ATE204870T1 - Verfahren zur herstellung von paroxetine - Google Patents

Verfahren zur herstellung von paroxetine

Info

Publication number
ATE204870T1
ATE204870T1 AT97108806T AT97108806T ATE204870T1 AT E204870 T1 ATE204870 T1 AT E204870T1 AT 97108806 T AT97108806 T AT 97108806T AT 97108806 T AT97108806 T AT 97108806T AT E204870 T1 ATE204870 T1 AT E204870T1
Authority
AT
Austria
Prior art keywords
represented
general formula
alkoxycarbonylpiperidine
paroxetine
producing
Prior art date
Application number
AT97108806T
Other languages
English (en)
Inventor
Shu-Zhong Wang
Yasushi Matsumura
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Application granted granted Critical
Publication of ATE204870T1 publication Critical patent/ATE204870T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
AT97108806T 1996-05-31 1997-06-02 Verfahren zur herstellung von paroxetine ATE204870T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13904896A JP3882224B2 (ja) 1996-05-31 1996-05-31 パロキセチンの製造方法

Publications (1)

Publication Number Publication Date
ATE204870T1 true ATE204870T1 (de) 2001-09-15

Family

ID=15236260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97108806T ATE204870T1 (de) 1996-05-31 1997-06-02 Verfahren zur herstellung von paroxetine

Country Status (9)

Country Link
US (2) US6433179B1 (de)
EP (1) EP0810225B1 (de)
JP (1) JP3882224B2 (de)
AT (1) ATE204870T1 (de)
CA (1) CA2205770A1 (de)
DE (1) DE69706366T2 (de)
ES (1) ES2162156T3 (de)
PT (1) PT810225E (de)
SI (1) SI0810225T1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1394160A1 (de) 1996-06-13 2004-03-03 SUMIKA FINE CHEMICALS Co., Ltd. Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid
SK283394B6 (sk) 1997-06-10 2003-07-01 Synthon B. V. Zlúčeniny 4-fenylpiperidínu a jej farmaceuticky prijateľné soli, spôsob ich prípravy, liečivo s ich obsahom a ich použitie
CH689805A8 (fr) * 1998-07-02 2000-02-29 Smithkline Beecham Plc Méthanesulfonate de paroxétine, procédé pour sa préparation et compositions pharmaceutiques le contenant.
GB9828767D0 (en) * 1998-12-29 1999-02-17 Smithkline Beecham Plc Novel process
GB9914583D0 (en) * 1999-06-22 1999-08-25 Smithkline Beecham Plc Novel process
GB9916187D0 (en) * 1999-07-09 1999-09-08 Smithkline Beecham Plc Novel process
CZ20023694A3 (cs) 2000-05-12 2003-05-14 Synthon B. V. Tosylátové soli 4-(p-fluorfenyl)-piperidin-3-methanolů
EP1301508A1 (de) * 2000-07-17 2003-04-16 Smithkline Beecham Plc Verfahren zur herstellung von 4-phenylpiperidin-derivate
US6777554B2 (en) 2001-02-05 2004-08-17 Teva Pharmaceutical Industries Ltd. Preparation of N-methylparoxetine and related intermediate compounds
NL1017421C2 (nl) * 2001-02-21 2002-01-15 Synthon Bv Werkwijze voor het vervaardigen van paroxetine.
WO2003072104A1 (en) * 2002-02-22 2003-09-04 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
US6956121B2 (en) * 2002-03-01 2005-10-18 Teva Pharmaceutical Industries Ltd. Preparation of paroxetine involving novel intermediates
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
CN103382434B (zh) 2005-01-18 2016-05-25 生物概念股份有限公司 利用含排列成图案的立柱的微通道分离细胞
WO2007015262A2 (en) * 2005-04-25 2007-02-08 Sun Pharmaceutical Industries Limited A process for the preparation of (-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl)]piperidine
US20070112031A1 (en) * 2005-11-14 2007-05-17 Gant Thomas G Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties
US20080033050A1 (en) 2006-08-04 2008-02-07 Richards Patricia Allison Tewe Method of treating thermoregulatory disfunction with paroxetine
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
CN102718756B (zh) * 2012-07-02 2013-11-20 浙江尖峰药业有限公司 盐酸帕罗西汀化合物及其合成方法
CN104447714A (zh) * 2014-11-18 2015-03-25 成都医路康医学技术服务有限公司 一种盐酸帕罗西汀的生产工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4268515A (en) * 1980-02-04 1981-05-19 Hoechst-Roussel Pharmaceuticals Inc. Spiro[dihydrobenzofuran-piperidines and-pyrrolidines], pharmaceutical compositions thereof and methods of use thereof
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
EP0190496A3 (de) 1984-12-13 1987-05-27 Beecham Group Plc Piperidinderivate mit gastro-intestinaler Wirkung
EP0223403B1 (de) * 1985-10-25 1993-08-04 Beecham Group Plc Piperidinderivat, seine Herstellung und seine Verwendung als Arzneimittel
IE66332B1 (en) 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
US5227379A (en) 1986-11-03 1993-07-13 Novo Nordisk A/S Piperidine compounds and their preparation and use
IL101851A (en) * 1991-06-13 1996-05-14 Janssen Pharmaceutica Nv 10-(4-piperidinyl- and piperidinylidene)-imidazo [1,2-a] (pyrrolo thieno or furano) [2,3] azepine derivatives their preparation and pharmaceutical compositions containing them and certain novel intermediates therefor
JP2607784B2 (ja) 1991-09-30 1997-05-07 株式会社神戸製鋼所 廻し溶接用エンドタブ
AR001982A1 (es) 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
JP3882224B2 (ja) * 1996-05-31 2007-02-14 旭硝子株式会社 パロキセチンの製造方法
EP1394160A1 (de) 1996-06-13 2004-03-03 SUMIKA FINE CHEMICALS Co., Ltd. Verfahren zur Herstellung von kristallinem Paroxetin-Hydrochlorid
US5672612A (en) 1996-09-09 1997-09-30 Pentech Pharmaceuticals, Inc. Amorphous paroxetine composition
GB9817195D0 (en) * 1998-08-07 1998-10-07 Smithkline Beecham Plc Novel process

Also Published As

Publication number Publication date
DE69706366D1 (de) 2001-10-04
ES2162156T3 (es) 2001-12-16
DE69706366T2 (de) 2002-05-29
SI0810225T1 (en) 2001-10-31
EP0810225B1 (de) 2001-08-29
CA2205770A1 (en) 1997-11-30
JP3882224B2 (ja) 2007-02-14
PT810225E (pt) 2001-12-28
US20020198387A1 (en) 2002-12-26
JPH09316072A (ja) 1997-12-09
EP0810225A1 (de) 1997-12-03
US6433179B1 (en) 2002-08-13

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties