ATE208199T1 - Arzneimittel gegen parkinsonsche krankheit - Google Patents

Arzneimittel gegen parkinsonsche krankheit

Info

Publication number: ATE208199T1
Authority: AT; Austria
Prior art keywords: lower alkyl; heterocycle; hydrogen; represents hydrogen; aryl
Prior art date: 1993-07-27

Application number

AT94921793T

Other languages

English (en)

Inventor

Fumio Suzuki

Junichi Shimada

Nobuaki Koike

Shunji Ichikawa

Joji Nakamura

Tomoyuki Kanda

Shigeto Kitamura

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-27

Filing date

1994-07-20

Publication date

2001-11-15

1994-07-20 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE208199T1 publication Critical patent/ATE208199T1/de

Links

208000018737 Parkinson disease Diseases 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
125000000623 heterocyclic group Chemical group 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000003118 aryl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910020008 S(O) Inorganic materials 0.000 abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000003710 aryl alkyl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
229910052760 oxygen Inorganic materials 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000002619 bicyclic group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
-1 polycyclic compound Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

AT94921793T 1993-07-27 1994-07-20 Arzneimittel gegen parkinsonsche krankheit ATE208199T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18429593		1993-07-27
PCT/JP1994/001196 WO1995003806A1 (en)	1993-07-27	1994-07-20	Remedy for parkinson's disease

Publications (1)

Publication Number	Publication Date
ATE208199T1 true ATE208199T1 (de)	2001-11-15

Family

ID=16150835

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94921793T ATE208199T1 (de)	1993-07-27	1994-07-20	Arzneimittel gegen parkinsonsche krankheit

Country Status (8)

Country	Link
US (1)	US5565460A (de)
EP (1)	EP0666079B1 (de)
AT (1)	ATE208199T1 (de)
AU (1)	AU7237294A (de)
CA (1)	CA2144330A1 (de)
DE (1)	DE69428977T2 (de)
ES (1)	ES2165393T3 (de)
WO (1)	WO1995003806A1 (de)

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CA2284737C (en) *	1997-03-24	2007-03-13	Kyowa Hakko Kogyo Co., Ltd.	[1,2,4]triazolo[1,5-c]pyrimidine derivatives
AU2639299A (en) *	1998-02-24	1999-09-15	Kyowa Hakko Kogyo Co. Ltd.	Remedies/preventives for parkinson's disease
US6448253B1 (en) *	1998-09-16	2002-09-10	King Pharmaceuticals Research And Development, Inc.	Adenosine A3 receptor modulators
US6506378B1 (en)	1998-12-16	2003-01-14	Arch Development Corporation	Vesicular monoamine transporter gene therapy in Parkinson's disease
SI1283839T1 (de)	2000-05-26	2005-08-31	Schering Corp
GB0100624D0 (en) *	2001-01-10	2001-02-21	Vernalis Res Ltd	Chemical compounds VII
WO2002079204A1 (en) *	2001-03-28	2002-10-10	Kyowa Hakko Kogyo Co., Ltd.	8-thiazolyl[1,2,4]triazolo[1,5-c]pyrimidine derivative
JP5280597B2 (ja)	2001-03-30	2013-09-04	サンスター技研株式会社	一液加熱硬化型エポキシ樹脂組成物および半導体実装用アンダーフィル材
HRP20030961B1 (en)	2001-05-24	2012-01-31	Eli Lilly And Company	Novel pyrrole derivatives as pharmaceutical agents
US6423844B1 (en) *	2001-06-06	2002-07-23	The United States Of America As Represented By The Secretary Of The Navy	Process for making 1,2,4-triazolo[4,3-a][1,3,5]triazine-3,5,7-triamine
WO2003022283A1 (en) *	2001-09-13	2003-03-20	Schering Corporation	Combination of an adenosine a2a receptor antagonist and an antidepressant or anxiolytic
AR037243A1 (es) *	2001-10-15	2004-11-03	Schering Corp	Antagonistas del receptor de adenosina a2a,a5-amino-imidazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]pirimidina, composiciones farmaceuticas y el uso de dichos compuestos para la preparacion de un medicamento
TW200300686A (en)	2001-11-30	2003-06-16	Schering Corp	Adenosine A2a receptor antagonists
US6916811B2 (en)	2001-11-30	2005-07-12	Schering Corporation	Adenosine A2a receptor antagonists
ES2283625T3 (es) *	2001-11-30	2007-11-01	Schering Corporation	Antagonistas del receptopr a2a de adenosina de (1,2,4)-triazol biciclicos.
ES2686123T3 (es)	2002-01-28	2018-10-16	Kyowa Hakko Kogyo Co., Ltd	Antagonistas del receptor A2A para su uso en el tratamiento de trastornos del movimiento
FR2842809A1 (fr) *	2002-07-26	2004-01-30	Greenpharma Sas	NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION
AU2003272886A1 (en) *	2002-09-24	2004-04-19	Kyowa Hakko Kogyo Co., Ltd.	(1,2,4)-TRIAZOLO(1,5-c)PYRIMIDINE DERIVATIVE
US20060106040A1 (en) *	2002-12-19	2006-05-18	Michael Grzelak	Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders
AU2003304527B2 (en) *	2002-12-19	2010-09-09	Merck Sharp & Dohme Corp.	Uses of adenosine A2a receptor antagonists
DE602004018637D1 (de)	2003-04-09	2009-02-05	Biogen Idec Inc	A2a-adenosinrezeptorantagonisten
WO2004092177A1 (en)	2003-04-09	2004-10-28	Biogen Idec Ma Inc.	Triazolopyrazines and methods of making and using the same
EP1618109A2 (de) *	2003-04-09	2006-01-25	Biogen Idec MA Inc.	Als a2a-adenosinrezeptorantagonisten geeignete triazolo[1,5-c]pyrimidine und pyrazolo[1,5-c]pyrimidine
US7285550B2 (en)	2003-04-09	2007-10-23	Biogen Idec Ma Inc.	Triazolotriazines and pyrazolotriazines and methods of making and using the same
EP1622912B1 (de) *	2003-04-23	2009-05-27	Schering Corporation	2-alkinyl- und 2-alkenyl-pyrazolo-[4,3-e] -1,2,4-triazolo-[1,5-c] -pyrimidinadenosin a2a rezeptorantagonisten
KR20060135901A (ko)	2004-04-21	2006-12-29	쉐링 코포레이션	피라졸로-[4,3-ｅ]-1,2,4-트리아졸로-[1,5-ｃ]피리미딘아데노신 Ａ2ａ 수용체 길항제
CA2622741A1 (en) *	2005-09-19	2007-03-29	Schering Corporation	2-heteroaryl-pyrazolo-[4, 3-e]-1, 2, 4-triazolo-[1,5-c]-pyrimidine as adenosine a2a receptor antagonists
PE20070521A1 (es) *	2005-09-23	2007-07-13	Schering Corp	7-[2-[4-(6-FLUORO-3-METIL-1,2-BENCISOXAZOL-5-IL)-1-PIPERAZINIL]ETIL]-2-(1-PROPINIL)-7H-PIRAZOL-[4,3-E]-[1,2,4]-TRIAZOL-[1,5-C]-PIRIMIDIN-5-AMINA COMO ANTAGONISTA DEL RECEPTOR DE ADENOSINA A2a
ES2273599B1 (es)	2005-10-14	2008-06-01	Universidad De Barcelona	Compuestos para el tratamiento de la fibrilacion auricular.
US7691869B2 (en)	2007-03-30	2010-04-06	King Pharmaceuticals Research And Development, Inc.	Pyrrolotriazolopyrimidine derivatives, pharmaceutical compositions containing them and methods of treating conditions and diseases mediated by the adenosine A2A receptor activity
AU2009222047A1 (en) *	2008-03-04	2009-09-11	Schering Corporation	1,2,4-triazolo[4,3-c]pyrimidin-3-one and pyrazolo [4,3-e] -1,2,4-triazolo [4,3-c] pyrimidin-3-one compounds for use as adenosine A2a receptor antagonists
WO2014101120A1 (en) *	2012-12-28	2014-07-03	Merck Sharp & Dohme Corp.	Heterobicyclo-substituted-7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with a2a antagonist properties
WO2014172372A1 (en)	2013-04-15	2014-10-23	Northwestern University	Treatment for dopaminergic disorders
JP6779204B2 (ja)	2014-11-18	2020-11-04	メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋＳｈａｒｐ＆ＤｏｈｍｅＣｏｒｐ．	Ａ２ａ拮抗薬特性を有するアミノピラジン化合物
US10138212B2 (en)	2015-02-06	2018-11-27	Merck Sharp & Dohme Corp.	Aminoquinazoline compounds as A2A antagonist
EP3307067B1 (de)	2015-06-11	2022-11-02	Merck Sharp & Dohme LLC	Aminopyrazinverbindungen mit a2a-antagonistischen eigenschaften
WO2017008205A1 (en)	2015-07-10	2017-01-19	Merck Sharp & Dohme Corp.	Substituted aminoquinazoline compounds as a2a antagonist
US11498923B2 (en)	2017-12-13	2022-11-15	Merck Sharp & Dohme Llc	Substituted imidazo[1,2-c]quinazolines as A2A antagonists
WO2022029063A1 (en)	2020-08-04	2022-02-10	Bayer Aktiengesellschaft	Pyrido[1,2,4]triazolo[1,5-c]pyrimidin-5-amines

Family Cites Families (8)

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Publication number	Priority date	Publication date	Assignee	Title
EP0181282A1 (de) *	1984-10-01	1986-05-14	Ciba-Geigy Ag	Triazolochinazolinverbindungen
JPS62135475A (ja) *	1985-09-30	1987-06-18	チバ−ガイギ−　アクチエンゲゼルシヤフト	２−置換−ｅ−融合−〔１，２，４〕トリアゾロ−〔１，５−Ｃ〕ピリミジン
DE3677445D1 (de) *	1985-09-30	1991-03-14	Ciba Geigy Ag	2-substituierte-e-kondensierte(1,5-c)-pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
US4831013A (en) *	1986-03-20	1989-05-16	Ciba-Geigy Corporation	2-substituted-e-fused-[1,2,4]triazolo[1,5-c]pyrimidines, pharmaceutical compositions, and uses thereof
EP0263071B1 (de) *	1986-09-30	1992-08-12	Ciba-Geigy Ag	2-Substituierte-e-kondensierte[1,2,4]Triazolo-[1,5-c]pyrimidine, pharmazeutische Zubereitungen und ihre Verwendung
GB2244487B (en) *	1990-05-29	1994-02-02	Ici Plc	Azole derivatives
US5356894A (en) *	1990-05-29	1994-10-18	Rodney Peter W	Morpholinyl substituted [1,2,4]-triazolo[1,5-a]triazine as antagonist
GB9111130D0 (en) *	1991-05-23	1991-07-17	Ici Plc	Azole derivatives

1994
- 1994-07-20 AT AT94921793T patent/ATE208199T1/de not_active IP Right Cessation
- 1994-07-20 DE DE69428977T patent/DE69428977T2/de not_active Expired - Fee Related
- 1994-07-20 US US08/367,346 patent/US5565460A/en not_active Expired - Fee Related
- 1994-07-20 AU AU72372/94A patent/AU7237294A/en not_active Abandoned
- 1994-07-20 CA CA002144330A patent/CA2144330A1/en not_active Abandoned
- 1994-07-20 WO PCT/JP1994/001196 patent/WO1995003806A1/ja not_active Ceased
- 1994-07-20 EP EP94921793A patent/EP0666079B1/de not_active Expired - Lifetime
- 1994-07-20 ES ES94921793T patent/ES2165393T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5565460A (en)	1996-10-15
WO1995003806A1 (en)	1995-02-09
EP0666079A1 (de)	1995-08-09
EP0666079B1 (de)	2001-11-07
AU7237294A (en)	1995-02-28
CA2144330A1 (en)	1995-02-09
EP0666079A4 (de)	1998-02-04
ES2165393T3 (es)	2002-03-16
DE69428977D1 (de)	2001-12-13
DE69428977T2 (de)	2002-07-11

Legal Events

Date	Code	Title	Description
2002-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69428977D1 (de)	2001-12-13	Arzneimittel gegen Parkinsonsche Krankheit
KR960702464A (ko)	1996-04-27	Dc-89 유도체[dc-89 derivative]
AU666702B2 (en)	1996-02-22	Morphinan derivative and medicinal use
DK0976748T3 (da)	2004-03-22	Pyrrolidinderivater med phospholispase A2-hæmmende aktivitet
CA2311742A1 (en)	1999-06-10	6-amino-9-benzyl-8-hydroxypurine derivatives
FI950016A0 (fi)	1995-01-02	Heterosykliset yhdisteet lääkeaineena
ATE142630T1 (de)	1996-09-15	Triazin-derivate und unkrautvertilgungsmittel daraus
GEP20022653B (en)	2002-03-25	Processes and Intermediates for Preparing Anti-Cancer Compounds
AU689304B2 (en)	1998-03-26	Quinazoline derivative
ES2070628T3 (es)	1995-06-01	Uso de compuestos analogos a 1,3-oxatiolano-nucleosidos en la fabricacion de un medicamento para el tratamiento de la hepatitis b.
AU2267495A (en)	1995-11-16	Benzamide derivatives as vasopressin antagonists
NO923721D0 (no)	1992-09-24	4-desoksy-4-epipodophyllotoxin-derivat eller farmasoeytiskakseptabelt salt derav
EP0686636A4 (de)	1997-01-22	Tricyclische benzazepin-und benzothiazepin derivate
IT1228288B (it)	1991-06-07	Composti ad attivita' antiserotoninica
YU46998B (sh)	1994-11-15	Postupak za dobijanje derivata cefema i medjuproizvoda za iste
ATE198890T1 (de)	2001-02-15	Antidepressiva
PT896822E (pt)	2003-07-31	4-aminopirrolo (3,2-d)pirimidinas como antagonistas do receptor de neuropeptideo y
ATE237619T1 (de)	2003-05-15	Sesquiterpen-derivate mit antiviraler aktivität
DE3675524D1 (de)	1990-12-13	Dem antibiotikum tan-749 aehnliche verbindungen und ihre herstellung.
ATE101139T1 (de)	1994-02-15	(alkylthio-3-propyl)-3-benzothiazolinderivate, ihre herstellung und diese enthaltende arzneimittel.
DE60026559D1 (de)	2006-05-04	Arzneimittel gegen essstörungen
GEP20063757B (en)	2006-02-27	Novel Benzothiazine and Benzothiadiazine Derivatives, Method for Preparing Same and Pharmaceutical Compositions Containing Same
IT1204960B (it)	1989-03-10	Composti dotati di attivita' antiallergica