ATE208764T1 - Isazole derivate als fibrinogen-rezeptor- antagonisten - Google Patents

Isazole derivate als fibrinogen-rezeptor- antagonisten

Info

Publication number
ATE208764T1
ATE208764T1 AT96920475T AT96920475T ATE208764T1 AT E208764 T1 ATE208764 T1 AT E208764T1 AT 96920475 T AT96920475 T AT 96920475T AT 96920475 T AT96920475 T AT 96920475T AT E208764 T1 ATE208764 T1 AT E208764T1
Authority
AT
Austria
Prior art keywords
isazole
derivatives
receptor antagonists
fibrinogen receptor
fibrinogen
Prior art date
Application number
AT96920475T
Other languages
English (en)
Inventor
Richard Eric Olson
John Wityak
Original Assignee
Du Pont Pharm Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Pharm Co filed Critical Du Pont Pharm Co
Application granted granted Critical
Publication of ATE208764T1 publication Critical patent/ATE208764T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT96920475T 1995-05-24 1996-05-24 Isazole derivate als fibrinogen-rezeptor- antagonisten ATE208764T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44959795A 1995-05-24 1995-05-24
US58694096A 1996-01-11 1996-01-11
PCT/US1996/007645 WO1996037482A1 (en) 1995-05-24 1996-05-24 Improved isoxazoline fibrinogen receptor antagonists

Publications (1)

Publication Number Publication Date
ATE208764T1 true ATE208764T1 (de) 2001-11-15

Family

ID=27035737

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96920475T ATE208764T1 (de) 1995-05-24 1996-05-24 Isazole derivate als fibrinogen-rezeptor- antagonisten

Country Status (9)

Country Link
EP (1) EP0832077B1 (de)
JP (1) JPH11511745A (de)
AR (1) AR002996A1 (de)
AT (1) ATE208764T1 (de)
AU (1) AU5876196A (de)
CA (1) CA2222050A1 (de)
DE (1) DE69617010T2 (de)
IL (1) IL118007A0 (de)
WO (1) WO1996037482A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602646D0 (sv) * 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
JP2000516230A (ja) * 1996-08-15 2000-12-05 デュポン ファーマシューティカルズ カンパニー Ｉｉｂ／ｉｉｉａ拮抗薬としての環状カルバメート類およびイソオキサゾリジン類
US5998424A (en) 1997-06-19 1999-12-07 Dupont Pharmaceuticals Company Inhibitors of factor Xa with a neutral P1 specificity group
IL133526A0 (en) 1997-06-19 2001-04-30 Du Pont Pharm Co Inhibitors of factor xa with a neutral p1 specificity group
US6319937B1 (en) * 1998-11-18 2001-11-20 Dupont Pharmaceuticals Company Isoxazoline fibrinogen receptor antagonists
TWI288745B (en) 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
CA2174415A1 (en) * 1993-11-24 1995-06-01 John Wityak Isoxazoline compounds useful as fibrinogen receptor antagonists

Also Published As

Publication number Publication date
JPH11511745A (ja) 1999-10-12
AU5876196A (en) 1996-12-11
IL118007A0 (en) 1996-08-04
CA2222050A1 (en) 1996-11-28
EP0832077B1 (de) 2001-11-14
DE69617010D1 (de) 2001-12-20
DE69617010T2 (de) 2002-06-27
EP0832077A1 (de) 1998-04-01
WO1996037482A1 (en) 1996-11-28
AR002996A1 (es) 1998-05-27

Similar Documents

Publication Publication Date Title
DE69605430D1 (de) Chinolin-2-on derivate als serotonin antagonisten
DE69531458D1 (de) Chinolinderivate als tachykinin nk3 rezeptor antagonisten
DE69728392D1 (de) Indolderivate verwendbar als endothelinrezeptorantagonisten
FI970107L (fi) Heterosyklisiä takykiniinireseptoriantagonisteja
EP0866705A4 (de) Fibrinogenrezeptorantagonisten
DE69325167D1 (de) Kondensierte indol-derivate als 5-ht4-rezeptor-antagonisten
NO972016D0 (no) Indolyl-Y-reseptorantagonister
ATE197300T1 (de) Indolderivate als 5-ht rezeptorantagoniste
DE69734833D1 (de) Vitronektin rezeptor antagonisten
DE69127791D1 (de) Diazabicyclononyl-Derivate als 5-HT3 Rezeptor Antagonisten
EP0810994A4 (de) Fibrinogen-rezeptor-antagonisten
DE59712958D1 (de) Substituierte Purinderivate als Vitronectinrezeptor-Antagonisten
FI960516A7 (fi) Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
ATE221052T1 (de) Tetrahydrochinolinderivate als eaa antagonisten
DE69718786D1 (de) Benzoxazinone als dopamine -d4- rezeptor-antagonisten
FI953916L (fi) Fibrinogeenireseptoriantagonisteja
ATE286022T1 (de) Naphthalin-carboxamide als tachykinin rezeptorantagonisten
EP0929218A4 (de) R2y rezeptor antagonisten
DE69703242D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69735811D1 (de) Piperazinoderivate als neurokinin-antagonisten
DE69717449D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
DE69617010D1 (de) Isazole derivate als fibrinogen-rezeptor-antagonisten
ATE206421T1 (de) Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten
FI943359A0 (fi) Atsasykliset-heterosykliset yhdisteet angiotensiini II reseptoriantagonisteina
FI941118A7 (fi) Bentsyyli-imidatsopyridiinijohdannainen angiotensiini II reseptoriantagonistina

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties