BE792533A - Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation - Google Patents

Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation

Info

Publication number
BE792533A
BE792533A BE792533DA BE792533A BE 792533 A BE792533 A BE 792533A BE 792533D A BE792533D A BE 792533DA BE 792533 A BE792533 A BE 792533A
Authority
BE
Belgium
Prior art keywords
pyrimidines
preparation process
new pyrazolo
pyrazolo
new
Prior art date
Application number
Other languages
English (en)
Inventor
Der K Robins
D E O'brien
T Novinson
R K Robins
R H Springer
Original Assignee
Int Chem & Nuclear Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Publication date
Priority claimed from US245870A external-priority patent/US3925385A/en
Publication of BE792533A publication Critical patent/BE792533A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE792533D 1971-12-09 Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation BE792533A (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20653871A 1971-12-09 1971-12-09
US245870A US3925385A (en) 1972-04-20 1972-04-20 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
US27346572A 1972-07-20 1972-07-20
US29984072A 1972-10-24 1972-10-24

Publications (1)

Publication Number Publication Date
BE792533A true BE792533A (fr) 1973-06-08

Family

ID=27498614

Family Applications (1)

Application Number Title Priority Date Filing Date
BE792533D BE792533A (fr) 1971-12-09 Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation

Country Status (15)

Country Link
JP (1) JPS4864097A (fr)
BE (1) BE792533A (fr)
BG (1) BG22401A3 (fr)
CH (1) CH603652A5 (fr)
DD (1) DD104530A5 (fr)
DE (1) DE2257547A1 (fr)
GB (1) GB1412017A (fr)
HU (1) HU168530B (fr)
IE (1) IE37189B1 (fr)
IL (1) IL40895A (fr)
LU (1) LU66597A1 (fr)
NL (1) NL7216539A (fr)
NO (1) NO137012C (fr)
RO (1) RO62762A (fr)
SE (1) SE398751B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4281000A (en) * 1979-07-09 1981-07-28 American Cyanamid Company Substituted pyrazolo (1,5-a)pyrimidines and their use as anxiolytic agents
AU557300B2 (en) * 1982-03-16 1986-12-18 Farmitalia Carlo Erba S.P.A. Substituted 1h-pyrazolo(1,5-alpha)pyrimidines and processes for their preparation
ZA831407B (en) * 1982-03-25 1983-11-30 Erba Farmitalia Substituted ethenyl derivatives of 1h-pyrazolo(1,5-a)pyrimidine and process for their preparation
NZ208554A (en) * 1983-06-23 1987-06-30 American Cyanamid Co (aryl and heteroaryl)-(7-(aryl and heteroaryl)-pyrazolo (1,5-a) pyrimidin-3-yl)-methanone derivatives and pharmaceutical compositions
DE3533050A1 (de) * 1985-09-17 1987-03-26 Basf Ag 7-amino-azolo(1,5-a)pyrimidine, verfahren zu ihrer herstellung und diese enthaltende fungizide, bzw. deren verwendung als fungizide
CA1330079C (fr) * 1988-10-13 1994-06-07 Michihiko Tsujitani Derive pyrrolo-(3,2-e)pyrazolo(1,5-a)pyrimidine et medicament en contenant
EP0591528B1 (fr) * 1991-04-22 1998-12-23 Otsuka Pharmaceutical Factory, Inc. DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE ET AGENT ANTI-INFLAMMATOIRECONTENANT CE DERIVE
DE4333705C2 (de) * 1993-10-02 2003-10-30 Guenter Ege Arylmethylsubstituierte Pyrazolo-azine, insbesondere 3-Arylmethylpyrazolo[1,5-a]pyrimidine und Verfahren zur Herstellung von 8-Arylmethyl-pyrazolo[5,1-c][1,2,4]triazinen
EP0714898B1 (fr) * 1994-06-21 2001-11-14 Otsuka Pharmaceutical Factory, Inc. DERIVE DE PYRAZOLO [1,5-a]PYRIMIDINE
WO1997011946A1 (fr) * 1995-09-28 1997-04-03 Otsuka Pharmaceutical Factory, Inc. Analgesiques
FR2771631B1 (fr) 1997-12-03 2001-02-02 Oreal Compositions de teinture des fibres keratiniques contenant des 3-amino pyrazolo-[1,5-a]-pyrimidines, procede de teinture, nouvelles 3-amino pyrazolo- [1,5-a]-pyrimidines et leur procede de preparation
US7161003B1 (en) * 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
EP1537116B1 (fr) * 2002-09-04 2010-06-02 Schering Corporation Pyrazolopyrimidines utilisable pour le traitement des maladies cancereuses
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
TWI252851B (en) * 2003-07-24 2006-04-11 Ferrer Int 7-substituted 3-nitro-pyrazolo[1,5-a]pyrimidines and compositions and methods related thereto
ES2222813B1 (es) * 2003-07-24 2005-12-16 Ferrer Internacional, S.A. N-(3-(3-sustituidas-pirazolo(1,5-a)pirimidin-7-il)-fenil)-sulfonamidas y composiciones y metodos relacionados.
SG11201506764WA (en) 2013-04-25 2015-09-29 Beigene Ltd Fused heterocyclic compounds as protein kinase inhibitors
JP6623353B2 (ja) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー 抗ｐｄ−１抗体並びにその治療及び診断のための使用
KR102003754B1 (ko) 2014-07-03 2019-07-25 베이진 엘티디 Pd-l1 항체와 이를 이용한 치료 및 진단
NZ749997A (en) 2016-07-05 2022-11-25 Beigene Ltd Combination of a pd-l antagonist and a raf inhibitor for treating cancer
KR102604975B1 (ko) 2016-08-16 2023-11-24 베이진 스위찰랜드 게엠베하 (s)-7-(1-아크릴로일피페리딘-4-일)-2-(4-페녹시페닐)-4,5,6,7-테트라-하이드로피라졸로 [1,5-a] 피리미딘-3-카르복스아미드의 제조 및 그 용도
EP3500299B1 (fr) 2016-08-19 2023-12-13 BeiGene Switzerland GmbH Combinaison de zanubrutinib avec un anticorps anti-cd20 ou anti-pd-1 pour l'utilisation dans le traitement du cancer
WO2018137681A1 (fr) 2017-01-25 2018-08-02 Beigene, Ltd. Formes cristallines de (s) -7- (1- (but-2-ynoyl) pipéridin-4-yl) -2- (4-phénoxyphényl) -4, 5, 6, 7-tétrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, préparation et utilisations associées
KR102757960B1 (ko) 2017-06-26 2025-01-22 베이진 엘티디 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료
CN110997677A (zh) 2017-08-12 2020-04-10 百济神州有限公司 具有改进的双重选择性的Btk抑制剂
WO2019108795A1 (fr) 2017-11-29 2019-06-06 Beigene Switzerland Gmbh Traitement de lymphomes à cellules b indolentes ou agressives au moyen d'une combinaison comprenant des inhibiteurs de btk
US20220249491A1 (en) 2019-06-10 2022-08-11 Beigene Switzerland Gmbh Oral solid tablet comprising bruton's tyrosine kinase inhibitor and preparation method therefor
US11786531B1 (en) 2022-06-08 2023-10-17 Beigene Switzerland Gmbh Methods of treating B-cell proliferative disorder

Also Published As

Publication number Publication date
IL40895A (en) 1976-12-31
RO62762A (fr) 1978-05-15
NL7216539A (fr) 1973-06-13
IE37189L (en) 1973-06-09
IL40895A0 (en) 1973-01-30
JPS4864097A (fr) 1973-09-05
NO137012B (no) 1977-09-05
DD104530A5 (fr) 1974-03-12
HU168530B (fr) 1976-05-28
IE37189B1 (en) 1977-05-25
GB1412017A (en) 1975-10-29
NO137012C (no) 1977-12-14
BG22401A3 (bg) 1977-02-20
SE398751B (sv) 1978-01-16
LU66597A1 (fr) 1973-03-15
DE2257547A1 (de) 1973-06-14
CH603652A5 (fr) 1978-08-31

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