ATE210129T1 - Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten - Google Patents

Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten

Info

Publication number
ATE210129T1
ATE210129T1 AT96931264T AT96931264T ATE210129T1 AT E210129 T1 ATE210129 T1 AT E210129T1 AT 96931264 T AT96931264 T AT 96931264T AT 96931264 T AT96931264 T AT 96931264T AT E210129 T1 ATE210129 T1 AT E210129T1
Authority
AT
Austria
Prior art keywords
salts
carboxylic acid
active ingredients
acid derivatives
halo
Prior art date
Application number
AT96931264T
Other languages
English (en)
Inventor
Akira Yazaki
Yoshiko Niino
Yoshihiro Ohshita
Yuzo Hirao
Hirotaka Amano
Norihiro Hayashi
Yasuhiro Kuramoto
Original Assignee
Wakunaga Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26498637&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE210129(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wakunaga Pharma Co Ltd filed Critical Wakunaga Pharma Co Ltd
Application granted granted Critical
Publication of ATE210129T1 publication Critical patent/ATE210129T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
AT96931264T 1995-09-22 1996-09-20 Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten ATE210129T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26928095 1995-09-22
JP17846296 1996-06-19
PCT/JP1996/002710 WO1997011068A1 (en) 1995-09-22 1996-09-20 Novel pyridonecarboxylic acid derivatives or their salts and antibacterial agent comprising the same as the active ingredient

Publications (1)

Publication Number Publication Date
ATE210129T1 true ATE210129T1 (de) 2001-12-15

Family

ID=26498637

Family Applications (3)

Application Number Title Priority Date Filing Date
AT99111114T ATE241601T1 (de) 1995-09-22 1996-09-20 Zwischenverbindungen zur herstellung von neunen pyridoncarbonsäurederivate oder deren salzen
AT96931264T ATE210129T1 (de) 1995-09-22 1996-09-20 Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten
AT99124494T ATE222906T1 (de) 1995-09-22 1996-09-20 Pyridoncarbonsäurederivate als antibakterielle wirkstoffe

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT99111114T ATE241601T1 (de) 1995-09-22 1996-09-20 Zwischenverbindungen zur herstellung von neunen pyridoncarbonsäurederivate oder deren salzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99124494T ATE222906T1 (de) 1995-09-22 1996-09-20 Pyridoncarbonsäurederivate als antibakterielle wirkstoffe

Country Status (16)

Country Link
US (3) US5998436A (de)
EP (3) EP0911327B1 (de)
JP (3) JP3103380B2 (de)
KR (2) KR100343331B1 (de)
CN (3) CN1105715C (de)
AT (3) ATE241601T1 (de)
AU (1) AU721805B2 (de)
BR (2) BR9612862B8 (de)
CA (3) CA2290712C (de)
DE (3) DE69623358T2 (de)
DK (3) DK0992501T3 (de)
ES (3) ES2200439T3 (de)
HU (3) HU225224B1 (de)
PT (3) PT952151E (de)
RU (3) RU2167873C2 (de)
WO (1) WO1997011068A1 (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0594379U (ja) * 1992-05-11 1993-12-24 株式会社イナックス 便器洗浄水タンクの手洗鉢
CA2268190A1 (en) * 1997-08-06 1999-02-18 Suntory Limited 1-aryl-1,8-naphthylidin-4-one derivative as type iv phosphodiesterase inhibitor
JP3477465B2 (ja) * 1999-07-01 2003-12-10 湧永製薬株式会社 キノリンカルボン酸誘導体又はその塩
WO2001017991A1 (en) * 1999-09-02 2001-03-15 Wakunaga Pharmaceutical Co., Ltd. Quinolinecarboxylic acid derivative or its salt
JP2005097116A (ja) * 1999-11-11 2005-04-14 Wakunaga Pharmaceut Co Ltd キノリンカルボン酸誘導体アルカリ金属塩及びこれを用いたキノリンカルボン酸誘導体の精製法
JP2005232000A (ja) * 2000-03-10 2005-09-02 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体又はその塩
IL155976A0 (en) * 2000-11-20 2003-12-23 Daiichi Seiyaku Co Dehalogeno compounds
MXPA03008056A (es) * 2001-03-05 2004-10-15 Johnson & Johnson Composiciones farmaceuticas liquidas con sabor oculto.
WO2003031443A1 (de) * 2001-10-04 2003-04-17 Morphochem Aktiengesellschaft für kombinatorische Chemie Dual action antibiotics
IS7839A (is) * 2002-11-22 2004-05-23 Merck Frosst Canada Ltd. 4-oxó-1-(3-setið fenýl-1,4-díhýdró-1,8-naftýridín-3-karboxamíð fosfódíesterasa-4 hindrar
KR101101982B1 (ko) 2003-04-30 2012-01-02 모르포켐 악티엥게셀샤프트 퓌르 콤비나토리셰 케미 옥사졸리디논-퀴놀린 하이브리드 항생제의 탄저병 및 기타감염증의 치료용의 용도
DE10340485B4 (de) 2003-09-03 2015-05-13 Morphochem AG Aktiengesellschaft für kombinatorische Chemie Verfahren zur Herstellung von Oxazolidinon-Chinolon Hybriden
WO2005026145A2 (en) * 2003-09-12 2005-03-24 Warner-Lambert Company Llc Quinolone antibacterial agents
KR100981351B1 (ko) * 2003-10-29 2010-09-10 주식회사 엘지생명과학 7-클로로-1-사이클로프로필-6-플루오로-4-옥소-1,4-디하이드로-1,8-나프티리딘-3-카복실산의 제조방법
US8158797B2 (en) * 2003-12-18 2012-04-17 Morphochem Aktiengesellschaft Fur Kombinatorische Chemie Oxazolidinone-quinolone hybrid antibiotics
ATE401326T1 (de) 2003-12-18 2008-08-15 Morphochem Ag Komb Chemie Oxazolidinon-chinolon hybrid antibiotika
EP2816033A1 (de) * 2004-07-30 2014-12-24 Abbvie Inc. Herstellung von Pyridoncarboxylischer Säure-Antibakterien
US7576216B2 (en) 2004-07-30 2009-08-18 Abbott Laboratories Preparation of pyridonecarboxylic acid antibacterials
US20090156577A1 (en) * 2004-09-09 2009-06-18 Benjamin Davis 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
AU2005286593A1 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
ES2901955T3 (es) * 2004-10-08 2022-03-24 Abbvie Inc Sal meglumínica y formas cristalinas de la misma de un farmaco (delafloxacina)
MX2007005892A (es) 2004-11-17 2007-06-19 Wakunaga Pharma Co Ltd Derivados de acido piridonacarboxilico novedosos y sales de los mismos.
EP1831170A4 (de) * 2004-12-14 2009-10-14 Astrazeneca Ab Substituierte aminopyridine und deren verwendung
US20080233053A1 (en) * 2005-02-07 2008-09-25 Pharmalight Inc. Method and Device for Ophthalmic Administration of Active Pharmaceutical Ingredients
EP2286800A1 (de) 2005-04-11 2011-02-23 Abbott Laboratories Pharmazeutische Zubereitungen mit verbesserter Löslichkeit für schwerlösliche Wirkstoffe
RU2281773C1 (ru) * 2005-06-03 2006-08-20 Зимин Дмитрий Владимирович Лекарственная форма, обладающая антибактериальным воздействием, и способ ее изготовления
CN101563336A (zh) * 2006-03-16 2009-10-21 诺瓦提斯公司 用于治疗特别是黑素瘤的杂环有机化合物
EP2102165A2 (de) * 2006-11-24 2009-09-23 AC Immune S.A. N-(methyl)-1h-pyrazol-3-amin, n-(methyl)-pyridin-2-amin und n-(methyl)-thiazol-2-amin derivate zur behandlung von krankheiten, die mit amyloid oder amyloid-ähnlichen proteinen zusammenhängen, wie z.b. alzheimer
US7902227B2 (en) 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
KR20170039758A (ko) 2008-09-24 2017-04-11 멜린타 테라퓨틱스, 인크. 퀴놀론 화합물의 제조 방법
EP2373166A4 (de) 2008-11-15 2014-11-05 Rib X Pharmaceuticals Inc Antimikrobielle zusammensetzungen
DE102009021535B8 (de) 2009-05-15 2012-12-13 Stabilo International Gmbh Verschlusskappe
EP2311823A1 (de) 2009-10-15 2011-04-20 AC Immune S.A. 2,6-Diaminopyridinverbindungen zur Behandlung von Krankheiten im Zusammenhang mit Amyloidproteinen oder zur Behandlung von Augenkrankheiten
KR20120101722A (ko) * 2009-12-25 2012-09-14 우베 고산 가부시키가이샤 아미노피리딘 화합물
CN103936717B (zh) * 2013-01-22 2016-08-10 上海医药工业研究院 一种delafloxacin中间体及其制备方法
CN103936718B (zh) * 2013-01-22 2016-06-29 上海医药工业研究院 一种高纯度delafloxacin的制备方法
EP2969004B1 (de) 2013-03-15 2026-02-25 Melinta Subsidiary Corp. Delafloxacin zur verwending in der behandlung von infektionen bei adipösen patienten
CN104098548B (zh) * 2013-04-11 2017-07-18 上海医药工业研究院 一种Delafloxacin的精制方法
TW201609652A (zh) * 2013-11-12 2016-03-16 陶氏農業科學公司 用於氟化化合物之過程（三）
CN104876911A (zh) * 2014-02-27 2015-09-02 南京工业大学 一种简易的方法合成德拉沙星
TWI732337B (zh) 2014-06-20 2021-07-01 美商梅琳塔有限責任公司 醫藥組成物及其用途
AU2015346023A1 (en) 2014-11-14 2017-06-01 Melinta Subsidiary Corp. Method for treating, preventing, or reducing the risk of skin infection
AU2017219216B2 (en) * 2016-02-19 2019-12-19 Novartis Ag Tetracyclic pyridone compounds as antivirals
CN108084161A (zh) * 2017-12-28 2018-05-29 北京沃邦医药科技有限公司 德拉沙星及其中间体的制备方法
CN108033948A (zh) * 2017-12-28 2018-05-15 北京沃邦医药科技有限公司 一种德拉沙星及其中间体的制备
CN114507230B (zh) * 2020-11-17 2023-07-21 西华大学 一种双环吡啶酮类衍生物、其合成方法及其用途
CN114539213A (zh) * 2021-08-18 2022-05-27 广东工业大学 一种氟喹诺酮类化合物及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3776917A (en) * 1972-06-05 1973-12-04 Schering Corp 2-amino-6-phenalkyl-aminopyridines and derivatives thereof
US3849429A (en) * 1973-03-30 1974-11-19 Olin Corp Halogenation of diaminopyridines in acidic media
DE2514558A1 (de) * 1974-04-12 1975-10-23 Sandoz Ag Neue organische verbindungen und verfahren zu deren herstellung
IE55898B1 (en) * 1982-09-09 1991-02-14 Warner Lambert Co Antibacterial agents
DE3337593A1 (de) * 1982-10-27 1984-05-03 Degussa Ag, 6000 Frankfurt 2-amino-3-acylamino-6-benzylamino-pyridin-derivate mit antiepileptischer wirkung
FR2548664B1 (fr) * 1983-07-06 1986-03-21 Provesan Sa Derives 7-(pyrrol-l-yl) des acides l-ethyl-1,4-dihydro-4-oxoquinoleine-3-carboxyliques et l-ethyl-1,4-dihydro-4-oxo-(1,8-naphtyridine)-3-carboxyliques substitues, leur preparation et leur application en tant que medicaments
US4994599A (en) * 1987-11-20 1991-02-19 Abbott Laboratories Intermediates for producing quinolone-3-carboxylic acids
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
SU1250565A1 (ru) * 1985-01-31 1986-08-15 Институт Химии Башкирского Филиала Ан Ссср Способ получени 2-аминопиридинов
DE3608762A1 (de) * 1985-03-23 1986-10-02 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von 2-amino-3-nitro-6-(4-fluor-benzylamino)-pyridin sowie 2-amino-3-carbethoxyamino-6-(4-fluor-benzylamino)-pyridin
US5328908A (en) * 1988-10-24 1994-07-12 Procter & Gamble Pharmaceuticals, Inc. Antimicrobial quinolone thioureas
JPH03112919A (ja) * 1989-09-26 1991-05-14 Kao Corp 角質繊維染色剤組成物
JPH03112966A (ja) * 1989-09-26 1991-05-14 Koei Chem Co Ltd ３―アルキル―２，６―ジアミノピリジンの製造法
JP2993316B2 (ja) * 1992-05-27 1999-12-20 宇部興産株式会社 アリール基又は複素芳香環基置換アミノキノロン誘導体及びエイズ治療剤
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
EP0713487B1 (de) * 1993-08-13 2000-04-19 Dong Wha Pharmaceutical Industrial Co. Ltd. Neue chinoloncarbonsäurederivate
DE4425659A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Neue N1-diverse 6-Fluor-8-difluormethoxy substituierte Chinoloncarbonsäuren
DE4425647A1 (de) * 1994-07-20 1996-01-25 Bayer Ag Heterocyclyl-1-phenyl substituierte Chinoloncarbonsäuren
EP0775114B1 (de) * 1994-08-02 2000-03-22 The Procter & Gamble Company Verfahren zur herstellung von antimikrobiellen verbindungen
JPH0848252A (ja) * 1994-08-04 1996-02-20 Otec Japan:Kk 荷 車
DE69531305T2 (de) * 1994-10-20 2004-05-13 Wakunaga Seiyaku K.K. Pyridoncarboxylat- derivate oder salze davon und antibakterielle zusammensetzungen die diese als aktiven bestandteil enthalten
CA2211681C (en) * 1995-01-30 2003-05-13 Wakunaga Seiyaku Kabushiki Kaisha Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient
NL1000360C2 (nl) * 1995-05-15 1996-11-18 Akzo Nobel Nv Werkwijze ter bereiding van pyridine-2, 6-diamines

Also Published As

Publication number Publication date
KR100343331B1 (ko) 2002-07-15
ES2183473T3 (es) 2003-03-16
US5998436A (en) 1999-12-07
HUP9904389A3 (en) 2002-03-28
CA2232728A1 (en) 1997-03-27
DE69617750D1 (de) 2002-01-17
DK0911327T3 (da) 2002-04-02
PT992501E (pt) 2003-01-31
JP3103380B2 (ja) 2000-10-30
HU225224B1 (en) 2006-08-28
PT911327E (pt) 2002-05-31
CA2290709C (en) 2003-11-04
EP0911327A1 (de) 1999-04-28
CA2290712C (en) 2003-09-09
HK1016602A1 (en) 1999-11-05
PT952151E (pt) 2003-10-31
ATE222906T1 (de) 2002-09-15
RU2000113595A (ru) 2004-02-20
BR9612862B8 (pt) 2014-08-05
JP3187795B2 (ja) 2001-07-11
WO1997011068A1 (en) 1997-03-27
CN1201459A (zh) 1998-12-09
EP0952151B1 (de) 2003-05-28
MX9802192A (es) 1998-09-30
CA2232728C (en) 2003-11-04
JP2000136191A (ja) 2000-05-16
KR19990063671A (ko) 1999-07-26
DK0992501T3 (da) 2002-10-28
US6156903A (en) 2000-12-05
BR9610485B8 (pt) 2014-08-05
CA2290709A1 (en) 1997-03-27
BR9610485A (pt) 1999-07-27
DK0952151T3 (da) 2003-09-22
HU9904390D0 (en) 2000-01-28
EP0992501A3 (de) 2001-09-05
HUP9902714A3 (en) 2002-03-28
EP0992501B1 (de) 2002-08-28
CN1196683C (zh) 2005-04-13
EP0952151A3 (de) 2001-08-01
RU2171252C2 (ru) 2001-07-27
JP3304311B2 (ja) 2002-07-22
DE69623358T2 (de) 2003-05-08
US6133284A (en) 2000-10-17
KR100299430B1 (ko) 2001-09-06
AU707565B2 (en) 1999-07-15
DE69617750T2 (de) 2002-08-08
AU7001696A (en) 1997-04-09
BR9610485B1 (pt) 2010-08-10
RU2177945C1 (ru) 2002-01-10
ES2169811T3 (es) 2002-07-16
EP0911327B1 (de) 2001-12-05
CN1258674A (zh) 2000-07-05
HUP9902714A2 (hu) 1999-12-28
AU3122799A (en) 1999-08-12
ATE241601T1 (de) 2003-06-15
ES2200439T3 (es) 2004-03-01
EP0911327A4 (de) 1999-04-28
HU225225B1 (en) 2006-08-28
HU9904389D0 (en) 2000-01-28
CN1258672A (zh) 2000-07-05
CA2290712A1 (en) 1997-03-27
HK1028032A1 (en) 2001-02-02
EP0952151A2 (de) 1999-10-27
DE69628466T2 (de) 2004-04-01
JPH11322715A (ja) 1999-11-24
RU2167873C2 (ru) 2001-05-27
CN1105715C (zh) 2003-04-16
EP0992501A2 (de) 2000-04-12
DE69623358D1 (de) 2002-10-02
DE69628466D1 (de) 2003-07-03
HUP9904390A3 (en) 2002-03-28
AU721805B2 (en) 2000-07-13
CN1136216C (zh) 2004-01-28

Similar Documents

Publication Publication Date Title
ATE210129T1 (de) Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten
DK0495776T3 (da) Stabiliserende nitrogenoxid/primær amin-komplekser, der er anvendelige som cardiovaskulære midler
DE60010076D1 (de) Chinolinderivate als antibakterielle mittel
ATE403430T1 (de) Neue carbamate- und harnstoffderivate als mittel gegen multidrugresistenz
PT1158973E (pt) Utilizacao de derivados de sulfamato para o tratamento dos disturbios do controlo de impulsos
DE69529670D1 (de) Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen
ATE346046T1 (de) Chinoline und deren in der 4-stellung durch eine piperazinhaltige gruppe substituierte nitrogenierte derivate und deren verwendung als antibakterielle mittel
DE60004504D1 (de) Tetrahydropyranderivate und deren verwendung als therapeutische mittel
DE69531305D1 (de) Pyridoncarboxylat- derivate oder salze davon und antibakterielle zusammensetzungen die diese als aktiven bestandteil enthalten
DE69315836D1 (de) Pyrazolpyridine für die behandlung der anämie
DE69708484D1 (de) Pyridinderivate,als Arzneimittel zur Behandlung von Geschwüren und als antibakterielle Mittel
DE69400352D1 (de) 3- oder 4-Glykosyloxybenzopyranderivat und dieses enthaltende antiallergisches Mittel
DE19780042D2 (de) Therapeutische Mittel, enthaltend organische Selenverbindungen gegen Asthma
DE69729565D1 (de) Neue pyridoncarbonsäure-derivate oder salze dieser derivate und antibakterielle mittel, die diese als aktiven wirkstoff enthalten
PT1144417E (pt) 4', 5'-di-hidropsolarenos substituidos na posicao 4' e suas utilizacoes terapeuticas
ATE220544T1 (de) Neue verwendung von pyrazolopyridinverbindungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification