ATE115952T1 - Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel. - Google Patents
Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel.Info
- Publication number
- ATE115952T1 ATE115952T1 AT89311135T AT89311135T ATE115952T1 AT E115952 T1 ATE115952 T1 AT E115952T1 AT 89311135 T AT89311135 T AT 89311135T AT 89311135 T AT89311135 T AT 89311135T AT E115952 T1 ATE115952 T1 AT E115952T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrimidindone
- derivatives
- production
- agents containing
- containing same
- Prior art date
Links
- 230000003288 anthiarrhythmic effect Effects 0.000 title 1
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical group O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- -1 pyrimidinedione derivative compound Chemical class 0.000 abstract 1
- 150000008512 pyrimidinediones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27199288 | 1988-10-29 | ||
| JP30684188 | 1988-12-06 | ||
| JP30684088 | 1988-12-06 | ||
| JP9641789 | 1989-04-18 | ||
| JP9641689 | 1989-04-18 | ||
| JP9641889 | 1989-04-18 | ||
| JP22927289 | 1989-09-06 | ||
| JP01246318 | 1989-09-25 | ||
| JP24631789 | 1989-09-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE115952T1 true ATE115952T1 (de) | 1995-01-15 |
Family
ID=27577291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT89311135T ATE115952T1 (de) | 1988-10-29 | 1989-10-27 | Pyrimidindion-derivate, verfahren zu deren herstellung und diese enthaltende antiarrythmische mittel. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5008267A (de) |
| EP (1) | EP0369627B1 (de) |
| KR (1) | KR920002307B1 (de) |
| AT (1) | ATE115952T1 (de) |
| AU (1) | AU613805B2 (de) |
| DE (1) | DE68920125T2 (de) |
| DK (1) | DK170203B1 (de) |
| ES (1) | ES2066000T3 (de) |
| FI (1) | FI95245C (de) |
| HU (1) | HU210780B (de) |
| NO (1) | NO174711C (de) |
| NZ (1) | NZ231165A (de) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5308848A (en) * | 1989-10-24 | 1994-05-03 | Mitsui Toatsu Chemicals, Incorporated | Pyrimidinedione derivatives and antiarrythmic agents containing the same |
| JPH03173885A (ja) * | 1989-12-01 | 1991-07-29 | Mitsui Toatsu Chem Inc | ピリミジンジオン誘導体化合物、該化合物の製造法および該化合物を含む抗不整脈剤 |
| JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
| DE4032766A1 (de) * | 1990-10-16 | 1992-04-30 | Basf Ag | Phenylpiperidinoylamine und diese enthaltende arzneimittel |
| EP0640341A1 (de) * | 1993-08-27 | 1995-03-01 | Mitsui Toatsu Chemicals, Incorporated | Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren |
| EP0697407B1 (de) | 1994-08-19 | 1997-06-25 | MITSUI TOATSU CHEMICALS, Inc. | Pyrimidin-Dion-Derivate und diese enthaltende antiarrhythmische Zusammensetzungen |
| ATE207063T1 (de) * | 1994-12-07 | 2001-11-15 | Byk Gulden Lomberg Chem Fab | Uracilderivate |
| EP0722732A1 (de) * | 1995-01-24 | 1996-07-24 | Mitsui Toatsu Chemicals, Inc. | Pyrimidindionderivate enthaltendes Arzneimittel mit verlängerter Wirkstoffabgabe |
| DE19600934A1 (de) | 1996-01-12 | 1997-07-17 | Basf Ag | Substituierte Aza- und Diazacycloheptan- und Cyclooctanverbindungen und deren Verwendung |
| IT1293807B1 (it) * | 1997-08-01 | 1999-03-10 | Recordati Chem Pharm | Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico |
| US6399614B1 (en) | 1997-08-01 | 2002-06-04 | Recordati S.A. Chemical And Pharmaceutical Company | 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring |
| US6716838B1 (en) | 1999-05-19 | 2004-04-06 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils as anticoagulative agents |
| US6458952B1 (en) * | 1999-05-19 | 2002-10-01 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6664255B1 (en) * | 1999-05-19 | 2003-12-16 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrazinones useful for selective inhibition of the coagulation cascade |
| US7015230B1 (en) | 1999-05-19 | 2006-03-21 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl uracils useful for selective inhibition of the coagulation cascade |
| US6653316B1 (en) * | 1999-05-19 | 2003-11-25 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6867217B1 (en) | 1999-05-19 | 2005-03-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade |
| US6906068B1 (en) | 1999-05-19 | 2005-06-14 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl 1,2,4 - triazinones useful as anticoagulants |
| US6750342B1 (en) * | 1999-05-19 | 2004-06-15 | Pharmacia Corporation | Substituted polycyclic aryl and heteroaryl pyrimidinones useful for selective inhibition of the coagulation cascade |
| US6660885B2 (en) | 2000-03-13 | 2003-12-09 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade |
| CA2405561A1 (en) * | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade |
| WO2001077079A2 (en) | 2000-04-05 | 2001-10-18 | Pharmacia Corporation | Polycyclic aryl and heteroaryl substituted 4-pyridones useful for selective inhibition of the coagulation cascade |
| JP2004501077A (ja) * | 2000-04-17 | 2004-01-15 | ファルマシア・コーポレーション | 凝固カスケードの選択的阻害に有用な多環式アリールおよびヘテロアリール置換１，４−キノン |
| JP2004517074A (ja) * | 2000-11-20 | 2004-06-10 | ファルマシア・コーポレーション | 凝血カスケードを選択的に阻害するのに有用な置換された多環アリールおよびヘテロアリールピリジン類 |
| PL215049B1 (pl) * | 2001-08-02 | 2013-10-31 | Sumitomo Chemical Co | Zwiazek pirydonowy o wlasciwosciach chwastobójczych |
| US20040068113A1 (en) * | 2001-11-20 | 2004-04-08 | South Michael S. | Substituted polycyclic aryl and heteroaryl pyridines useful for selective inhibition of the coagulation cascade |
| JP4958774B2 (ja) | 2004-07-02 | 2012-06-20 | コーセプト セラピューティクス， インコーポレイテッド | 改変されたピリミジン糖質コルチコイドレセプター調節因子 |
| KR101925955B1 (ko) | 2011-03-18 | 2018-12-06 | 코어셉트 쎄라퓨틱스, 잉크. | 피리미딘 사이클로헥실 글루코코르티코이드 수용체 조절제 |
| CN102617486B (zh) * | 2012-03-01 | 2014-04-16 | 江西吉翔医药化工有限公司 | 一种6-氯-1,3-二甲基脲嘧啶的制备方法 |
| CN103288751B (zh) * | 2013-06-03 | 2016-04-20 | 四川百利药业有限责任公司 | 一种高纯度盐酸尼非卡兰的制备方法 |
| SMT202000071T1 (it) * | 2013-06-21 | 2020-03-13 | Myokardia Inc | Composti di pirimidinadione contro le condizioni cardiache |
| ES2987563T3 (es) | 2018-06-04 | 2024-11-15 | Corcept Therapeutics Inc | Moduladores del receptor de glucocorticoides ciclohexenilo pirimidina |
| CN111116492B (zh) * | 2019-01-25 | 2021-07-09 | 青岛吉澳医药科技有限公司 | 氘代苯甲氨嘧啶二酮衍生物及其用途 |
| US11903945B2 (en) | 2019-12-11 | 2024-02-20 | Corcept Therapeutics Incorporated | Methods of treating antipsychotic-induced weight gain with miricorilant |
| WO2021226258A1 (en) | 2020-05-06 | 2021-11-11 | Corcept Therapeutics Incorporated | Formulations of pyrimidine cyclohexyl glucocorticoid receptor modulators |
| MX2022013804A (es) | 2020-05-06 | 2022-11-30 | Corcept Therapeutics Inc | Polimorfos de moduladores de los receptores de pirimidin-ciclohexil-glucocorticoides. |
| IL303881A (en) | 2020-12-21 | 2023-08-01 | Corcept Therapeutics Inc | Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators |
| US12616698B2 (en) | 2021-05-05 | 2026-05-05 | Corcept Therapeutics Incorporated | Methods for reducing liver fat and for treating fatty liver disorders |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE787103A (fr) * | 1971-08-04 | 1973-02-02 | Pfizer | Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant |
| DE2329399A1 (de) * | 1973-06-08 | 1975-01-02 | Wuelfing J A Fa | 4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| LU77339A1 (de) * | 1977-05-16 | 1979-01-19 |
-
1989
- 1989-10-24 US US07/425,730 patent/US5008267A/en not_active Expired - Lifetime
- 1989-10-26 NZ NZ231165A patent/NZ231165A/en unknown
- 1989-10-27 ES ES89311135T patent/ES2066000T3/es not_active Expired - Lifetime
- 1989-10-27 DK DK535789A patent/DK170203B1/da not_active IP Right Cessation
- 1989-10-27 AT AT89311135T patent/ATE115952T1/de not_active IP Right Cessation
- 1989-10-27 NO NO894299A patent/NO174711C/no unknown
- 1989-10-27 AU AU43869/89A patent/AU613805B2/en not_active Expired
- 1989-10-27 DE DE68920125T patent/DE68920125T2/de not_active Expired - Lifetime
- 1989-10-27 HU HU895468A patent/HU210780B/hu unknown
- 1989-10-27 EP EP89311135A patent/EP0369627B1/de not_active Expired - Lifetime
- 1989-10-27 FI FI895121A patent/FI95245C/fi active IP Right Grant
- 1989-10-28 KR KR1019890015569A patent/KR920002307B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK535789A (da) | 1990-04-30 |
| FI95245B (fi) | 1995-09-29 |
| HU210780B (en) | 1995-07-28 |
| US5008267A (en) | 1991-04-16 |
| FI95245C (fi) | 1996-01-10 |
| NZ231165A (en) | 1992-02-25 |
| KR920002307B1 (ko) | 1992-03-21 |
| ES2066000T3 (es) | 1995-03-01 |
| NO174711C (no) | 1994-06-22 |
| FI895121A0 (fi) | 1989-10-27 |
| DE68920125D1 (de) | 1995-02-02 |
| EP0369627A3 (en) | 1990-12-12 |
| DK535789D0 (da) | 1989-10-27 |
| KR900006300A (ko) | 1990-05-07 |
| EP0369627B1 (de) | 1994-12-21 |
| NO894299L (no) | 1990-04-30 |
| AU4386989A (en) | 1990-05-31 |
| HU895468D0 (en) | 1990-01-28 |
| DK170203B1 (da) | 1995-06-12 |
| NO894299D0 (no) | 1989-10-27 |
| DE68920125T2 (de) | 1995-08-03 |
| EP0369627A2 (de) | 1990-05-23 |
| NO174711B (no) | 1994-03-14 |
| HUT52764A (en) | 1990-08-28 |
| AU613805B2 (en) | 1991-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EELA | Cancelled due to lapse of time |