ATE209207T1 - Androgen rezeptor modulator verbindungen und verfahren - Google Patents

Androgen rezeptor modulator verbindungen und verfahren

Info

Publication number
ATE209207T1
ATE209207T1 AT97931460T AT97931460T ATE209207T1 AT E209207 T1 ATE209207 T1 AT E209207T1 AT 97931460 T AT97931460 T AT 97931460T AT 97931460 T AT97931460 T AT 97931460T AT E209207 T1 ATE209207 T1 AT E209207T1
Authority
AT
Austria
Prior art keywords
compounds
androgen receptor
methods
receptor modulator
disclosed
Prior art date
Application number
AT97931460T
Other languages
English (en)
Inventor
James P Edwards
Robert Higuchi
Todd Jones
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Application granted granted Critical
Publication of ATE209207T1 publication Critical patent/ATE209207T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Electrotherapy Devices (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
AT97931460T 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren ATE209207T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2199796P 1996-06-27 1996-06-27
PCT/US1997/011222 WO1997049709A1 (en) 1996-06-27 1997-06-26 Androgen receptor modulator compounds and methods

Publications (1)

Publication Number Publication Date
ATE209207T1 true ATE209207T1 (de) 2001-12-15

Family

ID=21807289

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931460T ATE209207T1 (de) 1996-06-27 1997-06-26 Androgen rezeptor modulator verbindungen und verfahren

Country Status (12)

Country Link
EP (1) EP0918774B9 (de)
JP (1) JP2000513362A (de)
AT (1) ATE209207T1 (de)
AU (1) AU728178B2 (de)
BR (1) BR9710988A (de)
DE (1) DE69709752T2 (de)
DK (1) DK0918774T3 (de)
ES (1) ES2168650T3 (de)
NO (1) NO311645B1 (de)
PT (1) PT918774E (de)
RU (1) RU2214412C2 (de)
WO (1) WO1997049709A1 (de)

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US7003304B1 (en) 1997-09-19 2006-02-21 Thompson Investment Group, Llc Paging transceivers and methods for selectively retrieving messages
US6636733B1 (en) 1997-09-19 2003-10-21 Thompson Trust Wireless messaging method
US6983138B1 (en) 1997-12-12 2006-01-03 Richard J. Helferich User interface for message access
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US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
KR20020038741A (ko) 1999-08-27 2002-05-23 윌리암 엘. 레스페스 안드로겐 수용체 조절 화합물 및 방법
JP2003508397A (ja) * 1999-08-27 2003-03-04 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲンレセプターモジュレーターとしての８−置換−６−トリフルオロメチル−９−ピリド［３，２−ｇ］キノリン化合物
AU7586600A (en) 1999-09-14 2001-04-17 Ligand Pharmaceuticals Incorporated Rxr modulators with improved pharmacologic profile
PT1955700E (pt) 1999-09-30 2011-05-04 Harbor Biosciences Inc Tratamento terap?utico de doen?as associadas ao receptor de androg?nios
WO2001059448A1 (fr) * 2000-02-10 2001-08-16 Chugai Seiyaku Kabushiki Kaisha Procede de criblage d'un agent antiandrogene
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
WO2002000653A2 (en) * 2000-06-28 2002-01-03 Bristol-Myers Squibb Company Fused cyclic compounds as modulators of nuclear hormone receptor function
US20040077605A1 (en) 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
MXPA02012605A (es) 2000-06-28 2003-05-14 Squibb Bristol Myers Co Moduladores selectivos del receptor androgeno y metodo para su identificacion, dise°o y uso.
AU2001267904A1 (en) 2000-06-30 2002-01-14 Chugai Seiyaku Kabushiki Kaisha Novel antiandrogenic agent
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
WO2002024702A1 (en) * 2000-09-19 2002-03-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7214690B2 (en) 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
US7026484B2 (en) 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
ES2291507T3 (es) * 2001-10-19 2008-03-01 MERCK & CO., INC. Moduladores de receptor de androgenos y procedimientos de uso de los mismos.
US7087636B2 (en) 2001-12-19 2006-08-08 Bristol-Myers Squibb Company Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
AU2002367424A1 (en) * 2001-12-28 2003-07-24 Takeda Chemical Industries, Ltd. Androgen receptor antagonists
US7705182B2 (en) 2002-02-28 2010-04-27 University Of Tennessee Research Foundation Multi-substituted selective androgen receptor modulators and methods of use thereof
CN1315836C (zh) * 2002-04-26 2007-05-16 奥索-麦克尼尔药品公司 用作雄激素受体调节剂的2－(喹诺酮基)－稠合杂环
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
DE20301728U1 (de) 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
WO2004045518A2 (en) 2002-11-15 2004-06-03 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
BRPI0406778A (pt) 2003-01-17 2006-01-17 Warner Lambert Co Antagonistas de receptores de androgênio
MXPA06001751A (es) 2003-08-22 2006-05-12 Ligand Pharm Inc Derivados de 6-cicloamino-2-quinolinona como compuestos moduladores de receptor de androgeno.
US7256208B2 (en) 2003-11-13 2007-08-14 Bristol-Myers Squibb Company Monocyclic N-Aryl hydantoin modulators of androgen receptor function
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7388027B2 (en) 2004-03-04 2008-06-17 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US8519158B2 (en) 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
EP1991223B1 (de) * 2006-02-10 2010-07-14 Janssen Pharmaceutica, N.V. Neue imidazolopyrazolderivate als selektive androgen-rezeptor-modulatoren
RU2381229C2 (ru) * 2007-10-17 2010-02-10 Государственное образовательное учреждение высшего профессионального образования "Пермская государственная фармацевтическая академия Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ПГФА Росздрава) 11b-(ГEТ)АРИЛ-2,3,6,11b-ТЕТРАГИДРООКСАЗОЛО[2',3':2,1]ПИРРОЛО[3,4-b]ХИНОЛИН-5,11-ДИОНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
US8268872B2 (en) 2008-02-22 2012-09-18 Radius Health, Inc. Selective androgen receptor modulators
CA2716320C (en) 2008-02-22 2014-01-28 Radius Health, Inc. Selective androgen receptor modulators
EP2130831A1 (de) 2008-06-06 2009-12-09 InterMed Discovery GmbH CDC25-Hemmer
KR101703202B1 (ko) * 2009-04-30 2017-02-06 닛산 가가쿠 고교 가부시키 가이샤 3환성 벤조피란 화합물의 신규한 결정형태 및 그 제조방법
AU2011212813B2 (en) 2010-02-04 2014-10-23 Radius Health, Inc. Selective androgen receptor modulators
HUE030072T2 (en) 2010-05-12 2017-04-28 Radius Health Inc Therapeutic prescriptions
US8642632B2 (en) 2010-07-02 2014-02-04 Radius Health, Inc. Selective androgen receptor modulators
US9133182B2 (en) 2010-09-28 2015-09-15 Radius Health, Inc. Selective androgen receptor modulators
JP5889337B2 (ja) 2011-01-20 2016-03-22 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム Ｍｒｉマーカー、送達および抜取りシステムならびにこれらの製造方法および使用方法
US9421264B2 (en) 2014-03-28 2016-08-23 Duke University Method of treating cancer using selective estrogen receptor modulators
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
MX389702B (es) 2016-06-22 2025-03-20 Ellipses Pharma Ltd Compuestos para usarse en el tratamiento de cancer de mama que expresa el receptor de androgenos (ar+).
CN106397317B (zh) * 2016-09-26 2019-03-22 天津师范大学 1,2,3,4-四氢喹啉化合物及其合成方法与应用
CN106565723B (zh) * 2016-11-04 2019-08-27 江苏师范大学 一种呋喃并吡啶、苯并吡啶类衍生化合物的制备方法
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
WO2020214834A1 (en) 2019-04-19 2020-10-22 Ligand Pharmaceuticals Inc. Crystalline forms and methods of producing crystalline forms of a compound
CN116969959B (zh) * 2023-08-03 2025-10-31 浙江大学 取代四氢喹啉类衍生物及其应用

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AU5856090A (en) * 1989-07-07 1991-02-06 Endorecherche Inc. Androgen derivatives for use in the inhibition of sex steroid activity
EP0540099B1 (de) * 1991-10-29 1996-04-17 Glaxo Wellcome Inc. Wasserlösliche Camptothecinderivate
US5677336A (en) * 1993-10-21 1997-10-14 Ligand Pharmaceuticals Incorporated Non-steroid androgen receptor antagonist compounds and methods
EP1043325B1 (de) * 1994-12-22 2004-06-16 Ligand Pharmaceuticals Incorporated Steroidrezeptor-Modulator Verbindungen und Methoden

Also Published As

Publication number Publication date
JP2000513362A (ja) 2000-10-10
EP0918774B1 (de) 2001-11-21
RU2214412C2 (ru) 2003-10-20
EP0918774B9 (de) 2002-04-10
PT918774E (pt) 2002-05-31
NO311645B1 (no) 2001-12-27
WO1997049709A1 (en) 1997-12-31
NO986100L (no) 1998-12-23
EP0918774A1 (de) 1999-06-02
NO986100D0 (no) 1998-12-23
DE69709752D1 (de) 2002-02-21
AU728178B2 (en) 2001-01-04
DE69709752T2 (de) 2002-07-18
AU3508497A (en) 1998-01-14
BR9710988A (pt) 2002-01-15
ES2168650T3 (es) 2002-06-16
DK0918774T3 (da) 2002-05-21

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee