ATE210727T1 - Abgeschwächtes impf- und gentransferase-virus, verfahren zu dessen herstellung und arzneimittel, das es enthält - Google Patents

Abgeschwächtes impf- und gentransferase-virus, verfahren zu dessen herstellung und arzneimittel, das es enthält

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Publication number
ATE210727T1
ATE210727T1 AT95933386T AT95933386T ATE210727T1 AT E210727 T1 ATE210727 T1 AT E210727T1 AT 95933386 T AT95933386 T AT 95933386T AT 95933386 T AT95933386 T AT 95933386T AT E210727 T1 ATE210727 T1 AT E210727T1
Authority
AT
Austria
Prior art keywords
virus
vrna
viral
promoter
progeny
Prior art date
Application number
AT95933386T
Other languages
English (en)
Inventor
Gerd Hobom
Gabriele Neumann
Annette Menke
Original Assignee
Hobom Gerd Prof Dr Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hobom Gerd Prof Dr Dr filed Critical Hobom Gerd Prof Dr Dr
Application granted granted Critical
Publication of ATE210727T1 publication Critical patent/ATE210727T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95933386T 1994-09-30 1995-09-18 Abgeschwächtes impf- und gentransferase-virus, verfahren zu dessen herstellung und arzneimittel, das es enthält ATE210727T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94115505A EP0704533A1 (de) 1994-09-30 1994-09-30 Abgeschwächtes Impfvirus, Verfahren zur dessen Herstellung und Arzneimittel die es enthalten
PCT/EP1995/003663 WO1996010641A1 (en) 1994-09-30 1995-09-18 An attenuated vaccination and gene-transfer virus, a method to make the virus and a pharmaceutical composition comprising the virus

Publications (1)

Publication Number Publication Date
ATE210727T1 true ATE210727T1 (de) 2001-12-15

Family

ID=8216345

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95933386T ATE210727T1 (de) 1994-09-30 1995-09-18 Abgeschwächtes impf- und gentransferase-virus, verfahren zu dessen herstellung und arzneimittel, das es enthält

Country Status (10)

Country Link
US (1) US6524588B1 (de)
EP (3) EP0704533A1 (de)
JP (1) JP2000509962A (de)
AT (1) ATE210727T1 (de)
AU (1) AU3607695A (de)
DE (1) DE69524618T2 (de)
ES (1) ES2165434T3 (de)
FI (1) FI971272A7 (de)
NZ (1) NZ293600A (de)
WO (1) WO1996010641A1 (de)

Families Citing this family (33)

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GB9809666D0 (en) * 1998-05-06 1998-07-01 Isis Innovation Modified viruses
EP1035209A1 (de) * 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stabile rekombinante Influenzaviren, die frei von Helfervirus sind
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
DE122008000035I1 (de) * 1999-04-06 2009-05-20 Wisconsin Alumni Res Found Rekombinante influenzaviren zur vakzinherstellung und gentherapie
EP1201760A1 (de) * 2000-10-30 2002-05-02 ARTEMIS Pharmaceuticals GmbH Influenza Virus Vektor für humane dentritische Zellen
US20030099670A1 (en) * 2001-02-09 2003-05-29 Gert Hobom Influenza viruses with enhanced transcriptional and replicational capacities
EA200701097A1 (ru) 2004-11-19 2007-10-26 Висконсин Эламни Рисёч Фаундэйшн Рекомбинантные векторы вируса гриппа с тандемными транскрипционными единицами
WO2007133682A2 (en) * 2006-05-11 2007-11-22 Geneohm Sciences, Inc. 100% sequence identity detection methods for variable genomes
BRPI0906452A2 (pt) * 2008-02-08 2015-07-14 Colgate Palmolive Co Composição, dispositivo, método para produzir ou inibir a formação de cáries dentais, reduzir, reparar ou inibir as leões pré-cárie do esmalte, reduzir ou inibir a desmineralização e promover a remineralização dos dentes, reduzir a hipersensibilidade dos dentes, reduzir ou inibir a gengivite, promover a cura de feridas ou de cortes na boca, reduzir os níveis de bactérias que produzem ácido, aumentar os níveis relativos de bactérias arginolíticas, inibir a formação de composição, dispositivo, método para reduzir ou inibir a formação de cáries dentais, reduzir, reparar ou inibir as leões pré-cárie dp esmalte, reduzir ou inibir a desmineralização e promover a remineralização dos dentes, reduzir a hipersibilidade dos dentes, reduzir ou inibir a gengivite, promover a cura de feridas ou de cortes na boca, reduzir os níveis de bactérias que produzem ácido, aumentar os níveis relativos de bactérias arginolíticas, inibir a formação de biofilme microbiano na cavidade oral, elevar e/ou manter o ph da placa em níveis de pelos menos um ph de 5,5, reduzir o acúmulo de placa, tratar, aliviar ou reduzir a boca seca, limpar os dentes e a cavidade oral, reduzir a erosão, branquear os dentes, imunizar os dentes contra as bactérias cariogênicas, e/ ou promover a saúde sistêmica, incluindo a saúde cardiovascular, e, uso de um aminoácido básico
CN101938955A (zh) 2008-02-08 2011-01-05 高露洁-棕榄公司 牙线
JP5624477B2 (ja) * 2008-02-08 2014-11-12 コルゲート・パーモリブ・カンパニーＣｏｌｇａｔｅ−Ｐａｌｍｏｌｉｖｅ Ｃｏｍｐａｎｙ 口腔ケア製品ならびにその使用および製造の方法
CN101938970A (zh) * 2008-02-08 2011-01-05 高露洁-棕榄公司 牙齿密封剂
TWI386176B (zh) * 2008-02-08 2013-02-21 Colgate Palmolive Co 口腔保健牙刷
CA2706516C (en) * 2008-02-08 2014-12-16 Colgate-Palmolive Company Cleaning compositions and methods
TW200950812A (en) * 2008-02-08 2009-12-16 Colgate Palmolive Co Effervescent compositions
EP2249794A4 (de) * 2008-02-08 2014-01-08 Colgate Palmolive Co Zusammensetzungen und verfahren mit basischen aminosäurepeptiden und proteasen
WO2009100277A2 (en) 2008-02-08 2009-08-13 Colgate-Palmolive Company Compositions and devices
JP2011511798A (ja) * 2008-02-08 2011-04-14 コルゲート・パーモリブ・カンパニー 塩基性アミノ酸および可溶性炭酸塩を含む組成物
TWI409084B (zh) * 2008-02-08 2013-09-21 美國棕欖公司 治療口乾症之組成物及方法
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
US9315464B1 (en) 2013-01-31 2016-04-19 Nant Holdings Ip, Llc Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN104593330A (zh) * 2015-01-19 2015-05-06 中国科学院微生物研究所 含有a型流感特异性启动子的重组293t细胞及其应用
US11197925B2 (en) 2016-02-19 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
EP3921413A1 (de) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanisierte zelllinie
CN114929269A (zh) 2019-05-01 2022-08-19 威斯康星校友研究基金会(Warf) 用于疫苗开发的改进的流感病毒复制
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたｎａを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166057A (en) * 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5690937A (en) * 1995-06-05 1997-11-25 Aviron Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene

Also Published As

Publication number Publication date
US6524588B1 (en) 2003-02-25
DE69524618T2 (de) 2002-08-14
WO1996010641A1 (en) 1996-04-11
ES2165434T3 (es) 2002-03-16
EP0783586A1 (de) 1997-07-16
FI971272A7 (fi) 1997-05-26
AU3607695A (en) 1996-04-26
EP0783586B1 (de) 2001-12-12
JP2000509962A (ja) 2000-08-08
EP1091000A1 (de) 2001-04-11
NZ293600A (en) 1999-01-28
DE69524618D1 (de) 2002-01-24
FI971272A0 (fi) 1997-03-26
EP0704533A1 (de) 1996-04-03

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