ATE207460T1 - Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung - Google Patents
Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendungInfo
- Publication number
- ATE207460T1 ATE207460T1 AT96925086T AT96925086T ATE207460T1 AT E207460 T1 ATE207460 T1 AT E207460T1 AT 96925086 T AT96925086 T AT 96925086T AT 96925086 T AT96925086 T AT 96925086T AT E207460 T1 ATE207460 T1 AT E207460T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- benzocycloalkene
- compounds
- preparation
- binding affinity
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000001419 Melatonin receptor Human genes 0.000 title 1
- 108050009605 Melatonin receptor Proteins 0.000 title 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 abstract 1
- 229960003987 melatonin Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP19083095 | 1995-07-26 | ||
| PCT/JP1996/002091 WO1997005098A1 (en) | 1995-07-26 | 1996-07-25 | Benzocycloalkene compounds with melatonine receptor binding affinity, their production and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE207460T1 true ATE207460T1 (de) | 2001-11-15 |
Family
ID=16264480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96925086T ATE207460T1 (de) | 1995-07-26 | 1996-07-25 | Benzocycloalken-verbindungen mit bindungsaffinität an den melatonin-rezeptor, ihre herstellung und verwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5922771A (de) |
| EP (1) | EP0848699B1 (de) |
| CN (1) | CN1191528A (de) |
| AT (1) | ATE207460T1 (de) |
| AU (1) | AU6531296A (de) |
| CA (1) | CA2224260A1 (de) |
| DE (1) | DE69616357T2 (de) |
| WO (1) | WO1997005098A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000010965A2 (en) | 1998-08-20 | 2000-03-02 | Takeda Chemical Industries, Ltd. | Quaternary ammonium salts and their use as anti-hiv agents |
| IT1317049B1 (it) | 2000-06-23 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Composti utili per la preparazione di medicamenti ad attivita'inibitrice della fosfodiesterasi iv. |
| FR2814165B1 (fr) * | 2000-09-15 | 2002-11-22 | Adir | Nouveaux derives biphenyles substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2849849B1 (fr) * | 2003-01-13 | 2006-08-04 | Merck Sante Sas | Nouveaux acides carboxyliques et derives pour le traitement et la prevention du diabete et des dyslipemies |
| WO2016046833A2 (en) * | 2014-09-24 | 2016-03-31 | Symed Labs Limited | Improved processes for the preparation of agomelatine using novel intermediates |
| JP6893476B2 (ja) | 2016-01-08 | 2021-06-23 | 武田薬品工業株式会社 | 自閉症スペクトラム障害の予防または治療剤 |
| AU2017205519B2 (en) | 2016-01-08 | 2022-01-27 | Takeda Pharmaceutical Company Limited | Prophylactic or therapeutic agent for delirium |
| US20250228798A1 (en) * | 2024-01-17 | 2025-07-17 | Rivo Bio, Inc. | Indane-, indene-, azaindane-, and azaindene-amines as activators of serotonin receptors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3642785A (en) * | 1969-08-11 | 1972-02-15 | Merck & Co Inc | Indenyl-3-aliphatic amines |
| US4656190A (en) * | 1983-11-14 | 1987-04-07 | Merck & Co., Inc. | Indene derivatives and their use as PAF-antagonists |
| US5071875A (en) * | 1989-09-25 | 1991-12-10 | Northwestern University | Substituted 2-amidotetralins as melatonin agonists and antagonists |
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5158948A (en) * | 1990-11-16 | 1992-10-27 | Abbott Laboratories | Tetracyclic spirobenzazepine dopamine antagonists |
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1996008466A1 (en) * | 1994-09-12 | 1996-03-21 | Takeda Chemical Industries, Ltd. | Benzocycloalkene compounds, their production and use |
| FR2729147A1 (fr) * | 1995-01-11 | 1996-07-12 | Adir | Nouveaux composes (hetero) cycliques alkyles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2734814B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| FR2734816B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux aryl (alkyl) propylamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
-
1996
- 1996-07-25 DE DE69616357T patent/DE69616357T2/de not_active Expired - Fee Related
- 1996-07-25 EP EP96925086A patent/EP0848699B1/de not_active Expired - Lifetime
- 1996-07-25 AU AU65312/96A patent/AU6531296A/en not_active Abandoned
- 1996-07-25 CA CA002224260A patent/CA2224260A1/en not_active Abandoned
- 1996-07-25 CN CN96195801A patent/CN1191528A/zh active Pending
- 1996-07-25 WO PCT/JP1996/002091 patent/WO1997005098A1/en not_active Ceased
- 1996-07-25 US US08/693,058 patent/US5922771A/en not_active Expired - Fee Related
- 1996-07-25 AT AT96925086T patent/ATE207460T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69616357D1 (de) | 2001-11-29 |
| CN1191528A (zh) | 1998-08-26 |
| EP0848699B1 (de) | 2001-10-24 |
| US5922771A (en) | 1999-07-13 |
| WO1997005098A1 (en) | 1997-02-13 |
| DE69616357T2 (de) | 2002-07-11 |
| CA2224260A1 (en) | 1997-02-13 |
| EP0848699A1 (de) | 1998-06-24 |
| AU6531296A (en) | 1997-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |