ATE207498T1 - NEUTROPHIL INHIBITORS FROM NEMATODES - Google Patents

NEUTROPHIL INHIBITORS FROM NEMATODES

Info

Publication number
ATE207498T1
ATE207498T1 AT93911273T AT93911273T ATE207498T1 AT E207498 T1 ATE207498 T1 AT E207498T1 AT 93911273 T AT93911273 T AT 93911273T AT 93911273 T AT93911273 T AT 93911273T AT E207498 T1 ATE207498 T1 AT E207498T1
Authority
AT
Austria
Prior art keywords
nematodes
compositions
neutrophil
neutrophil inhibitors
inhibitors
Prior art date
Application number
AT93911273T
Other languages
German (de)
Inventor
Matthew Moyle
David Lee Foster
George Phillip Vlasuk
Original Assignee
Corvas Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corvas Int Inc filed Critical Corvas Int Inc
Application granted granted Critical
Publication of ATE207498T1 publication Critical patent/ATE207498T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F02—COMBUSTION ENGINES; HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS
    • F02B—INTERNAL-COMBUSTION PISTON ENGINES; COMBUSTION ENGINES IN GENERAL
    • F02B75/00—Other engines
    • F02B75/02—Engines characterised by their cycles, e.g. six-stroke
    • F02B2075/022—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle
    • F02B2075/027—Engines characterised by their cycles, e.g. six-stroke having less than six strokes per cycle four

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Such compositions may comprise a glycoprotein isolated from nematodes. These compositions are useful in the therapy of conditions which involve abnormal or undesired inflammatory responses.
AT93911273T 1992-05-11 1993-05-11 NEUTROPHIL INHIBITORS FROM NEMATODES ATE207498T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88172192A 1992-05-11 1992-05-11
US99697292A 1992-12-24 1992-12-24
PCT/US1993/004502 WO1993023063A1 (en) 1992-05-11 1993-05-11 Novel neutrophil inhibitors

Publications (1)

Publication Number Publication Date
ATE207498T1 true ATE207498T1 (en) 2001-11-15

Family

ID=27128632

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93911273T ATE207498T1 (en) 1992-05-11 1993-05-11 NEUTROPHIL INHIBITORS FROM NEMATODES

Country Status (13)

Country Link
US (1) US6756211B1 (en)
EP (1) EP0731709B1 (en)
JP (1) JP3509860B2 (en)
AT (1) ATE207498T1 (en)
AU (1) AU687737B2 (en)
CA (1) CA2135390A1 (en)
DE (1) DE69331018T2 (en)
DK (1) DK0731709T3 (en)
ES (1) ES2168095T3 (en)
MX (1) MX9302750A (en)
NZ (3) NZ252591A (en)
PT (1) PT731709E (en)
WO (1) WO1993023063A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1749534B1 (en) 1997-12-31 2013-08-21 University Of Iowa Research Foundation Use of parasitic biological agents from for prevention and control of inflammatory bowel disease
EP1186303A3 (en) * 2000-09-06 2003-12-10 Pfizer Products Inc. Pharmaceutical combinations, for the treatment of stroke and traumatic brain injury, containing a neutrophil inhibiting factor and an selective NMDA-NR2B receptor antagonist
WO2006062776A2 (en) * 2004-11-29 2006-06-15 The Regents Of The University Of California Hydroxyapatite-binding peptides for bone growth and inhibition
DE102007021199B4 (en) * 2006-07-17 2016-02-11 Evonik Degussa Gmbh Compositions of organic polymer as matrix and inorganic particles as filler, process for their preparation and their use and moldings produced therewith
CA2866819C (en) 2012-03-13 2022-01-04 James Cook University Method for treating inflammation
JP2016532456A (en) 2013-09-18 2016-10-20 ジェームス・クック・ユニバーシティー Modified anti-inflammatory protein and method of use
EP3554257B1 (en) 2016-12-15 2023-07-12 Société des Produits Nestlé S.A. Compositions and methods that modulate white blood cells or neutrophils in a companion animal

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431739A (en) * 1979-11-05 1984-02-14 Genentech, Inc. Transformant bacterial culture capable of expressing heterologous protein
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
US5019648A (en) * 1987-07-06 1991-05-28 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
DE68923107T2 (en) * 1988-02-26 1996-01-18 Biogen Inc DNA sequences, recombinant DNA molecules and methods for the production of lipocortin III, IV, V, and VI.
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
JPH05504470A (en) * 1989-10-20 1993-07-15 ニューイングランド・メディカル・センター・ホスピタルズ・インコーポレーテッド Inhibition of PADGEM-mediated cell binding
US5314992A (en) * 1991-11-25 1994-05-24 Trustees Of Dartmouth College Lipocortin-1 receptor protein and its uses

Also Published As

Publication number Publication date
CA2135390A1 (en) 1993-11-25
NZ505450A (en) 2002-02-01
PT731709E (en) 2002-04-29
MX9302750A (en) 1994-02-28
JPH07508177A (en) 1995-09-14
DK0731709T3 (en) 2002-02-11
EP0731709A4 (en) 1997-06-11
WO1993023063A1 (en) 1993-11-25
NZ252591A (en) 1997-02-24
AU687737B2 (en) 1998-03-05
US6756211B1 (en) 2004-06-29
DE69331018D1 (en) 2001-11-29
ES2168095T3 (en) 2002-06-01
AU4246493A (en) 1993-12-13
EP0731709A1 (en) 1996-09-18
DE69331018T2 (en) 2002-06-13
EP0731709B1 (en) 2001-10-24
JP3509860B2 (en) 2004-03-22
NZ299623A (en) 2000-11-24

Similar Documents

Publication Publication Date Title
CA2129339A1 (en) Inhibitors of thrombosis
GEP20012446B (en) Inhibitors of Interleukin- 1β Converting Enzyme
EP0684830A4 (en) Inhibitors of thrombosis.
NO942064L (en) inhibitors
BG101841A (en) CELLULAR ADHESION INHIBITORS
TR199801168T2 (en) �nterleukin-1 beta inhibits the inhibitory enzyme.
ATE318841T1 (en) BIARYLALKANEOUS ACIDS USED AS CELL ADHESION INHIBITORS
DE69925508D1 (en) CELL ADHESION AND INFLAMMATORY IMMUNOSUPPRESSIVE COMPOUNDS
ATE237342T1 (en) LEUKOCYTE ADHESION INHIBITORS
DK1029921T3 (en) Serpin-resistant t-PA, mutants, genes
KR950700323A (en) Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
FI942625A0 (en) Peptide phosphinyloxymethyl ketones as inhibitors of the interleukin-1beta variable enzyme
ATE261932T1 (en) INHIBITORS OF ALPHA-4 BETA-1-MEDIATED CELL ADHESION
ATE207498T1 (en) NEUTROPHIL INHIBITORS FROM NEMATODES
DE68925032D1 (en) LEUCOCYTE ADHESION INHIBITOR.
FI943511A7 (en) Pyrroloimidazolyl- and imidazopyridinyl-substituted 1H-benzimidazole derivatives as aromatase inhibitors
ATE228760T1 (en) THROMBIN INHIBITORS
FI943850A0 (en) 3-alkyloxy, aryloxy or arylalkyloxybenzo (b) thiophene-2-carboxamides as cell adhesion inhibitors
MX9306686A (en) ANTI-INFLAMMATORY FACTOR AND METHOD FOR ITS INSULATION.
ATE204478T1 (en) INHIBITION OF LEUKOCYTE ADHESION
DK0787007T3 (en) Anti-inflammatory factor, isolation method and use
NO954081L (en) Cytotoxic factor associated with disseminated sclerosis, its detection and quantification
DE69332904D1 (en) INHIBITION OF HIV INFECTION
ES2062332T3 (en) ANTI-INFLAMMATORY BENZOXAZOLONES.
ATE276272T1 (en) ANTI-INFLAMMATORY PEPTIDES

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee