IT1283635B1 - Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi - Google Patents

Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi

Info

Publication number: IT1283635B1
Authority: IT; Italy
Prior art keywords: group; pct; optionally substituted; alkaloids; mappia foetida
Prior art date: 1996-05-10

Application number

IT96MI000944A

Other languages

English (en)

Inventor

Ezio Bombardelli

Luisella Verotta

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-10

Filing date

1996-05-10

Publication date

1998-04-23

1996-05-10 Application filed by Indena Spa filed Critical Indena Spa

1996-05-10 Publication of ITMI960944A0 publication Critical patent/ITMI960944A0/it

1996-05-10 Priority to IT96MI000944A priority Critical patent/IT1283635B1/it

1997-05-02 Priority to PT97922937T priority patent/PT912573E/pt

1997-05-02 Priority to SI9730181T priority patent/SI0912573T1/xx

1997-05-02 Priority to PCT/EP1997/002244 priority patent/WO1997043290A1/en

1997-05-02 Priority to CA002253914A priority patent/CA2253914C/en

1997-05-02 Priority to EP97922937A priority patent/EP0912573B1/en

1997-05-02 Priority to US09/155,960 priority patent/US6121277A/en

1997-05-02 Priority to SK1540-98A priority patent/SK283050B6/sk

1997-05-02 Priority to DE69709357T priority patent/DE69709357T2/de

1997-05-02 Priority to HK99104790.6A priority patent/HK1019600B/xx

1997-05-02 Priority to KR1019980709040A priority patent/KR20000010893A/ko

1997-05-02 Priority to CZ19983620A priority patent/CZ287901B6/cs

1997-05-02 Priority to RU98122224/04A priority patent/RU2169149C2/ru

1997-05-02 Priority to AU28901/97A priority patent/AU715482B2/en

1997-05-02 Priority to JP54044797A priority patent/JP3483257B2/ja

1997-05-02 Priority to PL97329765A priority patent/PL188228B1/pl

1997-05-02 Priority to CN97194492A priority patent/CN1082509C/zh

1997-05-02 Priority to ES97922937T priority patent/ES2169389T3/es

1997-05-02 Priority to DK97922937T priority patent/DK0912573T3/da

1997-05-02 Priority to AT97922937T priority patent/ATE211140T1/de

1997-11-10 Publication of ITMI960944A1 publication Critical patent/ITMI960944A1/it

1998-04-23 Application granted granted Critical

1998-04-23 Publication of IT1283635B1 publication Critical patent/IT1283635B1/it

1998-11-06 Priority to NO19985186A priority patent/NO311839B1/no

Links

241000261227 Mappia foetida Species 0.000 title abstract 3
239000004480 active ingredient Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
239000003814 drug Substances 0.000 title 1
229940079593 drug Drugs 0.000 title 1
229930013930 alkaloid Natural products 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000004754 (C2-C12) dialkylamino group Chemical group 0.000 abstract 1
WSXJPXFVULHYMX-KRWDZBQOSA-N 7-[(1s)-1-hydroxypropyl]-8-methyl-11h-indolizino[1,2-b]quinolin-9-one Chemical compound C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)[C@@H](O)CC)C4=NC2=C1 WSXJPXFVULHYMX-KRWDZBQOSA-N 0.000 abstract 1
KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
101100295738 Gallus gallus COR3 gene Proteins 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
WSXJPXFVULHYMX-UHFFFAOYSA-N S-Mappicine Natural products C1=CC=C2C=C(CN3C4=CC(=C(C3=O)C)C(O)CC)C4=NC2=C1 WSXJPXFVULHYMX-UHFFFAOYSA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000001769 aryl amino group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
229940127093 camptothecin Drugs 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
229910052700 potassium Inorganic materials 0.000 abstract 1
239000011591 potassium Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)

IT96MI000944A 1996-05-10 1996-05-10 Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi IT1283635B1 (it)

Priority Applications (21)

Application Number	Priority Date	Filing Date	Title
IT96MI000944A IT1283635B1 (it)	1996-05-10	1996-05-10	Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi
KR1019980709040A KR20000010893A (ko)	1996-05-10	1997-05-02	마피아 포에티다(mappia foetida)에서 분리한캄토테신골격화합물 및 이들의 신규한 치료제 및 의약품기질로서의 용도
RU98122224/04A RU2169149C2 (ru)	1996-05-10	1997-05-02	Соединения со структурой камптотецина, способы их получения, фармацевтические композиции
PCT/EP1997/002244 WO1997043290A1 (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
CA002253914A CA2253914C (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
EP97922937A EP0912573B1 (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
US09/155,960 US6121277A (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from Mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
SK1540-98A SK283050B6 (sk)	1996-05-10	1997-05-02	Kamptotecínové alkaloidy, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
DE69709357T DE69709357T2 (de)	1996-05-10	1997-05-02	Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel
HK99104790.6A HK1019600B (en)	1996-05-10	1997-05-02	Camtothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
PT97922937T PT912573E (pt)	1996-05-10	1997-05-02	Compostos com o esqueleto da camptotecina isolados a partir de mappia foetida e sua utilizacao como sintoes para novos medicamentos bem como agentes terapeuticos
CZ19983620A CZ287901B6 (cs)	1996-05-10	1997-05-02	Deriváty camptothecinu a farmaceutický prostředek
SI9730181T SI0912573T1 (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
AU28901/97A AU715482B2 (en)	1996-05-10	1997-05-02	Camptothecin-skeleton compounds isolated from mappia foetida and the use thereof as syntones for novel medicaments as well as therapeutical agents
JP54044797A JP3483257B2 (ja)	1996-05-10	1997-05-02	Ｍａｐｐｉａｆｏｅｔｉｄａから単離したカンプトセシン―骨格化合物および新規な医薬ならびに治療薬のためのシントンとしてのその使用
PL97329765A PL188228B1 (pl)	1996-05-10	1997-05-02	Związki o szkielecie kamptotecyny, sposób ich wytwarzania i kompozycja farmaceutyczna je zawierająca
CN97194492A CN1082509C (zh)	1996-05-10	1997-05-02	从马比木分离的喜树碱骨架化合物及其作为新药物及治疗剂的合成子的用途
ES97922937T ES2169389T3 (es)	1996-05-10	1997-05-02	Compuestos de esqueleto de camptotecina aislados a partir de mappia foetida y el uso de los mismos como sintones para nuevos medicamentos, asi como agentes terapeuticos.
DK97922937T DK0912573T3 (da)	1996-05-10	1997-05-02	Camptothecinderivater, som er isoleret fra Mappia foetida, og anvendelse deraf som syntoner for nye lægemidler og som terapeutiske midler
AT97922937T ATE211140T1 (de)	1996-05-10	1997-05-02	Campothecinderivate, isoliert aus mappia foetida, und ihre verwendung als arzneimittel
NO19985186A NO311839B1 (no)	1996-05-10	1998-11-06	Forbindelser med camptothecin-grunnstruktur, isolert fra Mappia foetida, og anvendelse derav som utgangsmaterialer for nyelegemidler samt som terapeutiske midler

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT96MI000944A IT1283635B1 (it)	1996-05-10	1996-05-10	Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi

Publications (3)

Publication Number	Publication Date
ITMI960944A0 ITMI960944A0 (it)	1996-05-10
ITMI960944A1 ITMI960944A1 (it)	1997-11-10
IT1283635B1 true IT1283635B1 (it)	1998-04-23

Family

ID=11374242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT96MI000944A IT1283635B1 (it)	1996-05-10	1996-05-10	Composti a scheletro camptotecinico isolati da mappia foetida e loro uso come sintoni per farmaci o come principi attivi

Country Status (19)

Country	Link
US (1)	US6121277A (it)
EP (1)	EP0912573B1 (it)
JP (1)	JP3483257B2 (it)
KR (1)	KR20000010893A (it)
CN (1)	CN1082509C (it)
AT (1)	ATE211140T1 (it)
AU (1)	AU715482B2 (it)
CA (1)	CA2253914C (it)
CZ (1)	CZ287901B6 (it)
DE (1)	DE69709357T2 (it)
DK (1)	DK0912573T3 (it)
ES (1)	ES2169389T3 (it)
IT (1)	IT1283635B1 (it)
NO (1)	NO311839B1 (it)
PL (1)	PL188228B1 (it)
PT (1)	PT912573E (it)
RU (1)	RU2169149C2 (it)
SK (1)	SK283050B6 (it)
WO (1)	WO1997043290A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2792937B1 (fr)	1999-04-27	2001-08-10	Cemaf	NOUVEAUX DERIVES DE PYRROLO-(3,4-b) QUINOLEINE, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION A TITRE DE MEDICAMENT
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7312228B2 (en)	2003-05-12	2007-12-25	Purdue Research Foundation	Cytotoxic indeno and isoindoloisoquinolones
ITMI20051348A1 (it) *	2005-07-14	2007-01-15	Indena Spa	Analoghi della camptotecina loro processo di ottenimento loro uso e formulazioni che li contengono
CN100339377C (zh) *	2005-09-05	2007-09-26	合肥中科大生物技术有限公司	喜树碱衍生物及其制备
CN1319971C (zh) *	2005-09-09	2007-06-06	合肥中科大生物技术有限公司	喜树碱衍生物及其用途
WO2012176145A1 (en) *	2011-06-22	2012-12-27	Council Of Scientific & Industrial Research	Insecticidal compositions isolated from nothapodites foetida and process for the extraction thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1269862B (it) *	1994-05-30	1997-04-15	Indena Spa	Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
RU2133732C1 (ru) *	1995-03-27	1999-07-27	Глитч, Инк.	Способ извлечения карбоновых кислот из водного раствора

1996
- 1996-05-10 IT IT96MI000944A patent/IT1283635B1/it active IP Right Grant
1997
- 1997-05-02 PL PL97329765A patent/PL188228B1/pl not_active IP Right Cessation
- 1997-05-02 ES ES97922937T patent/ES2169389T3/es not_active Expired - Lifetime
- 1997-05-02 KR KR1019980709040A patent/KR20000010893A/ko not_active Ceased
- 1997-05-02 US US09/155,960 patent/US6121277A/en not_active Expired - Fee Related
- 1997-05-02 WO PCT/EP1997/002244 patent/WO1997043290A1/en not_active Ceased
- 1997-05-02 PT PT97922937T patent/PT912573E/pt unknown
- 1997-05-02 CN CN97194492A patent/CN1082509C/zh not_active Expired - Fee Related
- 1997-05-02 JP JP54044797A patent/JP3483257B2/ja not_active Expired - Fee Related
- 1997-05-02 SK SK1540-98A patent/SK283050B6/sk not_active IP Right Cessation
- 1997-05-02 RU RU98122224/04A patent/RU2169149C2/ru not_active IP Right Cessation
- 1997-05-02 CZ CZ19983620A patent/CZ287901B6/cs not_active IP Right Cessation
- 1997-05-02 DK DK97922937T patent/DK0912573T3/da active
- 1997-05-02 EP EP97922937A patent/EP0912573B1/en not_active Expired - Lifetime
- 1997-05-02 AU AU28901/97A patent/AU715482B2/en not_active Ceased
- 1997-05-02 AT AT97922937T patent/ATE211140T1/de not_active IP Right Cessation
- 1997-05-02 DE DE69709357T patent/DE69709357T2/de not_active Expired - Lifetime
- 1997-05-02 CA CA002253914A patent/CA2253914C/en not_active Expired - Fee Related
1998
- 1998-11-06 NO NO19985186A patent/NO311839B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL188228B1 (pl)	2004-12-31
ITMI960944A1 (it)	1997-11-10
WO1997043290A1 (en)	1997-11-20
ATE211140T1 (de)	2002-01-15
AU715482B2 (en)	2000-02-03
KR20000010893A (ko)	2000-02-25
SK154098A3 (en)	1999-04-13
JP2000503666A (ja)	2000-03-28
RU2169149C2 (ru)	2001-06-20
EP0912573B1 (en)	2001-12-19
NO985186L (no)	1998-11-06
JP3483257B2 (ja)	2004-01-06
CA2253914C (en)	2002-10-22
HK1019600A1 (en)	2000-02-18
DK0912573T3 (da)	2002-04-15
DE69709357T2 (de)	2002-08-22
NO311839B1 (no)	2002-02-04
CN1082509C (zh)	2002-04-10
CN1218474A (zh)	1999-06-02
DE69709357D1 (de)	2002-01-31
ES2169389T3 (es)	2002-07-01
SK283050B6 (sk)	2003-02-04
NO985186D0 (no)	1998-11-06
EP0912573A1 (en)	1999-05-06
CZ362098A3 (cs)	1999-06-16
CA2253914A1 (en)	1997-11-20
PT912573E (pt)	2002-06-28
US6121277A (en)	2000-09-19
CZ287901B6 (cs)	2001-03-14
AU2890197A (en)	1997-12-05
ITMI960944A0 (it)	1996-05-10
PL329765A1 (en)	1999-04-12

Legal Events

Date	Code	Title	Description
1998-04-23	0001	Granted

Publication	Publication Date	Title
BR0111263A (pt)	2003-06-17	Derivados de 2-aminocarbonil-9h-purina
YU40997A (sh)	2000-10-30	Novi oksadiazoli, postupci za njihovo pripremanje
NO20005715L (no)	2000-11-13	Nye substituerte cykliske forbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske sammensetninger inneholdende dem
DK0889877T3 (da)	2001-10-01	Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
IT1230859B (it)	1991-11-08	2 alchinilfenoli sostituiti ad azione anti infiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
EA200000431A3 (ru)	2001-02-26	Новые замещенные димерные соединения, способ их получения и фармацевтические композиции, содержащие их
MXPA02011352A (es)	2005-07-01	Nuevos derivados de benzofurano.
BR9710614A (pt)	2000-01-11	Esteres arilcicloalcanos carboxìlicos, seu uso, composição farmacêutica e preparação.
PL329765A1 (en)	1999-04-12	Compounds having a camtotectin skeleton solated from mappia foetida and their application as syntones in novel drugs and as therapeutic agents as well
NO960441L (no)	1996-02-02	Benzopyraner og farmasöytiske forbindelser inneholdende dem
EP0335979A4 (en)	1992-02-26	Thienopyrimidine derivatives
MXPA04001171A (es)	2004-05-20	Compuestos policiclicos condensados.
DE69629474D1 (de)	2003-09-18	Antifungale tetrahydrofurane
ES2194320T3 (es)	2003-11-16	Sustancias naturales antivirales o antitumorales y uso de las mismas.
FR2756562B1 (fr)	1999-01-08	Nouveaux composes de n-benzenesulfonyl-l-proline, procede de preparation et utilisation en therapeutique
NO20003604L (no)	2000-09-12	Nye tricykliske forbindelser, fremgangsmÕte ved deres fremstilling og farmasøytiske sammensetninger inneholdende dem
AU6509190A (en)	1991-04-28	Fungicidal 3-imino-1,4-oxathiins
AU5588598A (en)	1998-06-10	Heregulin antagonists and methods for their use
AU562377B2 (en)	1987-06-11	1,1-diphenyl-propanol-derivatives
EP0049999A3 (en)	1982-06-23	Cyclic compounds and their preparation and use
ES8707939A1 (es)	1987-09-01	Procedimiento para preparar derivados de n-carboxialquil-2--oxo-3-diaril-5,6-triazinas
EA200001157A2 (ru)	2001-06-25	Новые замещенные производные (дигидро)бензоксазина и (дигидро)бензотиазина, способ их получения и содержащие их фармацевтические композиции
PT1317413E (pt)	2005-11-30	Derivados bifenilados substituidos, processo para a sua preparacao e as composicoes farmaceuticas que os contem
GB0114699D0 (en)	2001-08-08	Organic compounds
DE69528984D1 (de)	2003-01-09	Hemmung der leukotrienbiosynthese mittels harnstoffderivaten