DK0936217T3 - 1-Phenylpyrazol-forbindelser og medicinsk anvendelse heraf - Google Patents

1-Phenylpyrazol-forbindelser og medicinsk anvendelse heraf

Info

Publication number: DK0936217T3
Authority: DK; Denmark
Prior art keywords: medical use; compounds; phenylpyrazole compounds; phenylpyrazole; hyperuricacidemia
Prior art date: 1996-10-25

Application number

DK97909603T

Other languages

English (en)

Inventor

Seigo Ishibuchi

Hiroshi Morimoto

Atsushi Fukunari

Hiroyoshi Inoue

Yoichi Naka

Original Assignee

Mitsubishi Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-25

Filing date

1997-10-22

Publication date

2002-03-04

1997-10-22 Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp

2002-03-04 Application granted granted Critical

2002-03-04 Publication of DK0936217T3 publication Critical patent/DK0936217T3/da

Links

150000002397 1-phenylpyrazoles Chemical class 0.000 title abstract 2
RDOIWPYCJROHHU-UHFFFAOYSA-N 5-amino-1-[3-cyano-4-(2-methylpropoxy)phenyl]pyrazole-4-carboxylic acid Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1N1C(N)=C(C(O)=O)C=N1 RDOIWPYCJROHHU-UHFFFAOYSA-N 0.000 abstract 1
201000005569 Gout Diseases 0.000 abstract 1
108010093894 Xanthine oxidase Proteins 0.000 abstract 1
102100033220 Xanthine oxidase Human genes 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229940124597 therapeutic agent Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Epoxy Compounds (AREA)

DK97909603T 1996-10-25 1997-10-22 1-Phenylpyrazol-forbindelser og medicinsk anvendelse heraf DK0936217T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP28447996		1996-10-25
JP5578697		1997-03-11
JP26130597		1997-09-26
PCT/JP1997/003840 WO1998018765A1 (fr)	1996-10-25	1997-10-22	Composes de 1-phenylpyrazole et leur application pharmaceutique

Publications (1)

Publication Number	Publication Date
DK0936217T3 true DK0936217T3 (da)	2002-03-04

Family

ID=27295710

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97909603T DK0936217T3 (da)	1996-10-25	1997-10-22	1-Phenylpyrazol-forbindelser og medicinsk anvendelse heraf

Country Status (16)

Country	Link
US (1)	US6015829A (da)
EP (1)	EP0936217B1 (da)
JP (1)	JP3220987B2 (da)
KR (1)	KR100345942B1 (da)
CN (1)	CN1105708C (da)
AT (1)	ATE208379T1 (da)
AU (1)	AU731055B2 (da)
CA (1)	CA2269721C (da)
DE (1)	DE69708142T2 (da)
DK (1)	DK0936217T3 (da)
ES (1)	ES2167720T3 (da)
ID (1)	ID21775A (da)
IL (1)	IL129409A (da)
PL (1)	PL332946A1 (da)
PT (1)	PT936217E (da)
WO (1)	WO1998018765A1 (da)

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JP4532408B2 (ja) *	2003-03-13	2010-08-25	田辺三菱製薬株式会社	腫瘍形成抑制剤
JP4914210B2 (ja) *	2004-06-14	2012-04-11	日本ケミファ株式会社	縮合ピリミジン誘導体、及びキサンチンオキシダーゼ阻害剤
ATE440820T1 (de) *	2004-08-27	2009-09-15	Astellas Pharma Inc	2-phenylpyridinderivat
US7612108B2 (en) *	2004-08-27	2009-11-03	Astellas Pharma Inc.	2-phenylthiophene derivative
EP1883405A4 (en)	2005-05-09	2010-01-27	Takeda Pharmaceuticals North A	METHODS OF TREATING NEPHROLITHIASIS
JP5242393B2 (ja) *	2005-08-03	2013-07-24	タケダファーマシューティカルズユー．エス．エー．インコーポレイティド	高血圧症の治療方法
KR20080066938A (ko)	2005-10-07	2008-07-17	깃세이 야쿠힌 고교 가부시키가이샤	질소 함유 복소환 화합물 및 그것을 함유하는 의약 조성물
CA2621038A1 (en)	2005-10-07	2007-04-19	Astellas Pharma Inc.	Triarylcarboxylic acid derivative
MX2008010646A (es) *	2006-02-24	2008-10-14	Astellas Pharma Inc	Agente para tratar o prevenir ulcera digestiva.
CA2658342A1 (en)	2006-07-19	2008-01-24	Nippon Medical School Foundation	Therapeutic agent for amyotrophic lateral sclerosis
US20090124623A1 (en) *	2006-11-13	2009-05-14	Christopher Lademacher	Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors
KR20150024919A (ko) *	2006-11-13	2015-03-09	다케다 파마슈티칼스 유에스에이, 인코포레이티드	크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법
AU2008206231A1 (en) *	2007-01-19	2008-07-24	Takeda Pharmaceuticals U.S.A., Inc.	Methods for preventing or reducing the number of gout flares using xanthine oxidoreductase inhibitors and anti-inflammatory agents
MX2009010491A (es) *	2007-04-11	2009-11-09	Kissei Pharmaceutical	Derivado heterociclico de 5 miembros y su uso para propositos medicos.
US8003647B2 (en) *	2007-04-11	2011-08-23	Kissei Pharmaceutical Co., Ltd.	(Aza)indole derivative and use thereof for medical purposes
JP5330990B2 (ja) *	2007-04-11	2013-10-30	キッセイ薬品工業株式会社	含窒素複素環化合物およびそれを含有する医薬組成物
CN101386605B (zh) *	2008-10-23	2010-09-08	中国科学院上海药物研究所	非布司他新型晶体及其制备方法
US20100311756A1 (en) *	2009-01-22	2010-12-09	Takeda Pharmaceuticals North America, Inc.	Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof
WO2010098428A1 (ja)	2009-02-27	2010-09-02	帝人ファーマ株式会社	遷移金属触媒を用いたカップリング法によるフェニル置換複素環誘導体の製造法
CN101580495A (zh) *	2009-05-25	2009-11-18	沈阳药科大学	5-取代苯基-3-异噁唑甲酸及其酯类化合物、组合物及其制备方法
TWI423962B (zh)	2009-10-07	2014-01-21	Lg Life Sciences Ltd	有效作為黃嘌呤氧化酶抑制劑之新穎化合物、其製備方法及含該化合物之醫藥組成物
CA2788437A1 (en) *	2010-02-19	2011-08-25	Takeda Pharmaceuticals U.S.A., Inc.	Methods for stabilizing joint damage in subjects using xanthine oxidoreductase inhibitors
CN103068807B (zh)	2010-08-27	2016-05-25	帝人制药株式会社	通过使用钯化合物的偶合法的苯基取代杂环衍生物的制备方法
CA2812034C (en)	2010-09-10	2018-10-23	Takeda Pharmaceuticals U.S.A., Inc.	Methods for concomitant treatment of theophylline and febuxostat
CN102766099B (zh) *	2012-08-07	2015-09-23	沈阳药科大学	具有黄嘌呤氧化酶抑制活性的化合物及其盐、制备方法和用途
CN103848798B (zh)	2012-11-30	2016-01-06	镇江新元素医药科技有限公司	2-芳基硒唑化合物及其药物组合物
HRP20180644T1 (hr)	2013-03-29	2018-06-01	Teijin Pharma Limited	Derivat pirazola
CN105294584A (zh) *	2015-11-30	2016-02-03	中国医科大学	1-取代苯基-1h-1,2,3-三唑类化合物、制备方法及其用途
CN106279024B (zh) *	2016-07-19	2018-09-14	华南理工大学	一种黄嘌呤氧化还原酶抑制剂及其制备方法与应用
CN106632245B (zh) *	2016-09-30	2019-11-15	华南理工大学	氮取代基苯基吡唑类黄嘌呤氧化还原酶抑制剂及制备与应用
CN108218777A (zh) *	2017-12-13	2018-06-29	华南理工大学	一种硫取代苯基吡唑类xor抑制剂及制备与应用
CN110078668B (zh) *	2019-05-16	2023-03-24	华南理工大学	一种苯基咪唑类xor抑制剂及制备与应用
CN119431324B (zh) *	2024-10-23	2025-10-31	沈阳药科大学	1-(4/5-氰基-6-取代嘧啶-2-基)-1h-吡唑-4-甲酸类化合物及其制备方法与应用

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US4495195A (en) *	1982-11-01	1985-01-22	Eli Lilly And Company	Xanthine oxidase inhibiting 3(5)-phenyl-substituted-5(3)-pyrazole-carboxylic acid derivatives, compositions, and methods of use
DE3420985A1 (de) *	1983-10-15	1985-04-25	Bayer Ag, 5090 Leverkusen	Substituierte 5-acylamino-1-phenylpyrazole
JPS6097948A (ja) *	1983-10-15	1985-05-31	バイエル・アクチエンゲゼルシヤフト	置換５‐アシルアミノ‐１‐フエニルピラゾール類
IL73418A (en) *	1983-11-07	1988-02-29	Lilly Co Eli	5-cyano-1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
IL73419A (en) *	1983-11-07	1988-02-29	Lilly Co Eli	1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them
DE3423582A1 (de) *	1984-06-27	1986-01-09	Bayer Ag, 5090 Leverkusen	Substituierte 5-acylamino-1-phenylpyrazole
US4666504A (en) *	1984-09-25	1987-05-19	Eli Lilly And Company	Pollen formation inhibiting 1-phenyl-4-carboxy-5-pyrazolecarboxamides
US5064851A (en) *	1990-07-24	1991-11-12	Pfizer Inc.	3-(1-substituted-pyrazoyl)-2-oxindole derivatives, compositions and use
DK0513379T3 (da) *	1990-11-30	1996-09-30	Teijin Ltd	2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne
IL104311A (en) *	1992-02-05	1997-07-13	Fujisawa Pharmaceutical Co	Pyrazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
US5436258A (en) *	1992-09-09	1995-07-25	Eli Lilly And Company	Prevention of bone resorption
JP3113110B2 (ja) *	1993-01-19	2000-11-27	帝人株式会社	イソキサゾールおよびイソチアゾール誘導体

1996
- 1996-10-25 ID IDW990226A patent/ID21775A/id unknown
1997
- 1997-10-22 AU AU47230/97A patent/AU731055B2/en not_active Ceased
- 1997-10-22 DK DK97909603T patent/DK0936217T3/da active
- 1997-10-22 US US09/155,155 patent/US6015829A/en not_active Expired - Lifetime
- 1997-10-22 JP JP51740198A patent/JP3220987B2/ja not_active Expired - Fee Related
- 1997-10-22 EP EP97909603A patent/EP0936217B1/en not_active Expired - Lifetime
- 1997-10-22 PL PL97332946A patent/PL332946A1/xx unknown
- 1997-10-22 DE DE69708142T patent/DE69708142T2/de not_active Expired - Lifetime
- 1997-10-22 KR KR1019997003538A patent/KR100345942B1/ko not_active Expired - Fee Related
- 1997-10-22 PT PT97909603T patent/PT936217E/pt unknown
- 1997-10-22 WO PCT/JP1997/003840 patent/WO1998018765A1/ja not_active Ceased
- 1997-10-22 AT AT97909603T patent/ATE208379T1/de not_active IP Right Cessation
- 1997-10-22 CN CN97180548A patent/CN1105708C/zh not_active Expired - Fee Related
- 1997-10-22 CA CA002269721A patent/CA2269721C/en not_active Expired - Fee Related
- 1997-10-22 ES ES97909603T patent/ES2167720T3/es not_active Expired - Lifetime
- 1997-10-22 IL IL12940997A patent/IL129409A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2269721A1 (en)	1998-05-07
AU731055B2 (en)	2001-03-22
ES2167720T3 (es)	2002-05-16
JP3220987B2 (ja)	2001-10-22
EP0936217A1 (en)	1999-08-18
DE69708142D1 (de)	2001-12-13
KR20000052738A (ko)	2000-08-25
ID21775A (id)	1999-07-22
PT936217E (pt)	2002-05-31
CN1240432A (zh)	2000-01-05
PL332946A1 (en)	1999-10-25
EP0936217B1 (en)	2001-11-07
IL129409A0 (en)	2000-02-17
HK1021982A1 (en)	2000-07-21
ATE208379T1 (de)	2001-11-15
US6015829A (en)	2000-01-18
WO1998018765A1 (fr)	1998-05-07
IL129409A (en)	2002-02-10
DE69708142T2 (de)	2002-07-11
KR100345942B1 (ko)	2002-07-27
CN1105708C (zh)	2003-04-16
AU4723097A (en)	1998-05-22
CA2269721C (en)	2003-04-29
EP0936217A4 (en)	2000-01-05

Publication	Publication Date	Title
DK0936217T3 (da)	2002-03-04	1-Phenylpyrazol-forbindelser og medicinsk anvendelse heraf
NO882036L (no)	1988-11-14	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske ketoner.
NO953305D0 (no)	1995-08-23	Antranilsyrederivat
NO941052D0 (no)	1994-03-23	Benzimidazolforbindelser, deres anvendelse og fremstilling
DK0850926T3 (da)	2003-02-17	Difluorprostaglandinderivater og deres anvendelse
FI943948A0 (fi)	1994-08-26	Heterosykliset hiilihappojohdannaiset
PT718293E (pt)	2002-08-30	Composto ciclodepsipeptidico
NO922147D0 (no)	1992-05-29	Heterocykliske derivater
DK0841929T3 (da)	2003-09-01	Quinoloner og deres terapeutiske anvendelse
GR3032220T3 (en)	2000-04-27	Use of 2-(N-(2-aminoethyl)amino)acetic acid derivatives for the treatment of diseases which are mediated by non-enzymatical glycosylation
DE60025848D1 (en)	2006-04-13	Pyrimidin-derivate als selective inhibitoren von cox-2
NO941977D0 (no)	1994-05-27	Indolderivater, fremgangsmåte for fremstilling av disse, og medisinsk anvendelse derav
ATE79257T1 (de)	1992-08-15	Verwendung von tetrahydrobenz(c,d>indol-6carboxamiden zur herstellung von arzneimitteln zur behandlung von angstzustaenden.
DE69834500D1 (de)	2006-06-14	Xanthinderivative zur behandlung von hirnischämie
ATE92489T1 (de)	1993-08-15	Imid-derivate, ihre herstellung und verwendung.
DK0682947T3 (da)	1998-05-04	Medikament til terapeutisk og profylaktisk behandling af sygdomme forårsaget af glatmuskelcelle-hyperplasi
DK0411408T3 (da)	1993-12-20	Monoklint metazachlor og fremgangsmåde til fremstilling heraf
DK413188D0 (da)	1988-07-22	Benzimidazol-derivater til terapeutisk anvendelse og fremgangsmaade til fremstilling deraf
DK0437645T3 (da)	1995-05-01	Imidazolylpropylguanidinderivat, fremgangsmåde til fremstilling deraf og lægemidler indeholdende denne forbindelse
ATE95697T1 (de)	1993-10-15	Uricosuretische zusammensetzung.
NO20015733D0 (no)	2001-11-23	MAG-ekspresjonspromotorer