BRPI0413820A - derivados de 6-cicloamino-2-quinolinona como compostos moduladores de receptor de androgênio - Google Patents

derivados de 6-cicloamino-2-quinolinona como compostos moduladores de receptor de androgênio

Info

Publication number
BRPI0413820A
BRPI0413820A BRPI0413820-1A BRPI0413820A BRPI0413820A BR PI0413820 A BRPI0413820 A BR PI0413820A BR PI0413820 A BRPI0413820 A BR PI0413820A BR PI0413820 A BRPI0413820 A BR PI0413820A
Authority
BR
Brazil
Prior art keywords
androgen receptor
cycloamino
modulating compounds
receptor modulating
quinolinone derivatives
Prior art date
Application number
BRPI0413820-1A
Other languages
English (en)
Inventor
Lin Zhi
Esther Martinborough
Yixing Shen
Thomas Lot Sevens Lau
Min Wu
Yun Oliver Long
Original Assignee
Ligand Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34216080&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0413820(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ligand Pharm Inc filed Critical Ligand Pharm Inc
Publication of BRPI0413820A publication Critical patent/BRPI0413820A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"DERIVADOS DE 6-CICLOAMINO-2-QUINOLINONA COMO COMPOSTOS MODULADORES DE RECEPTOR DE ANDROGêNIO". A presente invenção é dirigida a compostos, composições farmacêuticas e a métodos para modular processos mediados por AR. São também fornecidos métodos de preparar esses compostos e composições farmacêuticas.
BRPI0413820-1A 2003-08-22 2004-08-23 derivados de 6-cicloamino-2-quinolinona como compostos moduladores de receptor de androgênio BRPI0413820A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49712503P 2003-08-22 2003-08-22
PCT/US2004/027483 WO2005018573A2 (en) 2003-08-22 2004-08-23 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds

Publications (1)

Publication Number Publication Date
BRPI0413820A true BRPI0413820A (pt) 2006-10-24

Family

ID=34216080

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0413820-1A BRPI0413820A (pt) 2003-08-22 2004-08-23 derivados de 6-cicloamino-2-quinolinona como compostos moduladores de receptor de androgênio

Country Status (9)

Country Link
US (1) US7816372B2 (pt)
EP (1) EP1656142A4 (pt)
JP (2) JP4709759B2 (pt)
CN (1) CN1838956A (pt)
AU (1) AU2004266160A1 (pt)
BR (1) BRPI0413820A (pt)
CA (1) CA2536349A1 (pt)
MX (1) MXPA06001751A (pt)
WO (1) WO2005018573A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7026484B2 (en) 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US7214690B2 (en) 2001-02-23 2007-05-08 Ligand Pharmaceuticals Incorporated Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods
JP4709759B2 (ja) 2003-08-22 2011-06-22 リガンド・ファーマシューティカルズ・インコーポレイテッド アンドロゲン受容体モジュレーター化合物としての６−シクロアミノ−２−キノリノン誘導体
US8519158B2 (en) * 2004-03-12 2013-08-27 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
BRPI0609191B8 (pt) 2005-06-17 2021-05-25 Ligand Pharm Inc métodos e compostos moduladores de receptor de androgênio
WO2007025303A2 (en) 2005-08-26 2007-03-01 The Regents Of The University Of California Non-steroidal antiandrogens
EP2008099A4 (en) * 2006-04-03 2009-12-23 Medexis S A DETECTION OF MEMBRANE ANDROGEN RECEPTOR (MAR) ACTIVE SUBSTANCES
JP2009079037A (ja) * 2007-09-06 2009-04-16 Sumitomo Chemical Co Ltd アミロイドβタンパク質の蓄積を抑制するための医薬組成物
JP5539221B2 (ja) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用
ES2550319T3 (es) * 2010-09-28 2015-11-06 Radius Health, Inc Moduladores selectivos del receptor de andrógenos
MY176727A (en) * 2012-12-03 2020-08-20 Pfizer Selective androgen receptor modulators
WO2015108988A2 (en) * 2014-01-17 2015-07-23 Ligand Pharmaceuticals, Inc. Methods and compositions for modulating hormone levels
MX371014B (es) 2014-05-15 2020-01-10 Pfizer Forma cristalina de 6-[(4r)-4-metil-1,2-dióxido-1,2,6-tiadiazinan- 2-il]isoquinolin-1-carbonitrilo.
ES2864079T3 (es) * 2014-05-30 2021-10-13 Pfizer Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
US10696637B2 (en) 2015-07-17 2020-06-30 Fujifilm Corporation Nitrogen-containing heterocyclic compound
CA3048602A1 (en) * 2016-12-27 2018-07-05 Fujifilm Corporation Antitumor agent and bromodomain inhibitor
KR20220003554A (ko) 2019-04-19 2022-01-10 리간드 파마슈티칼스 인코포레이티드 화합물의 결정질 형태 및 결정질 형태를 제조하는 방법

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JP5539221B2 (ja) 2007-12-21 2014-07-02 リガンド・ファーマシューティカルズ・インコーポレイテッド 選択的アンドロゲン受容体モジュレーター（ｓａｒｍ）およびその使用

Also Published As

Publication number Publication date
CN1838956A (zh) 2006-09-27
US20070066650A1 (en) 2007-03-22
US20080227810A9 (en) 2008-09-18
EP1656142A4 (en) 2011-06-22
CA2536349A1 (en) 2005-03-03
WO2005018573A3 (en) 2005-05-06
AU2004266160A1 (en) 2005-03-03
WO2005018573A2 (en) 2005-03-03
JP2007503398A (ja) 2007-02-22
JP4709759B2 (ja) 2011-06-22
JP2010195799A (ja) 2010-09-09
US7816372B2 (en) 2010-10-19
EP1656142A2 (en) 2006-05-17
MXPA06001751A (es) 2006-05-12

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]