ATE194284T1 - Angiotensin ii antagonisten als prophylaktisches und therapeutisches mittel für nierenkrankheiten - Google Patents

Angiotensin ii antagonisten als prophylaktisches und therapeutisches mittel für nierenkrankheiten

Info

Publication number: ATE194284T1
Authority: AT; Austria
Prior art keywords: stands; prophylactic; angiotensin; antagonists; therapeutic agent
Prior art date: 1993-04-22

Application number

AT94106203T

Other languages

English (en)

Inventor

Kohei Nishikawa

Yumiko Shibouta

Keiji Kubo

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-22

Filing date

1994-04-21

Publication date

2000-07-15

1994-04-21 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194284T1 publication Critical patent/ATE194284T1/de

Links

230000000069 prophylactic effect Effects 0.000 title abstract 2
229940123413 Angiotensin II antagonist Drugs 0.000 title 1
239000002333 angiotensin II receptor antagonist Substances 0.000 title 1
239000003814 drug Substances 0.000 title 1
208000017169 kidney disease Diseases 0.000 title 1
229940124597 therapeutic agent Drugs 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
208000007342 Diabetic Nephropathies Diseases 0.000 abstract 1
206010018364 Glomerulonephritis Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000033679 diabetic kidney disease Diseases 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
229940043274 prophylactic drug Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1
229940126585 therapeutic drug Drugs 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Obesity (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT94106203T 1993-04-22 1994-04-21 Angiotensin ii antagonisten als prophylaktisches und therapeutisches mittel für nierenkrankheiten ATE194284T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP9594293		1993-04-22

Publications (1)

Publication Number	Publication Date
ATE194284T1 true ATE194284T1 (de)	2000-07-15

Family

ID=14151326

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94106203T ATE194284T1 (de)	1993-04-22	1994-04-21	Angiotensin ii antagonisten als prophylaktisches und therapeutisches mittel für nierenkrankheiten

Country Status (12)

Country	Link
US (7)	US5719173A (de)
EP (1)	EP0622077B1 (de)
JP (1)	JP3810020B2 (de)
AT (1)	ATE194284T1 (de)
BR (1)	BR1100756KB1 (de)
CA (1)	CA2121871C (de)
CY (1)	CY2204B1 (de)
DE (1)	DE69425085T2 (de)
DK (1)	DK0622077T3 (de)
ES (1)	ES2149226T3 (de)
GR (1)	GR3033862T3 (de)
PT (1)	PT622077E (de)

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JP3810020B2 (ja)	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤
JP2003306432A (ja) *	1993-04-22	2003-10-28	Takeda Chem Ind Ltd	腎疾患の予防または治療剤
US5721263A (en) *	1993-06-07	1998-02-24	Takeda Chemical Industries, Ltd.	Pharmaceutical composition for angiotensin II-mediated diseases
US5918903A (en) *	1995-02-10	1999-07-06	Enshu Co., Ltd.	Seat belt hanging and holding member
EP0843559A2 (de) *	1996-06-11	1998-05-27	Zonagen, Inc.	Arzneistoffverabreichungssystem auf chitosanbasis
AU5576498A (en) *	1997-02-05	1998-08-26	Sankyo Company Limited	Prophylactic or therapeutic agent for diabetic complication
US8273866B2 (en) *	2002-02-20	2012-09-25	Merck Sharp & Dohme Corp.	RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
PL356422A1 (en) *	2000-02-18	2004-06-28	Takeda Chemical Industries, Ltd.	Tnf-alpha inhibitors
US7087608B2 (en)	2000-03-03	2006-08-08	Robert Charles Atkins	Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy
WO2004071534A1 (ja) *	2003-02-17	2004-08-26	Takeda Pharmaceutical Company Limited	腎疾患の予防・治療剤
US7021099B2 (en) *	2003-06-12	2006-04-04	General Motors Corporation	Extraction system for hot formed parts
US7301036B2 (en) *	2003-12-19	2007-11-27	Merck & Co., Inc.	Cyclic guanidines, compositions containing such compounds and methods of use
EP1806137A4 (de)	2004-10-29	2011-03-30	Kowa Co	Therapeutischer wirkstoff zur behandlung von glomerulärer erkrankung
TW200719896A (en) *	2005-04-18	2007-06-01	Astrazeneca Ab	Combination product
AR057455A1 (es)	2005-07-22	2007-12-05	Merck & Co Inc	Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica
AR065850A1 (es) *	2007-03-28	2009-07-08	Takeda Pharmaceutical	Composicion farmaceutica solida que comprende un derivado de benzimidazol-7-carboxilato y un agente de control de ph
WO2010047369A1 (ja) *	2008-10-22	2010-04-29	協和発酵キリン株式会社	糖尿病性腎症の治療剤
CN102933233A (zh)	2010-06-17	2013-02-13	日东电工株式会社	肾纤维化处理剂

Family Cites Families (23)

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US5128256A (en) *	1987-01-12	1992-07-07	Stratagene	DNA cloning vectors with in vivo excisable plasmids
DE3928177A1 (de) *	1989-04-08	1991-02-28	Thomae Gmbh Dr K	Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer
DE69013607T2 (de) *	1989-08-02	1995-03-02	Takeda Chemical Industries Ltd	Pyrazol-Derivate, Verfahren zu deren Herstellung und Anwendung.
DE3927170A1 (de) *	1989-08-17	1991-02-21	Boehringer Ingelheim Kg	Inhalator
IL95975A (en) *	1989-10-24	1997-06-10	Takeda Chemical Industries Ltd	N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them
US5250554A (en) *	1989-10-24	1993-10-05	Takeda Chemical Industries, Ltd.	Benzimidazole derivatives useful as angiotensin II inhibitors
EP0430300A3 (en) *	1989-12-01	1992-03-25	Takeda Chemical Industries, Ltd.	Xanthine derivatives, their production and use
EP0434038A1 (de) *	1989-12-22	1991-06-26	Takeda Chemical Industries, Ltd.	Kondensierte Imidazolderivate, ihre Herstellung und Verwendung
US5162326A (en) *	1990-02-15	1992-11-10	Takeda Chemical Industries, Ltd.	Pyrimidinedione derivatives, their production and use
US5284661A (en) *	1990-02-22	1994-02-08	Takeda Chemical Industries, Ltd.	Fused thiophene derivatives, their production and use
CA2037630C (en) *	1990-03-07	2001-07-03	Akira Morimoto	Nitrogen-containing heterocylic compounds, their production and use
US5196444A (en) *	1990-04-27	1993-03-23	Takeda Chemical Industries, Ltd.	1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
ES2121773T3 (es) *	1990-06-08	1998-12-16	Hoechst Marion Roussel Inc	Derivados de bencimidazol, su procedimiento de preparacion, productos intermedios, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
DE69123582T2 (de) *	1990-06-22	1997-05-15	E.I. Du Pont De Nemours & Co., Wilmington, Del.	Behandlung des chronischen nierenversagens mit imidazol-angiotensin-ii-rezeptorantagonisten
WO1992004343A1 (fr) *	1990-09-04	1992-03-19	Yamanouchi Pharmaceutical Co., Ltd.	Nouveau derive de tetrahydrobenzazole
AU636066B2 (en) *	1990-10-30	1993-04-08	Takeda Chemical Industries Ltd.	Thienoimidazole derivatives, their production and use
GB9027210D0 (en) *	1990-12-14	1991-02-06	Smithkline Beecham Plc	Medicaments
TW274551B (de) *	1991-04-16	1996-04-21	Takeda Pharm Industry Co Ltd
IL102183A (en) *	1991-06-27	1999-11-30	Takeda Chemical Industries Ltd	Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them
ATE264323T1 (de) *	1992-09-14	2004-04-15	Takeda Chemical Industries Ltd	Heterocyclische verbindungen und ihre verwendung als angiotensin ii antagonisten
EP0603712B1 (de) *	1992-12-22	2001-08-16	Takeda Chemical Industries, Ltd.	Heterocyclische Verbindungen mit Angiotensin-II-antagonistischer Wirkung und ihre Anwendung
JP3810020B2 (ja) *	1993-04-22	2006-08-16	武田薬品工業株式会社	腎疾患の予防または治療剤

1994
- 1994-04-20 JP JP08170594A patent/JP3810020B2/ja not_active Expired - Fee Related
- 1994-04-21 AT AT94106203T patent/ATE194284T1/de active
- 1994-04-21 CA CA002121871A patent/CA2121871C/en not_active Expired - Fee Related
- 1994-04-21 ES ES94106203T patent/ES2149226T3/es not_active Expired - Lifetime
- 1994-04-21 DE DE69425085T patent/DE69425085T2/de not_active Expired - Lifetime
- 1994-04-21 PT PT94106203T patent/PT622077E/pt unknown
- 1994-04-21 DK DK94106203T patent/DK0622077T3/da active
- 1994-04-21 EP EP94106203A patent/EP0622077B1/de not_active Expired - Lifetime
1996
- 1996-08-14 US US08/696,475 patent/US5719173A/en not_active Expired - Lifetime
1997
- 1997-05-12 BR BRPP1100756-7KB1A patent/BR1100756KB1/pt unknown
- 1997-11-06 US US08/965,416 patent/US5889036A/en not_active Expired - Lifetime
1998
- 1998-12-08 US US09/207,043 patent/US6040324A/en not_active Expired - Fee Related
1999
- 1999-12-20 US US09/467,488 patent/US6319938B1/en not_active Expired - Fee Related
2000
- 2000-07-06 GR GR20000401469T patent/GR3033862T3/el unknown
- 2000-12-08 CY CY0000058A patent/CY2204B1/xx unknown
2001
- 2001-10-16 US US09/977,476 patent/US6469037B2/en not_active Expired - Fee Related
2002
- 2002-08-26 US US10/227,537 patent/US6686383B2/en not_active Expired - Fee Related
2003
- 2003-10-02 US US10/676,118 patent/US7135490B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2121871C (en)	2006-12-12
DE69425085T2 (de)	2000-11-09
US20020045652A1 (en)	2002-04-18
US6469037B2 (en)	2002-10-22
EP0622077B1 (de)	2000-07-05
EP0622077A1 (de)	1994-11-02
JPH072667A (ja)	1995-01-06
US6040324A (en)	2000-03-21
PT622077E (pt)	2000-10-31
GR3033862T3 (en)	2000-10-31
CY2204B1 (en)	2002-11-08
US5889036A (en)	1999-03-30
US20040082636A1 (en)	2004-04-29
DE69425085D1 (de)	2000-08-10
DK0622077T3 (da)	2000-10-23
CA2121871A1 (en)	1994-10-23
JP3810020B2 (ja)	2006-08-16
US5719173A (en)	1998-02-17
US6686383B2 (en)	2004-02-03
US7135490B2 (en)	2006-11-14
ES2149226T3 (es)	2000-11-01
BR1100756KB1 (pt)	2011-10-18
US6319938B1 (en)	2001-11-20
US20030114509A1 (en)	2003-06-19

Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69425085D1 (de)	2000-08-10	Angiotensin II Antagonisten als prophylaktisches und therapeutisches Mittel für Nierenkrankheiten
DE69725978D1 (de)	2003-12-11	Chalcon-derivate und medikamente die diese enthalten
ATE239471T1 (de)	2003-05-15	Kombination eines angiotensin-ii antagonistisch wirkendes benzimidazols mit ein diuretikum
DE60010076D1 (de)	2004-05-27	Chinolinderivate als antibakterielle mittel
ATE165825T1 (de)	1998-05-15	Phenyl heterocyclen als cyclooxygenase-2 inhibitoren
ATE210129T1 (de)	2001-12-15	Neue pyridoncarbonsäure-derivate oder ihre salze und antibakterielle mittel, die diese als aktiven wirkstoff enthalten
ATE381542T1 (de)	2008-01-15	Nr1h4-kern-rezeptor-bindende verbindungen
ATE402164T1 (de)	2008-08-15	Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
MXPA03008756A (es)	2004-02-18	Derivados de n-(arilsulfonil) beta-aminoacidos que comprenden un grupo aminometilo substituido, el metodo de preparacion de los mismos y las composiciones farmaceuticas que los contienen.
ATE479655T1 (de)	2010-09-15	Neue aminoazetidin-, aminopyrrolidin- und aminopiperidinderivative
ATE377602T1 (de)	2007-11-15	Morphinanderivate und ihre medizinische anwendung
CA2534798A1 (en)	2005-03-31	Thiazole derivatives as cannabinoid receptor modulators
ATE433971T1 (de)	2009-07-15	Neue azolderivate
ATE337318T1 (de)	2006-09-15	Spiroverbindungen und diese als wirkstoff enthaltende adhäsionsmolekülinhibitoren
SG161217A1 (en)	2010-05-27	New heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents
YU40798A (en)	1999-11-22	Benzopyran derivatives having leukotriene-antagonistic action
SE0101038D0 (sv)	2001-03-23	Novel compounds
ATE373000T1 (de)	2007-09-15	Pyrazolopyridin-derivate als antiherpesmittel
ATE374751T1 (de)	2007-10-15	3,4-dihydro-1h-chinolin-2-onderivate als norepinephrin-wiederaufnahme-hemmern
ATE386716T1 (de)	2008-03-15	Biphenylderivate