ATE208776T1 - Pyrazolo(1,5-a) pyrimidin-derivate - Google Patents

Pyrazolo(1,5-a) pyrimidin-derivate

Info

Publication number: ATE208776T1
Authority: AT; Austria
Prior art keywords: halogen; alkyl; phenyl; substituted; hydrogen
Prior art date: 1994-06-21

Application number

AT95920260T

Other languages

English (en)

Inventor

Yasuo Shoji

Makoto Inoue

Takashi Okamura

Kinji Hashimoto

Masayuki Ohara

Tsuneo Yasuda

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-21

Filing date

1995-06-05

Publication date

2001-11-15

1995-06-05 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE208776T1 publication Critical patent/ATE208776T1/de

Links

LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 12
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
125000003545 alkoxy group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 5
239000001257 hydrogen Substances 0.000 abstract 5
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
150000002431 hydrogen Chemical class 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000001544 thienyl group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000000951 phenoxy group Chemical class [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
-1 phenylthio-substituted phenyl Chemical group 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000004076 pyridyl group Chemical class 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT95920260T 1994-06-21 1995-06-05 Pyrazolo(1,5-a) pyrimidin-derivate ATE208776T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP13863594		1994-06-21
JP5399795		1995-03-14
PCT/JP1995/001104 WO1995035298A1 (en)	1994-06-21	1995-06-05	PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE

Publications (1)

Publication Number	Publication Date
ATE208776T1 true ATE208776T1 (de)	2001-11-15

Family

ID=26394734

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95920260T ATE208776T1 (de)	1994-06-21	1995-06-05	Pyrazolo(1,5-a) pyrimidin-derivate

Country Status (13)

Country	Link
US (1)	US5707997A (de)
EP (1)	EP0714898B1 (de)
KR (1)	KR100315837B1 (de)
CN (1)	CN1046730C (de)
AT (1)	ATE208776T1 (de)
AU (1)	AU680370B2 (de)
CA (1)	CA2169719C (de)
DE (1)	DE69523864T2 (de)
DK (1)	DK0714898T3 (de)
ES (1)	ES2164153T3 (de)
PT (1)	PT714898E (de)
TW (1)	TW307767B (de)
WO (1)	WO1995035298A1 (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5843951A (en) *	1995-09-28	1998-12-01	Otsuka Pharmaceutical Factory Inc.	Analgesic composition of pyrazolo(1,5-A) pyrimidines
US6664261B2 (en) *	1996-02-07	2003-12-16	Neurocrine Biosciences, Inc.	Pyrazolopyrimidines as CRF receptor antagonists
US6313124B1 (en)	1997-07-23	2001-11-06	Dupont Pharmaceuticals Company	Tetrazine bicyclic compounds
US6191131B1 (en)	1997-07-23	2001-02-20	Dupont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6124289A (en) *	1996-07-24	2000-09-26	Dupont Pharmaceuticals Co.	Azolo triazines and pyrimidines
AU747708B2 (en) *	1996-07-24	2002-05-23	Du Pont Pharmaceuticals Company	Azolo triazines and pyrimidines
US6060478A (en) *	1996-07-24	2000-05-09	Dupont Pharmaceuticals	Azolo triazines and pyrimidines
US7094782B1 (en)	1996-07-24	2006-08-22	Bristol-Myers Squibb Company	Azolo triazines and pyrimidines
BR9808845A (pt) *	1997-03-14	2000-08-01	Otsuka Pharma Co Ltd	Derivado de pirimidina, agentes para a cura de uma doença alérgica, da asma e de uma dermatite atópica, agentes para inibição da produção de no de tnf-alfa, de citoquinas e da 5-lipoxigenase, processos para curar uma doença alérgica, a asma e uma dermatite atópica e para inibir a produção de no, de tnf-alfa e de citoquinas e a 5-lipoxigenase e usos de um composto
AU2321000A (en) *	1999-01-29	2000-08-18	Sumitomo Chemical Company, Limited	Fat accumulation inhibitory agents
AU4331500A (en)	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolotriazines as crf antagonists
AU4203500A (en)	1999-04-06	2000-10-23	Du Pont Pharmaceuticals Company	Pyrazolopyrimidines as crf antagonists
US20020061897A1 (en)	2000-03-30	2002-05-23	Elliott Richard L.	Neuropeptide Y antagonists
US6630476B2 (en)	2000-07-07	2003-10-07	Bristol-Myers Squibb Pharma Company	Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
SE0102764D0 (sv)	2001-08-17	2001-08-17	Astrazeneca Ab	Compounds
EP1506196B1 (de) *	2001-11-01	2012-01-18	Icagen, Inc.	Pyrazolopyrimidine als natriumkanalblocker
US20040028716A1 (en) *	2002-06-14	2004-02-12	Marks Andrew R.	Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
US7205308B2 (en)	2002-09-04	2007-04-17	Schering Corporation	Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
DE60313872T2 (de)	2002-09-04	2008-01-17	Schering Corp.	Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
US7119200B2 (en)	2002-09-04	2006-10-10	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
KR20050058507A (ko)	2002-09-04	2005-06-16	쉐링 코포레이션	사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
KR20050057139A (ko)	2002-09-04	2005-06-16	쉐링 코포레이션	사이클린 의존성 키나제 억제제로서의 피라졸로피리미딘
US7161003B1 (en) *	2002-09-04	2007-01-09	Schering Corporation	Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP1545533A1 (de)	2002-09-04	2005-06-29	Schering Corporation	Pyrazolopyrimidine als hemmstoffe cyclin-abhängiger kinasen
US8673924B2 (en)	2002-09-04	2014-03-18	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7196078B2 (en)	2002-09-04	2007-03-27	Schering Corpoartion	Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
RU2380369C9 (ru)	2002-09-04	2011-07-10	Шеринг Корпорейшн	Новые пиразолопиримидины как ингибиторы циклин-зависимой киназы
US8580782B2 (en)	2002-09-04	2013-11-12	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US6949895B2 (en) *	2003-09-03	2005-09-27	Axcelis Technologies, Inc.	Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) *	2004-01-22	2006-09-06	Novartis Ag	Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
WO2006040645A1 (en) *	2004-10-11	2006-04-20	Ranbaxy Laboratories Limited	N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
GB0519957D0 (en)	2005-09-30	2005-11-09	Sb Pharmco Inc	Chemical compound
TW200639163A (en)	2005-02-04	2006-11-16	Genentech Inc	RAF inhibitor compounds and methods
EP1856119A1 (de) *	2005-03-01	2007-11-21	Basf Aktiengesellschaft	5,6-dialkyl-7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
WO2006092428A2 (de) *	2005-03-02	2006-09-08	Basf Aktiengesellschaft	2-substituierte 7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
KR20110084339A (ko)	2005-07-09	2011-07-21	아스트라제네카 아베	당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한 헤테로아릴 벤즈아미드 유도체
CA2621983A1 (en) *	2005-09-09	2007-03-22	Schering Corporation	Azafused cyclin dependent kinase inhibitors
PE20070543A1 (es)	2005-10-06	2007-06-14	Schering Corp	Pirazolopirimidinas como inhibidores de protein quinasas
CA2670636A1 (en) *	2006-11-27	2008-06-05	H. Lundbeck A/S	Heteroaryl amide derivatives
CN103204852A (zh) *	2007-04-10	2013-07-17	H.隆德贝克有限公司	作为p2x7拮抗剂的杂芳基酰胺类似物
WO2010116176A1 (en)	2009-04-09	2010-10-14	Astrazeneca Ab	Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
KR20140077963A (ko)	2011-10-20	2014-06-24	글락소스미스클라인 엘엘씨	시르투인 조절제로서의 치환된 비시클릭 아자-헤테로사이클 및 유사체
US20140288052A1 (en) *	2011-10-20	2014-09-25	GlaxoSmithKline, LLC	Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
AR085073A1 (es) *	2012-01-11	2013-09-11	Richmond Sa Com Ind Y Financiera Lab	Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden
EP3087074A1 (de) *	2013-12-23	2016-11-02	Norgine BV	Benzolfulfonamide als ccr9-inhibitoren
JP2017501145A (ja)	2013-12-23	2017-01-12	ノージンビーブイ	Ｃｃｒ９調節因子として有用な化合物
WO2015143652A1 (en) *	2014-03-26	2015-10-01	Merck Sharp & Dohme Corp.	TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
KR20250174699A (ko) *	2018-10-30	2025-12-12	크로노스 바이오, 인코포레이티드	Cdk9 활성을 조절하기 위한 화합물, 조성물 및 방법
CN119661538B (zh) *	2024-11-06	2025-10-17	中国科学院精密测量科学与技术创新研究院	一种吡唑并[3,4-d]嘧啶-4-酮类衍生物及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3925385A (en) *	1972-04-20	1975-12-09	Icn Pharmaceuticals	6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) *	1971-12-09	1973-06-08	Int Chem & Nuclear Corp	Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
JPS6157587A (ja) *	1984-08-29	1986-03-24	Shionogi & Co Ltd	縮合複素環誘導体および抗潰瘍剤
US4950585A (en) *	1987-08-18	1990-08-21	Konica Corporation	Coupler for photographic use
JP2585462B2 (ja) *	1989-10-25	1997-02-26	株式会社大塚製薬工場	ピラゾロ［１，５―ａ］ピリミジン誘導体
DE69130683T2 (de) *	1991-04-22	1999-05-06	Otsuka Pharmaceutical Factory, Inc., Naruto, Tokushima	PYRAZOLO[1,5-a]PYRIMIDINDERIVATE UND SIE ENTHALTENDE ANTIINFLAMMATORISCHE MITTEL
ES2148179T3 (es) *	1991-09-06	2000-10-16	Yoshitomi Pharmaceutical	Compuesto de 4-amino(alquil)ciclohexan-1-carboxamida y uso del mismo.
US5571813A (en) *	1993-06-10	1996-11-05	Beiersdorf-Lilly Gmbh	Fused pyrimidine compounds and their use as pharmaceuticals

1995
- 1995-06-05 EP EP95920260A patent/EP0714898B1/de not_active Expired - Lifetime
- 1995-06-05 ES ES95920260T patent/ES2164153T3/es not_active Expired - Lifetime
- 1995-06-05 DE DE69523864T patent/DE69523864T2/de not_active Expired - Fee Related
- 1995-06-05 US US08/602,824 patent/US5707997A/en not_active Expired - Lifetime
- 1995-06-05 DK DK95920260T patent/DK0714898T3/da active
- 1995-06-05 CA CA002169719A patent/CA2169719C/en not_active Expired - Fee Related
- 1995-06-05 KR KR1019960700854A patent/KR100315837B1/ko not_active Expired - Fee Related
- 1995-06-05 PT PT95920260T patent/PT714898E/pt unknown
- 1995-06-05 AU AU25765/95A patent/AU680370B2/en not_active Ceased
- 1995-06-05 AT AT95920260T patent/ATE208776T1/de not_active IP Right Cessation
- 1995-06-05 WO PCT/JP1995/001104 patent/WO1995035298A1/ja not_active Ceased
- 1995-06-05 CN CN95190760A patent/CN1046730C/zh not_active Expired - Fee Related
- 1995-06-16 TW TW084106201A patent/TW307767B/zh active

Also Published As

Publication number	Publication date
KR100315837B1 (ko)	2002-02-28
PT714898E (pt)	2002-04-29
CN1131948A (zh)	1996-09-25
DE69523864T2 (de)	2002-06-13
CA2169719A1 (en)	1995-12-28
AU2576595A (en)	1996-01-15
DK0714898T3 (da)	2002-03-18
TW307767B (de)	1997-06-11
AU680370B2 (en)	1997-07-24
CN1046730C (zh)	1999-11-24
KR960703919A (ko)	1996-08-31
CA2169719C (en)	2002-04-16
DE69523864D1 (de)	2001-12-20
WO1995035298A1 (en)	1995-12-28
US5707997A (en)	1998-01-13
EP0714898A1 (de)	1996-06-05
EP0714898B1 (de)	2001-11-14
ES2164153T3 (es)	2002-02-16
EP0714898A4 (de)	1997-04-02

Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2009-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69523864D1 (de)	2001-12-20	PYRAZOLO[1,5-a] PYRIMIDIN-DERIVATE
EP0955293A4 (de)	2000-02-23	Neue harnstoffderivate
EP0945452A4 (de)	2002-06-05	Zuckerderivate, geliermittel, geliermittelzubereitungen, verfahren zu ihrer herstellung und gelzubereitungen
FI906204A0 (fi)	1990-12-17	Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi
ATE345122T1 (de)	2006-12-15	Stabile emulsionszubereitungen
EP0731106A4 (de)	1998-12-23	Neue peptid-derivate
EP0365364A3 (de)	1991-12-11	2-Azetidinonderivate
BR9608040A (pt)	1999-01-12	Composto pentacíclico
ES2063300T3 (es)	1995-01-01	Derivado de acido aminobencensulfonico.
MY141488A (en)	2010-04-30	Hydroximic acid derivatives, processes for their preparation, and compositions comprising them
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
ATE383860T1 (de)	2008-02-15	Chinazolinderivate und -arzneimittel
AU5387990A (en)	1990-11-01	Thiazole derivatives
AU623500B2 (en)	1992-05-14	Carboxylimino benzothiazole derivatives
PT852226E (pt)	2004-03-31	Derivados de pirimidina
EP0820997A4 (de)	1998-08-12	Pyrazol[1,5-a]pyrimidin derivate
DK23089D0 (da)	1989-01-19	Thioformamidderivater og deres anvendelse
IL92646A0 (en)	1990-08-31	Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them
WO1996022286A3 (en)	1996-09-19	Arthropodicidal oxazines and thiazines
AU2661800A (en)	2000-08-01	Azadioxacycloalkenes and their use for combating harmful fungi and animal pests
EP0418655A3 (en)	1991-12-18	Conjugated gamma-hydroxybutenolide compounds and antiulcer agents containing the same as an effective ingredient