ATE211140T1 - Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel - Google Patents

Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel

Info

Publication number: ATE211140T1
Authority: AT; Austria
Prior art keywords: group; pct; optionally substituted; alkaloids; alkyl
Prior art date: 1996-05-10

Application number

AT97922937T

Other languages

English (en)

Inventor

Ezio Bombardelli

Luisella Verotta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1997-05-02

Publication date

2002-01-15

1997-05-02 Application filed by Indena Spa filed Critical Indena Spa

2002-01-15 Application granted granted Critical

2002-01-15 Publication of ATE211140T1 publication Critical patent/ATE211140T1/de

Links

241000261227 Mappia foetida Species 0.000 title abstract 3
229940126601 medicinal product Drugs 0.000 title 1
229930013930 alkaloid Natural products 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004754 (C2-C12) dialkylamino group Chemical group 0.000 abstract 1
WSXJPXFVULHYMX-KRWDZBQOSA-N 7-[(1s)-1-hydroxypropyl]-8-methyl-11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)[C@@H](O)CC)C4=NC2=C1 WSXJPXFVULHYMX-KRWDZBQOSA-N 0.000 abstract 1
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
WSXJPXFVULHYMX-UHFFFAOYSA-N S-Mappicine Natural products C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(O)CC)C4=NC2=C1 WSXJPXFVULHYMX-UHFFFAOYSA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
229940127093 camptothecin Drugs 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

AT97922937T 1996-05-10 1997-05-02 Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel ATE211140T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT96MI000944A IT1283635B1 (it)	1996-05-10	1996-05-10	Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi
PCT/EP1997/002244 WO1997043290A1 (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents

Publications (1)

Publication Number	Publication Date
ATE211140T1 true ATE211140T1 (de)	2002-01-15

Family

ID=11374242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97922937T ATE211140T1 (de)	1996-05-10	1997-05-02	Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel

Country Status (19)

Country	Link
US (1)	US6121277A (de)
EP (1)	EP0912573B1 (de)
JP (1)	JP3483257B2 (de)
KR (1)	KR20000010893A (de)
CN (1)	CN1082509C (de)
AT (1)	ATE211140T1 (de)
AU (1)	AU715482B2 (de)
CA (1)	CA2253914C (de)
CZ (1)	CZ287901B6 (de)
DE (1)	DE69709357T2 (de)
DK (1)	DK0912573T3 (de)
ES (1)	ES2169389T3 (de)
IT (1)	IT1283635B1 (de)
NO (1)	NO311839B1 (de)
PL (1)	PL188228B1 (de)
PT (1)	PT912573E (de)
RU (1)	RU2169149C2 (de)
SK (1)	SK283050B6 (de)
WO (1)	WO1997043290A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2792937B1 (fr)	1999-04-27	2001-08-10	Cemaf	NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7312228B2 (en)	2003-05-12	2007-12-25	Purdue Research Foundation	Cytotoxic indeno and isoindoloisoquinolones
ITMI20051348A1 (it) *	2005-07-14	2007-01-15	Indena Spa	Analoghi della camptotecina loro processo di ottenimento loro uso e formulazioni che li contengono
CN100339377C (zh) *	2005-09-05	2007-09-26	合肥中科大生物技术有限公司	喜树碱衍生物及其制备
CN1319971C (zh) *	2005-09-09	2007-06-06	合肥中科大生物技术有限公司	喜树碱衍生物及其用途
WO2012176145A1 (en) *	2011-06-22	2012-12-27	Council Of Scientific & Industrial Research	Insecticidal compositions isolated from nothapodites foetida and process for the extraction thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
RU2133732C1 (ru) *	1995-03-27	1999-07-27	Глитч, Инк.	Способ извлечения карбоновых кислот из водного раствора

1996
- 1996-05-10 IT IT96MI000944A patent/IT1283635B1/it active IP Right Grant
1997
- 1997-05-02 PL PL97329765A patent/PL188228B1/pl not_active IP Right Cessation
- 1997-05-02 ES ES97922937T patent/ES2169389T3/es not_active Expired - Lifetime
- 1997-05-02 KR KR1019980709040A patent/KR20000010893A/ko not_active Ceased
- 1997-05-02 US US09/155,960 patent/US6121277A/en not_active Expired - Fee Related
- 1997-05-02 WO PCT/EP1997/002244 patent/WO1997043290A1/en not_active Ceased
- 1997-05-02 PT PT97922937T patent/PT912573E/pt unknown
- 1997-05-02 CN CN97194492A patent/CN1082509C/zh not_active Expired - Fee Related
- 1997-05-02 JP JP54044797A patent/JP3483257B2/ja not_active Expired - Fee Related
- 1997-05-02 SK SK1540-98A patent/SK283050B6/sk not_active IP Right Cessation
- 1997-05-02 RU RU98122224/04A patent/RU2169149C2/ru not_active IP Right Cessation
- 1997-05-02 CZ CZ19983620A patent/CZ287901B6/cs not_active IP Right Cessation
- 1997-05-02 DK DK97922937T patent/DK0912573T3/da active
- 1997-05-02 EP EP97922937A patent/EP0912573B1/de not_active Expired - Lifetime
- 1997-05-02 AU AU28901/97A patent/AU715482B2/en not_active Ceased
- 1997-05-02 AT AT97922937T patent/ATE211140T1/de not_active IP Right Cessation
- 1997-05-02 DE DE69709357T patent/DE69709357T2/de not_active Expired - Lifetime
- 1997-05-02 CA CA002253914A patent/CA2253914C/en not_active Expired - Fee Related
1998
- 1998-11-06 NO NO19985186A patent/NO311839B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT1283635B1 (it)	1998-04-23
PL188228B1 (pl)	2004-12-31
ITMI960944A1 (it)	1997-11-10
WO1997043290A1 (en)	1997-11-20
AU715482B2 (en)	2000-02-03
KR20000010893A (ko)	2000-02-25
SK154098A3 (en)	1999-04-13
JP2000503666A (ja)	2000-03-28
RU2169149C2 (ru)	2001-06-20
EP0912573B1 (de)	2001-12-19
NO985186L (no)	1998-11-06
JP3483257B2 (ja)	2004-01-06
CA2253914C (en)	2002-10-22
HK1019600A1 (en)	2000-02-18
DK0912573T3 (da)	2002-04-15
DE69709357T2 (de)	2002-08-22
NO311839B1 (no)	2002-02-04
CN1082509C (zh)	2002-04-10
CN1218474A (zh)	1999-06-02
DE69709357D1 (de)	2002-01-31
ES2169389T3 (es)	2002-07-01
SK283050B6 (sk)	2003-02-04
NO985186D0 (no)	1998-11-06
EP0912573A1 (de)	1999-05-06
CZ362098A3 (cs)	1999-06-16
CA2253914A1 (en)	1997-11-20
PT912573E (pt)	2002-06-28
US6121277A (en)	2000-09-19
CZ287901B6 (cs)	2001-03-14
AU2890197A (en)	1997-12-05
ITMI960944A0 (de)	1996-05-10
PL329765A1 (en)	1999-04-12

Legal Events

Date	Code	Title	Description
2002-04-15	UEP	Publication of translation of european patent specification
2012-02-15	REN	Ceased due to non-payment of the annual fee

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AP9701039A0 (en)	1997-07-31	Derivatives of 2- (2-oxo-ethlidene)-imidazolidin-4-one.
ATE203515T1 (de)	2001-08-15	Meta-substituierte phenylsulphonamidderivate
BG103964A (en)	2000-08-31	SUBSTITUTED PYRAZOLS AS p38 KINASE INHIBITORS
YU40997A (sh)	2000-10-30	Novi oksadiazoli, postupci za njihovo pripremanje
MEP24608A (en)	2010-10-10	Azetidine derivatives, preparation thereof and pharmaceutical compositions containing same
TR199802202T2 (xx)	1999-02-22	�kameli indezol t�revleri; t�m�r nekroz fakt�r� (TNF) �retimi.
PL327466A1 (en)	1998-12-07	Novel derivatives of barbituric acid, method of obtaining them and pharmaceutic agents containing such compounds
DE69622031D1 (de)	2002-08-01	INDOLDERIVATE ALS cGMP-PDE INHIBITOREN
PT918776E (pt)	2004-07-30	Sintese total de acilfulvenos antitumorais
EP0901469A4 (de)	2000-11-15	Arylalkylpiperazin-verbindungen als antioxidantien
IL136359A (en)	2003-03-12	Dihydrobenzofuran substituted phthalazin-1-one derivatives and pharmaceutical compositions containing the same
MXPA02011352A (es)	2005-07-01	Nuevos derivados de benzofurano.
DE69709357D1 (de)	2002-01-31	Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel
ES2125161A1 (es)	1999-02-16	Nuevos derivados de 2-(3h)-oxazolona.
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
AU2713897A (en)	1997-12-05	Antiviral 2,4-pyrimidinedione derivatives and process for the preparation thereof
EP0335979A4 (en)	1992-02-26	Thienopyrimidine derivatives
DE59304311D1 (de)	1996-11-28	N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika
MXPA04001171A (es)	2004-05-20	Compuestos policiclicos condensados.
CA2203850A1 (en)	1997-10-30	Novel n-phenyl-n-phenyliminonethylbenzamidines and their analogues as muscarinic receptor agonists
EP0315434A3 (de)	1990-01-10	Pyridoxalhydrazon-Derivate, ihre Herstellung und Verwendung und diese enthaltende Arzneimittel
EP0547231A4 (en)	1994-06-08	Phospholipase a 2? inhibitor
YU78100A (sh)	2003-04-30	4,5,6 i 7-indol i indolin derivati, njihova izrada i upotreba
NO20003604D0 (no)	2000-07-13	Nye tricykliske forbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem