ATE209211T1 - Kontrastzusammensetzungen für kernmagnetische resonanz - Google Patents

Kontrastzusammensetzungen für kernmagnetische resonanz

Info

Publication number
ATE209211T1
ATE209211T1 AT97120436T AT97120436T ATE209211T1 AT E209211 T1 ATE209211 T1 AT E209211T1 AT 97120436 T AT97120436 T AT 97120436T AT 97120436 T AT97120436 T AT 97120436T AT E209211 T1 ATE209211 T1 AT E209211T1
Authority
AT
Austria
Prior art keywords
magnetic resonance
nuclear magnetic
contrast compositions
compositions
resonance contrast
Prior art date
Application number
AT97120436T
Other languages
English (en)
Inventor
Allan Dean Sherry
Garry E Kiefer
Original Assignee
Univ Texas
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/662,075 external-priority patent/US4639365A/en
Application filed by Univ Texas, Dow Chemical Co filed Critical Univ Texas
Application granted granted Critical
Publication of ATE209211T1 publication Critical patent/ATE209211T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
    • C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D259/00—Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
AT97120436T 1984-10-18 1993-06-28 Kontrastzusammensetzungen für kernmagnetische resonanz ATE209211T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/662,075 US4639365A (en) 1984-10-18 1984-10-18 Gadolinium chelates as NMR contrast agents
US07/923,715 US5362476A (en) 1984-10-18 1992-07-31 Alkyl phosphonate polyazamacrocyclic cheates for MRI

Publications (1)

Publication Number Publication Date
ATE209211T1 true ATE209211T1 (de) 2001-12-15

Family

ID=34922820

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93916827T ATE169827T1 (de) 1984-10-18 1993-06-28 Tetraazamakrocyclische metallkomplexe
AT97120436T ATE209211T1 (de) 1984-10-18 1993-06-28 Kontrastzusammensetzungen für kernmagnetische resonanz

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT93916827T ATE169827T1 (de) 1984-10-18 1993-06-28 Tetraazamakrocyclische metallkomplexe

Country Status (19)

Country Link
US (2) US5362476A (de)
EP (2) EP0855401B1 (de)
JP (1) JP3411919B2 (de)
CN (1) CN1040750C (de)
AT (2) ATE169827T1 (de)
AU (1) AU4654893A (de)
CA (1) CA2140557A1 (de)
DE (2) DE69331203T2 (de)
DK (1) DK0855401T3 (de)
ES (1) ES2167667T3 (de)
FI (1) FI950397A7 (de)
HU (1) HUT70447A (de)
IL (1) IL106164A0 (de)
MX (1) MX9304624A (de)
NO (1) NO306466B1 (de)
PH (1) PH30934A (de)
PT (1) PT855401E (de)
WO (1) WO1994003464A1 (de)
ZA (1) ZA935541B (de)

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US5714604A (en) * 1993-05-06 1998-02-03 The Dow Chemical Company Process for the preparation of azamacrocyclic or acyclic aminophosphonate ester derivatives
US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
EP0955044B1 (de) 1995-06-26 2005-11-16 Chelator LLC Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
US5952732A (en) * 1997-11-10 1999-09-14 Scarpitti; Ernest A Vehicle security system
US6685914B1 (en) 1999-09-13 2004-02-03 Bristol-Myers Squibb Pharma Company Macrocyclic chelants for metallopharmaceuticals
EP1246830B1 (de) * 1999-09-13 2003-11-12 Bristol-Myers Squibb Pharma Company Makrozyclische liganden für metallpharmazeutika
EP1362861B1 (de) * 1999-09-13 2005-12-14 Bristol-Myers Squibb Pharma Company Makrocyclische Chelatbildner für Metallopharmazeutika
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
ATE420201T1 (de) * 2000-08-07 2009-01-15 Univ Vanderbilt Nachweis der cox-2 aktivität und von anandamid- metaboliten
US7048907B2 (en) * 2001-02-05 2006-05-23 Biophysics Assay Laboratory, Inc. Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products
EP1429783A4 (de) * 2001-09-04 2006-08-09 Univ Texas Tech Vielseitig einsetzbare chelate für die multimodale bildeinstellung
WO2003035114A1 (en) * 2001-10-22 2003-05-01 Dow Global Technologies Inc. Radiopharmaceutical agent for the treatment of early stage cancer
EP1481268A4 (de) * 2002-02-07 2005-06-29 Covalent Partners Llc Nanofilm und membranzusammensetzungen
US20040034223A1 (en) * 2002-02-07 2004-02-19 Covalent Partners, Llc. Amphiphilic molecular modules and constructs based thereon
US20040106741A1 (en) * 2002-09-17 2004-06-03 Kriesel Joshua W. Nanofilm compositions with polymeric components
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
WO2008073458A2 (en) 2006-12-11 2008-06-19 Bracco Imaging S.P.A. Fibrin-binding peptides and conjugates thereof
EP2476703A1 (de) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Mit einem Bakterium kreuzreagierende menschliche Antikörper und ein Autoantigen aus atherosklerotischen Plaques
US7595699B1 (en) * 2008-03-04 2009-09-29 Freescale Semiconductor, Inc. Look loop circuit and method having improved lock time
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
BR112013000236B1 (pt) * 2010-07-06 2018-11-13 Catexel Limited método de produzir um composto, e, sal protonado
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
IL260957B2 (en) 2016-02-09 2023-11-01 Bracco Suisse Sa Chimeric, Recombinant Protein Glycoprotein Selectin-P Ligand-1 (PSGL-1) Conjugates, Preparations Containing Them and Uses Thereof

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US3932451A (en) * 1973-11-27 1976-01-13 E. I. Du Pont De Nemours & Company 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids
US3930867A (en) * 1974-01-07 1976-01-06 E. I. Du Pont De Nemours And Company Macrocyclic polyamines as sensitizers for silver halide emulsions
US4038312A (en) * 1975-08-22 1977-07-26 E. I. Du Pont De Nemours And Company Tricyclic phosphorous triamides
US3996276A (en) * 1975-08-22 1976-12-07 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic phosphorous triamides
US3987128A (en) * 1975-08-22 1976-10-19 E. I. Du Pont De Nemours And Company Tetracyclic tetraamino phosphoranes and method of preparation
US4085106A (en) * 1976-01-07 1978-04-18 E. I. Du Pont De Nemours And Company Bicyclic and tricyclic trisaminomethanes
GB1529150A (en) * 1977-05-17 1978-10-18 Tabushi I Alkyl substituted cyclic alkyltetramines
US4337154A (en) * 1979-04-04 1982-06-29 Nippon Shokubai Kagaku Kogyo Co., Ltd. Crosslinked composite semipermeable membrane
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Also Published As

Publication number Publication date
ES2167667T3 (es) 2002-05-16
ZA935541B (en) 1994-02-24
DE69331203D1 (de) 2002-01-03
DE69320481D1 (de) 1998-09-24
JP3411919B2 (ja) 2003-06-03
FI950397L (fi) 1995-01-30
FI950397A0 (fi) 1995-01-30
JPH08500346A (ja) 1996-01-16
ATE169827T1 (de) 1998-09-15
DE69320481T2 (de) 1999-03-18
PT855401E (pt) 2002-04-29
EP0652885B1 (de) 1998-08-19
DE69331203T2 (de) 2002-05-08
DK0855401T3 (da) 2002-05-21
FI950397A7 (fi) 1995-01-30
CN1040750C (zh) 1998-11-18
IL106164A0 (en) 1993-10-20
PH30934A (en) 1997-12-23
EP0855401A1 (de) 1998-07-29
NO306466B1 (no) 1999-11-08
EP0855401B1 (de) 2001-11-21
AU4654893A (en) 1994-03-03
HU9500283D0 (en) 1995-03-28
NO950346L (no) 1995-01-30
WO1994003464A1 (en) 1994-02-17
EP0652885A1 (de) 1995-05-17
NO950346D0 (no) 1995-01-30
US5362476A (en) 1994-11-08
MX9304624A (es) 1994-08-31
CN1084514A (zh) 1994-03-30
CA2140557A1 (en) 1994-02-17
HUT70447A (en) 1995-10-30
US5630997A (en) 1997-05-20

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee