (no)	1998-10-19
CN1049336C (zh)	2000-02-16
DE69330926D1 (de)	2001-11-22
EP0579507B1 (de)	2001-10-17
CA2100399A1 (en)	1994-01-18
DK0579507T3 (da)	2001-11-12
AU666377B2 (en)	1996-02-08
HU9302035D0 (en)	1993-10-28
CN1111986A (zh)	1995-11-22
ZA934969B (en)	1995-01-09
IL106307A (en)	1997-06-10
RU2127111C1 (ru)	1999-03-10
UA27720C2 (uk)	2000-10-16
NO932547L (no)	1994-01-18
TW232653B (de)	1994-10-21
DE69330926T2 (de)	2002-04-11
CZ284881B6 (cs)	1999-03-17
US5434174A (en)	1995-07-18

Legal Events

Date	Code	Title	Description
2002-03-15	UEP	Publication of translation of european patent specification
2005-04-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69330926D1 (de)	2001-11-22	Isoxazolderivate zur Behandlung von Darmreizungssyndromen
NO891896L (no)	1990-10-22	Fremgangsmaate og innretning for behandling av medisinsk spesialavfall.
DE3854540D1 (de)	1995-11-09	Behandlungsapparat und Verfahren.
LV10449A (lv)	1995-02-20	Jauni hromana un tiohromana atvasinajumi
DE69114653D1 (de)	1995-12-21	Sterilisierendes Gemisch und Verfahren zur Sterilisation.
DE69018043D1 (de)	1995-04-27	Behandlung von Geflügel.
NO901141D0 (no)	1990-03-12	Additiv og fremgangsmaate for behandling av underjordiske formasjoner.
DE3777861D1 (de)	1992-05-07	Behandlung von gasen.
NO912548L (no)	1992-12-29	Fremgangsmaate for behandling av avfallsprodukter.
ATE124681T1 (de)	1995-07-15	Arzneimittelzusammensetzungen zur behandlung von psoriasis.
DE3850508D1 (de)	1994-08-11	Behandlungsverfahren eines Phthalocyanins.
DE3688528D1 (de)	1993-07-08	Optische analoge datenverarbeitungsanordnungen zur behandlung von bipolaren und komplexen daten.
NO904873L (no)	1991-05-13	Fremgangsmaate og anordning for behandling av sinkslig.
DE68923219D1 (de)	1995-08-03	Behandlung von Abfällen.
ATE96802T1 (de)	1993-11-15	23-oxo (keto) und 23-imino-derivate von monound diepoxy ll-f28249 verbindungen.
ATE70181T1 (de)	1991-12-15	Verwendung von oxochinazolinderivaten bei der behandlung von hyperurikaemie.
NO864728D0 (no)	1986-11-26	Fremgangsmaate og apparat for kryopresipitering av blodplasma.
NO864272D0 (no)	1986-10-24	Fremgangsmaate og anordning for haandtering av boreroer.
DE3883878D1 (de)	1993-10-14	Behandlungsapparat und Verfahren.
DE69117943D1 (de)	1996-04-18	Behandlung von tieren
ATE84435T1 (de)	1993-01-15	Einrichtung zur behandlung von gasen.
ATE74334T1 (de)	1992-04-15	Behandlung von gasen.
DE3771706D1 (de)	1991-08-29	Behandlung von knochenschwund.
NO905643D0 (no)	1990-12-28	Fremgangsmaate for behandling av manganslam.
ATE56878T1 (de)	1990-10-15	Verfahren und zusammensetzung zur vorbeugung und behandlung von virus-infektionen.