ATE208379T1 - 1-phenylpyrozol-verbindungen und ihre medizinische anwendung - Google Patents

1-phenylpyrozol-verbindungen und ihre medizinische anwendung

Info

Publication number: ATE208379T1
Authority: AT; Austria
Prior art keywords: compounds; phenylpyrozole; medical uses; hyperuricacidemia; isobutoxyphenyl
Prior art date: 1996-10-25

Application number

AT97909603T

Other languages

English (en)

Inventor

Seigo Yoshitomi Phar Ishibuchi

Yoshitomimachi Oaza-Koiwai

Hiroshi Yoshitomi Pha Morimoto

Yoshitomimchi Oaza-Koiwai

Atsushi Yoshitomi Pha Fukunari

Hiroyoshi Yoshitomi Phar Inoue

Yoichi Yoshitomi Phar Ind Naka

Yoshitomimachi Koiwai

Original Assignee

Welfide Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-22

Publication date

2001-11-15

1997-10-22 Application filed by Welfide Corp filed Critical Welfide Corp

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE208379T1 publication Critical patent/ATE208379T1/de

Links

150000001875 compounds Chemical class 0.000 title abstract 2
150000002397 1-phenylpyrazoles Chemical class 0.000 abstract 1
RDOIWPYCJROHHU-UHFFFAOYSA-N 5-amino-1-[3-cyano-4-(2-methylpropoxy)phenyl]pyrazole-4-carboxylic acid Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1N1C(N)=C(C(O)=O)C=N1 RDOIWPYCJROHHU-UHFFFAOYSA-N 0.000 abstract 1
201000005569 Gout Diseases 0.000 abstract 1
108010093894 Xanthine oxidase Proteins 0.000 abstract 1
102100033220 Xanthine oxidase Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)

AT97909603T 1996-10-25 1997-10-22 1-phenylpyrozol-verbindungen und ihre medizinische anwendung ATE208379T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP28447996		1996-10-25
JP5578697		1997-03-11
JP26130597		1997-09-26
PCT/JP1997/003840 WO1998018765A1 (fr)	1996-10-25	1997-10-22	Composes de 1-phenylpyrazole et leur application pharmaceutique

Publications (1)

Publication Number	Publication Date
ATE208379T1 true ATE208379T1 (de)	2001-11-15

Family

ID=27295710

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97909603T ATE208379T1 (de)	1996-10-25	1997-10-22	1-phenylpyrozol-verbindungen und ihre medizinische anwendung

Country Status (16)

Country	Link
US (1)	US6015829A (de)
EP (1)	EP0936217B1 (de)
JP (1)	JP3220987B2 (de)
KR (1)	KR100345942B1 (de)
CN (1)	CN1105708C (de)
AT (1)	ATE208379T1 (de)
AU (1)	AU731055B2 (de)
CA (1)	CA2269721C (de)
DE (1)	DE69708142T2 (de)
DK (1)	DK0936217T3 (de)
ES (1)	ES2167720T3 (de)
ID (1)	ID21775A (de)
IL (1)	IL129409A (de)
PL (1)	PL332946A1 (de)
PT (1)	PT936217E (de)
WO (1)	WO1998018765A1 (de)

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JP4894517B2 (ja) *	2004-08-27	2012-03-14	アステラス製薬株式会社	２−フェニルピリジン誘導体
EP1783124A4 (de)	2004-08-27	2009-07-08	Astellas Pharma Inc	2-phenylthiophenderivat
CA2607953A1 (en) *	2005-05-09	2006-11-16	Tap Pharmaceutical Products, Inc.	Methods for treating nephrolithiasis
EP1940397A4 (de) *	2005-08-03	2010-01-20	Takeda Pharmaceuticals North A	Verfahren zur behandlung von hypertonie
JP5222561B2 (ja) *	2005-10-07	2013-06-26	キッセイ薬品工業株式会社	含窒素芳香族複素環化合物およびそれを含有する医薬組成物
CN101282934A (zh)	2005-10-07	2008-10-08	安斯泰来制药株式会社	三芳基羧酸衍生物
ATE555810T1 (de) *	2006-02-24	2012-05-15	Astellas Pharma Inc	Mittel zur behandlung oder prävention von verdauungsgeschwüren
JP5110536B2 (ja) *	2006-07-19	2012-12-26	学校法人日本医科大学	筋萎縮性側索硬化症治療薬
US20090124623A1 (en) *	2006-11-13	2009-05-14	Christopher Lademacher	Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
EP2101761A4 (de) *	2006-11-13	2010-01-27	Takeda Pharmaceuticals North A	Verfahren zur konservierung der nierenfunktion mit xanthin-oxidoreductase-hemmern
CN101646440A (zh) *	2007-01-19	2010-02-10	武田制药北美公司	使用黄嘌呤氧化还原酶抑制剂和抗炎剂预防痛风突发或减少痛风突发次数的方法
MX2009010491A (es) *	2007-04-11	2009-11-09	Kissei Pharmaceutical	Derivado heterociclico de 5 miembros y su uso para propositos medicos.
JP5330990B2 (ja) *	2007-04-11	2013-10-30	キッセイ薬品工業株式会社	含窒素複素環化合物およびそれを含有する医薬組成物
JP5330989B2 (ja) *	2007-04-11	2013-10-30	キッセイ薬品工業株式会社	（アザ）インドール誘導体及びその医薬用途
CN101386605B (zh) *	2008-10-23	2010-09-08	中国科学院上海药物研究所	非布司他新型晶体及其制备方法
US20100311756A1 (en) *	2009-01-22	2010-12-09	Takeda Pharmaceuticals North America, Inc.	Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
SG173884A1 (en)	2009-02-27	2011-10-28	Teijin Pharma Ltd	Process for producing phenyl-substituted heterocyclic derivative through coupling using transition metal catalyst
CN101580495A (zh) *	2009-05-25	2009-11-18	沈阳药科大学	5-取代苯基-3-异噁唑甲酸及其酯类化合物、组合物及其制备方法
TWI423962B (zh)	2009-10-07	2014-01-21	Lg Life Sciences Ltd	有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
WO2011103439A1 (en) *	2010-02-19	2011-08-25	Takeda Pharmaceuticals North America, Inc.	Methods for stabilizing joint damage in subjects using xanthine oxidoreductase inhibitors
SG187843A1 (en)	2010-08-27	2013-03-28	Teijin Pharma Ltd	Method for producing phenyl-substituted heterocyclic derivative by means of coupling method using a palladium compound
AU2011299153B2 (en)	2010-09-10	2014-10-30	Takeda Pharmaceuticals U.S.A., Inc.	Methods for concomitant treatment of theophylline and febuxostat
CN102766099B (zh) *	2012-08-07	2015-09-23	沈阳药科大学	具有黄嘌呤氧化酶抑制活性的化合物及其盐、制备方法和用途
CN103848798B (zh)	2012-11-30	2016-01-06	镇江新元素医药科技有限公司	2-芳基硒唑化合物及其药物组合物
CN105189476B (zh)	2013-03-29	2017-07-07	帝人制药株式会社	吡唑衍生物
CN105294584A (zh) *	2015-11-30	2016-02-03	中国医科大学	1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN106279024B (zh) *	2016-07-19	2018-09-14	华南理工大学	一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106632245B (zh) *	2016-09-30	2019-11-15	华南理工大学	氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用
CN108218777A (zh) *	2017-12-13	2018-06-29	华南理工大学	一种硫取代苯基吡唑类xor抑制剂及制备与应用
CN110078668B (zh) *	2019-05-16	2023-03-24	华南理工大学	一种苯基咪唑类xor抑制剂及制备与应用
CN119431324B (zh) *	2024-10-23	2025-10-31	沈阳药科大学	1-(4/5-氰基-6-取代嘧啶-2-基)-1h-吡唑-4-甲酸类化合物及其制备方法与应用

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DE3420985A1 (de) *	1983-10-15	1985-04-25	Bayer Ag, 5090 Leverkusen	Substituierte 5-acylamino-1-phenylpyrazole
IL73418A (en) *	1983-11-07	1988-02-29	Lilly Co Eli	5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
IL73419A (en) *	1983-11-07	1988-02-29	Lilly Co Eli	1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3423582A1 (de) *	1984-06-27	1986-01-09	Bayer Ag, 5090 Leverkusen	Substituierte 5-acylamino-1-phenylpyrazole
US4666504A (en) *	1984-09-25	1987-05-19	Eli Lilly And Company	Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
ES2092580T3 (es) *	1990-11-30	1996-12-01	Teijin Ltd	Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo.
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JP3113110B2 (ja) *	1993-01-19	2000-11-27	帝人株式会社	イソキサゾールおよびイソチアゾール誘導体

1996
- 1996-10-25 ID IDW990226A patent/ID21775A/id unknown
1997
- 1997-10-22 WO PCT/JP1997/003840 patent/WO1998018765A1/ja not_active Ceased
- 1997-10-22 PT PT97909603T patent/PT936217E/pt unknown
- 1997-10-22 PL PL97332946A patent/PL332946A1/xx unknown
- 1997-10-22 ES ES97909603T patent/ES2167720T3/es not_active Expired - Lifetime
- 1997-10-22 AU AU47230/97A patent/AU731055B2/en not_active Ceased
- 1997-10-22 KR KR1019997003538A patent/KR100345942B1/ko not_active Expired - Fee Related
- 1997-10-22 DE DE69708142T patent/DE69708142T2/de not_active Expired - Lifetime
- 1997-10-22 EP EP97909603A patent/EP0936217B1/de not_active Expired - Lifetime
- 1997-10-22 JP JP51740198A patent/JP3220987B2/ja not_active Expired - Fee Related
- 1997-10-22 CN CN97180548A patent/CN1105708C/zh not_active Expired - Fee Related
- 1997-10-22 US US09/155,155 patent/US6015829A/en not_active Expired - Lifetime
- 1997-10-22 CA CA002269721A patent/CA2269721C/en not_active Expired - Fee Related
- 1997-10-22 AT AT97909603T patent/ATE208379T1/de not_active IP Right Cessation
- 1997-10-22 IL IL12940997A patent/IL129409A/en not_active IP Right Cessation
- 1997-10-22 DK DK97909603T patent/DK0936217T3/da active

Also Published As

Publication number	Publication date
IL129409A0 (en)	2000-02-17
AU731055B2 (en)	2001-03-22
US6015829A (en)	2000-01-18
DE69708142T2 (de)	2002-07-11
HK1021982A1 (en)	2000-07-21
KR20000052738A (ko)	2000-08-25
JP3220987B2 (ja)	2001-10-22
DE69708142D1 (de)	2001-12-13
KR100345942B1 (ko)	2002-07-27
PL332946A1 (en)	1999-10-25
EP0936217A1 (de)	1999-08-18
CN1105708C (zh)	2003-04-16
AU4723097A (en)	1998-05-22
PT936217E (pt)	2002-05-31
IL129409A (en)	2002-02-10
DK0936217T3 (da)	2002-03-04
ID21775A (id)	1999-07-22
EP0936217B1 (de)	2001-11-07
WO1998018765A1 (fr)	1998-05-07
EP0936217A4 (de)	2000-01-05
CA2269721C (en)	2003-04-29
ES2167720T3 (es)	2002-05-16
CA2269721A1 (en)	1998-05-07
CN1240432A (zh)	2000-01-05

Legal Events

Date	Code	Title	Description
2004-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE208379T1 (de)	2001-11-15	1-phenylpyrozol-verbindungen und ihre medizinische anwendung
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
FI935529A0 (fi)	1993-12-09	Aminometylensubstituerade icke-aromatiska heterocykliska foereningar
NO941052L (no)	1994-09-26	Benzimidazolforbindelser, deres anvendelse og fremstilling
ATE225770T1 (de)	2002-10-15	Difluoroprostaglandin-derivate und ihre anwendung
CA2266107A1 (en)	1998-04-09	Aralkyl and aralkylidene heterocyclic lactams and imides
NO960393L (no)	1996-07-09	Heterosykliske fenylforbindelser som COX-2-inhibitorer
ATE179706T1 (de)	1999-05-15	N-heteroaryl-n'-phenylharnstoffderivate, ihre herstellung und verwendung
PT718293E (pt)	2002-08-30	Composto ciclodepsipeptidico
DK0863136T3 (da)	2004-02-02	Azetidin- og pyrrolidinderivater
DE50011034D1 (de)	2005-09-29	N-substituierte 4-aminopteridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GR3032220T3 (en)	2000-04-27	Use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives for the treatment of diseases which are mediated by non-enzymatical glycosylation
ATE316962T1 (de)	2006-02-15	Pyrimidin-derivate als selective inhibitoren von cox-2
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
ATE92489T1 (de)	1993-08-15	Imid-derivate, ihre herstellung und verwendung.
EP0919233B8 (de)	2003-08-13	Therapeutisches mittel zur behandlung von nierenerkrankungen
NO903585L (no)	1991-02-18	Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksaziner.
DK0437645T3 (da)	1995-05-01	Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse