ATE206421T1 - Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten - Google Patents

Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten

Info

Publication number
ATE206421T1
ATE206421T1 AT96905333T AT96905333T ATE206421T1 AT E206421 T1 ATE206421 T1 AT E206421T1 AT 96905333 T AT96905333 T AT 96905333T AT 96905333 T AT96905333 T AT 96905333T AT E206421 T1 ATE206421 T1 AT E206421T1
Authority
AT
Austria
Prior art keywords
piperazone
derivatives
receptor antagonists
heterocyclic substituted
tachykinin receptor
Prior art date
Application number
AT96905333T
Other languages
English (en)
Inventor
Timothy P Burkholder
Elizabeth M Kudlacz
Tieu-Binh Le
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of ATE206421T1 publication Critical patent/ATE206421T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/14Antitussive agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Peptides Or Proteins (AREA)
AT96905333T 1995-03-15 1996-02-06 Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten ATE206421T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40478895A 1995-03-15 1995-03-15
PCT/US1996/001437 WO1996028441A1 (en) 1995-03-15 1996-02-06 Heterocyclic substituted piperazinone derivatives as tachykinin receptor antagonists

Publications (1)

Publication Number Publication Date
ATE206421T1 true ATE206421T1 (de) 2001-10-15

Family

ID=23601038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96905333T ATE206421T1 (de) 1995-03-15 1996-02-06 Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten

Country Status (21)

Country Link
US (2) US5840726A (de)
EP (1) EP0815105B1 (de)
JP (1) JP3825472B2 (de)
KR (1) KR19980703032A (de)
CN (1) CN1067068C (de)
AR (1) AR002715A1 (de)
AT (1) ATE206421T1 (de)
AU (1) AU697599B2 (de)
CA (1) CA2215333C (de)
DE (1) DE69615670T2 (de)
DK (1) DK0815105T3 (de)
ES (1) ES2164235T3 (de)
FI (1) FI973671A0 (de)
HU (1) HUP9702149A3 (de)
IL (1) IL117453A (de)
NO (1) NO314693B1 (de)
NZ (1) NZ302948A (de)
PT (1) PT815105E (de)
TW (1) TW464647B (de)
WO (1) WO1996028441A1 (de)
ZA (1) ZA961954B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1209125A (zh) * 1995-12-18 1999-02-24 藤泽药品工业株式会社 作为速激肽拮抗剂的哌嗪类衍生物
DE19939910A1 (de) * 1999-08-23 2001-03-01 Morphochem Ag Neue Verbindungen, die Tryptase-Aktivität hemmen
US7456222B2 (en) * 2002-05-17 2008-11-25 Sequella, Inc. Anti tubercular drug: compositions and methods
US20040033986A1 (en) * 2002-05-17 2004-02-19 Protopopova Marina Nikolaevna Anti tubercular drug: compositions and methods
CN101404986B (zh) * 2002-05-17 2011-09-28 赛奎拉公司 用于诊断和治疗感染性疾病的组合物和制药方法
WO2005034857A2 (en) * 2003-09-05 2005-04-21 Sequella, Inc. Methods and compositions comprising diamines as new anti-tubercular therapeutics
WO2009136965A1 (en) * 2008-05-06 2009-11-12 Sequella, Inc. Compositions and methods comprising capuramycin analogues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3132882A1 (de) * 1981-08-20 1983-03-03 Cassella Ag, 6000 Frankfurt Neue piperazinone, ihre herstellung und verwendung
FI97540C (fi) * 1989-11-06 1997-01-10 Sanofi Sa Menetelmä terapeuttisesti käyttökelpoisten, aromaattisesti substituoitujen piperidiini- ja piperatsiinijohdannaisten valmistamiseksi
IL99320A (en) * 1990-09-05 1995-07-31 Sanofi Sa Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr) * 1991-05-03 1993-09-03 Sanofi Elf Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
WO1994003483A1 (en) * 1992-07-30 1994-02-17 Chiron Corporation Endothelin receptor-binding compounds
GB9222486D0 (en) * 1992-10-26 1992-12-09 Merck Sharp & Dohme Therapeutic agents
ATE158580T1 (de) * 1993-05-06 1997-10-15 Merrell Pharma Inc Substituierte pyrrolidin-3-alkyl-piperidine verwendbar als tachykinin-antagonisten
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same

Also Published As

Publication number Publication date
AU4930696A (en) 1996-10-02
DK0815105T3 (da) 2002-01-21
NZ302948A (en) 2001-05-25
IL117453A (en) 2000-07-26
HUP9702149A2 (hu) 1999-06-28
FI973671L (fi) 1997-09-12
JP3825472B2 (ja) 2006-09-27
JPH11501917A (ja) 1999-02-16
CA2215333C (en) 2002-01-01
CN1178529A (zh) 1998-04-08
IL117453A0 (en) 1996-07-23
WO1996028441A1 (en) 1996-09-19
FI973671A7 (fi) 1997-09-12
EP0815105A1 (de) 1998-01-07
PT815105E (pt) 2002-03-28
CA2215333A1 (en) 1996-09-19
NO314693B1 (no) 2003-05-05
KR19980703032A (ko) 1998-09-05
US5864045A (en) 1999-01-26
ES2164235T3 (es) 2002-02-16
DE69615670T2 (de) 2002-08-08
MX9706872A (es) 1997-11-29
CN1067068C (zh) 2001-06-13
AR002715A1 (es) 1998-04-29
EP0815105B1 (de) 2001-10-04
HUP9702149A3 (en) 1999-07-28
DE69615670D1 (de) 2001-11-08
NO974205D0 (no) 1997-09-12
FI973671A0 (fi) 1997-09-12
AU697599B2 (en) 1998-10-08
TW464647B (en) 2001-11-21
US5840726A (en) 1998-11-24
NO974205L (no) 1997-11-13
ZA961954B (en) 1996-09-17

Similar Documents

Publication Publication Date Title
DE69531458D1 (de) Chinolinderivate als tachykinin nk3 rezeptor antagonisten
FI970107L (fi) Heterosyklisiä takykiniinireseptoriantagonisteja
DE69728392D1 (de) Indolderivate verwendbar als endothelinrezeptorantagonisten
ATE197300T1 (de) Indolderivate als 5-ht rezeptorantagoniste
NO951613D0 (no) Ikke-peptidyl tachykinin reseptorantagonister
ATE222892T1 (de) Pyrimidinderivate als 5ht2c-rezeptorantagonisten
DE69714265D1 (de) Tetrahydrochinolinderivate als eaa antagonisten
ATE400554T1 (de) 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives als muskarin-rezeptor antagonisten
DE69418045D1 (de) Amidderivate als 5ht1d rezeptor antagonisten
DE69626220D1 (de) 3-azetidinylalkylpiperidine oder -pyrrolidine als tachykinin antagonisten
FI973283L (fi) 5-(4-substituoitu piperidinyyli-1)-3-aryyli-valeriaanahappojohdannaisia takykiniinireseptoriantagonisteina
ATE286022T1 (de) Naphthalin-carboxamide als tachykinin rezeptorantagonisten
ATE240954T1 (de) Oxazolidinone als 5-ht2a-antagonisten
DE69703242D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
ID24468A (id) 2-asilaminopropanamina sebagai antagonis reseptor tachykinin
ATE206421T1 (de) Heterocyclisch substituierte piperazonderivate als tachykinin rezeptor antagonisten
ATE325118T1 (de) Piperazinoderivate als neurokinin-antagonisten
DE69717449D1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor-antagonisten
ATE208764T1 (de) Isazole derivate als fibrinogen-rezeptor- antagonisten
ID24309A (id) 2-asilaminopropanamina sebagai antagonis reseptor tachykinin
FI941118A0 (fi) Bentsyyli-imidatsopyridiinijohdannainen angiotensiini II reseptoriantagonistina
ATE286882T1 (de) Carboxy substituierte carboxamidderivative als tachykinin rezeptorantagoniste
DK0940391T3 (da) Quinolinderivater som tachykinin-NK3-receptor-antagonister
FI941117L (fi) Bentsyyli-imidatsopyridiinijohdannaiset angiotensiini II reseptoriantagonisteina

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee