ATE208760T1 - 3-amino-2-mercaptobenzoesäure-derivate und verfahren zu ihrer herstellung - Google Patents
3-amino-2-mercaptobenzoesäure-derivate und verfahren zu ihrer herstellungInfo
- Publication number
- ATE208760T1 ATE208760T1 AT96810865T AT96810865T ATE208760T1 AT E208760 T1 ATE208760 T1 AT E208760T1 AT 96810865 T AT96810865 T AT 96810865T AT 96810865 T AT96810865 T AT 96810865T AT E208760 T1 ATE208760 T1 AT E208760T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- unsubstituted
- compounds
- carbon atoms
- formula
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- OBQCWOHPSPQUDZ-UHFFFAOYSA-N 3-amino-2-sulfanylbenzoic acid Chemical class NC1=CC=CC(C(O)=O)=C1S OBQCWOHPSPQUDZ-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 229930195734 saturated hydrocarbon Natural products 0.000 abstract 2
- 229930195735 unsaturated hydrocarbon Natural products 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- GRHZLQBPAJAHDM-SPRQWYLLSA-N [(3as,4r,6ar)-2,3,3a,4,5,6a-hexahydrofuro[2,3-b]furan-4-yl] n-[(2s,4s,5s)-5-[[2-(2,6-dimethylphenoxy)acetyl]amino]-4-hydroxy-1,6-diphenylhexan-2-yl]carbamate Chemical compound CC1=CC=CC(C)=C1OCC(=O)N[C@H]([C@@H](O)C[C@H](CC=1C=CC=CC=1)NC(=O)O[C@@H]1[C@@H]2CCO[C@@H]2OC1)CC1=CC=CC=C1 GRHZLQBPAJAHDM-SPRQWYLLSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- DZRJLJPPUJADOO-UHFFFAOYSA-N chaetomin Natural products CN1C(=O)C2(Cc3cn(C)c4ccccc34)SSC1(CO)C(=O)N2C56CC78SSC(CO)(N(C)C7=O)C(=O)N8C5Nc9ccccc69 DZRJLJPPUJADOO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 150000002019 disulfides Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 230000003641 microbiacidal effect Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/14—Thiadiazoles; Hydrogenated thiadiazoles condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
- C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/63—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Cephalosporin Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH363795 | 1995-12-21 | ||
| US08/770,353 US5770758A (en) | 1995-12-21 | 1996-12-20 | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208760T1 true ATE208760T1 (de) | 2001-11-15 |
Family
ID=25693502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96810865T ATE208760T1 (de) | 1995-12-21 | 1996-12-12 | 3-amino-2-mercaptobenzoesäure-derivate und verfahren zu ihrer herstellung |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5770758A (de) |
| EP (1) | EP0780372B3 (de) |
| JP (1) | JP4217924B2 (de) |
| KR (1) | KR100470887B1 (de) |
| CN (2) | CN1163491C (de) |
| AT (1) | ATE208760T1 (de) |
| AU (1) | AU713526B2 (de) |
| BR (1) | BR9606092A (de) |
| CA (1) | CA2193460C (de) |
| CZ (1) | CZ291857B6 (de) |
| DE (1) | DE69616956T3 (de) |
| DK (1) | DK0780372T3 (de) |
| ES (1) | ES2168121T7 (de) |
| HU (1) | HU221600B (de) |
| IL (3) | IL119819A (de) |
| MX (2) | MX9606665A (de) |
| PL (1) | PL187885B1 (de) |
| PT (1) | PT780372E (de) |
| RU (1) | RU2176241C2 (de) |
| SK (1) | SK283840B6 (de) |
| ZA (1) | ZA9610774B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002013A (en) * | 1995-12-21 | 1999-12-14 | Novartis Corporation | 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation |
| GB9724586D0 (en) * | 1997-11-20 | 1998-01-21 | Rhone Poulenc Agriculture | New herbicides |
| PL210065B1 (pl) | 2002-09-25 | 2011-11-30 | Memory Pharm Corp | Związki indazole, benzotiazole i benzoizotiazole, kompozycje farmaceutyczne je zawierające oraz zastosowanie związków |
| DE10313887A1 (de) * | 2003-03-27 | 2004-10-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zum selektiven Gewinnen von Gold aus goldhaltigen Materialien |
| ES2528669T3 (es) | 2003-04-08 | 2015-02-11 | Progenics Pharmaceuticals, Inc. | Formulaciones farmacéuticas que contienen metilnaltrexona |
| NZ544674A (en) * | 2003-07-10 | 2009-03-31 | Achillion Pharmaceuticals Inc | Substituted arylthiourea derivatives useful as inhibitors of viral replication |
| CA2560741C (en) | 2004-03-25 | 2013-08-06 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof |
| AR057035A1 (es) | 2005-05-25 | 2007-11-14 | Progenics Pharm Inc | SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS |
| AR057325A1 (es) | 2005-05-25 | 2007-11-28 | Progenics Pharm Inc | Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos |
| CN101395161A (zh) * | 2006-03-02 | 2009-03-25 | 马林克罗特公司 | 噻二唑化合物及其在光疗中的用途 |
| TWI489984B (zh) | 2006-08-04 | 2015-07-01 | Wyeth Corp | 用於非經腸道傳輸化合物之配方及其用途 |
| BRPI0809579B8 (pt) | 2007-03-29 | 2021-05-25 | Progenics Pharm Inc | formas cristalinas e seus usos |
| PL2139890T3 (pl) | 2007-03-29 | 2014-11-28 | Wyeth Llc | Antagoniści obwodowych receptorów opioidowych i ich zastosowania |
| PE20090700A1 (es) | 2007-03-29 | 2009-07-13 | Progenics Pharm Inc | Compuestos heterociclicos como antagonistas del receptor opioide periferico |
| WO2009099411A1 (en) | 2008-02-06 | 2009-08-13 | Progenics Pharmaceuticals, Inc. | Preparation and use of (r),(r)-2,2'-bis-methylnaltrexone |
| CA2676881C (en) | 2008-09-30 | 2017-04-25 | Wyeth | Peripheral opioid receptor antagonists and uses thereof |
| CN101492429B (zh) * | 2008-12-10 | 2010-12-15 | 上海泰禾(集团)有限公司 | 一种苯并-[1，2，3]-噻二唑-7-甲酸三氟乙酯的提纯方法 |
| CN117024373B (zh) * | 2023-08-23 | 2025-07-25 | 首建科技有限公司 | 一种2-氨基-4-甲基苯并噻唑的制备工艺 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4150140A (en) * | 1976-12-23 | 1979-04-17 | The Upjohn Company | Benzothiazolyl oxanic acids, esters and salts |
| DE2757924A1 (de) * | 1977-12-24 | 1979-07-05 | Hoechst Ag | Verfahren zur herstellung von vinylchlorid-polymerisaten |
| DE3601286A1 (de) * | 1986-01-17 | 1987-07-23 | Consiglio Nazionale Ricerche | Sammelmittel fuer die selektive flotation von blei- und zinkerzen und verfahren zu deren herstellung |
| DE19775050I2 (de) * | 1987-08-21 | 2010-12-16 | Syngenta Participations Ag | Benzothiadiazole und ihre Verwendung in Verfahren und Mitteln gegen Pflanzenkrankheiten. |
| DK0384889T3 (da) * | 1989-02-21 | 1993-11-15 | Ciba Geigy Ag | Middel til beskyttelse af planter mod sygdomme |
| EP0529600B1 (de) | 1991-08-30 | 1996-11-06 | Hoechst Aktiengesellschaft | Verfahren zur Herstellung von 2-Aminobenzthiazolen |
| JPH0690518A (ja) * | 1992-09-09 | 1994-03-29 | Toshiba Corp | 地絡継電器 |
| JP3310104B2 (ja) * | 1994-04-04 | 2002-07-29 | 三新化学工業株式会社 | ２−アミノチオフェノール類の製造方法 |
| JP4332816B2 (ja) * | 1994-10-17 | 2009-09-16 | シンジェンタ パーティシペーションズ アクチエンゲゼルシャフト | 置換３−アミノベンゾニトリルの製造方法 |
-
1996
- 1996-12-12 IL IL11981996A patent/IL119819A/en not_active IP Right Cessation
- 1996-12-12 AT AT96810865T patent/ATE208760T1/de active
- 1996-12-12 PT PT96810865T patent/PT780372E/pt unknown
- 1996-12-12 EP EP96810865.4A patent/EP0780372B3/de not_active Expired - Lifetime
- 1996-12-12 DK DK96810865T patent/DK0780372T3/da active
- 1996-12-12 ES ES96810865T patent/ES2168121T7/es active Active
- 1996-12-12 IL IL13390096A patent/IL133900A/en not_active IP Right Cessation
- 1996-12-12 DE DE69616956.8T patent/DE69616956T3/de not_active Expired - Lifetime
- 1996-12-19 MX MX9606665A patent/MX9606665A/es unknown
- 1996-12-19 SK SK1636-96A patent/SK283840B6/sk not_active IP Right Cessation
- 1996-12-19 CZ CZ19963773A patent/CZ291857B6/cs not_active IP Right Cessation
- 1996-12-19 HU HU9603527A patent/HU221600B/hu not_active IP Right Cessation
- 1996-12-19 CA CA002193460A patent/CA2193460C/en not_active Expired - Fee Related
- 1996-12-19 MX MXPA02000515A patent/MXPA02000515A/es active IP Right Grant
- 1996-12-19 PL PL96317601A patent/PL187885B1/pl unknown
- 1996-12-19 BR BR9606092A patent/BR9606092A/pt active IP Right Grant
- 1996-12-20 US US08/770,353 patent/US5770758A/en not_active Expired - Lifetime
- 1996-12-20 CN CNB001316702A patent/CN1163491C/zh not_active Expired - Lifetime
- 1996-12-20 JP JP35519496A patent/JP4217924B2/ja not_active Expired - Lifetime
- 1996-12-20 RU RU96124374/04A patent/RU2176241C2/ru not_active IP Right Cessation
- 1996-12-20 AU AU76404/96A patent/AU713526B2/en not_active Ceased
- 1996-12-20 CN CN96117901A patent/CN1078888C/zh not_active Expired - Lifetime
- 1996-12-20 ZA ZA9610774A patent/ZA9610774B/xx unknown
-
2000
- 2000-01-06 IL IL13390000A patent/IL133900A0/xx active IP Right Grant
-
2004
- 2004-06-30 KR KR1020040050522A patent/KR100470887B1/ko not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |