ATE207921T1 - Verfahren zur herstellung von tetrahydroindolizinen - Google Patents

Verfahren zur herstellung von tetrahydroindolizinen

Info

Publication number: ATE207921T1
Authority: AT; Austria
Prior art keywords: compound; tetrahydroindolizine; producing; solvent; useful
Prior art date: 1996-04-26

Application number

AT97919674T

Other languages

English (en)

Inventor

Shinji Kamihara

Kazuaki Kanai

Shigeru Noguchi

Original Assignee

Daiichi Seiyaku Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-26

Filing date

1997-04-24

Publication date

2001-11-15

1997-04-24 Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207921T1 publication Critical patent/ATE207921T1/de

Links

ZBPHPBWGQALQCS-UHFFFAOYSA-N 1,2,3,5-tetrahydroindolizine Chemical compound C1C=CC=C2CCCN21 ZBPHPBWGQALQCS-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 abstract 1
239000002841 Lewis acid Substances 0.000 abstract 1
150000004703 alkoxides Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
-1 carbonate diester Chemical class 0.000 abstract 1
150000007517 lewis acids Chemical class 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97919674T 1996-04-26 1997-04-24 Verfahren zur herstellung von tetrahydroindolizinen ATE207921T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP10725196		1996-04-26
JP10725296		1996-04-26
PCT/JP1997/001428 WO1997041124A1 (en)	1996-04-26	1997-04-24	Process for the preparation of tetrahydro-indolizines

Publications (1)

Publication Number	Publication Date
ATE207921T1 true ATE207921T1 (de)	2001-11-15

Family

ID=26447288

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97919674T ATE207921T1 (de)	1996-04-26	1997-04-24	Verfahren zur herstellung von tetrahydroindolizinen

Country Status (11)

Country	Link
US (2)	US6172230B1 (de)
EP (1)	EP0897924B1 (de)
KR (1)	KR20000064811A (de)
CN (2)	CN1087296C (de)
AT (1)	ATE207921T1 (de)
AU (1)	AU2406097A (de)
DE (1)	DE69707860T2 (de)
DK (1)	DK0897924T3 (de)
ES (1)	ES2166991T3 (de)
PT (1)	PT897924E (de)
WO (1)	WO1997041124A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6870500A (en) *	1999-09-06	2001-04-10	Takeda Chemical Industries Ltd.	Process for the preparation of 2,3-dihydroazepine derivatives
US7595400B2 (en)	2003-02-21	2009-09-29	Chugai Seiyaku Kabushiki Kaisha	Process for the preparation of hexacyclic compounds
US7910593B2 (en)	2004-04-09	2011-03-22	Chugai Seiyaku Kabushiki Kaisha	Water-soluble prodrugs
TW200744603A (en)	2005-08-22	2007-12-16	Chugai Pharmaceutical Co Ltd	Novel anticancer concomitant drug
US12098961B2 (en) *	2018-06-29	2024-09-24	Tecnimed S.R.L.	Non-contact infrared thermometer
CN110204482A (zh) *	2019-05-23	2019-09-06	久泰能源(准格尔)有限公司	一种4-羟基吡啶-2,6-二羧酸的制备方法
CA3146560A1 (en)	2019-07-10	2021-01-14	Cybrexa 2, Inc.	Peptide conjugates of cytotoxins as therapeutics
MY209459A (en)	2019-07-10	2025-07-09	Cybrexa 3 Inc	Peptide conjugates of microtubule-targeting agents as therapeutics

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4304728A (en) *	1979-04-05	1981-12-08	Lilly Industries Limited	6-Substituted pyranone compounds and their use as pharmaceuticals
US4894456A (en) *	1987-03-31	1990-01-16	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5364858A (en) *	1987-03-31	1994-11-15	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5227380A (en) *	1987-03-31	1993-07-13	Research Triangle Institute	Pharmaceutical compositions and methods employing camptothecins
US5244903A (en) *	1987-03-31	1993-09-14	Research Triangle Institute	Camptothecin analogs as potent inhibitors of topoisomerase I
US5106742A (en) *	1987-03-31	1992-04-21	Wall Monroe E	Camptothecin analogs as potent inhibitors of topoisomerase I
US5122526A (en) *	1987-03-31	1992-06-16	Research Triangle Institute	Camptothecin and analogs thereof and pharmaceutical compositions and method using them

1997
- 1997-04-24 PT PT97919674T patent/PT897924E/pt unknown
- 1997-04-24 CN CN97194126A patent/CN1087296C/zh not_active Expired - Fee Related
- 1997-04-24 KR KR1019980707765A patent/KR20000064811A/ko not_active Ceased
- 1997-04-24 WO PCT/JP1997/001428 patent/WO1997041124A1/ja not_active Ceased
- 1997-04-24 DE DE69707860T patent/DE69707860T2/de not_active Expired - Fee Related
- 1997-04-24 AU AU24060/97A patent/AU2406097A/en not_active Abandoned
- 1997-04-24 US US09/147,183 patent/US6172230B1/en not_active Expired - Fee Related
- 1997-04-24 DK DK97919674T patent/DK0897924T3/da active
- 1997-04-24 ES ES97919674T patent/ES2166991T3/es not_active Expired - Lifetime
- 1997-04-24 AT AT97919674T patent/ATE207921T1/de not_active IP Right Cessation
- 1997-04-24 EP EP97919674A patent/EP0897924B1/de not_active Expired - Lifetime
2000
- 2000-08-18 US US09/640,879 patent/US6337400B1/en not_active Expired - Fee Related
2002
- 2002-02-08 CN CN02104573A patent/CN1373130A/zh active Pending

Also Published As

Publication number	Publication date
EP0897924B1 (de)	2001-10-31
US6172230B1 (en)	2001-01-09
AU2406097A (en)	1997-11-19
CN1216992A (zh)	1999-05-19
DE69707860T2 (de)	2002-04-11
US6337400B1 (en)	2002-01-08
KR20000064811A (ko)	2000-11-06
EP0897924A4 (de)	1999-07-07
DK0897924T3 (da)	2001-11-19
EP0897924A1 (de)	1999-02-24
PT897924E (pt)	2002-03-28
CN1373130A (zh)	2002-10-09
WO1997041124A1 (en)	1997-11-06
DE69707860D1 (de)	2001-12-06
ES2166991T3 (es)	2002-05-01
CN1087296C (zh)	2002-07-10

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Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2008-01-15	REN	Ceased due to non-payment of the annual fee